Tag: M.W:100-200

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General synthesis procedure: (for example, 3a) To a solution of ninhydrin (1 mmol) and malononitrile in EtOH (4 mL) was added triethylamine (0.1 mmol), and the solution was stirred for 1 h at room temperature. Then, nitro ketene dithioacetal 1 (1 mmol) and propyldiamine 2 (1 mmol) were added in sequence. Upon completion (11 h), monitored by TLC, the mixture was filtered and the precipitate washed with EtOH (4 mL) to afford the pure product 3a., 7328-91-8

Big data shows that 7328-91-8 is playing an increasingly important role.

Reference£º
Article; Rezvanian, Atieh; Alizadeh, Abdolali; Tetrahedron; vol. 68; 49; (2012); p. 10164 – 10168,5;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4062-60-6,N1,N2-Di-tert-butylethane-1,2-diamine,as a common compound, the synthetic route is as follows.

General procedure: Toluene (5 mL), secondary diamine (2a,b or 4-c) (1 mmol), paraformaldehyde or 4-fluorobenzaldehyde (2 mmol), alpha,omega-diacetylene (2 mmol), and CuCl (10 mol.%, 0.1 mg) were placed under argon into a Schlenk flask (10 mL) mounted on a magnetic stirrer, and the mixture was stirred for 8 h at 100 C under argon atmosphere.The resulting mixture was cooled, filtered through a layer ofsilica gel, dried over Na2SO4. The solvent was evaporated. The product was purified by column chromatography, the eluent is indicated in the description of the compound., 4062-60-6

The synthetic route of 4062-60-6 has been constantly updated, and we look forward to future research findings.

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Article; Khabibullina; Zaynullina; Tyumkina; Yanybin; Ibragimov; Russian Chemical Bulletin; vol. 68; 7; (2019); p. 1407 – 1413; Izv. Akad. Nauk, Ser. Khim.; 7; (2019); p. 1407 – 1413,7;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10581-12-1,Tetramethylammonium acetate,as a common compound, the synthetic route is as follows.

General procedure: The appropriate ligand (H3LR)(0.18 mmol, R=OMe, Me H, Cl, Br), was deprotonated with 3.1 molar equiv. KH in3mL of DMA in a 25-50-mL round bottom flask. After H2 evolution ceased (?5-10 min), an excess 1.2 eq of Mn(OAc)2 was added along with 1mL of DMA andstirred for 30 min. Then 2.1 equivalents of [Me4N][OAc] were added along with 1mL ofDMA and the reaction was stirred at room temperature overnight. The mixture was filteredthrough a glass fritted funnel to remove insoluble material. The filtrate was layeredunder Et2O and allowed to stand for recrystallization. In most cases a whitecrystalline solid was obtained and isolated by filtration. In some cases, an oily residuewas obtained that through trituration with Et2O and scraping yields a white solid. Ineither case, the solids from DMA/Et2O was then redissolved in acetonitrile and filteredto remove insoluble material. Recrystallization was accomplished by slow vapor diffusionof Et2O into acetonitrile. The solids obtained were washed with diethyl ether anddried under vacuum. See below for characterization data for the remainingMn(II) complexes.

10581-12-1, The synthetic route of 10581-12-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cannella, Anthony F.; Surendhran, Roshaan; MacMillan, Samantha N.; Gupta, Rupal; Lacy, David C.; Journal of Coordination Chemistry; vol. 72; 8; (2019); p. 1287 – 1297;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 100ml two-necked flask, a suspension of 14 (910 mg, 1.91 mmol) in 30ml of EtOH is brought to reflux and MeOH is added until complete dissolution is obtained (35ml). A solution of LiOTf (2.986g, 19.1mmol) in 3ml of MeOH is added to the mixture, which is then kept at reflux for 30 min. The volume of the mixture is reduced to 20 ml by evaporating the solvent at low pressure, and the white precipitate thus obtained is filtered by washing with EtOH (856mg, 1.57mmol, yield 82%, p.f.: 206-207C)., 33454-82-9

The synthetic route of 33454-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI; UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA; PAGANI, Giorgio, A.; BEVERINA, Luca; SASSI, Mauro; SALAMONE, Matteo, Marco; MARI, Claudio, Maria; RUFFO, Riccardo; WO2013/38243; (2013); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

General procedure: To a solution of amine or its hydrochloride salt (1.0 mmol) in MeOH (7 mL) K2CO3(1.0 mmol for morpholine and aniline, 2.0 mmol for benzylamine and propargylamine, 3.0 mmol for valine methyl ester hydrochloride and tacd, 4.0 mmol for cyclam, 6.0 mmol for tacn tryhydrochloride) was added and the mixture was stirred for 30 min. Then alpha-halohydrazone (1.0 mmol for morpholine and aniline, 2.0 mmol for benzylamine, propargylamine and valine methyl ester hydrochloride, 3.1 mmol for tacn and tacd or 4.2 mmol for cyclam) was added in one portion with vigorous stirring. The reaction mixture was stirred for 1 h and evaporated in vacuo.Water (50 mL) was added to the residue and further purification was performed as following:For products 2a-d, 3-9: The precipitate was filtered off and washed with appropriate solvent (water for 2a-c, MeOH for 7-9, Et2O for 3-6, acetone for 2d) and dried with air.For products 2f,g: EtOAc (50 mL) was added, the organic extract was separated, washed with brine (50 mL), dried with Na2SO4and evaporated. The residue was purified by column chromatography on silica gel (hexane-EtOAc (5:1) ? EtOAc) to give products 2fand 2g.

4730-54-5, As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.

Reference£º
Article; Semakin, Artem N.; Kokuev, Aleksandr O.; Nelyubina, Yulia V.; Sukhorukov, Alexey Yu.; Zhmurov, Petr A.; Ioffe, Sema L.; Tartakovsky, Vladimir A.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2471 – 2477;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1,4,7-triazonane (100 mg, 0.77 mmol, 1.0 eq) in DCM (2 mL, 20 vol) was cooled to 0-5 C. and added DIPEA (0.40 mL, 2.32 mmol, 3.0 eq) and Chloroacetyl chloride (0.18 mL, 2.32 mmol, 3.0 eq). The reaction mass was slowly warmed to 25-30 C. and stirred for 4 h. The progress of the reaction was monitored by TLC (10% methanol in DCM). After complete consumption of the 1,4,7-triazonane, water was added to the reaction mass and layers separated. The separated organic layer was evaporated under vacuum to get a syrupy mass. The crude product was purified through silica gel chromatography. 114 mg (60.0%) 1H NMR (400 MHz, CDCl3): delta 4.09 (s, 6H), 3.78 (t, 6H), 3.57 (t, 6H). Purity by LC-MS: 95.32%, RT: 1.33

4730-54-5, As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.

Reference£º
Patent; BicycleTx Limited; Beswick, Paul John; Ivanova-Berndt, Gabriela; Mudd, Gemma Elizabeth; Pavan, Silvia; Skynner, Michael; Teufel, Daniel Paul; Van Rietschoten, Katerine; (88 pag.)US2018/311300; (2018); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3030-47-5,N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine,as a common compound, the synthetic route is as follows.

The ligand pmdien (0.2 ml, 1 mmol) was added to a stirred solutionof Ni(ClO4)2*6H2O (0.36 g, 1 mmol) in methanol (35 ml). The colour of solution turned to violet. Solution of tdaH2 (0.075 g,0.5 mmol) neutralized with KOH (0.056 g, 1 mmol) in water (5 ml) was added. Violet colour turned to green and after a while white precipitate was formed. Precipitate was removed by filtration and filtrate was left for crystallization. After a week green crystals (suitable for X-ray analyses) were collected on a frit funnel, washed with methanol and dried in air., 3030-47-5

3030-47-5 N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine 18196, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Bie?ko, Alina; Kopel, Pavel; Kizek, Rene; Kruszy?ski, Rafa?; Bie?ko, Dariusz; Titi?, Jan; Bo?a, Roman; Inorganica Chimica Acta; vol. 416; (2014); p. 147 – 156;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-67-4,H-D-Met-OH,as a common compound, the synthetic route is as follows.

Methionine (0.3 mmol,)And NaOH (0.3 mmol) were dissolved in 30 ml of a mixed solvent (VC2H5OH: VH2O = 5: 1)Stirring for 5 hours,So that it is fully dissolved; then add CuCl2 (0.3mmol),Stirring for 24 hours;Then, 3,4,7,8-tetramethyl-1,10-phenanthroline (0.3 mmol) was added,Stirring for 48 hours;Filter, take its clear liquid into 20ml of small test tube, the ether added to the filtrate above the filtrate and ether volume ratio is about 1: 2.5, standing, about a week after the blue crystal., 348-67-4

The synthetic route of 348-67-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Capital Normal University; Lu, Xiaoming; Zhang, Bo; Zhang, Weichuan; Cheng, Yifeng; Sun, Xiaojing; (60 pag.)CN105440059; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1-3Synthesis of Compound No. 3A 200 ml four-necked flask was charged with 72.08 g (0.75 mol) of methanesulfonic acid and 7.10 g (0.05 mol) of phosphorous pentoxide. After purging with nitrogen, the contents were heated to 100 C. to dissolve. After cooling, 9.76 g (0.05 mol) of acridone was added thereto, and 11.91 g (0.05 mol) of bis(fluorophenyl) sulfoxide dissolved in 11.91 g of chlorobenzene was then added dropwise, followed by causing the system to react at 50 C. for 2 hours. The reaction mixture was poured into a mixture of 200 g of ice water, 80 g of methanol, and 200 g of toluene in a 1 L beaker, stirred for 1 hour, and left to stand. The upper layer was discarded. To the lower layer were added 200 g of methylene chloride and 9.36 g (0.06 mol) of lithium trifluoromethanesulfonate, followed by stirring for 1 hour. The methylene chloride layer was washed with three 300 ml portions of water and concentrated under reduced pressure to give 28.27 g of compound No. 3 of the invention composed of cation No. 19 and a nonafluorobutanesulfonate anion (yield: 100%; HPLC purity: 95.5%)., 33454-82-9

33454-82-9 Lithium trifluoromethanesulfonate 3664839, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; ADEKA CORPORATION; US2012/136155; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4045-44-7, 1,2,3,4,5-Pentamethylcyclopenta-1,3-diene is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a flame-dried, N2-purged three neck round-bottom flask, fit with a condenser, was added paraformaldehyde (580 mg) and dry THF (10.5 mL). The resulting suspension was heated at reflux under N2 for 2 h and then cooled to RT. To a separate flame-dried, N2-purged round bottom flask was added 1,2,3,4,5-pentamethylcyclopentadiene (0.6 mL, 3.83 mmol, 1.0 mol equiv.), tetrabutylammonium iodide (140 mg, 0.38 mmol, 0.1 mol equiv.), dry THF (8.0 mL), and a stir bar. The solution was cooled to 0 C and n-butyllithium (2.33 M, 4.6 mmol, 1.2 equiv) was added dropwise. A white precipitate immediately began to form. The suspension was stirred for 45 min at 0 C, and then the paraformaldehyde solution (230 mg, 7.66 mmol, 2.0 mol equiv.) was added and the resulting mixture was then stirred for 18 h, letting the ice bath expire. The solvent was then removed under reduced pressure and the solids were taken up in diethyl ether. This mixture was washed sequentially with 1.0 M HCl, sat. NaHCO3 aq., and H2O. The organic solution was dried over Na2SO4 and the solvent was removed under reduced pressure. The crude mixture was then purified by flash column chromatography to give a light yellow oil in 56% yield. 1H NMR (300 MHz, CDCl3) delta 3.50 (s, 2H), 1.77 (d, J = 18.8 Hz, 12H), 0.87 (s, 3H). 13C NMR (126 MHz, CDCl3) delta 138.0, 136.2, 65.3, 58.4, 16.8, 11.3, 9.7., 4045-44-7

As the paragraph descriping shows that 4045-44-7 is playing an increasingly important role.

Reference£º
Article; Peterson, Gregory I.; Church, Derek C.; Yakelis, Neal A.; Boydston, Andrew J.; Polymer; vol. 55; 23; (2014); p. 5980 – 5985;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI