7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
N1-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-yl)-2,2-dimethylpropane-1,3-diamineA suspension of 3-(2,5-dichloropyrimidin-4-yl)-l-(phenylsulfonyl)-1H-indole (0.590g, 1.46mmol), 3,3-dimethylaminopropyldiamine (149mg, 1.46mmol) in EtOH/DMF (4: 1, lOmL) was heated at 130¡ãC (mW) for 20min. The mixture was diluted with EtOAc (30mL), washed with sat. NaHC03 (5mL), brine (5mL) dried (MgS04), filtered and concentrated under reduced pressure to afford the title compound (600mg, 1.28mmol, 87percent) as a white solid which was used in the next step without any further purification.
7328-91-8, The synthetic route of 7328-91-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SYROS PHARMACEUTICALS, INC.; PARAZA PHARMA, INC.; CIBLAT, Stephane; DEROY, Patrick; LEBLANC, Melissa; MARINEAU, Jason, J.; MOORE, Joel; ROY, Stephanie; SIDDIQUI, M., Arshad; SPROTT, Kevin; WINTER, Dana, K.; KABRO, Anzheliika; LEGER, Serge; MILLER, Tom; SCHMIDT, Darby; BRADLEY, Michael; WO2015/58163; (2015); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI