With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.
Under anhydrous anaerobic conditions, 214 mg (1 mmol) of 4′-methyl-2,2′-bipyridinyl-4-carboxylic acid was added to 50 mL of bisChlorinated sulfoxide solvent, heated to 80 C reflux, stirring 3h after the reaction, the solvent spin to remove, the remaining solid dissolved in 50mL of anhydrous methylene chloride, 0 in the case of ice drop 244 mg (hydrazinocarbonyl) ferrocene and 130 muL of triethylamine in anhydrous dichloromethane was added dropwise. After completion of the dropwise addition, the reaction was stopped after stirring for 3 h in an ice bath. The reaction was quenched to room temperature, the solvent was removed by spin- (V: V = 40: 1), and the solvent was dried to give 4′-methyl-2,2′-bipyridyl-4- (hydrazinocarbonyl) bis Ferrocene, 103946-54-9
The synthetic route of 103946-54-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shaanxi Normal University; Zhang Chengxiao; Han Danjuan; Qi Honglan; (14 pag.)CN106892947; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI