Tag: M.W:100-200

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Huang, X. H.; Song, J. J.; Li, H.; Gong, M. T.; Zhang, Y. researched the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ).COA of Formula: C10H14N2.They published the article 《Selective removal of nicotine from the main stream smoke by using a surface-imprinted polymer monolith as adsorbent》 about this compound( cas:494-52-0 ) in Journal of Hazardous Materials. Keywords: nicotine removal stream smoke surface imprinted polymer monolith adsorbent; Adsorption; Molecularly imprinted polymer; Nicotine; Selective removal; Surface-imprinted monolith. We’ll tell you more about this compound (cas:494-52-0).

Using molecularly imprinted polymer as a selective adsorbent for gaseous toxicants is a novel attempt. In present work, a nicotine surface-imprinted monolith (MIM) was used for the selective removal of nicotine from smoke. First, the retention capacity and selectivity for this MIM was tested by using it as the stationary phase in gas chromatog. and chromatog. conditions optimized. Then, the gas phase adsorption isotherms of MIM were constructed and the adsorption thermodn. explored. At last, the applicability for MIM in the removal of nicotine in smoke was explored. Results indicated a stronger retention capacity and a higher selectivity of MIM toward the template vapor, with a capacity factor (87.88) and a selectivity factor (10.15) under the optimized conditions. A higher standard adsorption enthalpy change for this MIM toward the template (|ΔH0a| = 65.53 kJ mol-1) than that for the non-imprinted monolith (NIM) column (|ΔH0a| = 47.46 kJ mol-1) was observed The adsorption isotherm for MIM appears the BET type II shape, while that for the NIM was approx. linear. When this MIM was used as the adsorbent, it exhibited a high performance in the selective removal of nicotine from the main stream smoke, with an adsorption percentage of 99.43%.

Compounds in my other articles are similar to this one((S)-3-(Piperidin-2-yl)pyridine)COA of Formula: C10H14N2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C5H8O3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about A facile and highly chemoselective protection of primary hydroxyl groups with 2-methyl-1-butene. Author is Figadere, Bruno; Franck, Xavier; Cave, Andre.

The chemoselective formation of tert-amyl ethers of primary hydroxyl groups in the presence of secondary hydroxyl groups is described. Thus, treatment of BuCH(OH)CH2OH with 1 equiv 2-methyl-1-butene in the presence BF3.Et2O afforded 78% BuCH(OH)CH2OCMe2Et and < 3% bis-tert-amyl ether. Compounds in my other articles are similar to this one((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Synthetic Route of C5H8O3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Computed Properties of C5H8O3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Synthesis of 2′-C-α-methyl-2′,3′-dideoxynucleosides. Author is Giri, Indrajit; Bolon, Pascal J.; Chu, Chung K..

A general method for the synthesis of 2′-C-α-methyl-2′,3′-dideoxynucleosides is presented. Stereofacial selectivity of the 2-C-methylation reaction of γ-lactone I (R = SiPh2CMe3, CH2Ph, CH2OCH2CH2OMe) has been investigated, in which the presence of a bulky group at the 5-hydroxymethyl produced the α-isomer as a major product. During glycosylation, the α-Me group directed the formation of nucleosides in favor of the β-isomer. This methodol. is applied to the synthesis of some new pyrimidine and purine nucleosides.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Alijevic, Omar; McHugh, Damian; Rufener, Lucien; Mazurov, Anatoly; Hoeng, Julia; Peitsch, Manuel published the article 《An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors》. Keywords: Nicotiana solanaceae tobacco alkaloids nAChR nicotine anabasine anatabine; Anabasine; Anatabine; Nicotiana tabacum; Nicotine; Nornicotine; Solanaceae; Tobacco alkaloids; nAChR; α4β2; α7.They researched the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ).Reference of (S)-3-(Piperidin-2-yl)pyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:494-52-0) here.

Nicotinic acetylcholine receptor (nAChR) subtype-selective pharmacol. profiles of tobacco alkaloids are essential for understanding the physiol. effects of tobacco products. In this study, automated electrophysiol. was used to functionally characterize the effects of distinct groups of tobacco alkaloids on human α4β2 and α7 nAChRs. We found that, in tobacco alkaloids, pyridine as a hydrogen bond acceptor and a basic nitrogen atom at a distance of 4-7 Å are pharmacophoric elements necessary for mol. recognition by α4β2 and α7 nAChRs with various degrees of selectivity, potency, and efficacy. While four alkaloids-nicotine, nornicotine, anabasine and R-anatabine-potently activated α4β2, they were also weak agonists of α7 nAChRs. Nicotine was the most potent agonist of α4β2, while anabasine elicited the highest activation of α7. None of the tobacco alkaloids enhanced nAChR activity elicited by the endogenous ligand acetylcholine; therefore, none was considered to be a pos. allosteric modulator (PAM) of either α4β2 or α7 nAChRs. In contrast, we identified tobacco alkaloids, such as the tryptophan metabolite 6-hydroxykynurenic acid, that decreased the activity of both α4β2 and α7 nAChRs. Our study identified a class of alkaloids with pos. and neg. effects against human α4β2 and α7 nAChRs. It also revealed human α4β2 to be the principal receptor for sensing the most abundant alkaloids in tobacco leaves.

Compounds in my other articles are similar to this one((S)-3-(Piperidin-2-yl)pyridine)Reference of (S)-3-(Piperidin-2-yl)pyridine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Category: catalyst-ligand. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Circular dichroism (CD) of marmelo lactones and the effect of the unsaturation at C-5 on the Cotton effect of γ-lactone. Author is Nishida, Yoshihiro; Konno, Toshio; Ohrui, Hiroshi; Meguro, Hiroshi.

The CD of the (+)-marmelo lactone A (I) and the (+)-marmelo lactone B (II) had distinct cotton effects at 217 nm (n→π*) and 230∼235 nm (π→π*). The sign of the 217 nm bond is opposite to that of the saturated lactones III (R = CH2OH, CH2CH2CHMe2, CH2I), is independent of the C(2) configuration and the θ are higher than those of saturated lactones which indicate the formation of inherently dissym. chromophores between a lactone CO group and a C(5) double bond. This is substantiated by the CD of III (R = CO2H, CO2Et, cis-CH:CHCMe:CH2, trans-CH:CHCMe:CH2) and is not explicable based on exciton theory. Empirically the Cotton effect sign associated with n→π* transitions for the absolute configuration at C(4) of γ-lactones with a double bond at C(5) is pos. for the (4S) lactone and neg. for the (4R) lactone.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-(Piperazin-1-yl)nicotinonitrile, is researched, Molecular C10H12N4, CAS is 149554-29-0, about The discovery of potent antagonists of NPBWR1 (GPR7).Application In Synthesis of 6-(Piperazin-1-yl)nicotinonitrile.

The synthesis and evaluation of small mol. antagonists of the G protein-coupled receptor NPBWR1 (GPR7) are reported for the first time. [4-(5-Chloropyridin-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[(1R)-1-(4-methoxyphenyl)ethyl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone (I) emerged as a hit from a high-throughput screen. Examination of substituents that focused on replacing the 5-chloropyridine and 4-methoxybenzylamino groups of I led to the identification of compounds that exhibited subnanomolar potencies as low as 660 pM {II [X = NH]} in the functional assay and 200 pM in the binding assay {II [X = O]}.

In some applications, this compound(149554-29-0)Application In Synthesis of 6-(Piperazin-1-yl)nicotinonitrile is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Plant growth regulators and Axl and immune checkpoint inhibitors from the edible mushroom Leucopaxillus giganteus, the main research direction is Leucopaxillus lung cancer anticancer plant growth regulator Axl PDL1; Leucopaxillus giganteus ; Axl inhibitor; immune checkpoint inhibitor; plant growth regulator; structure determination.Formula: C5H8O3.

A novel compound, (R)-4-ethoxy-2-hydroxy-4-oxobutanoic acid (), and six known compounds (-) were isolated from the fruiting bodies of the wild edible mushroom Leucopaxillus giganteus. The planar structure of was determined by the interpretation of spectroscopic data anal. The absolute configuration of was determined by comparing sp. rotation of the synthetic compounds In the plant regulatory assay, the isolated compounds (-) and the chem. prepared compounds (-) were evaluated their biol. activity against the lettuce (Lactuca sativa) growth. Compounds and – showed the significant regulatory activity of lettuce growth. showed the strongest inhibition activity among the all the compounds tested. In the lung cancer assay, all the compounds were assessed the mRNA expression of Axl and immune checkpoints (PD-L1, PD-L2) in the human A549 alveolar epithelial cell line by RT-PCR. Compounds – showed significant inhibition activity against Axl and/or immune checkpoint.

In some applications, this compound(32780-06-6)Formula: C5H8O3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Lawler, Tameka S.; Stanfill, Stephen B.; Tran, Hang T.; Lee, Grace E.; Chen, Patrick X.; Kimbrell, J. Brett; Lisko, Joseph G.; Fernandez, Carolina; Caudill, Samuel P.; Rey de Castro, B.; Watson, Clifford H. published the article 《Chemical analysis of snus products from the United States and northern Europe》. Keywords: snus moisture nicotine TSNA United States Europe.They researched the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ).Safety of (S)-3-(Piperidin-2-yl)pyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:494-52-0) here.

Snus is an oral tobacco product that originated in Sweden. Snus products are available as fine-cut loose tobacco or in pre-portioned porous “”pouches.”” Some snus products undergo tobacco pasteurization during manufacturing, a process that removes or reduces nitrite-forming microbes, resulting in less tobacco-specific nitrosamine content in the product. Some tobacco companies and researchers have suggested that snus is potentially less harmful than traditional tobacco and thus a potential smoking cessation aid or an alternative to continued cigarette consumption. Although snus is available in various countries, limited information exists on snus variants from different manufacturers. Moisture, pH, nicotine, and tobacco-specific N’-nitrosamines (TSNAs) were quantified in 64 snus products made by 10 manufacturers in the United States and Northern Europe (NE). Reported means, standard Errors, and differences are least-square (LS) estimates from bootstrapped mixed effects models, which accounted for correlation among repeated measurements. Minor alkaloids and select flavors were also measured. Among all product types, moisture (27.4%-59.5%), pH (pH 5.87-9.10), total nicotine (6.81-20.6 mg/g, wet), unprotonated nicotine (0.083-15.7 mg/g), and total TSNAs (390-4,910 ng/g) varied widely. The LS-mean unprotonated nicotine concentration of NE portion (7.72 mg/g, SE = 0.963) and NE loose (5.06 mg/g, SE = 1.26) snus were each significantly higher than US portion snus (1.00 mg/g, SE = 1.56). Concentrations of minor alkaloids varied most among products with the highest total nicotine levels. The LS-mean NNN+NNK were higher in snus sold in the US (1360 ng/g, SE = 207) than in NE (836 ng/g, SE = 132) countries. The most abundant flavor compounds detected were pulegone, eucalyptol, and menthol. Phys. and chem. characteristics of US and NE products labeled as snus can vary considerably and should not be considered “”equivalent””. Our findings could inform public health and policy decisions pertaining to snus exposure and potential adverse health effects associated with snus.

In some applications, this compound(494-52-0)Safety of (S)-3-(Piperidin-2-yl)pyridine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 32780-06-6, is researched, SMILESS is O=C1O[C@H](CO)CC1, Molecular C5H8O3Journal, Green Chemistry called Chemo-enzymatic synthesis of key intermediates (S)-γ-hydroxymethyl-α,β-butenolide and (S)-γ-hydroxymethyl-γ-butyrolactone via lipase-mediated Baeyer-Villiger oxidation of levoglucosenone, Author is Flourat, A. L.; Peru, A. A. M.; Teixeira, A. R. S.; Brunissen, F.; Allais, F., the main research direction is lipase Baeyer Villiger oxidation levoglucosenone.Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

Levoglucosenone (LGO), a valuable chiral platform chem. that can be efficiently produced from catalytic fast pyrolysis of cellulose, has been efficiently converted into optically pure (S)-γ-hydroxymethyl-α,β-butenolide (HBO) using a two-step sequence involving a lipase-mediated Baeyer-Villiger oxidation and an acid hydrolysis. In the same fashion, (S)-γ-hydroxymethyl-γ-butyrolactone (2H-HBO) was successfully obtained through a three-step sequence (Baeyer-Villiger, palladium-catalyzed hydrogenation and acid hydrolysis). The use of solid buffers in the lipase-mediated Baeyer-Villiger oxidation has proved beneficial in two ways: not only the reaction time and the enzymic load were both reduced four-fold (from 8 to 2 h and 464 to 113 U mmol-1) to reach conversions ≥83%, but solid buffers also prevented lipase from denaturation, thus preserving its enzymic activity and allowing its use for further oxidation cycles.

In some applications, this compound(32780-06-6)Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Name: (S)-3-(Piperidin-2-yl)pyridine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Increased leaf nicotine content by targeting transcription factor gene expression in commercial flue-cured tobacco (Nicotiana tabacum L.). Author is Liu, Hai; Kotova, Tatyana I.; Timko, Michael P..

Nicotine, the most abundant pyridine alkaloid in cultivated tobacco (Nicotiana tabacum L.), is a potent inhibitor of insect and animal herbivory and a neurostimulator of human brain function. Nicotine biosynthesis is controlled developmentally and can be induced by abiotic and biotic stressors via a jasmonic acid (JA)-mediated signal transduction mechanism involving members of the APETALA 2/ethylene-responsive factor (AP2/ERF) and basic helix-loop-helix (bHLH) transcription factor (TF) families. AP2/ERF and bHLH TFs work combinatorically to control nicotine biosynthesis and its subsequent accumulation in tobacco leaves. Here, we demonstrate that overexpression of the tobacco NtERF32, NtERF221/ORC1, and NtMYC2a TFs leads to significant increases in nicotine accumulation in T2 transgenic K326 tobacco plants before topping. Up to 9-fold higher nicotine production was achieved in transgenics overexpressing NtERF221/ORC1 under the control of a constitutive GmUBI3 gene promoter compared to wild-type plants. The constitutive 2XCaMV35S promoter and a novel JA-inducible 4XGAG promoter were less effective in driving high-level nicotine formation. Methyljasmonic acid (MeJA) treatment further elevated nicotine production in all transgenic lines. Our results show that targeted manipulation of NtERF221/ORC1 is an effective strategy for elevating leaf nicotine levels in com. tobacco for use in the preparation of reduced risk tobacco products for smoking replacement therapeutics.

In some applications, this compound(494-52-0)Name: (S)-3-(Piperidin-2-yl)pyridine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI