Catalyst ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

1) Under a nitrogen atmosphere,4,4′-dimethyldiphenylamine (1.97 g, 10 mmol)CuI (28.5 mg, 0.15 mmol),1,10-phenanthroline (54 mg, 0.3 mmol)Potassium hydroxide (1.12 g, 15 mmol),2-iodo-dithiophene (3.16 g, 12 mmol),Water (7 mL) and xylene (20 mL)The reaction was carried out at 130 ¡ã C for 24 hours,The reaction mixture was poured into methylene chloride (100 mL), washed with water, and the organic phase was collected and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was passed through a silica gel column. The mobile phase was a 1: 3 by volume mixture of dichloromethane and petroleum ether to give intermediate P3;2)The intermediate P3 (3.35 g, 10 mmol) was dissolved in dry dichloromethane (50 mL)Anhydrous aluminum trichloride (1.6 g, 12 mmol) was added portionwise at 0 ¡ã C,After stirring for 20 minutes,A solution of oxalyl chloride (5 mmol) in dichloromethane (10 mL) was slowly added dropwise,Drop finished, rose to room temperature to continue stirring 6 hours, the reaction completed,A 10percent aqueous hydrochloric acid solution (10 mL) was added dropwise to the reaction solution,The organic phases were collected, washed with saturated sodium bicarbonate solution and water, dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure,The residue was passed through a silica gel column and the mobile phase was a 1: 1 by volume mixture of dichloromethane and petroleum ether to give intermediate P4;3) 5,6-diamino-1, 10-phenanthroline A (2.10 g, 10 mmol)Intermediate P4 (10 mmol) and glacial acetic acid (40 mL) were refluxed at 120 & lt; 0 & gt; C for 24 hours,Down to room temperature,The solvent was distilled off under reduced pressure,The residue was extracted with chloroform,Washed with 10percent sodium bicarbonate solution and saturated brine, respectively,Dried over anhydrous sodium sulfate.The solvent was distilled off under reduced pressure, the residue was passed through a silica gel column,The mobile phase is a 1: 1 by volume mixture of methylene chloride and ethyl acetate,The organic photosensitive dye D2, the yield of 56percent

168646-54-6, As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Patent; China Academy of Sciences Huaxue Academe; Zhang, Lipeng; Fan, Xinheng; Chen, Qiang; Jiang, Kejian; Yang, Lianming; (14 pag.)CN104672237; (2017); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1435-55-8, Hydroquinidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

From dihydroquinidine To a 0 C. solution of 1.22g dihydroquinidine (0.0037 mol) in 30mL of CH2 Cl2 was added 0.78mL of Et3 N (0.0056 mol; 1.5 eq), followed by 0.71mL of p-chlorobenzoyl chloride (0.005 mol; 2 eq) in 1mL CH2 Cl2 After stirring 30 minutes at 0 C. and 1 hour at room temperature, the reaction was quenched by the addition of 10% Na2 CO3 (20mL). After separation, the aqueous layer was extracted with three 10mL portions of CH2 Cl2. The combined organic layers were dried over Na2 S04 and the solvent removed under vacuum. The crude product was purified as described above. Dihydroquinidine p-chlorobenzoate (1) was obtained in 91% yield (1.5g) as a white foam.

1435-55-8, 1435-55-8 Hydroquinidine 16401293, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Massachusetts Institute of Technology; US4965364; (1990); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

6813-38-3, [2,2′-Bipyridine]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6813-38-3, Take the product I obtained 2g and 10mL 98% H2SO4, 100mL CH3OH into the flask with a stirrer, reflux at 105 C overnight, the end of the reaction to a large amount of water appears white flocculent precipitate, slowly adding NaOH solution adjusted to pH 9.0 , With CH2C12 extract to retain the organic phase, anhydrous Na2S04 dry, evaporated to dry the solvent to obtain white crystals, the yield of 88%.

As the paragraph descriping shows that 6813-38-3 is playing an increasingly important role.

Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhao, Qiang; Huang, Wei; Huang, Tianci; Liu, Shujuan; Xu, Wenjuan; Zhu, Yana; (10 pag.)CN106188151; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,56-54-2

To a solution of epi-quinine (232 mg, 0.71 mmol) in DMSO (5 mL) was added LiH (11.1 mg, 1.1 mmol, 1.5 equiv) and the suspension was stirred for 1 h at room temperature. Then 2-chloro-1,10-phenanthroline (181 mg, 0.84 mmol, 1.2 equiv) was added and the mixture was stirred for 18 h at room temperature and 6 h at 80?85 ¡ãC. The cooled mixture was diluted with ethyl acetate (50 mL) and washed with brine (10 ¡Á 15 mL), the solvent was removed in vacuo, and the residue purified on silica gel (CHCl3 / MeOH 10:1) to afford 246 mg (67percent) of white solid.

As the paragraph descriping shows that 56-54-2 is playing an increasingly important role.

Reference£º
Article; Zieliska-Blajet, Mariola; Boratyski, Przemyslaw J.; Sidorowicz, Lukasz; Skarzewski, Jacek; Tetrahedron; vol. 72; 21; (2016); p. 2643 – 2648;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39069-02-8,2,9-Dibromo-1,10-phenanthroline,as a common compound, the synthetic route is as follows.,39069-02-8

To 1 mL of the solution of silver(I) tetrafluoroborate (1.17 mg, 0.00601 mmol) in dichloromethane was added 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (3.48 mg, 0.00601 mmol), and the mixture was stirred at room temperature for 15 minutes. Then, f23 (2.03 mg, 0.00601 mmol) was added to the reaction solution, which was stirred at 40C for five minutes. The reaction solution was subjected to recrystallization by slow diffusion of dichloromethane-ether and dried to provide 5.40 mg of the complex of the pale yellow crystal. [Show Image] The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 8.50 (brd, 2H), 8.13 (brs, 2H), 7.84 (brd, 2H), 7.62 (brd, 2H), 7.26-7.04 (m, 22H), 6.78 (br, 2H), 1.71 (s, 6H); 31P NMR (122 MHz, CDCl3); 31P NMR (122 MHz, CDCl3) delta -4.9 (d, J (31P-107Ag, 109Ag) = 392, 451 Hz). The composition of the obtained complex was determined according to the same method as in Example 15. The present complex corresponds to the above composition formula (5).

39069-02-8 2,9-Dibromo-1,10-phenanthroline 15448099, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.

103946-54-9, Weigh the NH2-C4 dichloro bridge 1mmolAnd 2.2 mmol of 4-methyl 4′-carboxy-2,2′-bipyridine was added to the reaction flask, vacuumed, and protected with nitrogen.Reacted at 40 C for 10 h,After adding KPF630mmol reaction for 2h,Spin dry, extract with dichloromethane (3 ¡Á 150mL), take the organic phase, spin dry into silica gel powder column, separate and purify,The yield was 59%.

103946-54-9 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid 11127621, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhang Yin; Wei Huanjie; Zhang Taiwei; Zhao Qiang; Liu Shujuan; Huang Wei; (11 pag.)CN107880076; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

100125-12-0, 3,8-Dibromo-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to a dichloromethane (DCM) solution (about 10 mL) of BrphenBr (33.6 mg, 0.100 mmol) and BINAP (63.5 mg, 98%, 0.100 mmol) under a stream of dry argon using Schlenk techniques at room temperature. After stirring for 5 h at room temperature, n-hexane was carefully dropped over the DCM solution, and orange-yellow crystals were obtained a few days later in 52.5% yield (67.9 mg)., 100125-12-0

The synthetic route of 100125-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Feng, Xiao-Yan; Xin, Xue-Lian; Guo, Ya-Meng; Chen, Ling-Ling; Liang, Yu-Ying; Xu, Min; Li, Xiu-Ling; Polyhedron; vol. 101; (2015); p. 23 – 28;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4568-71-2,3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Step A Preparation of 1-(3,4-dimethoxyphenyl)-4-(2-naphthyl)butan-1,4-dione Sodium acetate (2.38 g), 3-benzyl-4-methyl-5(2-hydroxyethyl)thiazolium chloride (3.78 g), 2-naphthaldehyde (10.92 g), 3,4-dimethoxybenzaldehyde (17.43 g), vinylsulfone (7.00 ml) and dimethylformamide (dry DMF, 35 ml) were stirred at room temperature for about 13 days. The reaction mixture was partitioned between chloroform and water and the layers separated. The pooled organic layers were washed with water, dried over anhydrous potassium carbonate and evaporated in vacuo to give about 24.9 g of an oil. The oil was chromatographed to give 1.8 g of crude product which was crystallized from methanol to give 623.2 mg of pure 1-(3,4-dimethoxyphenyl)-4-(2-naphthyl)butan-1,4-dione, m.p. 133¡ã C.

4568-71-2, As the paragraph descriping shows that 4568-71-2 is playing an increasingly important role.

Reference£º
Patent; Merck & Co., Inc.; US4539332; (1985); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4479-74-7, 2,2-Bipyridine-6,6-dicarboxylic Acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,2′-Bipyridine-6,6′-dicarboxylic acid (0.37 g,1.5 mmol) in mixture of thionyl chloride (10 ml) and DMF (0.3 ml) wasrefluxed for 2.5 h. Then thionyl chloride was removed, the solid residuewas dissolved in absolute THF (15 ml) and the resulting solution was addedportionwise to a solution of tetraethyl [iminodi(methylene)]bis(phosphonate)(1 g, 3.15 mmol) and Et3N (1 ml) in absolute THF (10 ml). The mixturewas stirred at room temperature for 16 h. Then water (5 ml) was addedand the organic layer was separated, washed with water and dried overanhydrous Na2SO4. The solvent was evaporated to leave dark oil. Thendiethyl ether (5 ml) was added to the oil and the mixture was ground untilprecipitate formation. The precipitate was filtered off, washed with colddiethyl ether and dried in air to afford product 3 as white powder. Yield1 g (79%), mp 116-118C. 1H NMR (600 MHz, CDCl3) delta: 1.19 (t, 12H,CH2Me, 3J 7.0 Hz), 1.36 (t, 12H, CH2Me, 3J 7.0 Hz), 3.94-4.01 (m, 8H,CH2Me), 4.20-4.27 (m, 8H, CH2Me), 4.39 (d, 4H, 2CH2P, 2J 11.1 Hz),4.76 (d, 4H, 2CH2P, 2J 11.2 Hz), 7.85 (d, 2H, 3,3′-CH, 3J 7.5 Hz), 7.97(t, 2H, 4,4′-CH, 3J 7.7 Hz), 8.50 (d, 2H, 5,5′-CH, 3J 7.2 Hz). 13C NMR(100 MHz, CDCl3) delta: 16.2 (d, J 5.1 Hz), 16.3 (d, J 5.0 Hz), 41.3 (d,J 155.9 Hz), 44.5 (d, J 154.7 Hz), 62.2 (d, J 6.0 Hz), 62.6 (d, J 5.7 Hz),122.1, 125.4, 138.2, 152.5, 153.1, 167.5. 31P NMR (162 MHz, CDCl3) delta:2 1.64, 21.65. MS (MALDI-TOF), m/z: 881 [M+K]+. Found (%): C, 45.72;H, 6.51; N, 14.78. Calc. for C32H54N4O14P4 (%): C, 45.61; H, 6.46;N, 14.70., 4479-74-7

The synthetic route of 4479-74-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Farat, Oleg K.; Kharcheva, Anastasia V.; Ioutsi, Vitaliy A.; Borisova, Natalia E.; Reshetova, Marina D.; Patsaeva, Svetlana V.; Mendeleev Communications; vol. 29; 3; (2019); p. 282 – 284;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

6813-38-3, [2,2′-Bipyridine]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6813-38-3, A monocarboxylic acid, 4-carboxy-4?-ethyl-2,2?-bipyridine 9 was identified as methyl ester as follows. Isolated mixture of 2 and 9 (Table 4, entry 5) was dissolved in 40 mL methanol, and 1 mL conc. H 2 SO 4 was added. The solution was refluxed for 24h, and then the cooled mixture was neutralized by adding aqueous NaHCO 3 solution. After removal of methanol at reduced pressure, H 2 O was added to the residue, and insoluble dimethyl 2,2′-bipyridine-4,4′-dicarboxylate S7 was filtered off and washed well with H 2 O. The filtrate and washings were combined and extracted with CH 2 Cl 2 . The organic layer was separated, dried with anhydrous Na 2 SO 4 , and the solvent was removed out under a reduced pressure. The colorless oil obtained was identified as 4-ethyl-4?-methoxycarbonyl-2,2?-bipyridine 16by its spectral data. The colorless oil solidified on standing several days in freezer. 4-Ethyl-4?-methoxycarbonyl-2,2?-bipyridine 16: mp 38-40C 1 H NMR (400 MHz, CDCl 3 ,TMS) ppm: 1.32 (3H, t, J=7.6 Hz), 2.76 (2H, q, J=7.6 Hz), 7.20 (1H, dd, J=5.0 Hz, 1.8 Hz), 7.86 (1H, dd, J=5.0 Hz, 1.8 Hz) 8.28 (1H, t, J=0.9 Hz), 8.61 (1H, d, J=5.0 Hz), 8.63 (2H, s), 8.82 (1H, dd, J=5.0 Hz, 0.9 Hz) 8.93 (1H, t, J=0.9 Hz); 13 C NMR (100 MHz, CDCl 3 , TMS) ppm: 14.4, 28.4, 52.7, 120.6, 120.9, 122.7, 123.9, 138.5, 149.3, 149.8, 154.2, 155.2, 157.5, 165.8. IR (ATR, cm -1 ) 3437, 3056, 2967, 2947, 2925, 2882, 2847, 1932, 1721, 1592, 1552, 1460, 1439, 1291, 1230, 1106, 963, 843, 747, 684; MS (EI) m/z(%) 242 (79) [M] + , 241 (96), 184 (100); Anal. Calcd for C 14 H 14 N 2 O 2 : C, 69.41; H, 5.82; N, 11.56. Found: C, 69.31; H, 6.00; N, 11.16.

The synthetic route of 6813-38-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yamazaki, Shigekazu; Synthetic Communications; vol. 49; 17; (2019); p. 2210 – 2218;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI