Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Article, Journal of Chromatography A called Chiral determination of nornicotine, anatabine and anabasine in tobacco by achiral gas chromatography with (1S)-(-)-camphanic chloride derivatization: Application to enantiomeric profiling of cultivars and curing processes, Author is Cai, Kai; Zhao, Huina; Yin, Runsheng; Lin, Yechun; Lei, Bo; Wang, Anping; Pan, Wenjie; Cai, Bin; Gao, Weichang; Wang, Feng, the main research direction is Chiral determination nornicotine anatabine anabasine tobacco; Alkaloids; Chiral derivatization; Cultivars; Curing processes; Tobacco; Validation.Safety of (S)-3-(Piperidin-2-yl)pyridine.
The alkaloid enantiomers are well-known to have different physiol. and pharmacol. effects, and to play an important role in enantioselectivity metabolism with enzymes catalysis in tobacco plants. Here, we developed an improved method for simultaneous and high-precision determination of the individual enantiomers of nornicotine, anatabine and anabasine in four tobacco matrixes, based on an achiral gas chromatog.-nitrogen phosphorus detector (GC-NPD) with commonly available Rtx-200 column using (1S)-(-)-camphanic chloride derivatization. The method development consists of the optimization of extraction and derivatization, screening of achiral column, anal. of the fragmentation mechanisms and evaluation of matrix effect (ME). Under the optimized exptl. conditions, the current method exhibited excellent detection capability for the alkaloid enantiomers, with coefficients of determination (R2) > 0.9989 and normality test of residuals P > 0.05 in linear regression parameters. The ME can be neglected for the camphanic derivatives The limit of detection (LOD) and limit of quantitation (LOQ) ranged from 0.087 to 0.24μg g – 1 and 0.29 to 0.81μg g – 1, resp. The recoveries and within-laboratory relative standard deviations (RSDR) were 94.3%∼104.2% and 0.51%∼3.89%, resp. The developed method was successfully applied to determine the enantiomeric profiling of cultivars and curing processes. Tobacco cultivars had a significant impact on the nornicotine, anatabine, anabasine concentration and enantiomeric fraction (EF) of (R)-nornicotine, whereas the only significant change induced by the curing processes was an increase in the EF of (R)-anabasine.
When you point to this article, it is believed that you are also very interested in this compound(494-52-0)Safety of (S)-3-(Piperidin-2-yl)pyridine and due to space limitations, I can only present the most important information.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI