Tag: M.W:100-200

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ) is researched.Computed Properties of C10H14N2.Deng, Yige; Ding, Songshuang; Zhu, Jiaming; Tian, Yuli; Qiao, Baoming; Shi, Xiangdong published the article 《Effect of drying density on change of main nitrogen compounds in drying process of cigar tobacco》 about this compound( cas:494-52-0 ) in Zhongguo Nongye Keji Daobao. Keywords: drying nitrogen compound cigar tobacco. Let’s learn more about this compound (cas:494-52-0).

In order to fully grasp the changes of nitrogen metabolites during the drying process of cigar tobacco leaves, to formulate a reasonable modulation process, the cigar tobacco variety ′Gu-5′ was used as material to study the effects of different air-drying densities (40, 60 and 80 pieces·rod-1) on the changes of the main nitrogen compounds in cigar tobacco leaves. The results showed that, under different air-drying densities, the changing trends of various nitrogen-containing compounds in tobacco leaves were basically consistent. Among them, the change of total nitrogen content showed a “”bimodal curve””, and the total nitrogen content was the lowest at the end of air-drying; soluble protein degradation mainly occurred during the wilting phase and the yellowing phase, and the accumulation of amino acids proceeded with protein degradation simultaneously, showing a “”fast-slow-fast”” variation trend; the total alkaloid content decreased slightly; nitrate did not change much between before and after air-drying. Among different air-drying densities, total nitrogen, protein and alkaloids of tobacco leaves were degraded the fastest under the treatment of 40 pieces·rod-1, and the three chem. components all reached the lowest value at 25 d after air-drying; amino acids content was fully accumulated during air-drying process and eventually reached 7.61 mg·g-1; its nitrate content was always the lowest during the whole air-drying process. Taken together, the drying d. of 40 pieces·rod-1 was more conducive to improving the quality and industrial availability of cigar tobacco leaves.

The article 《Effect of drying density on change of main nitrogen compounds in drying process of cigar tobacco》 also mentions many details about this compound(494-52-0)Computed Properties of C10H14N2, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

HPLC of Formula: 494-52-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Agonist efficiency from concentration-response curves: Structural implications and applications.

Agonists are evaluated by a concentration-response curve (CRC), with a midpoint (EC50) that indicates potency, a high-concentration asymptote that indicates efficacy, and a low-concentration asymptote that indicates constitutive activity. A third agonist attribute, efficiency (η), is the fraction of binding energy that is applied to the conformational change that activates the receptor. We show that η can be calculated from EC50 and the asymptotes of a CRC derived from either single-channel or whole-cell responses. For 20 agonists of skeletal muscle nicotinic receptors, the distribution of η-values is bimodal with population means at 51% (including acetylcholine, nornicotine, and dimethylphenylpiperazinium) and 40% (including epibatidine, varenicline, and cytisine). The value of η is related inversely to the size of the agonist′s headgroup, with high- vs. low-efficiency ligands having an average volume of 70 vs. 102 Å3. Most binding site mutations have only a small effect on acetylcholine efficiency, except for αY190A (35%), αW149A (60%), and those at αG153 (42%). If η is known, the EC50 and high-concentration asymptote can be calculated from each other. Hence, an entire CRC can be estimated from the response to a single agonist concentration, and efficacy can be estimated from EC50 of a CRC that has been normalized to 1. Given η, the level of constitutive activity can be estimated from a single CRC.

Different reactions of this compound((S)-3-(Piperidin-2-yl)pyridine)HPLC of Formula: 494-52-0 require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Enantio- and diastereoisomers of 2,4-dimethoxy-5-(2,3-dideoxy-5-O-tritylribofuranosyl)pyrimidine. 2′,3′-Dideoxy pyrimidine C-nucleosides by palladium-mediated glycal-aglycon coupling. Author is Zhang, Han Cheng; Daves, G. Doyle Jr..

Newly available enantiomeric 2,3-dideoxyglycals, (5S)- and (5R)-4,5-dihydro-5-[(triphenylmethoxy)methyl]furans and 2,4-dimethoxy-5-iodopyrimidine undergo palladium-mediated coupling by two different, complementary procedures to form enantiomeric pairs of (2′,3′-dideoxy-2′,3′-didehydrofuranosyl)- and (2′,3′-dideoxy-3′,4′-didehydrofuranosyl)pyrimidine C-nucleosides. Stereoselective reductions of the carbohydrate unsaturations produce all four enantio- and diastereoisomers of 2,4-dimethoxy-5-(2,3-dideoxy-5-O-tritylribofuranosyl)pyrimidine. The facile two-step syntheses of 2′,3′-deoxy C-nucleosides which involves preparation of a D-series C-nucleoside from an L-series glycal (and vice versa) represents a new strategy for C-nucleoside synthesis.

Different reactions of this compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Spleen is not required for therapeutic effects of 4OH-GTS-21, a selective α7 nAChR agonist, in the sub-acute phase of ischemic stroke in rats, published in 2021-01-15, which mentions a compound: 494-52-0, mainly applied to alpha nAChR agonist OHGTS therapeutic subacute ischemic stroke spleen; Alpha7; DMXBA; GTS-21; Ischemic stroke; Nicotinic; Spleen, Application In Synthesis of (S)-3-(Piperidin-2-yl)pyridine.

Acute ischemic stroke (AIS) causes both central and peripheral inflammation, while activation of α7 nicotinic acetylcholine receptors (nAChRs) provides both central and peripheral anti-inflammatory and anti-apoptotic effects. Here, we provide evidence that 4OH-GTS-21, a selective α7 agonist, produces its therapeutic effects via primarily central sites of action because 4OH-GTS-21 was found equally effective in splenectomized and non-spenectomized rats in the sub-acute phase of ischemic stroke (≤1 wk). However, the spleen may boost the therapeutic efficacy of 4OH-GTS-21 in certain behavioral tasks as our data also indicated. In our tests, AIS was modeled by transient middle cerebral artery occlusion (tMCAO). Splenectomy was done 2 wk before tMCAO. We determined that: (1) Daily 4OH-GTS-21 treatments for 7 days after tMCAO significantly reduced neurol. deficits and brain injury in both splenectomized and non-spelenectomized rats demonstrating that the spleen is not required for therapeutic benefits of 4OH-GTS-21; (2) The effects of 4OH-GTS-21 in the adhesive sticker removal test were significantly weaker in splenectomized animals suggesting that the spleen boosts the efficacy of 4OH-GTS-21 in the first week after tMCAO; and (3) Ischemic brain injury was not significantly affected by splenectomy in both vehicle-treated and 4OH-GTS-21-treated animals. These data support the hypothesis that the therapeutic efficacy of sub-chronic (≤1 wk) 4OH-GTS-21 primarily originates from central sites of action. These results validate brain availability as a critical factor for developing novel α7 ligands for AIS.

Different reactions of this compound((S)-3-(Piperidin-2-yl)pyridine)Application In Synthesis of (S)-3-(Piperidin-2-yl)pyridine require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Feitoza, Rodrigo B. B.; Lima, Helena R. P. published an article about the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1 ).Recommanded Product: (S)-3-(Piperidin-2-yl)pyridine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:494-52-0) through the article.

The Papilionoideae, which comprises 503 genera and approx. 14,000 species, is the largest and most diverse subfamily of the Fabaceae family. In this subfamily, the Crotalarieae, Genisteae, Podalyrieae, Thermopsideae, Sophoreae and Euchresteae tribes are closely related by micro and macromol. features, thus forming the genistoid clade. This group combines well-known genera, whereas other genera lack phytochem. and chemotaxonomic studies. Thus, this work aimed to characterize the special metabolites in these genera in order to define the chem. profile, the micromol. markers and the chem. diversity, as well as to evaluate the group evolutionary trends. Flavonoids and alkaloids were identified as chemosystematic markers for the studied tribes due to high occurrence number and structural diversity. Among flavonoids, the flavones and isoflavones predominated. Low protection indexes of flavonoid hydroxyls by O-glycosylation or O-methylation were observed, whereas C-prenylation and C-glycosylation were frequent, mainly at C-6 and C-8 positions. The flavone/flavonol ratio shows the predominance of the flavones. Quinolizidine and piperidine alkaloids were present in most genera. Pyrrolizidine alkaloids were found in a few genera from Thermopsideae, Genisteae and Crotalarieae, which suggests a mechanism of adaptive convergence. Cluster anal. allowed separation of genera for each tribe by chem. similarities. The micromol. trends of protection of flavonoid hydroxyls and alkaloid oxidation indicate the genistoid clade is through evolutionary transition, which is consistent with its phylogenetic position in the Papilionoideae subfamily.

Different reactions of this compound((S)-3-(Piperidin-2-yl)pyridine)Recommanded Product: (S)-3-(Piperidin-2-yl)pyridine require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A useful method for the synthesis of β-2′,3′-dideoxynucleosides via a thioglycoside, published in 1992-07-31, which mentions a compound: 32780-06-6, Name is (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, Molecular C5H8O3, Synthetic Route of C5H8O3.

A series of the protected β-2′,3′-dideoxypyrimidine nucleosides is synthesized stereoselectively by the coupling of Ph 5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-1-thio-D-glycero-pentofuranoside (I) with silyl derivatives of nucleoside bases in the presence of NBS at -78°. Thus, I was treated with bis(trimethylsilyl)thymine in CH2Cl2 in the presence of 4A mol. sieves and NBS at -78° to give 83% a mixture of β- and α-dideoxynucleosides II and III in the ratio of 3.7:1 resp.

Different reactions of this compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Synthetic Route of C5H8O3 require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 494-52-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Simultaneous determination of six alkaloids in tobacco and tobacco products by direct analysis of real-time triple quadrupole mass spectrometry with a modified pretreatment method. Author is Li, Chao; Li, E’xian; Ma, Ming; Liu, Xiuming; You, Junheng; Wu, Yiqin; Jiang, Wei; Liu, Zhihua; Qin, Yunhua.

In order to determine six alkaloids (mass fraction) of nicotine, nornicotine, myosmine, anatabine, anabasine, and nicotyrine in tobacco and tobacco products quickly, accurately, and simultaneously, a novel method based on direct anal. of real-time model in situ ionization technique combined tandem mass spectrometry with a modified sample pretreatment was established, in which exptl. parameters such as the type and amount of extraction solvent and injection rate were optimized, resp. The samples of five com. cigarettes and five kinds of tobacco leaves were analyzed by the established method, and the determined values were compared with those obtained using a gas chromatog. with mass spectrometry method: (1) Under optimized conditions (30 mL ultrapure water as extraction solvent and with extraction rate of 0.6 mm/s), anal. could be completed within 10 min. (2) The linear range of the method was 0.002-2000μg/g with R2=0.9957, the recovery ranged from 86.8 to 105.6%, and the limit of detection and the limit of quantification were 0.004-0.835μg/g and 0.013-2.787μg/g, resp. (3) The relative standard deviation between direct anal. of real-time method and the gas chromatog. with mass spectrometry method was 0.34-8.83%. The established method is rapid, reliable, and suitable for the ultrafast determination of six alkaloids in tobacco and tobacco products.

The article 《Simultaneous determination of six alkaloids in tobacco and tobacco products by direct analysis of real-time triple quadrupole mass spectrometry with a modified pretreatment method》 also mentions many details about this compound(494-52-0)Related Products of 494-52-0, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of C5H8O3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Multi-Gram Scale Synthesis of Chiral 3-Methyl-2,5-trans-tetrahydrofurans. Author is Qin, Shuanglin; Cao, Yuting; Luo, Yunhao; Jiang, Shende; Clark, J. Stephen; Wang, Xiaoji; Yang, Guang.

In this article, we report the rapid and facile synthesis of chiral 3-methyl-2,5-trans-tetrahydrofurans. This reaction utilizes cheap and easily available starting materials. A domino hydrolysis and intramol. Michael-type ring closure reaction was the key step. As a result, synthesis of the desired 3-methyl-2,5-trans-tetrahydrofurans could be achieved in gram-scale over seven linear steps with high chem. yield and high diastereoselectivity.

Although many compounds look similar to this compound(32780-06-6)Electric Literature of C5H8O3, numerous studies have shown that this compound(SMILES:O=C1O[C@H](CO)CC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about An Enantioselective Ring Expansion Route Leading to Furanose and Pyranose Nucleosides Featuring Spirodiketopiperazines at the Anomeric Position.Recommanded Product: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

A study directed at the enantioselective synthesis of spirodiketopiperazine homologs, e.g. I, of hydantocidin is described. Furanoid glycals, systems that are amenable to C-5 metalation in the presence of tert-butyllithium, are readily coupled to N-protected 2,3-azetidinediones provided that at least 1 equiv of BF3·OEt2 is present to curb enolization. The resulting 1:1 mixtures of carbinols undergo smooth ring expansion to spirocyclic keto amides when heated with pyridinium p-toluenesulfonate in benzene. 1,2-acyl shifts operate exclusively. Since attempts to engage these products in Beckmann rearrangement proved singularly unsuccessful, recourse was alternatively made to new methodol. based upon sequential Baeyer-Villiger oxidation and ammonolysis. The data show that the first of these steps occurs with exclusive migration of the quaternary carbon. Furthermore, nucleophilic attack by NH3 can be directed regioselectively to the anomeric region. If heating is supplied during acid-promoted cyclization to the spirodiketopiperazines, spiropyranose derivatives are produced in a complementary process. The central issue of this synthesis effort was the utilization of 4-phenylseleno-substituted furanoid glycals so as to ultimately enable introduction of the cis-diol functionality at C-3 and C-4 (hydantocidin numbering).

Although many compounds look similar to this compound(32780-06-6)Recommanded Product: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, numerous studies have shown that this compound(SMILES:O=C1O[C@H](CO)CC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Studies on structurally simple α,β-butenolides. II. (-)-(S)-γ-Hydroxymethyl-α,β-butenolide and derivatives from D-ribonolactone. Efficient synthesis of (-)-ranunculin, the main research direction is ribonolactone ethoxymethylene elimination; ranunculin total synthesis; butenolide hydroxymethyl preparation functionalization; condensation hydroxymethylbutenolide glucopyranosyl bromide; elimination ethoxymethyleneribonolactone.Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

Acid-catalyzed cyclocondensation reaction of D-ribonolactone with (EtO)3CH in refluxing THF for 12 h followed by pyrolysis at 220° and 40 Torr gave 68% of the title butenolide (I; R = H) (II). The preparation of chiral derivatives of II, e.g. I (R = Me, PhCH2, Bu, Ph3C, Ac), is described. Condensation reaction of II with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide in CHCl3 with stirring at room temp for 86 h gave 77% I (R = Q, R1 = Ac) which underwent deacetylation to give 85% (-)-ranunculin (I; R = Q, R1 = H).

After consulting a lot of data, we found that this compound(32780-06-6)Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI