Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4199-88-6,5-Nitro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: A 0.5 mmol quantity of copper(II) nitrate trihydrate was treated with 1.0 mmol of phen (or nphen) in ethanol (20 ml) under stirring conditions for 0.5 h. The product was isolated, washed with ethanol and set aside for crystallization by slow evaporation at room temperature. Green crystals were crystallized from the solution after a week. The structure of [Cu(phen)2(H2O)](NO3)2 has been previously determined by Nakai and Deguchi [43], by Catalan et al. [44], by Szpakolski et al. [45], by Zhou [46] and by Boutebdja et al. [47]. Complex 1: Yield was 87%. Anal. Calcd. for C24 H18 Cu N8 O12 (673.99 g mol-1) (%): C, 43.18; H, 2.67; N,16.63. Found: C, 42.77; H, 2.69; N, 16.63.

4199-88-6, The synthetic route of 4199-88-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Inci, Duygu; Aydin, Rahmiye; Vatan, Oezguer; Yilmaz, Dilek; Genckal, Hasene Mutlu; Zorlu, Yunus; Cava?, Tolga; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 145; (2015); p. 313 – 324;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: The synthesis of complexes was carried out by single potsynthesis. An anhydrous methanolic solution (10 mL) of 4-fluoro-N-salicylideneaniline (0.6456, 3 mmol) was addeddropwise to a vigorously stirred solution of 2,2?-bipyridine(0.1561, 1 mmol) in 10 mL methanol. To this solution ofligands, a methanolic solution of EuCl3 (0.2583 g, 1 mmol)was added slowly with continuous stirring. The pH of thereaction mixture obtained was adjusted to 6.0?7.0. Afteradjusting the pH, the reaction mixture was refluxed at 60 ¡ãC.The refluxing was continued for 5 h. The light yellow solutionso obtained was evaporated at room temperature to give thesolid compound which was extracted with diethyl ether. Thecompound obtained after extraction is C1 (Scheme 1).

17217-57-1, 17217-57-1 4,4′-Dimethoxy-2,2′-bipyridine 2733927, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Sengar, Manju; Narula, Anudeep Kumar; Journal of Fluorescence; vol. 29; 1; (2019); p. 111 – 120;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29176-55-4,2,9-Dichloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: Diaryl-substituted phenanthrolines were prepared by combining thedihalo-substituted phenanthroline with the appropriate phenylboronicacid in a 100 mL Schlenk flask. The solids were suspended in 30 mL oftoluene and 20 mL of 2 M Na2CO3(aq), then purged with Ar for 15 min.Subsequently, Pd(PPh3)4 (0.175 g, 0.15 mmol) was added to the flask,purged for an additional 15 min, then heated at reflux under Ar whilerapidly stirring. After 48 h, the biphasic mixture was cooled to roomtemperature and the two layers were isolated. The aqueous layer waswashed with dichloromethane and all organic fractions were combined,dried using anhydrous MgSO4, and filtered. The solvent was removedby rotary evaporation, and the solids were recrystallized with minimaltoluene followed by vacuum filtration. If necessary, the volume of theresulting filtrate was reduced and hexanes added to induce precipitation.The mixture was vacuum filtered and resulting white solids were collected., 29176-55-4

As the paragraph descriping shows that 29176-55-4 is playing an increasingly important role.

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Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

40000-20-2, 5-Bromo-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,40000-20-2

Synthesis of Compound 57: The compound 57a (3.9 g, 15.0 mmol),Phenoxazine (2.9 g, 16 mmol),Tert-butylphosphine (0.35 g, 2 mmol),Palladium acetate (0.4 g, 1.8 mmol) and cesium carbonate (9.7 g, 30 mmol) were dissolved in toluene,Under a nitrogen atmosphere,The reaction was heated under reflux for 10 hours.The solvent was evaporated in vacuo,The remaining material was stirred with pentane,filter,Purification by silica gel column chromatography,To obtain solid compound 5, (3.7 g, 10.2 mmol),Yield 62percent.

The synthetic route of 40000-20-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Tianma Organic Shine Display Co., Ltd.; Tianmawei Electronic Co., Ltd.; Wang Xiangcheng; Liu Ying; Ren Hongyang; He Wei; Liu Chen; (43 pag.)CN106831743; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.153-94-6,H-D-Trp-OH,as a common compound, the synthetic route is as follows.

General procedure: 5-Bromothiophene-2-sulfonylchloride (1g, 4.43 mmol) was added to a solution of the appropriate non-natural commercial amino acid (4.43 mmol) in H2O (4.43 mL) and dioxane (13.3 mL) containing Et3N (1.24 mL, 8.86 mmol). The mixture was stirred at room temperature overnight, the dioxane was evaporated and the residue was treated with EtOAc and washed with HCl 1 N and brine. Organic layers were then collected, dried over Na2SO4, and evaporated in vacuo.

153-94-6, As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.

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Article; Nuti, Elisa; Casalini, Francesca; Santamaria, Salvatore; Gabelloni, Pamela; Bendinelli, Sara; Da Pozzo, Eleonora; Costa, Barbara; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Margarida Bernardo; Fridman, Rafael; Da Settimo, Federico; Martini, Claudia; Rossello, Armando; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 2617 – 2629;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.

General procedure: The alkaloid (12.3 mmol, 1 eq.) and the appropriate substituted benzylic halide derivative(12.3 mmol, 1 eq.) were dissolved in THF (40 mL) with addition of a trace of NaI. The mixture washeated to reflux overnight and then cooled and stirred at ambient temperature for 1 h. In most cases theproduct precipitated as an off-white solid, but where this was not the case and the mixture containedonly a small amount of solid or no solid at all, then diethyl ether (20 mL) was added dropwise.The solid was removed via filtration and washed with THF (50 mL) or ether:THF, (1:1, v/v, 50 mL)and was dried under reduced pressure at 40 C. Where the solid formed was not a fine powder it was then taken up in DCM and this solution was then added dropwise to rapidly stirring ether (100 mL).This usually gives a finely divided solid that could be filtered and dried. (Note: The cinchonine derivedPTCs are usually very insoluble. The quinidine derived PTCs are often completely soluble at the endof the reaction.) The di(t-butyl)benzyl PTC was prepared according to the standard procedure aboveand was filtered directly from the reaction mixture.

485-71-2, 485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Tao; Scalabrino, Gaia; Frankish, Neil; Sheridan, Helen; Molecules; vol. 23; 7; (2018);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

168646-54-6, 0.33 g of 4,4′-dinitrobenzil (1.0 mmol) and 0.21 g of 5,6-diamine-1,10-phenanthroline (1.0 mmol) were put into a 100 mL single-necked flask, 30 mL of glacial acetic acid was added, Stirring, reaction under nitrogen 2h. After the reaction was completed, the solvent was removed by rotary evaporation and spin-dried. An appropriate amount of dichloromethane was added and the mixture was stirred for 10 min. Filtration, rotary evaporation of the solvent. The resulting solid was recrystallized from absolute ethanol, suction filtered and dried in vacuo to give 0.352 g of pale yellow crystals, The yield is 78.6percent. The reaction is:

The synthetic route of 168646-54-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jiangnan University; Zheng Changge; Xie Chen; Li Mingyue; (8 pag.)CN105884833; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-91-5,2,2′-Biquinoline,as a common compound, the synthetic route is as follows.

Under argon atmosphere, 1,2-bis(diphenylphosphino)benzene (91.7 mg, 0.205 mmol) was added to 5 mL of the suspension of silver(I) tetrafluoroborate (40.0 mg, 0.205 mmol) in dry dichloromethane, and the mixture was stirred at room temperature for one hour. Then, 2,2′-biquinoline (52.7 mg, 0.205 mmol) was added to the reaction solution, which was stirred at room temperature for another one hour. The pale yellow reaction solution was filtrated, and the filtrate was concentrated, subjected to recrystallization by slow diffusion of chloroform-ether, and dried to provide 171 mg of the pale yellow solid complex. The result of elemental analysis for the obtained complex is shown in Table 2-2, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (5).

119-91-5, 119-91-5 2,2′-Biquinoline 8412, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To 4mL of ice-bath cooled methanol was added drop-wise 1mL of thionyl chloride in 5min under nitrogen, the resulting mixture was stirred for 0.5h and amine derivatives 3a-3f were added. The reaction mixture was stirred at room temperature overnight until complete disappearance of the materials indicated by TLC. The solvent and the surplus SOCl2 were removed in vacuum. The residue was dissolved in 20mL of methanol and evaporated under reduced pressure. The procedure was repeated for three times. Then 20mL of ether was added to the residue and evaporated in vacuum, which also took three times. Target compounds 4a-4f were obtained in 86%-95% yield and used without further purification for the following step., 153-94-6

As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.

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Article; Tang, Hong-Jin; Zhang, Xiao-Wei; Yang, Lin; Li, Wei; Li, Jia-Huang; Wang, Jin-Xin; Chen, Jun; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 637 – 648;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128143-89-5,4′-Chloro-2,2′:6′,2”-terpyridine,as a common compound, the synthetic route is as follows.

Compound M (18.00 g, 34.25 mmol) and compound N (12.23 g, 34.25 mmol) were completely dissolved in 300 ml of tetrahydrofuran in a 500 ml round-bottomed flask under nitrogen atmosphere, and 2M aqueous potassium carbonate solution (150 ml)Tetrakis- (triphenylphosphine) palladium (1.18 g, 1.02 mmol) was added thereto, followed by heating and stirring at 75C for 3 hours. The temperature was lowered to room temperature (23 ¡À 5 C), the water layer was removed, dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and recrystallized from 120 ml of ethyl acetate to obtain Compound 10 (16.9 g, 74%

128143-89-5, 128143-89-5 4′-Chloro-2,2′:6′,2”-terpyridine 667748, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; LG CHEMICAL LTD; LG Chem, Ltd.; YANG JUNG HOON; Yang Jeong-hun; LEE DONG HOON; Lee Dong-hun; HUH JUNG OH; Huh Jeong-o; JANG BOON JAE; Jang Bun-jae; HEO DONG UK; Huh Dong-uk; HAN MI YEON; Han Mi-yeon; YUN HEE KYUNG; Yoon Hui-gyeong; (47 pag.)KR2019/9704; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI