Tag: M.W:100-200

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New chiral Schiff base-zinc complexes and their esterolytic catalytic activity

A new series of chiral Zn-Schiff base (imine) complexes has been prepared from mono-N-sulfonyl derivatives of (1R,2R)-diaminocyclohexane, N-heterocyclic aldehydes, and zinc salts. The formation and characterization of the (L)ZnX 2 complexes was established by NMR, IR and HRESI-MS. Spectroscopic and kinetic evidence indicates that these ligands may be bidentate or tridentate depending on conditions of the medium. The methanolysis of a chiral, racemic picolinate ester catalyzed by the Zn(II)-Schiff base complexes was studied kinetically. The rate constants were found to vary approximately a hundred-fold and in a complex way depending on the imine ligand and the Zn-counter anion, kobs = 5.0 ¡Á 10-6-4.8 ¡Á 10-4 M -1 s-1. A Job plot analysis of ternary complex formation of LZnX2 with two phosphonate transition state analogs suggests that two types of (imine)Zn(picolinate)X ternary complexes may be intermediates and that varying rate-limiting steps may be involved in the LZnX2- catalyzed methanolysis of picolinate esters.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 20439-47-8. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 20439-47-8

Stereoselective Protonation of Carbanions, 4. Enantioselective Protonation of Lactone Enolates

The prochiral lithium enolates derived from the five-membered lactones rac-1 and rac-2 were protonated by 37 OH- and 21 NH-chiral proton sources in THF at -78 deg C.The enantioselectivities, determined directly from the reaction mixture by chiral HPLC, are always higher for system 1, probably due to restricted rotation of the phenyl group in 1Li at low temperature (NMR) and range from 0-54percent ee.The strongest stereodifferentiation is observed if the OH or NH acids carry an adjacent O- or N-containing group (structures G-J0 which allows complexation with the lithium ion.A plausible transition state involving the dimeric lithium enolate is proposed. – Key Words: Protonation / Enantioselectivity / Lactone enolates / Chiral proton sources

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is an experimental science, Application In Synthesis of 2-Methyl-1H-indene, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2177-47-1, Name is 2-Methyl-1H-indene

Rhodium-catalyzed enantioselective diboration of simple alkenes

Enantioselective catalytic reactions that operate directly on inexpensive unactivated alkenes are extraordinarily useful for the preparation of chiral organic building blocks and new materials. While a number of such processes have been developed, our ability to meet the intensifying demand for inexpensive stereochemically complex materials will require a significant expansion of practical catalytic asymmetric reaction methodology. In this regard, the rhodium-catalyzed enantioselective diboration reaction has been developed in order to address a number of extant problems in catalytic alkene transformation simultaneously. This process provides an enantiomerically enriched reactive dimetalated intermediate which can be converted to a variety of difunctional reaction products. Copyright

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of 2-Methyl-1H-indene, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2177-47-1, in my other articles.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C7H19N3. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 105-83-9

Synthesis of {15-benzyloxy-3,7,11,17-tetraazabicyclo[11.3.1]heptadeca-1(17) ,13,15-triene}nickel(II) perchlorate and its analogs, and their catalytic behavior in reductive debromination of 1-bromo-4-tert-butylbenzene

New nickel(II) complexes with macrocyclic ligands bearing benzyloxy [(5), (9)], 2-methylbenzyloxy (7), 3-methylbenzyloxy (8), and hydroxy (6) groups on the pyridine ring have been synthesized. Structures of the hydroxy substituted macrocyclic ligand (L-OH¡¤3HCl¡¤H2O), and the benzyloxy substituted ligand (L-OBn¡¤3HCl) and its nickel(II) complex (5), as well as an analogous Ni(II) complex (8), have been revealed by X-ray crystallography. Their catalytic capabilities in the reductive debromination of 1-bromo-4-tert-butylbenzene have been elucidated, which has revealed that the pyridine ring can be a suitable position for the introduction of functional groups while maintaining the catalytic capabilities of the nickel(II) complexes.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 20439-47-8, molcular formula is C6H14N2, introducing its new discovery. name: (1R,2R)-Cyclohexane-1,2-diamine

Asymmetric organocatalytic efficiency of synthesized chiral beta-amino alcohols in ring-opening of glycidol with phenols

A series of novel chiral beta-amino alcohols 3-5 and 7-10 were synthesized by regioselective ring opening of epoxides and chiral amines with a straightforward method in high yields (up to 99 %). Kinetic resolution of racemic glycidol with phenols was achieved by using chiral amino alcohols as organocatalysts. Amino alcohols 5, 8 and 10 exhibited the highest enantioselectivities with p-cresol, phenol, and p-methoxyphenol by 63, 65, 58 % ee, respectively. The moderate enantioselectivities were observed with catalyst 9b towards all the nucleophiles (34-48 % ee). The ee values of the desired 3-aryloxy-1, 2-diols were determined by HPLC. This study presents an attractive tool for the synthesis of beta-blockers and structurally complex molecules.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Computed Properties of C6H15N3, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4730-54-5, Name is 1,4,7-Triazacyclononane, molecular formula is C6H15N3. In a Article, authors is Faraj, Joseph£¬once mentioned of 4730-54-5

Filiarial chyluria with nephrotic-range proteinuria and associated hypoalbuminaemia and hypogammaglobulinaemia secondary to bilateral lymphorenal fistulae

A 55-year-old man of Indian descent, presented to the emergency department with a 2-year history of passing ? milky’ white urine, associated with dysuria, urinary retention, bilateral flank pain and 15 kg weight loss. He had migrated to Australia from India at the age of 16, with no overseas travel since, and denied having any fevers, rigours or chills. He was found to have chyluria and nephrotic-range proteinuria with marked hypoalbuminaemia and hypogammaglobulinaemia. Due to his ethnic origin and by diagnostic exclusion, a presumptive diagnosis of filariasis was made. With bilateral lymphorenal disconnection, as definitive management, the patient’s chyluria and proteinuria resolved with restoration of normal plasma protein and immunoglobulin levels.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 344-25-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.344-25-2, Name is H-D-Pro-OH, molecular formula is C5H9NO2. In a Patent£¬once mentioned of 344-25-2

A II type diabetes drug for the treatment of vergeliptin intermediate preparation method (by machine translation)

The invention discloses a method for the treatment of type II diabetes drug the peculiar smell of preparing intermediates of method, the preparation method comprises: step one: the 2 – carboxy pyrrolidine and N – hydroxy phthalimide condensation obtain a compound of formula I; step two: in three (2 – phenylpyridyl) iridium, silver bromide, type II indicated by the presence of a compound, of formula I with a compound represented by the heating reaction trimethyl cyanogen silane (S)- 2 – cyano pyrrolidine; step three: (S)- 2 – cyano pyrrolidine with chloroacetyl chloride reaction to obtain the peculiar smell intermediate (S)- 1 – (2 – chloracetyl) – 2 – cyano pyrrolidine; This invention uses more extensive source of raw material of reaction high selectivity, a high yield of chiral compound, mild conditions and easy. (by machine translation)

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of N1,N2-Di-tert-butylethane-1,2-diamine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4062-60-6, Name is N1,N2-Di-tert-butylethane-1,2-diamine, molecular formula is C10H24N2. In a Article, authors is Patel, Dushyant V.£¬once mentioned of 4062-60-6

Novel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents

Molecules capable of engaging with multiple targets associated with pathological condition of Alzheimer’s disease have proved to be potential anti-Alzheimer’s agents. In our goal to develop multitarget-directed ligands for the treatment of Alzheimer’s disease, a novel series of carbazole-based stilbene derivatives were designed by the fusion of carbazole ring with stilbene scaffold. The designed compounds were synthesized and evaluated for their anti-AD activities including cholinesterase inhibition, Abeta aggregation inhibition, antioxidant and metal chelation properties. Amongst them, (E)-1-(4-(2-(9-ethyl-9H-carbazol-3-yl)vinyl)phenyl)-3-(2-(pyrrolidin-1-yl)ethyl)thiourea (50) appeared to be the best candidate with good inhibitory activities against AChE (IC50 value of 2.64 muM) and BuChE (IC50 value of 1.29 muM), and significant inhibition of self-mediated Abeta1?42 aggregation (51.29% at 25 muM concentration). The metal chelation study showed that compound (50) possessed specific copper ion chelating property. Additionally, compound (50) exhibited moderate antioxidant activity. To understand the binding mode of 50, molecular docking studies were performed, and the results indicated strong non-covalent interactions of 50 with the enzymes in the active sites of AChE, BuChE as well as of the Abeta1-42 peptide. Additionally, it showed promising in silico ADMET properties. Putting together, these findings evidently showed compound (50) as a potential multitarget-directed ligand in the course of developing novel anti-AD drugs.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 2926-30-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2926-30-9, Name is Sodium trifluoromethanesulfonate, molecular formula is CF3NaO3S. In a Article£¬once mentioned of 2926-30-9

Reaction products of nitronyl nitroxyl radicals with acids

Study of the structures of compounds generated by the reactions of 4,4,5,5-tetramethyl-2-phenyl-4,5-diliydro-1H-imidazole-1-oxyl 3-oxide with trifluoromethanesulfonic and picric acids demonstrated that these reactions produced salts of disproportionation products of nitronyl nitroxyl.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Product Details of 1723-00-8, Which mentioned a new discovery about 1723-00-8

DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE AND PHARMACEUTICALS CONTAINING THE SAME

The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI