Tag: M.W:100-200

SDS of cas: 494-52-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Preinfection effects of nectar secondary compounds on a bumble bee gut pathogen.

Bumble bee pollinators can be exposed to pathogens when foraging on flowers previously visited by infected individuals. Infectious cells may be deposited in floral nectar, providing a site for pathogens to interact with nectar secondary compounds prior to infecting bees. Some nectar secondary compounds can reduce pathogen counts in infected bumble bees, but we know less about how exposure to these compounds directly affects pathogens prior to being ingested by their host. We exposed the trypanosomatid gut pathogen, Crithidia bombi (Lipa & Triggiani 1988) (Trypanosomatida: Trypanosomatidae), to six different compounds found in nectar (aucubin, catalpol, nicotine, thymol, anabasine, and citric acid) for 1-h prior to ingestion by Bombus impatiens (Cresson 1863) (Hymenoptera: Apidae) workers that were then reared for 1 wk on a control diet. All of these compounds except citric acid reduce pathogen levels when consumed in hosts after infection, and citric acid is a common preservative found in citrus fruits and some honeys. We found that both citric acid and aucubin reduced Crithidia cell counts compared with controls. However, catalpol, nicotine, thymol, and anabasine did not have significant effects on Crithidia levels. These results suggest that Crithidia exposure in some floral nectars may reduce cell viability, resulting in a lower risk to visiting pollinators, but this effect may not be widespread across all flowering species.

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Metal catalyst and ligand design,
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Lory, Pedro M. J.; Estrella-Jimenez, Maria E.; Shashack, Matthew J.; Lokesh, Ganesh L.; Natarajan, Amarnath; Gilbertson, Scott R. published the article 《Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides》. Keywords: thioxanthenone dioxide carbamoyl amino preparation BRCT hepatitis C inhibitor.They researched the compound: 6-(Piperazin-1-yl)nicotinonitrile( cas:149554-29-0 ).Quality Control of 6-(Piperazin-1-yl)nicotinonitrile. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:149554-29-0) here.

Methods appropriate for the parallel synthesis of libraries based on the thioxanthen-9-one 10,10-dioxide scaffold are reported. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and com. available 3-carboxythioxanthen-9-one 10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alk. phosphatase reported replicon system for activity against hepatitis C virus.

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Metal catalyst and ligand design,
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Formula: C5H8O3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Facile, highly stereoselective synthesis of 2′,3′-dideoxy- and 2′,3′-didehydro-2′,3′-dideoxy nucleosides via a furanoid glycal intermediate. Author is Kim, Choung Un; Misco, Peter F..

Regiospecific and highly stereoselective electrophilic addition reactions to the furanoid glycal I were used as key steps in the synthesis of 2′,3′-dideoxyadenosine (II) and 2′,3′-didehydro-3′-deoxythymidine (III) antiviral nucleosides.

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Metal catalyst and ligand design,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Phytochemistry (Elsevier) called Alkaloid chemophenetics and transcriptomics of the Nicotiana genus, Author is Kaminski, Kacper Piotr; Bovet, Lucien; Laparra, Helene; Lang, Gerhard; De Palo, Damien; Sierro, Nicolas; Goepfert, Simon; Ivanov, Nikolai V., which mentions a compound: 494-52-0, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2, Product Details of 494-52-0.

In this study, we determined the pyridine alkaloid content (nicotine, nornicotine, anabasine, anatabine, cotinine, and myosmine) of 58 species and 2 subspecies of the Nicotiana genus by ultra-high-performance liquid chromatog. coupled with mass spectrometry. We observed clear correlation between Noctiflorae and Suaveolentes sections and their above average accumulation of anabasine in genus. In addition, the results demonstrated the presence of not only trace amounts but quantifiable levels of myosmine, an alkaloid previously detected in only minute quantities, in leaves and roots of 16 species. Anal. of gene expression of 58 species and 2 subspecies from Nicotiana genus by mRNA sequencing was performed for first time. Sequencing reads were mapped against annotated genes of N.tabacum reference genome and expression values were subsequently calculated Hierarchical clustering of alkaloid biosynthesis pathway genes and alkaloid content composition revealed patterns clearly segregating Nicotiana sections. Correlation of gene expression with alkaloid accumulation phenotypes was evident, including low putrescine methyltransferase expression for all species in the Suaveolentes section or clear correlation of nicotine demethylase with conversion rates of nicotine to nornicotine in majority of species. Multiple addnl. correlations between alkaloid accumulation and gene expression values were identified, which makes this study an important fundament toward future scientific exploration of the Nicotiana genus.

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Metal catalyst and ligand design,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-(Piperazin-1-yl)nicotinonitrile( cas:149554-29-0 ) is researched.Name: 6-(Piperazin-1-yl)nicotinonitrile.Hurth, Konstanze; Enz, Albert; Floersheim, Philipp; Gentsch, Conrad; Hoyer, Daniel; Langenegger, Daniel; Neumann, Peter; Pfaeffli, Paul; Sorg, Dieter; Swoboda, Robert; Vassout, Annick; Troxler, Thomas published the article 《SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists》 about this compound( cas:149554-29-0 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: SAR structure arylpiperazine moiety obeline somatostatin sst receptor antagonist. Let’s learn more about this compound (cas:149554-29-0).

The SAR of over 50 derivatives of octahydrobenzo[g]quinoline (obeline)-type somatostatin sst1 receptor antagonist 1 is presented, focusing on the modification of its arylpiperazine moiety. Sst1 affinities in this series cover a range of five orders of magnitude with the best derivatives displaying subnanomolar sst1 affinities and >10,000-fold selectivities over the sst2 receptor subtype as well as promising pharmacokinetic properties.

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Metal catalyst and ligand design,
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Electric Literature of C10H14N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Analysis of arglabin and its derivatives using high-performance liquid chromatography. Author is Adekenov, Sergazy M.; Shamilova, Saltanat T.; Khabarov, Ilya A..

This study has a two-fold objective: to develop a unified HPLC method for quality control of arglabin and its new hybrid mols. with alkaloids (cytisine, anabasine), and to study the relationship between their structures and chromatog. behaviors. Materials and methods : To develop a selective method that ensures the quality of arglabin and its derivatives, HPLC was used with the Zorbax SB-C18 anal. column. Dipole moments were calculated via the RHF method (RHF/6-31G(d, p)) and the B3LYP d. functional theory with full geometry optimization by using the GAUSSIAN 03 W program. Results : A novel anal. method has been developed using reversed-phase (RP) HPLC, which is selective and allows reliable as well as quant. determination of arglabin and its derivatives To confirm the selectivity of the developed method, the chromatog. capacity factors and column selectivity were calculated The relationship between retention time and structure (particularly, the nature of the substituent) was studied for the first time for arglabin and its derivatives using the B3LYP/6-31G(d) quantum chem. method. The influence of the dipole moment on the retention time of arglabin and its derivatives was confirmed. Conclusion : A novel unified quality control method using HPLC was developed to analyze arglabin, and its new hybrid mols. with alkaloids (cytisine and anabasine). For the first time, the relationship between the chromatog. behavior in RP-HPLC and the dipole moment for arglabin and its derivatives was revealed.

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Metal catalyst and ligand design,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Stereochemical control of nature’s biosynthetic pathways: a general strategy for the synthesis of polypropionate-derived structural units from a single chiral progenitor, the main research direction is polypropionate synthon hydroxymethylfuranone; ionomycin fragment preparation.HPLC of Formula: 32780-06-6.

A general strategy, based on (S)-5-hydroxymethyl-5H-furan-2-one, that permits the stereocontrolled construction of acyclic chains containing vicinal and/or alternating alkyl and hydroxy substituents is presented. Several structural subunits of ionomycin were synthesized from this common chiral intermediate.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Product Details of 494-52-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish. Author is Hawkey, Andrew B.; Hoeng, Julia; Peitsch, Manuel C.; Levin, Edward D.; Koshibu, Kyoko.

Zebrafish provide a valuable emerging complementary model for neurobehavioral research. They offer a powerful way to screen for the potential therapeutic effects of neuroactive drugs. A variety of behavioral tests for zebrafish have been developed and validated for assessing neurobehavioral function. The novel tank diving test is a straightforward, reproducible way of measuring anxiety-like behavior in zebrafish. When introduced into a novel tank, zebrafish normally dive to the bottom of the tank and then gradually explore the higher levels of the water column as time progresses. Buspirone is an effective anxiolytic drug in humans, which has been found, with acute administration, to reduce this anxiety-like response in zebrafish. The current study used the zebrafish model to evaluate the potential anxiolytic effects of alkaloids, commonly found in Solanaceae plants, with known neuropharmacol. relevant to mood regulation. In line with previous findings, acute treatment with anxiolytic pos. controls buspirone and the plant alkaloid nicotine reduced the anxiety-like diving response in the zebrafish novel tank diving test. Further, both buspirone and nicotine continued to produce anxiolytic-like effects in zebrafish after 5 days of exposure. In the same treatment paradigm, the effects of five other alkaloids-cotinine, anatabine, anabasine, harmane, and norharmane-were investigated. Cotinine, the major metabolite of nicotine, also caused anxiolytic-like effects, albeit at a dose higher than the ED of nicotine. Nicotine′s anxiolytic-like effect was not shared by the other nicotinic alkaloids, anabasine and anatabine, or by the naturally present monoamine oxidase inhibitors harmane and norharmane. We conclude that nicotine uniquely induces anxiolytic-like effects after acute and subchronic treatment in zebrafish. The zebrafish model with the novel tank diving test could be a useful complement to rodent models for screening candidate compounds for anxiolytic effects in nonclin. studies.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about First asymmetric total synthesis of (+)-steganacin. Determination of absolute stereochemistry. Author is Tomioka, Kiyoshi; Ishiguro, Tsuneo; Koga, Kenji.

(+)-Steganacin (I) was synthesized stereospecifically in 12 steps using the γ-lactone II as a chiral synthon. The key steps of the reaction were the specific asym. 1,4-addition of the chiral butenolide with lithiated trimethoxybenzaldehyde dithioacetal and the regio- and stereoselective introduction of Ac onto (+)-stegane to give I. The sign of optical rotation of I was opposite to that of natural steganacin, the absolute stereochem. of which was thus determined unequivocally.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called New synthesis of D-ribose from L-glutamic acid, published in 1971, which mentions a compound: 32780-06-6, mainly applied to ribose synthesis glutamic acid; stereospecific synthesis ribose; non carbohydrate saccharide preparation, Product Details of 32780-06-6.

L-Glutamic acid gave on HNO2 deamination a lactone, which was esterified to I (R = CO2Et), a suitable precursor to the preparation of D-ribose (II) without optical resolution. The reduction of I with NaBH4 gave I (R = CH2OH), converted to the benzyl ether I (R = CH2OCH2Ph) (III). Heating III with Na and HCO2Et in Et2O gave Na salt (IV) which was converted in 3 steps to 5-O-benzyl-2,3-dideoxy-D-glycero-pentofuranose (V). Consecutive bromination, methylation, and dehydrobromination gave the unsaturated pentose (VI), which was first oxidized with KMnO4, then hydrogenated over Pd-C, treated with 0.1N H2SO4. The mixture of II and D-xylose was separated through the anilide of II.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI