Tag: M.W:200-300

4479-74-7, 2,2-Bipyridine-6,6-dicarboxylic Acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2,2?-bipyridine-6,6?-dicarboxylic acid (244 mg,1.0 mmol), Ru(DMSO)4Cl2 (484 mg, 1.0 mmol), and Et3N (0.8ml) in methanol (10 ml) was degassed with N2 and refluxed for 4 h. The solution changed from bright yellow to dark before the appearance of a brown precipitate. After cooling to room temperature, the precipitate was filtered and washed with methanol (10 ml ¡Á 3) and ether (10 ml ¡Á 3) to get a reddish-brown powder. The powder was mixed with an excess of 4,4?-bipyridine in methanol (20 ml) and heated to reflux for 2 h. The solvent was removed and the resulted residue was re-dissolved in dichloromethane, washed with water to remove triethylamine hydrochloride, and dried over MgSO4 under N2. After purification by column chromatography on silica gel with dichloromethane-methanol (20:1 to 1:1, V:V) as eluent, complex1 was obtained as a dark red solid. Yield: 229 mg (35%).

4479-74-7, The synthetic route of 4479-74-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiang, Yi; Li, Fei; Huang, Fang; Zhang, Biaobiao; Sun, Licheng; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 34; 8; (2013); p. 1489 – 1495;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.

bpyAc (34.9 mg, 0.163 mmol) and fac-[Re(CO)3(dmso-O)3](PF6)(102.8 mg, 0.157 mmol) were dissolved in dry acetone (10 mL).The mixture was stirred at reflux for 4 h under argon. The solutionwas concentrated at ca. 2 mL and the precipitation of the productwas induced by slow diffusion of diethyl ether. A pure yellowpowder was isolated by filtration and washed with ether. Yield83 mg, 0.117 mmol (75%). Anal. Calc. for C17H16F6N2O6PReS(Mw = 707.56): C, 28.86; H, 2.28; N, 3.96; S, 4.53. Found: C,28.97; H, 2.35; N, 3.78; S, 4.62%. 1H NMR (d, 500 MHz, CD3NO2):9.31 (d, 3J60,50 = 5.6 Hz, 1H, H60), 8.99 (d, 3J6,5 = 5.6 Hz, 1H, H6), 8.92(s, 1H, H30), 8.52 (s, 1H, H3), 8.21 (d, 3J50,60 = 5.6 Hz, 1H, H50), 7.66(d, 3J5,6 = 5.5 Hz, 1H, H5), 2.67 (s, 3H, -CH3), 2.63 (s, 3H, -CH3(dmso)),2.61 (s, 3H, -CH3(dmso)). 1H NMR (d, 500 MHz, dmso-d6): 9.25 (d,3J60,50 = 5.5 Hz, 1H, H60), 9.04 (s, 1H, H30), 8.96 (d, 3J6,5 = 5.6 Hz, 1H,H6), 8.94 (s, 1H, H3), 8.14 (d, 3J50,60 = 5.7 Hz, 1H, H50), 7.69 (d,3J5,6 = 5.2 Hz, 1H, H5), 4.02 (s, 1H, -OH), 2.59 (s, 3H, -CH3). 13CNMR (d, 126 MHz, CD3NO2): 196.50 (s, COfac), 196.35 (s, COfac),191.30 (s, COfac), 164.35 (s, -COOH), 157.39 (s, C20), 154.89 (s,C40), 154.59 (s, C2), 154.25 (s, C60), 152.68 (s, C6), 142.04 (s, C4),128.94 (s, C5), 126.74 (s, C50), 125.19 (s, C3), 123.03 (s, C30), 37.64(d, 2C, -CH3(dmso)), 20.41 (s, -CH3). Selected IR bands (cm1, KBrpellets): 2029 (mCOfac), 1916 (mCOfac), 1710 (mCOacid), 947 (mSO),842 (mP-F), 558 (mP-F). UV-Vis (kmax, nm, CH2Cl2): 295, 318sh,331sh, 375., 103946-54-9

As the paragraph descriping shows that 103946-54-9 is playing an increasingly important role.

Reference£º
Article; Cavigli, Paolo; Balducci, Gabriele; Zangrando, Ennio; Demitri, Nicola; Amati, Agnese; Indelli, Maria Teresa; Iengo, Elisabetta; Inorganica Chimica Acta; vol. 439; (2016); p. 61 – 68;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5350-41-4,N,N,N-Trimethyl-1-phenylmethanaminium bromide,as a common compound, the synthetic route is as follows.

5350-41-4, General procedure: The desired amount of substrate, boronic acid (3 equiv), base (3equiv), Pd(OAc)2 (2.5 molpercent) and ligand (5 molpercent) were weighed out as solids, the vial was sealed and purged with argon, then solvent was added and the vial was purged again. The reactions were run for 14 h at the specified temperature. The crude material was filtered through a pad of Celite and washed three times with CHCl3. The solvent was removed under reduced pressure, an internal standard was added and the reaction was analysed by 1H NMR spectroscopy. For purification, the analysed mixture was concentrated, the product extracted with Et2O and filtered through anhydrous MgSO4 and further purified by flash column chromatography.

5350-41-4 N,N,N-Trimethyl-1-phenylmethanaminium bromide 21449, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Tuertscher, Paul L.; Davis, Holly J.; Phipps, Robert J.; Synthesis; vol. 50; 4; (2018); p. 793 – 803;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a three-necked flask equipped with a mechanical stirrer,Add anhydrous methanol 600 mL,D-tryptophan (102.1 g, 500 mmol), Room temperature stirring, using ice salt bath,The temperature of the reaction system was reduced to 0 C,A solution of thionyl chloride (71.4 g, 600 mmol)After the dropwise addition, the temperature was raised to room temperature for about 12 hours.Thin layer chromatography monitoring, when the raw material reaction is complete,Stop the reaction.After atmospheric distillation of most of the remaining thionyl chloride and methanol,Decompression in addition to thionyl chloride and methanol, cooling,To give the hydrochloride of solid tryptophan methyl ester (Isolated from air) can be used directly in the next step., 153-94-6

The synthetic route of 153-94-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Xi hua University; Yang, Weiqing; Li, Hongyang; Wang, Huizhen; (18 pag.)CN106432237; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (S,S)-diphenylethylenediamine (250 mg, 1.2 mmol) and triethylamine (0.5 ml) in THF is added dropwise a solution of dansyl chloride (318 mg, 1.2 mmol) in THF (2 ml) at 0 C. After stirring 16 h at RT the solvent is removed in vacuum and the residue is resolved in methylenchloride (20 ml). The organic solution is washed with NaHCO3 solution (5 ml), dried over Na2SO4 and after filtration the solvent is removed. Flash chromatographie afford (S,S)-5-dimethylamino-naphthalene-1-sulfonic acid (2-amino-1,2-diphenyl-ethyl)-amide as yellow oil which crystallizes by drying in vacuum. M: 445.59. 1H-NMR (400 MHz, CDCl3):8.36 (t, J=7.5 Hz, 2 H), 8.17 (dd, J=7.2, 1.2 Hz, 1 H), 7.47 (dd, J=8.8 Hz, 1 H), 7.34 (dd, J=8.5 Hz, 1 H), 7.24-7.16 (m, 4 H), 7.11 (d, J=7.5 Hz, 1 H), 6.99-6.74 (m, 6 H), 4.61 (d, J=8.5 Hz, 1 H), 4.20 (d, J=8.5 Hz, 1 H), 2.80 (s, 6 H).

29841-69-8, 29841-69-8 (1S,2S)-(-)-1,2-Diphenylethylenediamine 6931238, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Bilbe, Graeme; Cryan, John F.; Gentsch, Conrad; McAllister, Kevin Hall; Schmutz, Markus; Vassout, Annick; US2006/194791; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of Tetrabutylphosphonium Tetrafluoroborate:; Tetrabutylphosphonium chloride was added into an aqueous solution with excessive amount of sodium tetrafluoroborate (molar ratio: 1/1.1) and stirred for 24 hours. Then, adequate amount of methylene dichloride was added to extract the product. A mixture of the product and the methylene dichloride was washed with water until no chlorine ion was detected by a silver nitrate solution (0.1 mol/L). A product of tetrabutylphosphonium tetrafluoroborate was obtained after removing methylene dichloride in the product by rotary evaporation and drying., 2304-30-5

The synthetic route of 2304-30-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES; US2011/21846; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-91-5,2,2′-Biquinoline,as a common compound, the synthetic route is as follows.

General procedure: To an aqueous solution of terbium nitrate pentahydrate(1.0 mmol, 0.43 g) added an alcoholic solution of ligandHDPBD (3.2 mmol, 0.63 g) dropwise under vigorous stirringon magnetic stirrer. The pH of the resulting mixturewas adjusted to 6.5 with 0.05 M sodium hydroxide solution,resulting in the formation of white precipitates afterconstant stirring for two hours at a temperature of 50-60 C. The precipitates were filtered out and dried inhot air oven to obtained C1 complex.

119-91-5, 119-91-5 2,2′-Biquinoline 8412, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Bala, Manju; Kumar, Satish; Devi, Rekha; Khatkar, Avni; Taxak; Boora, Priti; Khatkar; Journal of Fluorescence; vol. 28; 3; (2018); p. 775 – 784;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The modification of CD and the subsequent later hydroxylationwere performed as reported in our previous works [26,27]. Briefly,an ice-cooled solution of CD in THF containing TEA was added drop-wise to the TMCS. The reaction mixture was stirred for 20 h at roomtemperature and then for 2 h at 60C. The product was extractedwith chloroform and washed with water. The obtained productwas hydrosilated with the Pt(COD)Cl2catalyst precursor and TMS(TMS/catalyst = 120 mol ratio) at 40C, using toluene as the sol-vent. The reaction mixture was stirred for 5 h at 90C under a N2atmosphere. Purification was performed by flash chromatography(hexane-acetone-TEA = 40:18:1).

485-71-2, 485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Campos, Cristian H.; Torres, Cecilia C.; Osorio-Vargas, Paula; Mella, Claudio; Belmar, Julio; Ruiz, Doris; Fierro, Jose L.G.; Reyes, Patricio; Journal of Molecular Catalysis A: Chemical; vol. 398; (2015); p. 190 – 202;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3779-42-8,3-Bromo-N,N,N-trimethylpropan-1-aminium bromide,as a common compound, the synthetic route is as follows.

Compound 43 (50 mg, 0.063 mmol) and (3-bromopropyl)- trimethylammonium bromide (164mg, 0.63 mmol, LOEQV.) are dissolved and potassium carbonate (130 mg, 0.95 mmol, 15 eqv. ) is suspended under argon in absolute DMF (30 ML) and the mixture is stirred at 55C for 12 h. The solvent is removed in vacuo at 50C and the residue applied to a pad (2 cm deep) of silica. The unreacted ammonium salts are washed off with methanol (lOOOmL) and the product is eluted with acetic acid: methanol: water (3: 2: 1 by vol. ). The solvent is removed under reduced pressure and the residue further purified by chromatography on a column (100G) of Sephadex LH-20 using n-butanol: water: acetic acid (4: 5: 1 by vol. , upper phase) as the eluent. The solvents are removed under reduced pressure and the residue dissolved in methanol and passed through a small column of anion exchange resin (Amberlite IRA 400, chloride form) using methanol as eluent. After evaporation of solvent, the crude product is dissolved in the minimum amount of methanol and diethylether (50 mL) added. The solution is centrifuged for 15 min. The supernatant liquid is evaporated to dryness and the residue dried at high vacuum to give the product as a violet solid. 1H-NMR : 5H (300MHZ, CD30D) : 0.90 (t, 3H, 3J= 7.5 Hz), 1.25-1. 41 (m, 8H), 1.45 (bs, 2H), 1.87 (bs, 2H), 2.38 (bs, 6H), 3,29 (bs, 27H), 3.67 (t, 6H, 3J= 7. 5 Hz), 4.01 (t, 2H, 3J= 7. 5 Hz), 4.30 (t, 6H, 3J= 7.5 Hz), 7.11 (d, 2H, 3J= 7.5 Hz), 7. 38 (d, 6H, 3J= 7.5 Hz), 7.95 (d, 2H, 3J= 7.5 Hz), 8.11 (d, 6H, 3J= 7. 5 Hz), 8.93 (bs, 8H)

3779-42-8, 3779-42-8 3-Bromo-N,N,N-trimethylpropan-1-aminium bromide 151145, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; DESTINY PHARMA LIMITED; SOLVIAS AG; WO2004/56828; (2004); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

Manganese(II) chloride (0.075 mmol, 10 mg), dipyridylacetylene(0.075 mmol, 14 mg) and biphenyl-4,4?-dicarboxylic acid (0.075 mmol, 18 mg) were suspendedin a mixture of dimethylformamide (8 mL), water (1 mL)and ethanol (1 mL) in a glass autoclave. The closed vesselwas then heated at 110 C over a period of 3 days. Then,the mixture was allowed to cool to rt in a rate of 5 C h-1,whereupon long needles formed which were filtered offand subjected to single crystal X-ray diffraction. Yield:14 mg (58%); dec. < 379 C. As the paragraph descriping shows that 787-70-2 is playing an increasingly important role. Reference£º
Article; Smeyanov, Alexey; Nieger, Martin; Gustus, Rene; Maus-Friedrichs, Wolfgang; Schmidt, Andreas; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 70; 12; (2015); p. 897 – 902;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI