Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33454-82-9,Lithium trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

In an Ar filled flask, 0.150 g (0.24 mmol) of [RuCI(p- cymene)(R,R-TsDPEN)] and 0.037 g (0.24 mmol) of LiOTf were combined. CH2CI2 (10 ml_) was added and the resulting orange mixture was left to stir at ambient temperature. 0.046 g of AgBF4 was then added. The orange suspension gradually darkened to brown and eventually to deep purple in colour. After 21 hours, the suspension was filtered through a 0.45 mm PTFE syringe filter. The brown filtrate was concentrated to dryness leaving a brown residue. Yield: 0.120 g (68 %). 1H and 19F(1HJ NMR (ppm, CD2CI2) showed that the product was obtained (ratio of the products: 1 :1).

33454-82-9, As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Patent; KANATA CHEMICAL TECHNOLOGIES INC.; WO2009/132443; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.294-90-6,1,4,7,10-Tetraazacyclododecane,as a common compound, the synthetic route is as follows.

To a suspension of cyclen (500 g, 29 rnrnol) and sodium acetate (7.86 g, 96 mrnol) in N,N-dirnethylacetarnide (DMA, 60 rnL) at 2O C was added a solution of t-butyl bromoacetate (18.7 g, 14.1 mL, 96 mmol) in DMA (20 rnL) dropwise over a period of 0.5 h. The temperature was maintained at -20 C during the addition, after which the reaction mixture was allowed to come to room temperature. After 24 h of vigorous stirring, thereaction mixture was poured into water (300 rnL) to give a clear solution. Solid KHCO3 (15 g, 150 rnrnol) was added portion wise, and 4 precipitated as a white solid. The precipitate was collected by filtration and dissolved in CHCI3 (250 mL). The solution was washed with water (100 mL), dried (MgSO4), filtered, and concentrated to about 2O3O tnL. Ether (250 mE) was added, after which HHY-330 crystallized as a white fluffy solid.Yield: 12.5 g (73%). ESI-MS found: [M+Ht = 515.5 (Moore, D. A. Org. Synth. 2008, 85,1O-14).

294-90-6, The synthetic route of 294-90-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI; EUROPEAN MOLECULAR BIOLOGY LABORATORY; HU, Hai-Yu; NAZARE, Marc; HAN LIM, Ngee; DING-PFENNIGDORFF, Danping; PLETTENBURG, Oliver; RITZELER, olaf; JURETSCHKE, Hans-Paul; SAAS, Joachim; BARTNIK, Eckart; FLORIAN, Peter; WENDT, Ulrich; SCHULTZ, Carsten; NAGASE, Hideaki; WO2015/75699; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62937-45-5, Example 66; 1-f5-4- (2-Methoxv- (1 R)-methvl-ethoxv)-phenyll-4- (6-methoxy-pyridin-3-vl)-4H- f . 2, 41triazol-3-vlmethvlLpyrrolidine- (2R)-carboxylic acid amide; A mixture of the product of preparation 62 (100mg, 0. 26mol), L-prolinamide (44mg, 0. 39mmol) and potassium carbonate (72mg, 0. 51mmol) were stirred in acetonitrile (10mi), for 18 hours at room temperature, and for 6 hours at 45C. The solvent was then evaporated under reduced pressure and the residue was taken up in ethyl acetate and washed with water and brine. The organic phase was dried over sodium sulfate, concentrated in vacuo, and purified by column chromatography on silica gel, eluting with dichloromethane : methanol : 0.88 ammonia, 98: 2: 0.2, to yield the title compound, 24mg. ‘H NMR (CDC13, 400MHz) d : 1.30 (d, 3H), 1.80 (m, 2H), 2.20 (t, 1H), 2.60 (m, 1H), 3. 10 (t, 1H), 3.20 (m, 1H) 3.40 (s, 3H), 3.50 (m, 1H), 3.60 (m, 1H), 3.80 (d, 1H), 3.90 (d, 1H) 4.00 (s, 3H) 4.60 (m, 1H), 5.10 (s, 1H), 6.80 (d, 1H), 6.90 (d, 2H), 7.30 (d, 2H), 7.40 (d, 1H), 8. 10 (s, 1 H). MS APCI+ m/z 467 [MH] +

62937-45-5 D-Prolinamide 447554, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/82866; (2005); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of the corresponding bis(isatin) 1-8 (5 mmol) and Girard?s reagent (2.5 mmol) in 7 mL of absolute ethanol were added three drops of trifluoroacetic acid. The reaction mixture was refluxed for 2 h. After spontaneous cooling of the solution to room temperature, the formed precipitate was filtered off, washed with absolute diethyl ether and dried in vacuum (12 mmHg)., 1126-58-5

The synthetic route of 1126-58-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bogdanov; Zaripova; Mustafina; Voloshina; Sapunova; Kulik; Mironov; Russian Journal of General Chemistry; vol. 89; 7; (2019); p. 1368 – 1376; Zh. Obshch. Khim.; vol. 89; 7; (2019); p. 1004 – 1012,9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.55 parts by mass of 4-methoxythioanisole, 1.95parts by mass of silver borofluoride, 1.77 parts by mass of 1 -chloromethyl naphthalene, and 10.0 parts by mass of acetone were uniformly mixed and reacted at 25 C. for 24 hours. Afier removal of silver chloride, the reaction solution was transferred to a rotary evaporator, and the solvent was distilled off. The obtained residue was reprecipitated with 10.0 parts by mass of acetone and 10.0 parts by mass of hexane. 3.44 parts by mass of the obtained precipitate, 1.56 parts by mass of lithium trifluoromethanesulfonate, and 10.0 parts by mass of acetone were uniformly mixed and reacted at 25C. for 24 hours. 10.0 parts by mass of distilled water were added to the reaction solution to wash the product. The solvent was distilled off under reduced pressure from the organic layer to obtain 3.87 parts by mass of compound 23. The ratio of the mass of the compound B to the total mass of the compound B and the compound A was 0.965. The yield with respect to 4-methoxythioanisole was 87%. The mass of the compound B was 3.73 g, and the mass of the compoundA was0.14g., 33454-82-9

The synthetic route of 33454-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASAHI KASEI E-MATERIALS CORPORATION; SHIMURA, Tadashi; KAMIMURA, Naoya; OTANI, Akira; SHIMADA, Hitoshi; (69 pag.)US2016/229801; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

348-67-4, H-D-Met-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step (1): To a 2 L four-necked flask was added 153.10 g of D-methionine, 420 g of water, 200 mL of methanol and 158.21 g of diethyl sulfate, and the mixture was stirred at room temperature, and 45 g of concentrated sulfuric acid After the end of heating to 30 ~ 40 , 10h, the recovery of methanol under reduced pressure.After the reaction with anhydrous sodium carbonate solid to adjust the pH to 8 ~ 9, continue 40 reaction 10h.After the reaction is over,The solvent was distilled off under reduced pressure.

348-67-4, 348-67-4 H-D-Met-OH 84815, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Anhui Zhishan New Materials Co., Ltd.; Wei Kaiju; Ren Mingxiu; Cui Yang; Chen Zhongming; Xie Yineng; (9 pag.)CN106928110; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Quaternary ammonium bromide 2(a-b) (1.0 equi.) is mixed withNaBF4/KPF6/LiCF3SO3 (3.05 equi.) in the presence of 10 mL deionizedwater at room temperature with stirring for about 1 h afforded theanion exchanged di/trimeric imidazolium salts. After the anion exchangedreaction, Soxhlet extraction is carried out to remove metallicbromide., 33454-82-9

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Article; Ganapathi, Pandurangan; Ganesan, Kilivelu; Journal of Molecular Liquids; vol. 233; (2017); p. 452 – 464;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4045-44-7, 1,2,3,4,5-Pentamethylcyclopenta-1,3-diene is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

All glassware was dried in a 10000C oven, assembled and kept under a nitrogen purge throughout reaction. All solvents used were anhydrous. To a 100 mL, three-neck round bottom flask equipped with a reflux condenser, teflon stir bar, gas inlet, glass stopper and septum was added cobalt octacarbonyl (6.Og; 17.5 mmol) . The septum was replaced and assembled reaction flask purged an additional 5 minutes. Dichloromethane (50 mL) was then canulated into reaction flask and solution stirred for 5 minutes. To the reaction solution was added 1,2,3,4,5- pentamethylcyclopentadiene (3.1g; 22.7 mmol) and 1,3- cyclohexadiene ((2.5 mL; 26.2 mmol) . Septum was replaced with glass stopper and reaction mixture was stirred and brought to a gentle reflux which was maintained for one (1) hour. The reaction was cooled just until reflux stopped followed by a second addition of 1, 2, 3, 4, 5-pentamethylcyclopentadiene (2.4 g; 17.6 mmol) . Reflux was then continued for another two (2) hours. The reaction was then cooled and stirred overnight at room temperature.The condenser was and replaced with a gas inlet and the volatile material removed under reduced pressure maintaining a flask temperature of 15 – 20C. The dark red crude material (7.89g) was then transferred into a glovebox. The crude material was dissolved in hexanes (30 mL) and loaded into a column of alumina (Brockman I – neutral) previously rinsed with hexanes (200 mL) . The title compound was then eluted as an orange-brown band with hexanes (80OmL) . The solvent was removed under reduced pressure yielding deep red crystals of the title compound (6.09g; 70% based on Co2 (CO) 8) .The synthesis can be represented as follows: Co2(CO)8 + 2C5Me5H + C6H8 ? 2 [Co (omega5-C5Me5) (CO)2] + C6Hi0 + 4C0Analytical Characterization: 1H NMR spectrum was taken using a Bruker Avance 300 Spectrometer 1H NMR (C6D6) delta 1.6 (s, 5 CH3)

4045-44-7, As the paragraph descriping shows that 4045-44-7 is playing an increasingly important role.

Reference£º
Patent; PRAXAIR TECHNOLOGY, INC.; WO2008/124599; (2008); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54258-41-2,54258-41-2, 1,10-Phenanthrolin-5-amine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

YC-2 (0.5000 g, 1.236 mmol) and HATU (0.5091 g, 1.339 mmol) were dissolved in 7.5 mL of DMF, and TEA (0.1355 g, 1.339 mmol).Under a nitrogen atmosphere, after stirring at room temperature for 1-2 hours, 5-amino-1,10-phenanthroline was added.(0.2010 g, 1.030 mmol), warmed to 60 C, and allowed to react overnight.After the reaction was cooled to room temperature, the DMF was removed by spin-drying, the mixture was applied to silica gel, and the column was separated by chromatography (DCM:MeOH = 40:1).0.3235 g of a pale yellow solid was obtained with a yield of 54%.

54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Suzhou University of Science and Technology; Sun Yanyan; (8 pag.)CN108558866; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,2-dimethylpropane-1,3-diamine (5.0?g, Aldrich) was added to a solution of HCOOH (10 equiv) and HCHO (37% aqueous solution, 10?equiv), and was heated at reflux overnight, whereupon the solution was made basic by addition of NaOH (2?M, aqueous) and extracted into diethyl ether (4?*?25?mL). The ether solution was dried over K2CO3, and the solvent removed by rotary evaporation. The resulting oil was distilled in vacuo from CaH2 to afford the product as a colorless oil (75%). 1H NMR (CDCl3, 400?MHz): delta 0.9 (m, 6H); 2.0 (m, 4H); 2.2 (m, 12H). GC-MS: [60?C (1?min) to 180?C (2?min) at 30?C¡¤min-1]; tr?=?5.2?min (158, M+)., 7328-91-8

As the paragraph descriping shows that 7328-91-8 is playing an increasingly important role.

Reference£º
Article; Large, Tao A.G.; Mahadevan, Viswanath; Keown, William; Stack, T. Daniel P.; Inorganica Chimica Acta; vol. 486; (2019); p. 782 – 792;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI