Tag: M.W:100-200

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ren, Mengjuan; Zhang, Mengyue; Yang, Huijuan; Shi, Hongzhi researched the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ).Reference of (S)-3-(Piperidin-2-yl)pyridine.They published the article 《Reducing the nicotine content of tobacco by grafting with eggplant》 about this compound( cas:494-52-0 ) in BMC Plant Biology. Keywords: tobacco eggplant grafting nicotine; Differentially expressed genes; Grafting; Nicotine content; Tobacco; Transcription factors. We’ll tell you more about this compound (cas:494-52-0).

Background: Nicotine is a stimulant and potent parasympathomimetic alkaloid that accounts for 96-98% of alkaloid content. A reduction in the amount of nicotine in cigarettes to achieve a non-addictive level is necessary. We investigated whether replacing tobacco root with eggplant by grafting can restrict nicotine biosynthesis and produce tobacco leaves with ultra-low nicotine content, and analyzed the gene expression differences induced by eggplant grafting. Results: The nicotine levels of grafted tobacco leaves decreased dramatically. The contents of nornicotine, anabasine, NNN, NNK, NAT, total TSNAs and the nicotine of mainstream cigarette smoke decreased, and the contents of amino acids and the precursors of alkaloids increased in grafted tobacco. Eggplant grafting resulted in the differential expression of 440 genes. LOC107774053 had higher degrees in two PPI networks, which were regulated by LOC107802531 and LOC107828746 in the TF-target network. Conclusions: Replacing tobacco root with eggplant by grafting can restrict nicotine biosynthesis and produce tobacco leaves with ultra-low or zero nicotine content. The differential expression of LOC107774053 may be associated with eggplant grafting.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bonneau, Guillaume; Peru, Aurelien A. M.; Flourat, Amandine L.; Allais, Florent researched the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6 ).Quality Control of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.They published the article 《Organic solvent- and catalyst-free Baeyer-Villiger oxidation of levoglucosenone and dihydrolevoglucosenone (Cyrene): a sustainable route to (S)-γ-hydroxymethyl-α,β-butenolide and (S)-γ-hydroxymethyl-γ-butyrolactone》 about this compound( cas:32780-06-6 ) in Green Chemistry. Keywords: catalyst Baeyer Villiger oxidation levoglucosenone Cyrene hydroxymethylbutenolide hydroxymethylbutyrolactone. We’ll tell you more about this compound (cas:32780-06-6).

A straightforward and sustainable route to (S)-γ-hydroxymethyl-α,β-butenolide (HBO) and (S)-γ-hydroxymethyl-α,β-butyrolactone (2H-HBO), two valuable chem. platforms for the synthesis of fine chems. such as drugs, pheromones, flavors and fragrances, has been optimized using renewable cellulose-based levoglucosenone (LGO) and Cyrene as starting materials and aqueous H2O2 as both a solvent and an oxidizing agent. Combined with short-path distillation, this procedure provides enantiopure HBO and 2H-HBO in yield as high as 72% at the kilo scale.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Computed Properties of C10H12N4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-(Piperazin-1-yl)nicotinonitrile, is researched, Molecular C10H12N4, CAS is 149554-29-0, about Synthesis of new and potent analogs of anti-tuberculosis agent 5-nitrofuran-2-carboxylic acid 4-(4-benzylpiperazin-1-yl)benzylamide with improved bioavailability. Author is Tangallapally, Rajendra P.; Lee, Robin E. B.; Lenaerts, Anne J. M.; Lee, Richard E..

Previously, the lead compound 5-nitrofuran-2-carboxylic acid 4-(4-benzylpiperazin-1-yl)benzylamide was identified in our anti-tuberculosis drug discovery program. Although this compound demonstrated excellent in vitro activity, it did not meet the expected in vivo profiles due to structural features that resulted in rapid metabolic cleavage and poor absorption, which therefore limited its bioavailability. In efforts to increase the bioavailability, a new series of analogs was successfully synthesized using three modification schemes: replacement of the benzyl group on the piperazine C-ring with carbamate and urea functional groups; introduction of a nitrogen atom into the aromatic ring-B; and expansion of the ring-B to a bicyclic tetrahydroisoquinoline moiety. These modifications retained strong activity and in some case gained superior anti-tuberculosis activity, increased absorption, and serum half life.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-3-(Piperidin-2-yl)pyridine(SMILESS: C1(C=NC=CC=1)[C@@H]1CCCCN1,cas:494-52-0) is researched.Synthetic Route of C24H40N4O4Rh2. The article 《EAT-18 is an essential auxiliary protein interacting with the non-alpha nAChR subunit EAT-2 to form a functional receptor》 in relation to this compound, is published in PLoS Pathogens. Let’s take a look at the latest research on this compound (cas:494-52-0).

Nematode parasites infect approx. 1.5 billion people globally and are a significant public health concern. There is an accepted need for new, more effective anthelmintic drugs. Nicotinic acetylcholine receptors on parasite nerve and somatic muscle are targets of the cholinomimetic anthelmintics, while glutamate-gated chloride channels in the pharynx of the nematode are affected by the avermectins. Here we describe a novel nicotinic acetylcholine receptor on the nematode pharynx that is a potential new drug target. This homomeric receptor is comprised of five non-α EAT-2 subunits and is not sensitive to existing cholinomimetic anthelmintics. We found that EAT-18, a novel auxiliary subunit protein, is essential for functional expression of the receptor. EAT-18 directly interacts with the mature receptor, and different homologs alter the pharmacol. properties. Thus we have described not only a novel potential drug target but also a new type of obligate auxiliary protein for nAChRs.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Recommanded Product: 32780-06-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Synthesis of S-(+)-4-(hydroxymethyl)-4-butanolide. Author is Pirillo, D.; Leggeri, P.; Traverso, G..

The title compound (I) was prepared from L-(+)-glutamic acid (II). II was converted to the hydroxy acid analog via diazotization; the hydroxy acid underwent lactonization to yield III (R = CO2H); the latter, Cl2CHOMe, and ZnCl2 gave III (R = COCl); and the product was reduced by NaBH4 to give I.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Total synthesis of (R,Z)-(-)-5-tetradecen-4-olide, the pheromone of the Japanese beetle and its biological activity test. Author is Kang, Suk Ku; Shin, Dong Soo; Lee, Jeong Oon; Goh, Hyun Gwan.

Wittig-Emmons olefination of glyceraldehyde derivative I with (MeO)2P(O)CH2CO2Me, followed by hydrogenation and lactonization, gave (S)-hydroxylactone II. Inversion of configuration, oxidation, and Wittig olefination with RCH:PPh3 [R = Me(CH2)7] gave the title compound III as a 96:4 mixture of (Z)- and (E)-isomers. III was tested as an attractant for the male Japanese beetle.

There is still a lot of research devoted to this compound(SMILES：O=C1O[C@H](CO)CC1)Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, and with the development of science, more effects of this compound(32780-06-6) can be discovered.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Brewster Angle Microscopy and X-ray GID Studies of Morphology and Crystal Structure in Monolayers of N-Tetradecyl-γ,δ-dihydroxypentanoic Acid Amide, published in 1997-06-12, which mentions a compound: 32780-06-6, mainly applied to tetradecyldihydroxypentanoic acid amide crystal surface structure, SDS of cas: 32780-06-6.

First-order phase transitions from the low-d. fluidlike phase to the condensed phase of monolayers of N-tetradecyl-γ,δ-dihydroxypentanoic acid amides at the air-water interface have been studied by π-A isotherms, Brewster angle microscopy (BAM), and synchrotron X-ray grazing incidence diffraction (GID). The thermodn. differences between enantiomeric and racemic monolayers are too small to be measured. Chiral discrimination is observable in the macroscopic domain morphol. by BAM. The domains of the condensed phase grow dendritically. The characteristic shapes of domains of the pure S and R enantiomers are mirror images of each other. The domains of the racemic mixture are quite similar; however, they have no mirror symmetry. Synchrotron X-ray grazing incidence diffraction (GID) measurements reveal an oblique lattice with tilt direction of mols. close to one of the nearest neighbors for condensed-phase monolayers of both enantiomer and racemate. The mols. of the racemic monolayers are more densely arranged indicating a week heterochiral interaction of the mols. The crystal structure changes only slightly with the surface pressure due to hydrogen bonds between the amide groups of mols. in the condensed phase. Thermodn. behavior, morphol. features, and two-dimensional crystal structure are discussed on the basis of the headgroup interactions, in particular the dominance of strong hydrogen-bonding chains of the amide groups only weakly affected by the hydroxyl groups and the chiral center.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 32780-06-6, is researched, Molecular C5H8O3, about (R)-Desmolactone, A Female-produced Sex Pheromone Component of the Cerambycid Beetle Desmocerus californicus californicus (subfamily Lepturinae), the main research direction is desmolactone sex pheromone isolation structure preparation cerambycid beetle.Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

The authors report the identification, synthesis, and field bioassays of a female-produced sex attractant pheromone for the cerambycid beetle Desmocerus californicus californicus Horn. Headspace volatiles from females contained a sex-specific compound, (R)-desmolactone [(4R,9Z)-hexadec-9-en-4-olide], which elicited strong responses from the antennae of adult males in coupled gas chromatog.-electroantennogram analyses. Short syntheses of both enantiomers were developed from com. chiral synthons. In field bioassays, significant numbers of males were collected in traps baited with (R)-desmolactone, whereas the (S)-enantiomer attracted no males. The racemate was less attractive than the pure (R)-enantiomer, indicating some degree of antagonism by the unnatural enantiomer. This compound is the first example of a new structural class of cerambycid pheromones and is the second pheromone identified for a species in the subfamily Lepturinae.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 494-52-0, is researched, Molecular C10H14N2, about The use of HPLC-PDA in determining nicotine and nicotine-related alkaloids from E-liquids: a comparison of five E-liquid brands purchased locally, the main research direction is nicotine alkaloid high performance liquid chromatog photodiode array detection; E-liquids; ECIGs; HPLC; aerosol; cigarettes; nicotine; nicotine-related alkaloids; smoke.COA of Formula: C10H14N2.

E-liquid manufacturers are under scrutiny concerning the purity and concentration accuracy of nicotine and the minor nicotine-related alkaloids (NRAs) packaged in their products. In this communication we report concentrations of nicotine and five NRAs (nornicotine, cotinine, anabasine, anatabine, myosmine) from locally purchased E-liquids Methods: Five brands of E-liquids (three bottles each) were purchased locally. Addnl., three bottles of reference E-liquid were prepared Concentrations of nicotine and NRAs from each bottle were measured by HPLC. Concentrations of these alkaloids were also determined from electronic cigarette-generated aerosol and traditional cigarette smoke. Results: Nicotine concentrations in E-liquid brands 1, 2, 3, 4, 5 and in the reference E-liquid were 17.8 ± 4.1, 23.2 ± 0.7, 24.0 ± 0.9, 24.9 ± 0.2, 19.7 ± 0.3 and 20.4 ± 0.1 mg/mL, resp. Concentrations normalized to 100% of product label were 74%, 97%, 100%, 104%, 109% and 102%, resp. E-liquid brand 1 showed significance (p < 0.001) between bottles, while the reference showed the least variability. Similar results were obtained for the NRAs. Results also indicated the NRAs in aerosol of the reference E-liquid are lower than in cigarette smoke. The amounts of NRAs present in E-liquids and E-liquid aerosol are less compared to cigarettes, however, inconsistencies and variation in nicotine concentrations supports the need for regulatory oversight. Here is a brief introduction to this compound(494-52-0)COA of Formula: C10H14N2, if you want to know about other compounds related to this compound(494-52-0), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Product Details of 32780-06-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about A practical synthesis of (R)-(-)-γ-hydroxymethyl-γ-butyrolactone from natural glutamic acid. Author is Ho, Pak-Tsun; Davies, Nancy.

Tosylation of I (R = OH), prepared from natural (S)-(+)-glutamic acid, gave 96% I (R = p-MeC6H4SO3), which was treated with MeONa-MeOH to give quant. II, which, upon treatment with F3CCO2H at -10°, cyclized with complete inversion of configuration to give 86% III.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI