Tag: M.W:200-300

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ category: catalyst-ligand, Which mentioned a new discovery about 295-64-7

INDAZOLE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein: W is C(=O)NHR1, C(=S)NHR1, or CH2het; Y is H, or CF; R1 is H, C16alkyl, or OC1-6alkyl; X is H, C1-6alkyl, or C3-7cycloalkyl; Z is H, halo, C1-6alkyl, OC1-6alkyl, or SC1-6alkyl; het is a five-(5) or six-(6) membered heterocyclic ring having 1-4 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen within the ring. The compounds are useful as antibacterial agents.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 295-64-7, help many people in the next few years.category: catalyst-ligand

Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 18531-94-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 18531-94-7, Name is (R)-[1,1′-Binaphthalene]-2,2′-diol, molecular formula is C20H14O2. In a Article£¬once mentioned of 18531-94-7

Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols

(Aqua)ruthenium(salen) complex 1c achieved good to high chemo- A nd enantioselective oxidative cross-coupling of arenols. The catalytic system can be used to selectively produce C1-symmetric bis(arenol)s from the combination of C3- A nd C7-substituted 2-naphthols or phenols even when there is no significant difference in oxidation potential between the cross-coupling partners. This unique cross-selectivity is dominated by steric rather than electronic effects of the arenols and can be controlled by chemoselective single-electron oxidation and oxidative carbon-carbon bond formation.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C17H19NO, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 112068-01-6, Name is (S)-Diphenyl(pyrrolidin-2-yl)methanol, molecular formula is C17H19NO. In a Article, authors is Gelbrich£¬once mentioned of 112068-01-6

Monomeric organoaluminium complexes RAl(OR*)2 and R2AlOR* with an optically active amino alkoxide ligand

The reactions of trialkylaluminium, R3Al, with (S)-(-)alpha,alpha-diphenyl-2-pyrrolidinyl-methanol have been investigated, in which unusual bis-complexes RAl(OR*)2 were obtained [OR=(S)-alpha,alpha-diphenyl-2-pyrrolidinyl-methoxide (Dpm), R=Me (1), Et (2), 1-Nor (3)]. A similar reaction carried out with R=t-Bu yields, by contrast, the expected mono-alkoxide R2AlOR* (4). All compounds were characterised by X-ray crystallography and NMR spectroscopy. The molecular structures are monomeric. In 1-3, the aluminium centres bonded to the nitrogen atoms of two chelating ligands are five-coordinate, while the metal atom contained in 4 is tetrahedrally surrounded. The absolute structures of all complexes were determined from X-ray diffraction data. The formation of the dative Al-N bonds is stereospecific in all cases.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 112068-01-6, help many people in the next few years.COA of Formula: C17H19NO

Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of 4-Bromo-2,2′-bipyridine. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 14162-95-9

A high molar extinction coefficient mono-anthracenyl bipyridyl heteroleptic ruthenium(II) complex: Synthesis, photophysical and electrochemical properties

In our quest to develop good materials as photosensitizers for photovoltaic dye-sensitized solar cells (DSSCs), cis-dithiocyanato-4-(2,3-dimethylacrylic acid)-2,2′- bipyridyl-4-(9-anthracenyl-(2,3-dimethylacrylic)-2,2′-bipyridyl ruthenium(II) complex, a high molar extinction coefficient charge transfer sensitizer, was designed, synthesized and characterized by spectroscopy and electrochemical techniques. Earlier studies on heteroleptic ruthenium(II) complex analogues containing functionalized oligo-anthracenyl phenanthroline ligands have been reported and documented. Based on a general linear correlation between increase in the length of p-conjugation bond and the molar extinction coefficients, herein, we report the photophysical and electrochemical properties of a Ru(II) bipyridyl complex analogue with a single functionalized anthracenyl unit. Interestingly, the complex shows better broad and intense metal-to ligand charge transfer (MLCT) band absorption with higher molar extinction coefficient (deltamax = 518 nm, sigma = 44900 M-1cm-1), and appreciable photoluminescence spanning the visible region than those containing higher anthracenyl units. It was shown that molar absorption coefficient of the complexes may not be solely depended on the extended p-conjugation but are reduced by molecular aggregation in the molecules.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of 5350-41-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5350-41-4, Name is N,N,N-Trimethyl-1-phenylmethanaminium bromide, molecular formula is C10H16BrN. In a Patent£¬once mentioned of 5350-41-4

STORAGE-STABLE ONE-COMPONENT POLYURETHANE PREPREGS AND SHAPED BODIES COMPOSED OF POLYURETHANE COMPOSITION THAT HAVE BEEN PRODUCED THEREFROM

The invention relates to storage-stable one-component (1K) polyurethane prepregs and to shaped bodies produced therefrom.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 3779-42-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3779-42-8, Name is 3-Bromo-N,N,N-trimethylpropan-1-aminium bromide, molecular formula is C6H15Br2N. In a Article£¬once mentioned of 3779-42-8

Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity

Noscapine, an opium-derived ‘kinder-gentler’ microtubule-modulating drug is in Phase I/II clinical trials for cancer chemotherapy. However, its limited water solubility encumbers its development into an oral anticancer drug with clinical promise. Here we report the synthesis of 9 third-generation, water-soluble noscapine analogs with negatively charged sulfonato and positively charged quaternary ammonium groups using noscapine, 9-bromonoscapine and 9-aminonoscapine as scaffolds. The predictive free energy of solvation was found to be lower for sulfonates (6a-c; 8a-c) compared to the quaternary ammonium-substituted counterparts, explaining their higher water solubility. In addition, sulfonates showed higher charge dispersability, which may effectively shield the hydrophobicity of isoquinoline nucleus as indicated by hydrophobicity mapping methods. These in silico data underscore efficient net charge balancing, which may explain higher water solubility and thus enhanced antiproliferative efficacy and improved bioavailability. We observed that 6b, 8b and 8c strongly inhibited tubulin polymerization and demonstrated significant antiproliferative activity against four cancer cell lines compared to noscapine. Molecular simulation and docking studies of tubulin-drug complexes revealed that the brominated compound with a four-carbon chain (4b, 6b, and 8b) showed optimal binding with tubulin heterodimers. Interestingly, 6b, 8b and 8c treated PC-3 cells resulted in preponderance of mitotic cells with multipolar spindle morphology, suggesting that they stall the cell cycle. Furthermore, in vivo pharmacokinetic evaluation of 6b, 8b and 8c revealed at least 1-2-fold improvement in their bioavailability compared to noscapine. To our knowledge, this is the first report to demonstrate novel water-soluble noscapine analogs that may pave the way for future pre-clinical drug development.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 112068-01-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.112068-01-6, Name is (S)-Diphenyl(pyrrolidin-2-yl)methanol, molecular formula is C17H19NO. In a article£¬once mentioned of 112068-01-6

Intramolecular Chirality Transfer [2 + 2] Cycloadditions of Allenoates and Alkenes

Intramolecular chirality transfer [2 + 2] cycloaddition of enantiomerically enriched allenoates and alkenes is presented. The use of a chiral catalyst was found to be critical to achieve high levels of diastereoselectivity compared to use of an achiral catalyst. The method developed leads to highly substituted cyclobutanes that would be difficult to prepare by alternative methods.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of 18531-99-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.18531-99-2, Name is (S)-[1,1′-Binaphthalene]-2,2′-diol, molecular formula is C20H14O2. In a Article£¬once mentioned of 18531-99-2

Properties of a binaphthyl-bridged porphyrin – Iron complex bearing hydroxy groups inside its cavity

Hydrogen-bond formation with the terminal oxygen atom is considered to be the basis of dioxygen molecule activation by cytochrome P450. In order to verify the effect of this hydrogen bond, we have undertaken the synthesis of a model complex: a binaphthyl-bridged porphyrin bearing hydroxy groups at suitable positions (“single coronet” or “SC”). The reactivity of the iron complex of the synthesized compound towards basic ligands, dioxygen and carbon monoxide has been studied. When a bulky axial ligand such as 1-methyladamantyl-2-methylimidazole is used, only the pentacoordinated complex is obtained, and, as expected, dioxygen binds as the sixth ligand only in the cavity of the compound. Under unusually low dioxygen partial pressures and in rigorously anhydrous toluene, the pentacoordinated iron complex is completely transformed into a new species which absorbs in the visible region at 420 and 559 nm, and which we have identified as the oxygenated complex. Surprisingly, this reaction seems to occur irreversibly, based on the fact that the initial complex is not recovered after bubbling nitrogen through the solution for several hours. On the other hand, saturation of the solution with carbon monoxide transforms the complex slowly but completely into the Fe11-CO complex which is stable in a dioxygen-saturated toluene solution at 0C. However, by raising the temperature, it is spontaneously transformed back into the dioxygen complex; this verifies the reversibility of the dioxygen binding process. Compared with its affinity towards carbon monoxide, the SC iron complex has a much stronger affinity towards dioxygen. This remarkable property may be partly explained by hydrogen bonding between the terminal atom of the dioxygen molecule and the hydroxy groups attached to the binaphthyl bridges of the porphyrin, and also by polar neighbouring-group effects. Ligand binding and debinding constants have been determined by laser flash photolysis. Ligand-iron bond strength and hydrogen bonding have been investigated by IR and Raman spectroscopy. The role of the hydroxy groups has also been emphasized by comparing the properties of SC with those of a binaphthyl-bridged porphyrin bearing methoxy groups instead of hydroxy groups.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 117408-98-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.117408-98-7, Name is (S)-4-tert-Butyl-2-(2-pyridyl)oxazoline, molecular formula is C12H16N2O. In a Article£¬once mentioned of 117408-98-7

Asymmetric Aza-Wacker-Type Cyclization of N-Ts Hydrazine-Tethered Tetrasubstituted Olefins: Synthesis of Pyrazolines Bearing One Quaternary or Two Vicinal Stereocenters

We have developed an asymmetric aza-Wacker-type cyclization of N-Ts hydrazine-tethered tetrasubstituted olefins, affording optically active pyrazolines bearing chiral tetrasubstituted carbon stereocenters. This reaction is tolerant to a broad range of substrates under mild reaction conditions, giving the desired chiral products with high enantioselectivities. Generation of two vicinal stereocenters on the C=C double bonds was also achieved with high selectivities, a process which has been rarely studied for Wacker-type reactions. A mechanistic study revealed that this aza-Wacker-type cyclization undergoes a syn-aminopalladation process. It was also found that for substrates bearing two linear alkyl substituents on the outer carbon atom of the olefin, both of which are larger than a methyl group, the alkyl substituent that is cis to the intranucleophilic group participates more readily in beta-hydride elimination. When one of the two alkyl substituents on the outer carbon atom of the olefin is a methyl group, beta-hydride elimination proceeds selectively at the methylene side, thus both diastereomers can be prepared via switching the configuration of the olefin. Furthermore, the product can be converted to a pharmaceutical compound in high yields over three steps.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application of 123640-38-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 123640-38-0, Name is 2,6-Di(1-pyrazolyl)pyridine, molecular formula is C11H9N5. In a Patent£¬once mentioned of 123640-38-0

COBALT COMPLEXES WITH TRICYANOBORATE OR DICYANOBORATE COUNTER-ANIONS FOR ELECTROCHEMICAL OR OPTOELECTRONIC DEVICES

The present invention relates to Formula (I) complexes of cobaltocations with dicyanoborate or tricyanoborate counter anions. The complexes are used as redox active species or dopant for hole transport materials in electrochemical and/or optoelectronic devices. The present invention relates additionally to electrolyte formulations comprising such salts. in which Xis H orF, Y 1 and Y2 are each independently C or N, z is 1 or 2, n is 2 or 3, The other variables are as defined in the claims.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI