With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.
787-70-2, Into a vessel was placed about 10 ml of dimethyl formamide (Fisher, 99%) which contained about 0.1 millimole of 4,4′ bipyridine under ambient atmospheric conditions. Into this, with stirring at ambient temperature (about 25 C.), was added about 0.3 millimoles of the zinc precursor polymer. Stirring was continued until the mixture was homogeneous, (about 10 minutes). The mixture was transferred in air to a Parr acid digestion bomb which was then sealed. The mixture was heated to 150 C. and held at that temperature for 3 days, yielding crystals of the zinc polymeric compound in about 94% yield based on the weight of the zinc precursor polymer compound. [0113] Synthesis of the Zinc Precursor Polymer [0114] The zinc precursor polymer compound used in the synthesis of the zinc polymeric compound of Example 3 was itself synthesized according to the following procedure. At room temperature (about 25 C.), into a vessel containing about 5.5 mL of a 0.01 molar bis-sodium biphenyl-4,4′-dicarboxylate aqueous solution (about 0.55 millimoles of the dicarboxylate, prepared as described below) was placed about 10 mL of a 0.1 molar aqueous Zn(NO3)2 solution (about 1.0 millimoles of zinc nitrate hexahydrate (Fisher) dissolved in 10 ml of deionized water). This immediately precipitated a mass of the zinc polymer precursor compound (stiochiometric formula [Zn(bpdc)(H2O)2].(H2O)], where ?bpdc? is biphenyl-4,4′-dicarboxylate). The precipitate was washed with distilled water and used as prepared. Yield was about 90% based on starting zinc nitrate. [0115] Bis-sodium-biphenyl-4,4′-dicarboxylate solution was prepared as described above in the preparation of the first cobalt precursor polymer, as described above in Example 1.
As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.
Reference£º
Patent; Li, Jing; Pan, Long; Huang, Xiaoying; US2004/110950; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI