Top Picks: new discover of 2,2′-(Methylazanediyl)diacetic acid

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Boron chemistry has evolved to become one of the most diverse and applied fields in organic synthesis and catalysis. Various valuable reactions such as hydroborylations and Suzuki?Miyaura cross-couplings (SMCs) are now considered as indispensable methods in the synthetic toolbox of researchers in academia and industry. The development of novel sterically-and electronically-demanding C(sp3)?Boron reagents and their subsequent metal-catalyzed cross-couplings attracts strong attention and serves in turn to expedite the wheel of innovative applications of otherwise challenging organic adducts in different fields. This review describes the significant progress in the utilization of classical and novel C(sp3)?B reagents (9-BBN and 9-MeO-9-BBN, trifluoroboronates, alkylboranes, alkylboronic acids, MIDA, etc.) as coupling partners in challenging metal-catalyzed C(sp3)?C(sp2) cross-coupling reactions, such as B-alkyl SMCs after 2001.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Extracurricular laboratory:new discovery of 68737-65-5

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The synthesis of N,N?-unsymmetrically tetrasubstituted cyclic 1,2-diamines derived from (1R,2R)-diaminocyclohexane is reported. We comment on the structural nature of these cyclic 1,2-diamines and discuss their characteristic features.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

New explortion of 3030-47-5

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Reference of 3030-47-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3030-47-5, Name is N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine, molecular formula is C9H23N3. In a Article,once mentioned of 3030-47-5

The crystal and molecular structure of [{Cu(pmdien)F(H2O)}2][BF4]2 1(pmdien = N,N,N’?N?,N?-pentamethyldiethylenetriamine) has been determined. The cation exists in the solid state as a unique dimer, held together by O-H … F hydrogen-bonding interactions [O … F 2.567(2), O-H 0.83(3), F … H 1.74(3) A, F … H-O 178.5(23)]. The O … F separation is the shortest ligand fluoride-ligand water hydrogen-bonding interaction in any copper(II) complex. The copper atom is five-co-ordinate and has a square-based pyramidal geometry comprising equatorially located pmdien (mean Cu-N 2.052 A), and fluoride [Cu-F 1.888(1) A] and axially located water [Cu-O 2.211(1) A].

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Top Picks: new discover of Sodium trifluoromethanesulfonate

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, name: Sodium trifluoromethanesulfonate, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2926-30-9, Name is Sodium trifluoromethanesulfonate, molecular formula is CF3NaO3S. In a Article, authors is Tanabe, Yoshiaki,once mentioned of 2926-30-9

Molybdenum-catalyzed conversion of molecular dinitrogen into ammonia under ambient reaction conditions has been achieved by using a proton source generated in situ from the ruthenium-catalyzed oxidation of water in combination with visible light and a photosensitizer. The preset reaction system is considered as a new model for the nitrogen fixation by photosynthetic bacteria.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Extended knowledge of N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine

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Synthetic Route of 105-83-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.105-83-9, Name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, molecular formula is C7H19N3. In a Article,once mentioned of 105-83-9

A new class of potent and highly selective antitumor agents has been synthesized. Bisimidazoacridones, where the tetracyclic ring systems are held together by either a N2-methyl-diethylenetriamine or 3,3′-diamino-N- methyldipropylamine linker, and related asymmetrical compounds, where one of the imidazoacridone ring system was replaced by a triazoloacridone ring system, were found to be cytostatic and cytotoxic in vitro. Some of these compounds, such as 5,5′-[(methylimino)bis(3,1-propanediylimino)]bis[6H- imidazo[4,5,1-de]acridin-6-one] (4b) showed remarkably high activity and selectivity for colon cancer in the National Cancer Institute screen. This antitumor effect was also apparent in colony survival assays utilizing the colon cancer line, HCT-116, and in in vivo assays involving xenografts of tumor derived from HCT-116 in nude mice. The tested compounds exhibited relatively low acute toxicity and were well-tolerated by the treated animals. The bisimidazoacridones interact with nucleic acids in vitro but preliminary experimental and modeling data indicate that in spite of their structure, they may not be bis-intercalators. While the precise mode of action of these compounds is not yet understood, they appear to be excellent candidates for clinical development.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Simple exploration of (1R,2R)-Cyclohexane-1,2-diamine

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A new class of chiral C2-symmetrical diamino-oligothiophenes is described to be effective in catalyzing Pd-mediated asymmetric allylic alkylations in a highly enantioselective manner. The combination of experimental as well as crystallographic evidence revealed the key role played by sulfur-based heteroaromatic rings in the stereodiscriminating step of the procedure. In particular, unprecedented non-covalent secondary interactions between the inner thiophene and the metal center proved to be essential to create the stereochemical environment necessary in order to guarantee excellent levels of chemical and optical yields.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Top Picks: new discover of 2,3′-Bipyridine

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In this paper, a simple method of headspace analysis (HSA) was applied to determine aroma components in Chinese southwest tobacco. Ninety-seven aroma compounds were extracted from tobacco under optimized experimental conditions. Meanwhile, it took 4 h for traditional method namely simultaneous distillation and extraction (SDE) for analysis, which is time-consuming and a waste of solvent. Compared with simultaneous distillation and extraction, headspace analysis is faster and more convenient in extracting tobacco aroma compounds. Moreover, six aroma compounds were first proposed in the research. The main aromatic components in tobacco detected by headspace can evaluate the tobacco quality and distinguish a specific variety from others. Headspace analysis method was proposed as an easy, rapid and environment-friendly method for the determination of aroma components in tobacco. The proposed method can not only enhance the extracting rate of aromas but meet the demand of qualitative analysis.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Some scientific research about 1,4,7-Triazacyclononane

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Reference of 4730-54-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4730-54-5, Name is 1,4,7-Triazacyclononane, molecular formula is C6H15N3. In a Review,once mentioned of 4730-54-5

Background: Dirofilariasis is an endemic disease in tropical and subtropical countries caused by about 40 different species of dirofilari. Dirofilariasis of the oral cavity is extremely rare and is usually seen as mucosal or submucosal nodules. We also present a case of dirofilariasis of the mandibular third molar region submucosally in a 26 year old male patient. Purpose: To identify, enlist and analyze the cases of dirofilariasis in maxillofacial region reported worldwide so as to understand the clinical presentation and encourage the consideration of helminthic infections as a possible differential diagnosis in maxillofacial swellings. Methods: Two authors KC and SK independently searched the electronic database of PUBMED, OVID, Google Scholar and manual search from other sources. A general search strategy was planned and anatomic areas of interest identified. The search was made within a bracket of 1 month by the independent authors KC and SK who assessed titles, abstracts and full texts of articles based on the decided keywords. The final selection of articles was screened for the cases that were reported in the maxillofacial region including the age, gender, site of occurrence and region of the world reported in. A geographic distribution of the reported cases was tabulated. Results: A total number of 265, 97, 1327, 3 articles were identified by PubMed, Ovid, GoogleScholar and manual search respectively. The final articles were manually searched for duplicates and filtered according to the inclusion/exclusion criteria which led to a final list of 58 unique articles that were included in the study. In total 99 cases were identified. Conclusion: Although intraoral dirofilarial infections are extremely uncommon, it should be considered in the differential diagnosis of an intraoral or facial swelling that does not completely respond to routine therapy especially in patients from endemic areas.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Brief introduction of 2,2′-(Methylazanediyl)diacetic acid

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Oxidative degradation experiments on five amines and two amino acids were performed in a new closed setup at atmospheric pressure. For most of the amines/amino acids significant degradation was not present under these conditions, except for MEA and MMEA. The degradation compounds found seem to follow the same patterns as described in literature. Volatile compounds as ammonia and alkylamine play an important role in understanding the initial degradation mechanisms. For MMEA, methylamine and ammonia were found in the same order of magnitude. Oxygen stochiometry of the degradation compounds could not be explained by initial air in the system. Oxygen in some of the degradation compounds could come from oxygen diffusing into the system as seen from proposed model and/or water reacting with iminium giving aldehyde and amine/ammonia. Temperature and dissolved metal seemed to influence oxygen and degradation rate for the MEA experiments.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Can You Really Do Chemisty Experiments About 344-25-2

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Chemistry is an experimental science, Formula: C5H9NO2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 344-25-2, Name is H-D-Pro-OH

Untargeted metabolomics aims to comprehensively profile metabolites as many as possible in biological samples. Recently, ion mobility-mass spectrometry (IM-MS) has emerged as a powerful technology for untargeted metabolomics. The emerging role of IM-MS in untargeted metabolomics enables the separation of metabolite isomers and generation of multidimension data to support the identification of metabolites. In this review, we first introduced the basic principles of IM-MS instruments commonly used for untargeted metabolomics. Then, we demonstrated the application of IM-MS for metabolite separation and identification of both known and unknown metabolites. Finally, we discussed the future developments of IM-MS technology to improve untargeted metabolomics.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI