Tag: M.W:100-200

3030-47-5, N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A general method was used to synthesize the copper(II) complexes 1-5: To a pre-heated equimolar amounts of Cu(ClO4)2¡¤6H2O (0.190g, 0.50mmol) and the amine ligand (pmedien or DPA, 0.50mmol) dissolved in H2O (15mL), an aqueous solution of the sodium salt of the polycarboxylate compound (0.25mmol) was added. The resulting intense blue solution was heated on a steam-bath for 15min, filtered through Celite and then allowed to crystallize at room temperature. The crystalline solid which separated over a period of 4-12days was collected by filtration, washed with propan-2-ol, ether and allowed to dry in air. Single crystals suitable for X-ray structure analysis were obtained from dilute solutions by crystallization from H2O.

3030-47-5, 3030-47-5 N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine 18196, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Mautner, Franz A.; Albering, Joerg H.; Vicente, Ramon; Andrepont, Chase; Gautreaux, Jacob G.; Gallo, August A.; Massoud, Salah S.; Polyhedron; vol. 54; (2013); p. 158 – 163;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.391604-55-0,2-(2,4-Difluorophenyl)pyridine,as a common compound, the synthetic route is as follows.

In a Schlenk’s flask were placed iridium(III) trichloride hydrate (500 mg, 1.42 mmol, 1 equivalent) and silver(I) trifluoromethanesulfonate (1.09 g, 4.26 mmol, 3.0 equivalents), and the interior of the flask was substituted with nitrogen. There were added 2-(2,4-difluorophenyl)pyridine (2 mL, s/s=4) and water (1 mL, s/s=2), and the mixture was heated at 200C on an oil bath with stirring for 3 hours. The resulting black mixture was evaporated to dryness, and the residue was purified by silica gel column chromatography (eluent: dichloromethane). The column fractions were condensed, and recrystallized from hexane/dichloromethane to give 571 mg of the title compound (5-6) as yellow green powder in 52.7% yield. NMR data of the product was identical to that of Example 12.

391604-55-0, 391604-55-0 2-(2,4-Difluorophenyl)pyridine 11263359, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; TAKASAGO INTERNATIONAL CORPORATION; WO2004/43974; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5,4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 1,4,7-triazacyclononane (2 mmol) in distilled ethanol (50 mL) containing molecular sieve was added 1 equiv of aldehyde. The reaction mixture was stirred at room temperature. The solution was filtered and the filtrate was evaporated under reduced pressure to yield the aminal adduct.

4730-54-5 1,4,7-Triazacyclononane 188318, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Roger, Melissa; Patinec, Veronique; Bourgeois, Martine; Tripier, Raphael; Triki, Smail; Handel, Henri; Tetrahedron; vol. 68; 27-28; (2012); p. 5637 – 5643;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The binuclear ruthenium aqua complex was prepared byreacting [{RuCl(Clphen)}2(tpy2ph)](TfO)2 (50.0 mg, 0.03 mmol) in2mL of CF3SO3H (Trifluoromethanesulfonic acid) at room temperature,under stirring and inert atmosphere. After 3 h, the productwas precipitated out with an aqueous LiTfO solution, filtered usinga sintered glass filter and washed with cold diethyl ether, andfinally dried in a desiccator under vacuum. Yield: 38.0 mg (68%). 1HNMR (D2O:acetone-d6 (7:3) 500 MHz) delta (ppm) (m, J, H): 10.04 (d,J 5.1 Hz, 1H), 9.97 (d, J 5.2 Hz, 1H), 9.21 (s, 1H), 9.20 (s, 4H), 8.90(d, J 8.3 Hz, 2H), 8.77 (d, J 8.0 Hz, 4H), 8.56 (d, J 5.8 Hz, 2H),8.54 (d, J 3.1 Hz, 1H), 8.46 (dd, J 8.3, 5.2 Hz, 1H), 8.41 (d,J 8.2 Hz, 2H), 8.33 (s, 1H), 8.26 (d, J 8.4 Hz, 1H), 8.08 (t, J 7.8 Hz,1H), 8.03 (t, J 7.9 Hz, 4H), 7.95 (d, J 5.5 Hz, 1H), 7.87 (d, J 5.5 Hz,1H), 7.75 (d, J 5.6 Hz, 4H), 7.50 (dd, J 8.4, 5.5 Hz, 1H), 7.40 (dd,J 8.2, 5.5 Hz, 1H), 7.32e7.28 (m, 4H). C62H42Cl2F12N10O14S4-Ru25H2O (1894.43) calcd.%: C 40.58, H 2.77, N 7.39; found: C 40.70,H 2.61, N 7.81., 33454-82-9

33454-82-9 Lithium trifluoromethanesulfonate 3664839, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Matias, Tiago A.; Parussulo, Andre L.A.; Benavides, Paola A.; Guimaraes, Robson R.; Dourado, Andre H.B.; Nakamura, Marcelo; de Torresi, Susana I. Cordoba; Bertotti, Mauro; Araki, Koiti; Electrochimica Acta; vol. 283; (2018); p. 18 – 26;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103505-54-0,[2,2′-Bipyridine]-6,6′(1H,1’H)-dione,as a common compound, the synthetic route is as follows.

(1) 6,6′-Dihydroxy-2,2′-bipyridine (6DHBP) (0.0379 g, 0.20 mmol) under a nitrogen atmosphereAnd phenyl ruthenium chloride dimer [(eta6-C6H6)RuCl2]2 (0.050 mg, 0.10 mmol) was added to a 50 mL two-necked flask, 20 mL of anhydrous methanol was added, and the temperature was raised to 60 C, and the reaction was stirred in the dark. After 20 h, after completion of the reaction, the mixture was cooled to room temperature, and the reaction mixture was filtered to remove insoluble materials, and the filtrate was collected. The solvent was distilled off under reduced pressure and dried in vacuo.Obtained 0.0644 g of metal ruthenium complex [(eta6-C6H6)Ru(6,6′-(OH)2-bpy)Cl]Cl catalyst.

103505-54-0, As the paragraph descriping shows that 103505-54-0 is playing an increasingly important role.

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Patent; Dalian University of Technology; Wang Wanhui; Wang Kanglei; Bian Fei; Liu Xin; Bao Ming; (10 pag.)CN109928873; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of the corresponding bis(isatin) 1-8 (5 mmol) and Girard?s reagent (2.5 mmol) in 7 mL of absolute ethanol were added three drops of trifluoroacetic acid. The reaction mixture was refluxed for 2 h. After spontaneous cooling of the solution to room temperature, the formed precipitate was filtered off, washed with absolute diethyl ether and dried in vacuum (12 mmHg)., 1126-58-5

The synthetic route of 1126-58-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bogdanov; Zaripova; Mustafina; Voloshina; Sapunova; Kulik; Mironov; Russian Journal of General Chemistry; vol. 89; 7; (2019); p. 1368 – 1376; Zh. Obshch. Khim.; vol. 89; 7; (2019); p. 1004 – 1012,9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10581-12-1,Tetramethylammonium acetate,as a common compound, the synthetic route is as follows.

A solution of H3F3ST (300mg, 0.39mmol) dissolved in 6mL of anhydrous dimethylacetamide (DMA) was treated with solid NaH (28mg, 1.2mmol). The mixture was stirred until gas evolution ceased. Fe(OAc)2 (68mg, 0.39mmol) and NMe4OAc (52mg, 0.39mmol), were added to the cloudy white reaction, and the solution was stirred. After 3h, 5mL of Et2O was added to the yellow solution to aid the precipitation of NaOAc. The reaction mixture was filtered through a medium porosity glass-fritted funnel to remove the insoluble species and the filtrate was dried under vacuum. The resulting pale yellow solid was redissolved in 5mL of acetonitrile (MeCN), stirred for 20min, and filtered using a fine porosity glass-fritted funnel. The filtrate was concentrated under vacuum to ca. 1mL and treated with Et2O (10mL) then pentane (40mL) to precipitate a pale yellow solid. The pale yellow solid was collected on a medium porosity glass-fritted funnel and dried under vacuum to give 182mg (91%) of product. FTIR (KBr disc, cm-1, selected bands): 3413, 3046, 2964, 2902, 2861, 1608, 1490, 1403, 1326, 1263, 1134, 1062, 976, 821, 710, 622, 605. MS (ES-, m/z): Exact mass calcd for C27H24N4O6S3F9Fe: 823.0, Found: 823.1.

10581-12-1, As the paragraph descriping shows that 10581-12-1 is playing an increasingly important role.

Reference£º
Article; Lau, Nathanael; Ziller, Joseph W.; Borovik; Polyhedron; vol. 85; (2015); p. 777 – 782;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33454-82-9,Lithium trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

The mixture of 1 (1.11 g, 4.3 mmol) and LiOTf (0.81 g, 5.1 mmol) in dryCH3CN was stirred at room tempareture. After stirring 18 h, the reaction mixturewas diluted with CH2Cl2. Filteration and removal of solvent under reducedpuressure afforded IL-tag 2 as a white solid in 88% yield (1.41 g, 3.8 mmol).(4-(hydroxymethyl)benzyl)methylpiperidinium trifluoromethane sulfonate(2). TLC (MeOH/CH3COOH 10:1): Rf 0.39. 1H NMR (MeOD-d4, 600 MHz)delta 7.56 (d, J = 8.4 Hz, 2 H), 7.53 (d, J = 8.4 Hz, 2 H), 4.70 (s, 2 H), 4.57 (s, 2 H),3.43 (td, J = 13.2, 4.2 Hz, 2 H), 3.36 (dt, J = 12.6, 4.2 Hz, 2 H), 3.00 (s, 3 H),2.05 – 1.94 (m, 4 H), 1.83 – 1.78 (m, 1 H) , 1.71 – 1.64 (m, 1 H). 13C NMR(MeOD-d4, 150 MHz) delta 146.0, 134.2, 128.4, 127.1, 121.9 (q, J = 316.4 Hz), 68.9,64.4, 61.9, 47.2, 22.2, 21.1. HRMS (ESI) m/z calcd for C14H22NO [M-TfO-]+,220.1696; found, 220.1688.

33454-82-9, 33454-82-9 Lithium trifluoromethanesulfonate 3664839, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Sasaki, Norihiko; Nokami, Toshiki; Itoh, Toshiyuki; Chemistry Letters; vol. 46; 5; (2017); p. 683 – 685;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62937-45-5,D-Prolinamide,as a common compound, the synthetic route is as follows.,62937-45-5

[01 1 18] Step 2 : (R)-6-(4-((2-carbamoylpyrrolidin- 1 -yl)methyl)phenyl)- 1 -cyclopentyl-N- ((4,6-dimethyl -2-oxo- 1 ,2-dihydropyridin-3-yl)methy 1)- 1 H-indazole-4-carboxamide [01 1 19] To a stirred solution of 1 -cyclopentyl-N-((4,6-dimethyl-2-oxo- 1 ,2-dihydropyridin- 3-yl)methyl)-6-(4-formylphenyl)-l H-indazole-4-carboxamide (0.175 g, 0.373 mmol) in methanol (3 mL) acetic acid (0.022 g, 0.373 mmol) and respective amine [[[amine quantity?]]] was added, resulting reaction mass was stirred at room temperature for 4 h. To this reaction mixture sodium cyanoborohydride (0.028 g, 0.448 mmol) was added at cooling condition and reaction mixture was stirred at room temperature for 48 h. On completion solvent was removed under reduced pressure and water was added to it, and then extracted with 10% MeOH/DCM. Combined organic layers were washed with water, dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to afford crude. The crude was purified by prep HPLC affording desired compound as TFA salt (12.3% yield). LCMS: 567.30 (M + 1)+; HPLC: 97.31% (@ 254 nm) (R,;5.366); NMR (OMSO-d6, 400 MHz) 6 1 1.52 (s, I H), 9.71 (s, I H), 8.64 (t, I H, J=4.4 Hz), 8.37 (s, IH), 8.17 (s, IH), 7.94- 7.97 (m, 3H), 7.87 (s, IH), 7.61-7.67 (m, 3H), 5.89 (s, lH), 5.31-5.38 (m, I H), 4.38-4.45 (m, 4H), 4.41 -4.13 (m, I H), 3.32 (2H merged in solvent peak), 2.22 (s, 3H), 2.14-2.21 (m, 3H), 2.12 (s, 3H), 1.82-2.08 (m, 7H), 1.70-1.72 (m, 2H).

62937-45-5 D-Prolinamide 447554, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William; WO2012/118812; (2012); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

294-90-6, 1,4,7,10-Tetraazacyclododecane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the three-necked flask was added 1,4,7,10-tetraazacyclododecane (100 g, 0.58 mol)10 ml of deionized water, stirred, 30% KOH solution was added dropwise,The pH was adjusted to 8.5 and then chloroacetic acid (263 g, 2.78 mol) was added,And then 30% KOH solution to adjust the pH to 8.5,Heated to 80 C for 24 h, during which the pH was maintained between 8.5 and 9.After the reaction, cooling, adding concentrated hydrochloric acid to adjust the pH to 2, a white precipitate produced, filtered. The filter cake was recrystallized from a water-ethanol solution and the resulting crystals were washed with ethanol, ether, dried,183 g of DOTA crystals was obtained in a yield of 78%.

294-90-6, The synthetic route of 294-90-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhejiang Dade Pharmaceutical Group Co., Ltd.; Wang Jianping; Wang Jianguo; (23 pag.)CN104447598; (2017); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI