Tag: M.W:100-200

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Peru, Aurelien A. M.; Flourat, Amandine L.; Gunawan, Christian; Raverty, Warwick; Jevric, Martyn; Greatrex, Ben W.; Allais, Florent researched the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6 ).Formula: C5H8O3.They published the article 《Chemo-enzymatic synthesis of chiral epoxides ethyl and methyl (S)-3-(oxiran-2-yl)propanoates from renewable levoglucosenone: an access to enantiopure (S)-dairy lactone》 about this compound( cas:32780-06-6 ) in Molecules. Keywords: levoglucosenone Baeyer Villiger oxidation acid hydrolysis hydrogenation; butyrolactone preparation green chem; octenyl tetrahydrofuranone preparation green chem; chirality; epoxide; flavor; levoglucosenone; total synthesis. We’ll tell you more about this compound (cas:32780-06-6).

Herein, starting from levoglucosenone (LGO), a biobased chiral compound was obtained through the flash pyrolysis of acidified cellulose, a safer and more sustainable chemo-enzymic synthetic pathway involving lipase-mediated Baeyer-Villiger oxidation, palladium-catalyzed hydrogenation, tosylation and treatment with sodium ethoxide/methoxide as key steps was proposed. This route afforded Et and Me (S)-3-(oxiran-2-yl)propanoates in 57% overall yield, resp. To demonstrate the potentiality of this new synthetic pathway from LGO, the synthesis of high value-added (S)-dairy lactone was undertaken from these epoxides and provided the target in 37% overall yield from LGO.

Although many compounds look similar to this compound(32780-06-6)Formula: C5H8O3, numerous studies have shown that this compound(SMILES:O=C1O[C@H](CO)CC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one(SMILESS: O=C1O[C@H](CO)CC1,cas:32780-06-6) is researched.HPLC of Formula: 123333-71-1. The article 《Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents》 in relation to this compound, is published in Nucleosides & Nucleotides. Let’s take a look at the latest research on this compound (cas:32780-06-6).

We have developed a novel class of 2-phosphonate 1,3-dioxolane nucleotide analogs, from which the guanine derivative displayed weak anti-HCMV activity. Further SAR studies led to the identification of both cis and trans guanine derivatives of THF analogs as potent anti-HCMV agents, both in vitro and in vivo, compared to ganciclovir and HPMPC.

Compounds in my other articles are similar to this one((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 32780-06-6, is researched, SMILESS is O=C1O[C@H](CO)CC1, Molecular C5H8O3Journal, Article, Journal of the American Chemical Society called Stereochemical Elucidation of Streptorubin B, Author is Haynes, Stuart W.; Sydor, Paulina K.; Corre, Christophe; Song, Lijiang; Challis, Gregory L., the main research direction is stereochem streptorubin B Streptomyces enantioselective synthesis.Formula: C5H8O3.

Streptorubin B is a structurally remarkable member of the prodiginine group of antibiotics produced by several actinobacteria, including the model organism Streptomyces coelicolor A3. Transannular strain within the pyrrolophane structure of this mol. causes restricted rotation that gives rise to the possibility of (diastereomeric) atropisomers. Neither the relative nor the absolute stereochem. of streptorubin B is known. NOESY NMR experiments were used to define the relative stereochem. of the major atropisomer of streptorubin B·HCl in solution as anti. We exploited this finding together with our knowledge of streptorubin B biosynthesis in S. coelicolor to determine the absolute stereochem. of the anti atropisomer. 2-Undecylpyrrole stereoselectively labeled with deuterium at C-4′ was synthesized and fed to a mutant of S. coelicolor, which was unable to produce streptorubin B because it was blocked in 2-undecylpyrrole biosynthesis, and in which the genes responsible for the last two steps of streptorubin B biosynthesis were overexpressed. 1H and 2H NMR anal. of the stereoselectively deuterium-labeled streptorubin B·HCl produced by this mutasynthesis strategy allowed us to assign the absolute stereochem. of the major (anti) atropisomer as 7’S. HPLC analyses of streptorubin B isolated from S. coelicolor on a homochiral stationary phase and comparisons with streptorubin B derived from an enantioselective synthesis showed that the natural product consists of an approx. 88:7:5 mixture of the (7’S, anti), (7’S, syn), and (7’R, anti) stereoisomers.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about A synthetic approach to the pseudopterosins using cascade technology. Author is Harrowven, David C.; Dennison, Shelagh T.; Howes, Peter.

A rapid synthetic entry toward the pseudopterosins, a class of diterpenes which display potent antiinflammatory and analgesic properties, is described. The key feature of this approach is the use of a sequential intramol., Lewis acid mediated Friedel-Crafts alkylation-Friedel-Crafts acylation sequence, viz, lactone I to phenalenone II, to establish the tricyclic carbon framework.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called Enantioselective synthesis of (-)-velbanamine and (+)-isovelbanamine using L-glutamic acid as chiral template, Author is Takano, Seiichi; Yonaga, Masahiro; Chiba, Kenji; Ogasawara, Kunio, which mentions a compound: 32780-06-6, SMILESS is O=C1O[C@H](CO)CC1, Molecular C5H8O3, Computed Properties of C5H8O3.

(-)-Velbanamine and (+)-isovelbanamine (I; R = Et, R1 = OH; R = OH, R1 = Et, resp.) were stereoselectively prepared from L-glutamic acid in 14 steps. I are potential intermediates for the Pandaca alkaloids in the natural configuration.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of the chiral synthon for the enantioselective syntheses of the eburnamine type alkaloids, published in 1982-08-01, which mentions a compound: 32780-06-6, mainly applied to eburnamine synthon chiral enantioselective, Synthetic Route of C5H8O3.

A chiral synthon (I) for the syntheses of (-)-eburnamonine (II) and related eburnamine type alkaloids has been prepared in a good yield from the known compound (III) originated from L-glutamic acid or D-mannitol.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Formula: C10H14N2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Ethylene response factor NtERF91 positively regulates alkaloid accumulations in tobacco (Nicotiana tabacum L.).

Tobacco alkaloid metabolism is regulated by various transcription factors (TFs). Here, we have characterized a non-NIC2 locus gene, Ethylene Response Factor 91 (ERF91), function in regulation of alkaloid accumulation in tobacco. NtERF91 was preferentially expressed in roots and induced by jasmonic acid. Addnl., NtERF91 was able to in vitro bind to the NtPMT2 and NtQPT2 promoters via directly targeting the GCC-box elements and transactivate NtQPT2 gene expression. Ectopic overexpression of NtERF91 not only increased the expression of most nicotine biosynthetic genes, but also altered alkaloid accumulation profile, resulting in dramatically anatabine accumulation. We conclude that NtERF91 plays an overlapped but distinct role in regulating tobacco alkaloid accumulations.

Compounds in my other articles are similar to this one((S)-3-(Piperidin-2-yl)pyridine)Formula: C10H14N2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Article, Journal of Pharmaceutical and Biomedical Analysis called A simple dilute-and-shoot method for screening and simultaneous quantification of nicotine and alkaloid impurities in electronic cigarette refills (e-liquids) by UHPLC-DAD, Author is Barhdadi, Sophia; Desmedt, Bart; Courselle, Patricia; Rogiers, Vera; Vanhaecke, Tamara; Deconinck, Eric, the main research direction is nicotine alkaloid impurity quantification electronic cigarette liquid UHPLC DAD; Accuracy profiles; Impurities; Nicotine; UHPLC-DAD; e-cigarettes.Synthetic Route of C10H14N2.

The electronic cigarette (e-cigarette) has emerged as a popular alternative to the traditional hazardous tobacco cigarette. The substantial increase in e-cigarette use also urgently calls for controlling the quality of e-cigarette refill liquid products (e-liquids). Currently, the most important quality indicator of e-liquid products is the quantification of nicotine and its related impurities. Although different methods have been published to measure nicotine and impurity levels, the majority of them use a targeted LC-MS/MS approach. There is, however, a need for more robust quantification methods that are easy to implement in most control (industrial and governmental) laboratories Therefore, in this study, a simple dilute-and-shoot UHPLC-DAD method has been developed and validated for the simultaneous quantification of nicotine and its alkaloid impurities in electronic cigarette refills. An optimal separation of the alkaloids was achieved in a runtime of 11 min. The method was successfully validated using the “”total error”” approach in accordance with the validation requirements of ISO-17025. During this validation, interference between the target components and a number of popular flavouring compounds such as vanillin, maltol, ethylacetate, etc. could be excluded. In addition, small changes to the column temperature, pH and molar concentration of the mobile phase buffer were deliberately introduced to assess the robustness of the method. Only a slightly different outcome between the newly developed UV-detection method and the targeted MS approach was found, due to the sensitivity of the different detection techniques. However, in the context of quality control of nicotine related impurities, for which the European Pharmacopoeia limits are currently applied, the sensitivity of the UHPLC-DAD method was found to be within the acceptable range. Despite the somewhat lower selectivity of the newly developed UV-detection technique vs. a targeted LC-MS/MS approach, it may be concluded that this method is a suitable alternative for quality control purposes.

Although many compounds look similar to this compound(494-52-0)Synthetic Route of C10H14N2, numerous studies have shown that this compound(SMILES:C1(C=NC=CC=1)[C@@H]1CCCCN1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ) is researched.Computed Properties of C10H14N2.Bade, Richard; White, Jason M.; Tscharke, Benjamin J.; Ghetia, Maulik; Abdelaziz, Ahmed; Gerber, Cobus published the article 《Anabasine-based measurement of cigarette consumption using wastewater analysis》 about this compound( cas:494-52-0 ) in Drug Testing and Analysis. Keywords: anabasine anatabine cigarette consumption waste water analysis; cigarettes, cotinine, nicotine, urinary excretion, wastewater-based epidemiology. Let’s learn more about this compound (cas:494-52-0).

Community tobacco use can be monitored over time using wastewater-based epidemiol. approaches by estimating the mass loads of nicotine and its metabolites, cotinine, or hydroxycotinine, in wastewater. The use of nicotine replacement therapies could vary in space and time and mask the true rates of tobacco consumption. Therefore, this work evaluated the content of tobacco specific markers, anatabine and anabasine, in cigarettes, in urine of smokers, and in wastewater. The results indicated that the anabasine content in both licit and illicit cigarettes in Australia is less variable than anatabine and is therefore considered a better measure of tobacco consumption. A study determining the excretion of tobacco-specific alkaloids of smoking and non-smoking volunteers gave an average urinary mass load of anabasine of 4.38μg/L/person and a daily mass load of 1.13μg/day/person. Finally, this was compared with the mass loads of anabasine from wastewater-based epidemiol. data of 3μg/day/person to estimate cigarette rates in a South Australian city: equivalent to 2.6 cigarettes/person/day. The rate of decline of cigarette use was greater when using anabasine as a measure of consumption compared with cotinine. This is the first study to estimate the rate of anabasine excretion, which can be used to estimate tobacco use independent of therapeutically prescribed nicotine.

Compounds in my other articles are similar to this one((S)-3-(Piperidin-2-yl)pyridine)Computed Properties of C10H14N2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application of 494-52-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish. Author is Alzualde, Ainhoa; Jaka, Oihane; Latino, Diogo A. R. S.; Alijevic, Omar; Iturria, Inaki; de Mendoza, Jorge Hurtado; Pospisil, Pavel; Frentzel, Stefan; Peitsch, Manuel C.; Hoeng, Julia; Koshibu, Kyoko.

Alkaloids are a structurally complex group of natural products that have a diverse range of biol. activities and significant therapeutic applications. In this study, we examined the acute, anxiolytic-like effects of nicotinic acetylcholine receptor (nAChR)-activating alkaloids with reported neuropharmacol. effects but whose effects on anxiety are less well understood. Because α4β2 nAChRs can regulate anxiety, we first demonstrated the functional activities of alkaloids on these receptors in vitro. Their effects on anxiety-like behavior in zebrafish were then examined using the zebrafish novel tank test (NTT). The NTT is a relatively high-throughput behavioral paradigm that takes advantage of the natural tendency of fish to dive down when stressed or anxious. We report for the first time that cotinine, anatabine, and methylanatabine may suppress this anxiety-driven zebrafish behavior after a single 20-min treatment. Effective concentrations of these alkaloids were well above the concentrations naturally found in plants and the concentrations needed to induce anxiolytic-like effect by nicotine. These alkaloids showed good receptor interactions at the α4β2 nAChR agonist site as demonstrated by in vitro binding and in silico docking model, although somewhat weaker than that for nicotine. Minimal or no significant effect of other compounds may have been due to low bioavailability of these compounds in the brain, which is supported by the in silico prediction of blood-brain barrier permeability. Taken together, our findings indicate that nicotine, although not riskfree, is the most potent anxiolytic-like alkaloid tested in this study, and other natural alkaloids may regulate anxiety as well.

Compounds in my other articles are similar to this one((S)-3-(Piperidin-2-yl)pyridine)Application of 494-52-0, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI