In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 20439-47-8, name is (1R,2R)-Cyclohexane-1,2-diamine, introducing its new discovery. Safety of (1R,2R)-Cyclohexane-1,2-diamine
Optical resolution of 2,2′-dihydroxy-1,1′-binaphthyl (1) with (R,R)-1,2-cyclohexanediamine (2) in toluene yielded optically pure (R)-1 in a yield of 160percent based on the theoretical amount of the enantiomer contained in the racemate by selective crystallization of a less soluble complex, (R)-1*(R,R)-2, and epimerization of more soluble complex, (S)-1*(R,R)-2.Also optically pure (S)-1 was obtained with the same enantiomer of the resolving agent, (R,R)-2, in a yield of 154percent. (R,R)-1,2-Diphenyl-1,2-ethanediamine (3) was a suitable resolving agent for both 1 and 6,6′-dibromo-2,2′-dihydroxy-1,1′-binaphthyl.Kinetic study indicated that the reversible first-order rate constants for the epimerizations of (S)-1*(R,R)-2 and (S)-1*(R,R)-3 were larger than that for the racemization of (S)-1.The activation energy and frequency factor for the epimerization of (S)-1*(R,R)-2 were 109 kJ mol-1 K-1 and 3E10 s-1, respectively, and those for (S)-1*(R,R)-3 were 96 kJ mol-1 and 1E8 s-1, while those for the racemization of (S)-1 were 85 kJ mol-1 K-1 and 9E5 s-1, respectively.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 20439-47-8 is helpful to your research. Safety of (1R,2R)-Cyclohexane-1,2-diamine
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI