With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4062-60-6,N1,N2-Di-tert-butylethane-1,2-diamine,as a common compound, the synthetic route is as follows.
Concentrated HCl (3.0 mL) was slowly added under cooling to N,N-di-tert-butylethylenediamine (1.0 mmol). Solvent was removed by rotary evaporator. Then trimethyl orthoacetate (10.0 mL) and 2 drops of formic acid were added. The mixture was stirred for 48 h at 120C. Solvent was removed and the white greasy solid was washed with THF and dried under reduced pressure. Yield: 0.11 g, 44%. 1H NMR (400 MHz, CDCl3): delta 4.15 (s, 4H), 2.61 (s, 3H), 1.57 (s, 18H) ppm; 13C NMR (100 MHz, CDCl3): delta 165.4, 57.8, 45.8, 29.1, 16.2 ppm.
4062-60-6 N1,N2-Di-tert-butylethane-1,2-diamine 77680, acatalyst-ligand compound, is more and more widely used in various.
Reference£º
Article; Lu, Bing; Zhu, Fan; Wang, Dan; Sun, Hongmei; Shen, Qi; Tetrahedron Letters; vol. 58; 25; (2017); p. 2490 – 2494;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI