Tag: M.W:200-300

7089-68-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7089-68-1,2-Chloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

Synthesis of 2-(1H-pyrazol-1-yl)-1,10-phenanthroline: 2-chloro-1,10-phenanthroline (2.13 g,10 mM), pyrazole (0.70 g, 10 mM), and potassium carbonate (1.50 g, 0.011 mM) weredissolved in 20mL of DMF. The mixture was refluxed for 24 h, then another batch ofpyrazole (0.34 g, 5.0 mM) and potassium carbonate (1.00 g, 7.2 mM) was added into theDMF solution and the reaction continued to reflux for another 48 h. After that, a fraction ofDMF was distilled out by vacuum and 40mL of ice water with crushed ice was added into the solution. The raw product then appeared and was separated by filtration. Then, theproduct was washed with ice water until the filtrate was neutral and the final product wasobtained by vacuum drying. 1H NMR (300MHz, CDCl3, 25 ¡ãC): delta = 9.19 (s, 2H), 8.40 (brs,2H), 8.28 (s, 1H), 7.82 (brs, 3H), 7.66 (s, 1H), 6.56 (s, 1H). HRMS (ESI): m/z calcd forC15H10N4+H+: 247.0978 [M+H+]; found: 247.0982. All other chemicals are analyticalgrade and used without purification.

As the paragraph descriping shows that 7089-68-1 is playing an increasingly important role.

Reference£º
Article; Li, Hong-Nan; Wei, Rui-Zheng; Chi, Yan-Hui; Wei, Wei; Du, Hua; Zhang, Shi-Guo; Shi, Jing-Min; Journal of Coordination Chemistry; vol. 66; 17; (2013); p. 3063 – 3071;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

53344-72-2,53344-72-2, 6,6′-Dichloro-2,2′-bipyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried Schlenk flask was evacuated and back-filled with argon three times. (Hetero)aryl (di)halide (1 equiv), base (1.5 equiv per halogen) and a solution of SPO (1.2 equiv per halogen) in anhydrous solvent (5 mL/mmol per halogen) were added to the flask. The solution was bubbled with argon for 10 min and Pd(OAc)2 (1 mol% per halogen) and ferrocene-based bidentate phosphine ligand (2 mol% per halogen) were added to the flask simultaneously [2.5 mol% Pd(OAc)2 per halogen and 5 mol% dppf per halogen for compounds 2j, 2l, 2r, 2t, 2w]. The resulting mixture was heated at the indicated temperature for the given time. Workup procedures are described below for two different conditions. Final purification of crude products was achieved by column chromatography on silica gel (40-60 mum) using CH2Cl2-MeOH as eluent. Reaction scale and yields are shown in Table 1 (2a-w), Scheme 1 (3a-h) and Scheme 2 (4a-g). Notice that all compounds with two phosphine oxide groups are beige-to-brown solids or slowly solidifying viscous brown oils. Conditions I: ligand: dppf, solvent: DMF, base: Cs2CO3 (2d-n, 2q, 2r, 2t-w, 4a-g) or K2CO3 (3a-h), temperature: 120 C, time: 7 h (20 h for 2j, 2l, 2r, 2w). Workup: after cooling, the reaction mixture was poured into a fourfold excess of brine. The mixture was extracted three times with CH2Cl2 (40 mL/mmol each). The combined organic layers were washed with brine to remove traces of DMF, dried over Na2SO4 and then evaporated to dryness. Conditions II: ligand: dippf, solvent: toluene, base: t-BuOK, temperature: 110 C, time: 7 h. Workup: after cooling, the reaction mixture was evaporated to dryness. Then, the mixture was diluted with CH2Cl2 (40 mL/mmol) and washed with water and brine (40 mL/mmol). The organic layer was dried over Na2SO4 and the CH2Cl2 was removed under reduced pressure.

As the paragraph descriping shows that 53344-72-2 is playing an increasingly important role.

Reference£º
Article; Zakirova, Gladis G.; Mladentsev, Dmitrii Yu.; Borisova, Nataliya E.; Synthesis; vol. 51; 11; (2019); p. 2379 – 2386;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of compounds (1.5 mg) in 6 M HCl (1 ml) was heated to 120 C for 24 h. The solution was then evaporated to dryness and the residue redissolved in H2O (100 mul) and was then placed in a 1 ml reaction vial and treated with a 2% solution of FDAA (200 mul) in acetone followed by 1.0 M NaHCO3 (40 mul). The reaction mixture was heated at 47 C for 1 h, cooled to room temperature, and then acidified with 2.0 M HCl (20 mul). In a similar fashion, standard D- and L-amino acids were derivatized separately. The derivatives of the hydrolysates and standard amino acids were subjected to analytical HPLC analysis (Shimadzu LC-20AD, C18 column; 5 mum, 4.6 mm ¡Á 250 mm; 1.0 ml/min) at 30 C using the following gradient program: solvent A, water + 0.2% TFA; solvent B, MeCN; linear gradient 0 min 25% B, 40 min 60% B, 45 min 100% B; UV detection at 340 nm [39]., 153-94-6

As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.

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Article; Nishanth Kumar; Mohandas; Nambisan, Bala; Peptides; vol. 53; (2014); p. 48 – 58;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

5350-41-4, N,N,N-Trimethyl-1-phenylmethanaminium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The desired amount of substrate, boronic acid (3 equiv), base (3equiv), Pd(OAc)2 (2.5 molpercent) and ligand (5 molpercent) were weighed out as solids, the vial was sealed and purged with argon, then solvent was added and the vial was purged again. The reactions were run for 14 h at the specified temperature. The crude material was filtered through a pad of Celite and washed three times with CHCl3. The solvent was removed under reduced pressure, an internal standard was added and the reaction was analysed by 1H NMR spectroscopy. For purification, the analysed mixture was concentrated, the product extracted with Et2O and filtered through anhydrous MgSO4 and further purified by flash column chromatography., 5350-41-4

The synthetic route of 5350-41-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tuertscher, Paul L.; Davis, Holly J.; Phipps, Robert J.; Synthesis; vol. 50; 4; (2018); p. 793 – 803;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a typical preparation a solid mixture of H2BPDC (H2BPDC = 4,4′-biphenyldicarboxylic acid; 0.630 g, 2.4 mmol), bpy (bpy = 4,4′-bipyridine; 0.198 g, 1.2 mmol), and Cu(NO3)2¡¤3H2O (0.630 g, 2.4 mmol) was dissolved in a mixture of DMF (DMF = N,N’-dimethylformamide; 180 mL), pyridine (1.8 mL), and methanol (18 mL). The resulting solution was stirred at 70C for 5 min, and then distributed to 20 mL vials. The vials were then heated at 120C in an isothermal oven for 24 h. After cooling the vials to room temperature, the solid product was removed by decanting with mother liquor and washed in DMF (3 * 20 mL) for 3 days. Solvent exchange was carried out with methanol (3 * 20 mL) at room temperature for 3 days. The material was then evacuated under vacuum at 140C for 6 h, yielding 0.605 g of Cu2(BPDC)2(BPY) in the form of blue crystals, correspond to 66% based on copper., 787-70-2

787-70-2 [1,1′-Biphenyl]-4,4′-dicarboxylic acid 13084, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Dang, Giao H.; Le, Dung T.; Truong, Thanh; Phan, Nam T.S.; Journal of Molecular Catalysis A: Chemical; vol. 400; (2015); p. 162 – 169;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7089-68-1, 2-Chloro-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7089-68-1, 2-(1H-Imidazol-1-yl)-1,10-phenanthroline was prepared according to the followingmethod. 2-Chloro-1,10-phenanthroline (4.29 g, 0.02 mol) and imidazole (1.63 g,0.024 mol) were dissolved with 100 mL of DMF and potassium carbonate (4.16 g, 0.030 mol) was added into the solution. After the reactants were refluxed for 72 h at110 ¡ãC, the solvent was removed by reduced pressure distillation. The pale yellow sediment appeared after 30 mL iced water was added into the remains and fully stirred.The pale yellow solid 2-(1H-imidazol-1-yl)-1,10-phenanthroline (4.5 g, yield: 91.8percent) was obtained after the sediment was washed with iced water until the pH value of the filtratewas 7. IR (cm-1): 3086 (w), 1593 (m), 1471 (vs), 1400 (m), 1295 (m), 1229 (m),1153 (m), 1049 (m), 973 (m), 820 (s), 765 (s), 726 (m), 648 (m); 1H NMR (300 MHz,CDCl3): 9.19?9.20 (m, 1H), 8.65 (s, 1H), 8.37?8.40 (d, 1H), 8.26?8.29 (d, 1H), 8.03 (s, 1H),7.73?7.81 (m, 5H); HRMS (ESI): C15H10N4 for MH, calculated 247.0984, found247.0985; Elemental Anal. Calcd for C15H10N4 (FW 246.0905): C, 73.20; H, 4.10; N,22.77percent. Found: C, 73.46; H, 4.25; N, 23.08percent.

7089-68-1 2-Chloro-1,10-phenanthroline 355193, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Zheng, Lu-Yi; Chi, Yan-Hui; Liang, Yuan; Cottrill, Ethan; Pan, Ning; Shi, Jing-Min; Journal of Coordination Chemistry; vol. 71; 23; (2018); p. 3947 – 3954;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148332-36-9,[2,2′:6′,2”-Terpyridine]-4′-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Typically, 2-(4-carboxyphenyl)-4,6-dipyrid-2-yltriazine (1.0 g,2.81 mmol) was heated to reflux in thionyl chloride (30 mL) for0.5 h, after which no solid suspension remained. The excess thionylchloride was removed by distillation and the residue was driedunder vacuum, dry methanol (60 mL) was added and the reactionmixture was heated to reflux until no solid suspension remained(2 h). The solution was cooled to room temperature and addedto H2O (300 mL) forming a voluminous precipitate of the methylester ligand which was isolated by filtration and dried in vacuowithout further purification. Typically, the ligand (0.25 g,0.68 mmol) was heated to reflux in DMF with RuCl3 (0.07 g,0.34 mmol) and AgNO3 (0.173 g, 1.02 mmol) after which the solutionwas filtered to remove AgCl(s). The filtrate was then decantedinto a solution of NH4PF6 (aq) (300 mL), and the resultant heavyprecipitate was isolated by filtration and washed with water, thendissolved in a minimal amount of acetonitrile for chromatographicpurification using silica and a 7:2 CH3CN/KNO3 (aq, sat) mixture aseluent. The collected fractions are combined, and to this addedNH4PF6 and enough DCM to effect a phase separation. After washingthe organic phase, the aqueous phase was discarded and theprocess repeated, with a final washing with water alone. Theorganic phase was dried and the residue taken up in a minimalamount of acetonitrile, then poured into H2O (300 mL) to give aheavy precipitate which was filtered and dried in vacuo. Yield:0.263 g (69percent), Rf = 0.55 (silica, 7:2 CH3CN/KNO3 (sat, aq) as eluent).1H NMR (400 MHz, CD3CN) d ppm 9.19 (d, J = 8.4 Hz, 4H), 9.14 (d,J = 7.7 Hz, 4H), 8.44 (d, J = 8.4 Hz, 4H), 8.16 (m, 4H), 7.73 (d,J = 5.3 Hz, 4H), 7.41 (m, 4H), 4.02 (s, 3H). ESI-MS: [M]2+ Cald. forC42H30N10O4Ru: 420.07475. Found: 420.07499.

148332-36-9, As the paragraph descriping shows that 148332-36-9 is playing an increasingly important role.

Reference£º
Article; Cooke, Michael W.; Santoni, Marie-Pierre; Loiseau, Frederique; Hasenknopf, Bernold; Hanan, Garry S.; Inorganica Chimica Acta; vol. 454; (2017); p. 208 – 215;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

35132-20-8, (1R,2R)-1,2-Diphenylethane-1,2-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

trans-RuH(eta1-BH4)[(R)-tolbinap][(R,R)-dpen] was synthesized. First, trans-RuCl2[(R)-tolbinap][(R,R)-dpen] was synthesized. That is, [RuCl2(benzene)]2 (129 mg; 0.258 mmol) (made by Aldrich Inc.) and (R)-TolBINAP (373 mg; 0.55 mmol) (made by AZmax Co., Ltd.) were weighed and placed in a 50 mL Schlenk reaction tube equipped with a stirrer coated with polytetrafluoroethylene, and after depressurizing the interior of the vessel to eliminate air, argon was introduced. After then adding DMF (9 mL) with a syringe, heating in an oil bath set to 100 C. was performed for 10 minutes under an argon atmosphere. After cooling the reaction solution to room temperature, (R, R)-DPEN (117 mg; 0.55 mmol) (made by Kankyo Kagaku Center Co., Ltd.) was added under an argon gas flow to the reddish-brown RuCl2[(R)-tolbinap](dmf)n solution, and stirring at 25 C. was performed for 3 hours. To a green-colored crude product obtained by distilling off the DMF under reduced pressure (1 mmHg), methylene chloride (10 mL) was added, and after dissolving as much of a yellow product as possible, a green impurity was removed by filtration. The yellow solution that was obtained by filtration whereafter concentrated to approximately 1 mL and then diethyl ether (5 mL) was added to precipitate solids. The solids obtained were separated by filtration and dried under reduced pressure(1 mmHg)to obtain trans-RuCl2[(R)-tolbinap][(R,R)-dpen] (340 mg; 0.32 mmol; yield: 58%) as a yellow powder. [TolBINAP] and [tolbinap] are abbreviations for 2,2′-bis(di-4-tolylphosphino)-1,1′-binaphthyl, ?DMF? and ?dmf? are abbreviations for N,N-dimethylformamide, and ?DPEN? and ?dpen? are abbreviations for 1,2-diphenylethylenediamine. [00030] The abovementioned trans-RuCl2[(R)-tolbinap] [(R,R)-dpen] (106.3 mg; 0.1 mmol) and sodium borohydride (94.6 mg; 2.5 mmol) (made by Nacalai Tesque, Inc.) were then weighed and placed in a 50 mL Schlenk reaction tube equipped with a stirrer coated with polytetrafluoroethylene, and after depressurizing the interior of the vessel to eliminate air, argon was introduced. After then adding a 1:1 volume ratio mixed solvent of benzene/ethanol (4 mL) with a syringe, heating in an oil bath set to 65 C. was performed for 5 minutes under an argon atmosphere. The reaction solution was thereafter stirred for 30 minutes at room temperature. After then drying and solidifying the crude product by distilling off the solvent under reduced pressure (1 mmHg), benzene (6 mL) was added under an argon gas flow to dissolve as much of a yellow product as possible and then the excess sodium borohydride was eliminated by filtration by celite (0.5 g). A yellow filtrate thus obtained was concentrated to approximately 1 ml by depressurization (1 mm Hg) and hexane (6 mL) was then added under an argon gas flow. Yellow solids thus precipitated were separated by filtration through a glass filter and dried under reduced pressure (1 mmHg) to obtain trans-RuH(eta1-BH4)[(R)-tolbinap] [(R,R)-dpen] (76.0 mg; yield: 70%; see formula (3) below) as a yellow powder. Decomposition temperature: 164 C.; 1HNMR(400 MHZ, C6D6) delta-13.60(t, 1, J=22.4 Hz, RuH), -0.40(brs, 4, BH4), 1.45(s, 3, CH3), 1.55(s, 3, CH3), 1.62(s, 3, CH3), 1.63(s, 3, CH3), 1.95(dd, 1, J=7.2 and 8.4 Hz, NHH), 2.38(d, 1, J=8.2 Hz, NHH) ,3.65(dd, 1, J=7.9 and 11.2 Hz, CHNH2), 3.82-3.88(m, 2, 2 NHH), 4.00(ddd, 1, J=7.9, 8.4 and 11.6 Hz, CHNH2), 6.13-8.12(m, 38, aromatics) ;31PNMR(161.7 MHz, C6D6) delta71.2(d, J=41.4 Hz), 75.2(d, J=41.4 Hz);IR(toluene)2316(s), 1862(s), 1092(s), 1080(s)cm-1; ESI-MS m/z1007.26([M-H]+), theoretical value (C62H60BN2P2Ru): 1007.34. The powder obtained was then recrystallized from a THF/hexane mixed solvent of a volume ratio of approximately 1:5 to obtain yellow prismatic crystals, and these were used for X-ray crystallography.

35132-20-8, 35132-20-8 (1R,2R)-1,2-Diphenylethane-1,2-diamine 2724998, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Nagoya Industrial Science Research Institute; US6720439; (2004); B1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

72914-19-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72914-19-3,4,4′-Di-tert-butyl-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

A magnetically stirred suspension of 4,4?-di-tert-butyl-2,2?-dipyridyl (118 mg, 0.44 mmol) and tetrakis(2-phenylpyridine-C2,N?)(mu-dichloro)-diiridium (214 mg, 0.2 mmol) in 10 mL of 1,2-ethanediol under nitrogen was heated to 150 C. The mixture was kept at this temperature for 15h. All the solids dissolved to yield a clear, yellow solution. After cooling the mixture to room temperature, 150 mL of water was added. The excess of bipyridine ligand was removed through three extractions with diethyl ether (50 mL), and the aqueous layer was subsequently heated to 60-70 C. NH4PF6 (1 g) in 10 mL of water was added, and the PF6 salt of the chromophore immediately precipitated. After cooling the suspension to 5 C, the yellow solid was separated through filtration, dried, and recrystallized through acetonitrile/ether diffusion. Yield: 280 mg (77%).

The synthetic route of 72914-19-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ye, Hongqiang; Ye, Qianwen; Cheng, Dongping; Li, Xiaonian; Xu, Xiaoliang; Tetrahedron Letters; vol. 59; 21; (2018); p. 2046 – 2049;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

92149-07-0,92149-07-0, 4,7-Dimethoxy-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under an argon atmosphere, add anhydrous Fe(acac)2 (127.0mg, 0.5mmol) to a 50mL Schlenk flask, and dissolve it in 6mL of anhydrous ethanol at 60 C; Then, a solution of 4,7-dimethoxy-1,10-phenanthroline (120 mg, 0.5 mmol) in ethanol (4 mL) was added dropwise to the system. The reaction was carried out at 60 C for half an hour, and then returned to room temperature and stirred overnight. The filtrate was collected by filtration, concentrated, washed twice with cold ethanol, and dried under vacuum for 12 h to obtain a dark brown solid product 17, with a yield of 60%.

The synthetic route of 92149-07-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Wang Qinggang; Wang Liang; Zhu Guangqian; Zhang Xianhui; Jing Chuyang; (29 pag.)CN110452272; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI