Catalyst ligands

103946-54-9, 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Bis-2,2′-bipyridine ruthenium dichloride (55 mg, 0.11 mmol) Methyl-2,2′-bipyridine-4-carboxylic acid (21 mg, 0.11 mmol) were protected from light in the presence of ethanol (10 mL, 50%) under argon for 5 hours. The reaction mixture was evaporated and the residue was dissolved in 1 mL CH3CN, Add 2 mL of saturated n-butylamine in acetone. The resulting precipitate was filtered, Washed with acetone, And vacuum dried, This gave 79 mg (85%) of Ru-CO2H as a red-orange powder. (Synthesis route shown in Figure 4)., 103946-54-9

103946-54-9 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid 11127621, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Capital Medical University; Li, Minna; Peng, Shiqi; Zhao, Ming; (10 pag.)CN106146565; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Chloro-propanoic acid (4.34 g, 0.04 mol) was dissolved in 5.0 mL of water on ice bath and carefully neutralized with cold water solution of 5.0 mL NaOH (1.60 g, 0.04 mol). Meso-1,2-diphenyl-ethylenediamine (4.24 g, 0.02 mol) was added to this solution. The mixture was being stirred for 4 h at 90 C, and during this period 5.0 mL NaOH water soltion (1.60 g, 0.04 mol) was introduced. After that, 5.6 mL 6 mol/L HCl was added and resulting solution was evaporated to the volume of 7.0 mL; 6.0 mL conc. HCl, 6.0 mL of ethanol and 6.0 mL of ether were added to the mixture. The white precipitate of meso-1,2-diphenyl-ethylenediamine-N,N’-di-3-propanoic acid dihydrochloride monohydrate, H2-1,2-dpheddp 2HCl H2O was separated by filtration and refined with solution water: ethanol = 1: 2. Yield: 4.00 g (44.69%). Anal. Calcd. for H2-1,2-dpheddp*2HCl*H2O = C20H28Cl2N2O5 (Mr = 447.344): C, 53.69; H, 6.31; N, 6.26. Found: C, 53.88; H, 6.70; N, 6.08.

29841-69-8, 29841-69-8 (1S,2S)-(-)-1,2-Diphenylethylenediamine 6931238, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Radi?, Gordana P.; Glodovi?, Verica V.; Ratkovi?, Zoran R.; Novakovi?, Sladana B.; Garcia-Granda, Santiago; Roces, Laura; Menendez-Taboada, Laura; Radojevi?, Ivana D.; Stefanovi?, Olgica D.; ?omi?, Ljiljana R.; Trifunovi?, Sre?ko R.; Journal of Molecular Structure; vol. 1029; (2012); p. 180 – 186;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to adichloromethane (DCM) solution (about 12 mL) of dap (21.4 mg,98percent, 0.100 mmol) and xantphos (59.0 mg, 98percent, 0.100 mmol) undera stream of dry argon by using Schlenk techniques at room temperatureand a vacuum-line system, then orange-red solutionwas obtained quickly and stirred for 1 h at room temperature.The above process can also be carried out in air with the existenceof oxygen. After filtration through absorbent cotton, layeringn-hexane onto the filtrate in air produced the product as orangeredcrystals in 35?44percent yield (39.1?49.3 mg).

168646-54-6, 168646-54-6 5,6-Diamino-1,10-phenanthroline 10910805, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Liu, Rong; Feng, Xiao-Yan; Li, Hao-Huai; Liu, Nian; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 92; (2015); p. 84 – 92;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 6-(2,2′:6′,2″-Terpyridine-4′-yloxy)-hexylamine To a suspension of KOH (2.70 g, 48 mmol) in anhydrous DMSO (50 mL) was added 6-Amino-1-hexanol (1.17 g, 10 mmol). The suspension was warmed up to 60 C. and stirred for additional 30 min, followed by addition of 4′-chloro-2,2′:6′,2″-terpyridine (2.68 g, 10 mmol). The reaction mixture was kept stirring for 2 d at the same temperature. The solution was then allowed to cool down to R.T., poured into deionized water (500 mL), stirred and allowed to precipitate overnight. The product was filtered off and dried up under high vacuum to give 2 as a pale yellow solid (2.90 g, 83.3%). 1H NMR (400 MHz, CDCl3): delta 1.47-1.86 (m, 8H), 2.74 (t, J=6.5 Hz, 2H, NCH2), 4.22 (t, J=6.5 Hz, 2H, OCH2), 7.34 (dd, J=2.0 Hz, 5.0 Hz, 2H, H5,5″(terpy)), 7.84 (td, J=2.0 Hz, 7.5 Hz, 2H, H4,4″(terpy)), 8.03 (s, 2H, H3′,5′(terpy), 8.67 (d, J=8.5 Hz, 2H, H3,3″terpy)), 8.70 (d, J=5.0 Hz, 2H, H6,6″(terpy)). GC-MS: m/z 348 (100%) (M+).

128143-89-5, 128143-89-5 4′-Chloro-2,2′:6′,2”-terpyridine 667748, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Massachusetts Institute of Technology; CHEN, Pangkuan; HOLTEN-ANDERSEN, Niels; (58 pag.)US2016/152638; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

5350-41-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5350-41-4,N,N,N-Trimethyl-1-phenylmethanaminium bromide,as a common compound, the synthetic route is as follows.

General procedure: To a 50mL Schlenk tube containing benzylic ammonium iodide (0.5mmol), arylboronic acid (2.0mmol), K3PO4 (2.25mmol), castalyst (5molpercent) and PPh3 (20molpercent) were added and the tube was purged with N2 for 3 times. Then 1,4-dioxane (2.0mL), subsequently, was introduced to the tube. The resulted mixture was allowed to stir for 24h at 80¡ãC under atmosphere of N2. After the completion of the reaction, the resulting mixture was filtered through a Celite pad and concentrated under the vacuum and directly purified by flash chromatography to give the desired product.

As the paragraph descriping shows that 5350-41-4 is playing an increasingly important role.

Reference£º
Article; Liu, Xi-Yu; Zhu, Hai-Bo; Shen, Ya-Jing; Jiang, Jian; Tu, Tao; Chinese Chemical Letters; vol. 28; 2; (2017); p. 350 – 353;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

139-07-1, N-Benzyl-N,N-dimethyldodecan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The API-IL benzalkonium salicylate was prepared from benzyldimethyldodecylammoniumchloride (benzalkonium chloride) and sodium salicylate according to a procedure similar tothat described in the literature [8]. Sodium salicylate (0.93 g, 5.8 mmol) and benzyldimethyldodecylammoniumchloride (2.05 g, 5.8 mmol) were dissolved in 20 mL of acetone/H2O(1:1). The reaction mixture was stirred overnight at room temperature. The remaining suspensionwas diluted with 20 mL of distilled water. The product was extracted with dichloromethane.Sodium chloride as a byproduct was removed by washing the dichloromethane phase successivelywith water. The presence of chloride ions in the washings was detected using AgNO3solution. The dichloromethane was evaporated under reduced pressure. The obtained API-ILwas further dried at 343 K in vacuum for 8 h. The water content of the API-IL was determinedby a Karl-Fischer measurement, and the value was about 350 ppm. The synthesized API-ILwas characterized by 1H NMR (Bruker DPX) and IR (Nicolet IR-470).The characterization values obtained are: IR (KBr, cm-1): 3437(s), 3027(w), 2921(s),2852(s), 1638(s), 1590(s), 1484(s), 1456(s), 1219(s), 1137(m), 758(m), 735(m);1H NMR:(400 MHz, CDCl3)delta in ppm: delta 7.97 (dd, J = 7.7, 1.7 Hz, 1H), 7.48 (m, 6H), 6.87 (d,J = 8.2 Hz, 1H), 6.76 (t, J = 7.4 Hz, 1H), 4.82 (s, 2H), 3.36 (m, 2H), 3.21 (s, 6H), 1.74 (s, 2H),1.24 (d, J = 7.4 Hz, 18H), 0.88 (t, J = 6.8 Hz, 3H). The 1H NMR spectra of BaSal is presentedin Fig. S1 of the Supplementary Material.Thermal stability was measured on a STA 409 PC simultaneous thermal analyzer (Germany)in the range of 303-773 K at a heating rate of 10 K¡¤min-1 under an air environment. Itcan be seen from Supplementary Fig. S2 that BaSal has good thermal stability with the lowdecomposition temperature of 454 K., 139-07-1

The synthetic route of 139-07-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yan, Zhenning; Shen, Shuangxia; Ma, Limin; Liu, Liyun; Chen, Xue; Journal of Solution Chemistry; vol. 47; 9; (2018); p. 1514 – 1528;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

170161-27-0, Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

170161-27-0, General procedure: The dibromide was added to a solution of tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate (39.1 mg, 78.0 mumol), KI (12.9 mg, 78.0 mumol) and K2CO3 (10.8 mg, 78.0 mumol) in CH3CN (2.50 mL) under N2 and stirred for 24 h at room temperature. The reaction mixture was concentrated under reduced pressure and extracted with EtOAc. The organic layer was washed with water and brine, dried with MgSO4 and concentrated in vacuo to obtain the corresponding tri-N-Boc-protected amine intermediate (130 mg). A solution of the intermediate was added to bis(pyridin-2-ylmethyl)amine (12.0 mg, 60.0 mumol), KI (9.96 mg, 60.0 mumol) and K2CO3 (8.30 mg, 60.0 mumol) in CH3CN (3.00 mL) under N2 and stirred at 80 C for 24 h. The reaction mixture was concentrated under reduced pressure and extracted with EtOAc. The organic layer was washed with water and brine, dried with MgSO4 and concentrated in vacuo to obtain the corresponding tri-N-Boc-protected amine intermediate. The intermediate was then dissolved in CHCl3 (2.50 mL) and treated with 95% aqueous TFA (2.50 mL) at 0 C for 6 h. The mixture was concentrated under reduced pressure and purified by preparative HPLC to obtain the desired compound 16.

170161-27-0 Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate 10940041, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Sakyiamah, Maxwell M.; Kobayakawa, Takuya; Fujino, Masayuki; Konno, Makoto; Narumi, Tetsuo; Tanaka, Tomohiro; Nomura, Wataru; Yamamoto, Naoki; Murakami, Tsutomu; Tamamura, Hirokazu; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 1130 – 1138;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of Co(OAc)2*4H2O (49.2 mg, 0.2 mmol), L1 (32.3 mg, 0.1 mmol), H2bpdc (48.4 mg, 0.2 mmol), NaOH (8.0 mg, 0.2 mmol), ethanol (4 mL) and water (10 mL) was heated at 140 C for 3 days in a 25 mL Teflon-lined vessel container. The mixture was then cooled to room temperature at a rate of 5 C/h. Purple crystals suitable for single-crystal X-ray diffraction were obtained by filtration and washed with distilled water in 58 % yield (based on Co(OAc)2*4H2O). Calcd. for C34H30CoN4O4 (Fw = 617.55): C 66.1, H 4.9, N 9.1 %. Found: C 65.9, H 5.1, N 9.3 %. IR (KBr, cm-1): 1605 s, 1560 m, 1510 m, 1430 m, 1300 m, 1178 w, 847 w, 758 m.

The synthetic route of 787-70-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Xu; Liu, Yong Guang; Yu, Baoyi; Cui, Guang Hua; Transition Metal Chemistry; vol. 41; 2; (2016); p. 213 – 223;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

[CuI(MeCN)4](ClO4) (50mg, 0.15mmol), PPh3 (80.4mg, 0.30mmol) and Ph2Phen (55.9mg, 0.17mmol) in MeCN (15ml) are stirred at room temperature for 1h. Slow evaporation of a MeCN solution of 3 afforded analytically pure complex as yellow crystalline solid. Yield (93.1mg, 59.8%). Elemental analysis for C60H46ClCuN2O4P2: calcd. C 70.65, H 4.55, N 2.75%; found: C 70.60, H 4.70, N 2.77%. Selected IR (KBr, cm-1): v(Cl-O) 1111. ESI-MS (positive): m/z 919 (M+). 1H NMR (300MHz, CDCl3): delta 8.83 (d, J=5.0Hz, 2H, phen H); 8.01 (s, 2H, phen H); 7.74 (d, J=5.0Hz, 2H, phen H); 7.62 (m, 6H, phenyl H); 7.57-7.51 (m, 4H, phenyl H); 7.37 (m, 6H, phenyl H); 7.26-7.14 (m, 24H, phenyl H). 31P{1H} NMR (162MHz, CDCl3): delta 2.97 (s, PPh3). UV/Vis (CH3CN): lambdamax /nm (epsilon/mol-1dm3cm-1): 228 (71180), 285 (58210), 381 sh (5810).

1662-01-7, As the paragraph descriping shows that 1662-01-7 is playing an increasingly important role.

Reference£º
Article; Hu, Lin-Li; Shen, Chang; Chu, Wing-Kin; Xiang, Jing; Yu, Fei; Xiang, Ge; Nie, Yan; Kwok, Chun-Leung; Leung, Chi-Fai; Ko, Chi-Chiu; Polyhedron; vol. 127; (2017); p. 203 – 211;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134030-21-0,N1,N2-Dimesitylethane-1,2-diamine,as a common compound, the synthetic route is as follows.

In a GPC bottle, N,N?- dimesityl-ethanediamine (2 mmol) and C6F5CHO (3 mmol) were introduced. The mixture was crushed with a glass rod and a few drops of glacial acetic acid were added while stirring. After adding glacial acetic acid (1 mL) a precipitate was formed. Another glacial acetic acid (1 mL) was added, and the precipitate obtained after filtration was washed with cold isopropanol (-20 C) and then dried. The product was obtained as a white powder. Yield: 0.34g, 35%. 1H NMR (250 MHz, CDCl3) delta 6.79 (s, 4H), 6.37 (s, 1H), 3.89 (m, 2H), 3.51 (m, 2H), 2.51 (s, 9H), 2.20 (s, 9H) . 13C NMR (250 MHz, CDCl3) delta 139.07, 135.46, 130.12, 71.56, 51.04, 20.71., 134030-21-0

The synthetic route of 134030-21-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Musengimana, Eric; Fatakanwa, Claver; Oriental Journal of Chemistry; vol. 29; 4; (2013); p. 1489 – 1496;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI