Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6813-38-3,[2,2′-Bipyridine]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.,6813-38-3

Thionyl chloride (300muL, 4.08mmol) was added to a suspension of 16 (400mg, 1.62mmol) in MeOH (30mL) in a dropwise fashion. The mixture was heated at reflux temperature overnight. Then, the solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 and water. The organic layer was washed with saturated aqueous NaHCO3 solution and dried over Na2SO4. Filtration, evaporation in vacuo, and recrystallization in AcOEt gave 17 (400mg, 91%): mp 200-202C; 1H NMR (CDCl3, 300MHz, delta; ppm), 8.92 (2H, d, J=4.2Hz), 8.85 (2H, s), 7.91 (2H, d, J=3.3Hz); 13C NMR (CDCl3, 75MHz, delta; ppm), 166.5, 156.0, 151.1, 140.0, 123.9, 120.0; MS (ESI) m/z 273.0 (MH+).

The synthetic route of 6813-38-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Miyake, Yuka; Itoh, Yukihiro; Hatanaka, Atsushi; Suzuma, Yoshinori; Suzuki, Miki; Kodama, Hidehiko; Arai, Yoshinobu; Suzuki, Takayoshi; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 1119 – 1129;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.

4-Hydroxyphenylacetic acid (40 mg, 0.263 mmol) and cinchonidine (77.4 mg, 0.263 mmol) were dissolved in isopropanol (IPA). The solution was left to evaporate and crystals were obtained after one week

The synthetic route of 485-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Amombo Noa, Francoise M.; Jacobs, Ayesha; Journal of Molecular Structure; vol. 1114; (2016); p. 30 – 37;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D-Tryptophan (100 g), and PTSA.H20 (186.28 g) were added to allyl alcohol (1000 ml) stirred at 25 to 35C, followed by addition of toluene (500ml). The resulting mixture was stirred at 80-95C till completion of reaction, as monitored by TLC. After completion, the mass was cooled, and 5% aqueous sodium bicarbonate solution was added to it. Extraction with ethyl acetate followed by separation and concentration of the organic layer gave a residue containing H-D-Trp-OAll (11). Yield: 108.01 g (90.3%) Purity: > 95% (HPLC)

153-94-6, As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.

Reference£º
Patent; EMCURE PHARMACEUTICALS LIMITED; GURJAR, Mukund Keshav; TRIPATHY, Narendra Kumar; PRAMANIK, Chinmoy Mriganka; DESHPANDE, Ashish Pramod; (25 pag.)WO2017/178950; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

(2); Synthesis of Rh+{2,2′-bis(diphenylphosphinyl)benzophenone} {(S,S)-DPEN}(SbF6-); Into [Rh+{2,2′-bis(diphenylphosphinyl)benzophenone}(cod)](SbF6-) obtained in the (1) after the distillation under reduced pressure were added 21.2 mg (0.1 mmol) of (S,S)-DPEN and 2 ml of methylene chloride, and then the solution was stirred under hydrogen atmosphere for 1 hour. The solvent was distilled off under reduced pressure and then the residue was dried to give 110 mg (yield: > 99%) of the title compound. 31p NMR (CDCl3) delta ppm; 48.28, 57.04 (2dd, Jp-p = 40.5 Hzo, Jp-Rh = 157.9 Hzo).

29841-69-8, As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

Reference£º
Patent; Takasago International Corporation; EP1661903; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 10 mL methanolic solution of pyridine-2-carboxamide (0.3663 g, 3 mmol) and 10 mL methanolic solution of 4,4′-dimethoxy-2,2′-bipyridine (0.2162 g, 1 mmol) was stirred at room temperature for half an hour. Solution of EuCl3 was prepared by dissolving 1 mmol (0.2583 g) of EuCl3 in 10 mL of methanol and this solution was added to the ligands solution drop by drop with continuous stirring. The pH of resulting solution was maintained between 6 and 7. The reaction mixture was refluxed at 70 ¡ãC for 4 h. After refluxing for 4 h, the solution was cooled to room temperature and left as such overnight. Complex C1 was obtained as white precipitate which was filtered off, washed with methanol nd then dried under vacuum. The synthesis of complexes C2-C4 were done by adopting the same method as given above. Complex C2 was obtained from 3 mmol PCAO (0.3663 g), 1 mmol DMBP (0.2162 g) and1 mmol EuCl3 (0.2583 g), complex C3 was obtained from 3 mmol PDCA(0.4473 g), 1 mmol DMBP (0.2162 g) and 1 mmol EuCl3 (0.2583 g) and complex C4 was obtained from 3 mmol PM (0.3 mL), 1 mmol DMBP(0.2162 g) and 1 mmol EuCl3 (0.2583 g)., 17217-57-1

The synthetic route of 17217-57-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sengar, Manju; Narula, Anudeep Kumar; Materials Research Bulletin; vol. 112; (2019); p. 242 – 250;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: [Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to a DCMsolution (about 12 mL) of dap (10.7 mg, 98percent, 0.0500 mmol) andxantphos (59.0 mg, 98percent, 0.100 mmol) under a stream of dry argonby using Schlenk techniques at room temperature and a vacuumlinesystem, then orange-red solution was obtained quickly andstirred for 1 h at room temperature. The above process can alsobe carried out in air with the existence of oxygen. After filtrationthrough absorbent cotton, layering n-hexane onto the DCM solutionin air produced the product as bluish violet to black-blue blockcrystals in 76percent yield (63.0 mg)., 168646-54-6

As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Liu, Rong; Feng, Xiao-Yan; Li, Hao-Huai; Liu, Nian; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 92; (2015); p. 84 – 92;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of methyl esters of L- and D-tryptophanes chlorohydrates; :1a,b 2a,b a : D b : L[0344] Thionylchloride (0.064 mol) was slowly added to a cooled (O0C) suspension of tryptophane (0.049 mol) in methanol (150 mL). The reaction mixture was warmed up to 4O0C and stirred at this temperature for six hours. All solvents were removed and the solid residue was triturated with ether. The solid was filtered off to give the required product.[0345] D-tryptophane (2a): yield 98 %, M.p. 232-233C. NMR1H (delta, ppm,DMSO-dtheta, 300 MHz): 3.39 (2H, m, CH2); 3.63 (3H, s, CH3O); 4.20 (1 H1 t, CH, JHH = 5.5 Hz); 7.07 (2H, dt, Ar, JHH = 21 Hz, 6 Hz); 7.26 (1 H, d, H2, JHH = 3 Hz); 7.39 (1 H, d, Ar, JHH = 7.8 Hz); 7.53 (1 H, d, Ar, JHH = 7.8 Hz). NMR13C (delta, ppm, DMSO-d6, 125.76 MHz): 26.01 (s), 52.61 (d), 106.26(s), 111.45(s), 117.84(s), 118.50(s), 121.05(s), 124.80(s), 126.79(s), 136.13(s), 169.57(s). m/z 218(M+)., 153-94-6

153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; WO2008/103470; (2008); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 19 Preparation of H-D-Glu(D-Trp-0-CH(CH3)0-CO-0-cyclohexyl)-0-Et hydrochloride salt, Apo854.HCI Cbz-D-Glu(OH)-0-Et (12.1 g, 39.1 mmol), HOSu (4.60 g, 40.0 mmol) andEDCI.HCI (7.67 g, 40.0 mmol) were mixed in DMF (100 mL) under ice-water bath temperature. The reaction mixture was allowed to warm to RT then stirred for overnight. The reaction mixture was cooled again in an ice-water bath and D-Trp- OH (8.17 g, 40.0 mmol) was added. The mixture was stirred at room temperature for overnight. The mixture was poured into a beaker containing 0.5N HCI (200 mL) and ice pellets. The mixture was extracted with ethyl acetate (2×200 mL + 1×100 mL). The organic layers were combined and washed with a 0.5N HCI solution (100 mL), water (2×100 mL) and brine (100 mL), dried over MgS04, then filtered. The filtrate was concentrated via rotary evaporation under reduced pressure and the resulting solid Cbz-D-Glu(D-Trp-OH)-0-Et was triturated with10% ethyl acetate in hexanes. The precipitated white solid was collected via suction filtration (17.6 g). Yield = 90 %; 1H NMR (DMSO-D6l 400 MHz) delta ppm: 12.58 (br. s, 1 H), 10.82 (s, 1H), 8.12 (d, J = 8.1 Hz, 1 H), 7.71 (d, J = 8.1 Hz, 1 H), 7.52 (d, J = 8.1 Hz, 1H), 7.23 – 7.42 (m, 6H), 7.12 (s, 1 H), 7.06 (t, J = 7.6 Hz, 1 H), 6.97 (t, J = 7.6 Hz, 1H), 4.97 – 5.10 (m, 2H), 4.41 – 4.51 (m, 1H), 3.95 – 4.15(m, 3H), 3.15 (dd, J = 14.1 , 5.1 Hz, 1H), 2.99 (dd, J = 15.2, 8.1 Hz, 1 H), 2.09 – 2.26 (m, 2H), 1.83 – 1.96 (m. 1 H), 1.65 – 1.81 (m, 1 H), 1.16 (t, J – 7.1 Hz, 3H); MS-ESI (m/z): 496 [ +1f. To a mixture of Cbz-D-Glu(D-Trp-OH)-0-Et {4.95 g, 0.0 mmol) with potassium carbonate (4.15 g, 30.0 mmol) and sodium iodide (6.00 g, 40.0 mmol) in Lambda/,/V-dimethylformamide (30 mL) at room temperature, 1-chtoroethylcyclohexyl carbonate (6.20 g, 30.0 mmol) was added. After being stirred at room temperature for overnight, additional W,/V-dimethylformamide (30 mL) was added and the reaction mixture was stirred at 40C for overnight. The reaction mixture was diluted with ethyl acetate then washed with water (3x) then with brine. The crude product Cbz-D-Glu(D-Trp-0-CH(CH3)-0-CO-0-cyclohexyl)-0-Et was purified by column chromatography on silica gel using a solvent gradient of a mixture of ethyl acetate in hexanes (20 to 40%) as eluant. Fractions rich in product were combined together and evaporated to dryness. Thus, the desired compound Cbz-D-Glu(D-Trp-0-CH(CH3)-0-CO-0-cyclohexyl)-0-Et (4.43 g) was obtained as a pale-yellow foam. Yield = 66 %; 1H NMR (DMSO-D6> 400 MHz) delta ppm: 10.86 (or. s, 1H), 8.36 (dd, J = 17.2, 7.1 Hz, 1 H), 7.66 – 7.77 (m, 1 H), 7.46(t, J = 8.0 Hz., 1H), 7.22 – 7.42 (m, 6H), 7.10 – 7.20 (m, 1 H), 7.02 – 7.10 (m, 1 H), 6.90 – 7.02 (m, 1 H), 6.58 – 6.70 (m, 0.5H), 6.46 – 6.58 (m, 0.5H), 5.04 (br. s, 2H), 4.38 – 4.61 (m, 2H), 3.93 – 4.15 (m, 3H), 2.90 – 3.17 (m, 2H), 2.20 (br. s, 2H), 1.54 – 1.96 (m, 6H), 1.02 – 1.53 (m, 12H); MS-ESI (m/z): 666 [M+1f. Cbz-D-Glu(D-Trp-0-CH(CH3)-0-CO-0-cyclohexyl)-0-Et (2.0 g, 3.0 mmol) and 10 % Pd/C (wet, 0.6 g) was mixed in ethanol (50 mL) and 2 HCI in ether (1.7 mL, 3.4 mmol). The reaction mixture was hydrogenated in a Parr apparatus at 20-25 psi of hydrogen pressure for an hour. The mixture was filtered through Celite and the cake was washed with ethanol. The filtrate was concentrated by rotary evaporation and the residue was triturated with a mixture of ether and hexanes. Thus, H-D-Glu(D-Trp-O-CH(CH3)-0-CO-0-cyclohexyl)-0-Ethydrochloride salt (Apo854.HCI, 0.80 g) was obtained as a pink solid foam. Yield = 47%; *H NMR (DMSO-D6, 400 MHz) delta ppm: 0.94 (br. s, 1 H), 8.57 (br. s, 4H), 7.47 (t, J = 8.1 Hz, 1H), 7.34 (d, J = 8.1 Hz, 1H), 7.19 (s, 1 H), 7.07 (t, J = 7.6 Hz, 1 H), 6.88 – 7.03 (m, 1 H), 6.58 – 6.72 (q, J = 5.1 Hz, 0.5H), 6.53 (q, J = 5.1 Hz,0.5H), 4.39 – 4.63 (m, 2H), 4.00 – 4.26 (m, 2H), 3.78 – 4.00 (m, 1 H), 2.93 – 3.18 (m, 2H), 2.18 – 2.41 (m, 2H), 1.88 – 2.02 (m, 2H), 1.82 (br. s, 2H), 1.63 (br. s, 2H), 1.13 – 1.53 (m, 12H); MS-ESI (m/z): 532 [M+1]+ (free base).

153-94-6, 153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; APOTEX TECHNOLOGIES INC.; TAM, Tim, Fat; LEUNG-TOUNG, Regis; WANG, Yingsheng; ZHAO, Yanqing; XIN, Tao; LI, Wanren; WODZINSKA, Jolanta, Maria; RABADIA, Vrajlal, S.; FEENEY, Christopher, John; WO2012/129671; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

119-91-5, 2,2′-Biquinoline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1 (0.332 g, 1.0 mmol) and CuI (0.191 g, 1.0 mmol) were dissolved in 5 ml CHCl3. After a few minutes, bq (0.257 g, 1.0 mmol) in 10 ml CHCl3 was added. The mixture was stirred at 40 C for 2 h. After this time, a burgundy solution was formed. Then the solvent was evaporated to dryness. A dark red solid was crystallized from CHCl3 to give microcrystals which are soluble in CHCl3, CH2Cl2, THF, DMSO, CH3CN and CO(CH3)2. Yield 52%. Anal. Calc. for C33H42CuIN5O3P: C, 50.94; H, 5.44; N, 9.00. Found: C, 50.78; H, 6.02; N, 8.91%. MS (CHCl3): 575.1 [Cu(bq)2]+ 100%, 319.0 [Cu(bq)]+ 13%, 650.2 [Cu(bq)1]+ 10%. NMR (298 K, CHCl3) 31P{1H}: -28 s?; 1H: 8.21 s? (H3), 7.95-7.80 (H4 and H7), 7.65-7.55 (H5 and H6), 9.19 s? (H8), 2.78 s (H1-P), 2.40 s? (H2-P), 3.43 s? (H3-P); 13C{1H}:119.39 s (C1, C3), 137.63 s (C4), 128.01 s (C5), 127.53 s (C6), 130.22 s (C7), 130.93 s (C8), 146.42 s (C9), 128.61 s (C10), 55.18 s? (C1-P), 55.57 s (C2-P), 66.74 s (C3-P)., 119-91-5

As the paragraph descriping shows that 119-91-5 is playing an increasingly important role.

Reference£º
Article; Starosta, Rados?aw; Brzuszkiewicz, Anna; Bykowska, Aleksandra; Komarnicka, Urszula K.; Bazanow, Barbara; Florek, Magdalena; Gadza?a, ?ukasz; Jackulak, Natalia; Krol, Jaros?aw; Marycz, Krzysztof; Polyhedron; vol. 50; 1; (2013); p. 481 – 489;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2 or 3 (0.50 mmol), the corresponding acids RCOOH (0.60 mmol),DCC (0.60 mmol), DMAP (0.1 mmol) in dry dichloromethane (15 mL) was stirred atroom temperature. When the reaction was completed, and checked by TLC, the mixturewas filtered to remove urea from the reaction, and the filtrate was diluted bydichloromethane (45 mL). Subsequently, the diluted organic phase was washed bysaturated aqueous NaHCO3 (30 mL), and brine (30 mL), dried over anhydrousNa2SO4, concentrated in vacuo, and purified by CC to give the pure 9R/S-acyloxyderivatives of cinchonidine and cinchonine 5a-j,l-o and 6a,c,e-o [17-19]. The dataof target compounds are shown as follows.

485-71-2, The synthetic route of 485-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Che, Zhi-Ping; Chen, Gen-Qiang; Jiang, Jia; Lin, Xiao-Min; Liu, Sheng-Ming; Sun, Di; Tian, Yue-E; Yang, Jin-Ming; Zhang, Song; Journal of Asian Natural Products Research; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI