Catalyst ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148332-36-9,[2,2′:6′,2”-Terpyridine]-4′-carboxylic acid,as a common compound, the synthetic route is as follows.,148332-36-9

Take the material according to the following specific mass or volume:Htpc (27.7 mg, 0.1 mmol),CrCl3¡¤6H2O (40 mg, 0.15 mmol),DMF (12.9 mmol, 1 mL),CH3CN (1mL),H2O (9mL),HNO3 (21 uL, 7 mol/L).The above materials were placed in a 25 mL reaction kettle.Stir for 0.5 to 1.5 hours,Warming up to 120 ¡ã C,After 3 days of reaction,Naturally cooled to room temperature,Light red crystals were observed,Is the target product,Filter it out of the mother liquor,Water washing,It is naturally dry after finishing.

148332-36-9 [2,2′:6′,2”-Terpyridine]-4′-carboxylic acid 2762749, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Chongqing Normal University; Chen Xin; Zhang Ruyi; Huang Kunlin; Ding Xumeng; Guo Yuanyuan; (9 pag.)CN108997432; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

787-70-2, A mixture of Cu(NO3)2 (0.2 mmol, 58.2 mg), 1,3-bip(0.20 mmol, 35.2 mg), NaOH(0.2 mmol, 8 mg) and H2bpdc(0.20 mmol, 58.2 mg) in DMF-H2O (6 mL, V:V 1:1) binary solventwas placed in a 25 mL Telfon-lined stainless steel container, whichwas heated to 150 C for 3 days, and then cooled to room temperatureover 24 h. Yield: 65% based on copper.Elemental analysis (%): calcd for C23H26CuN4O7 (Mr 534.03): C50.27, H 3.94, N 13.8; found: C 50.36, H 3.62, N 13.81. IR(cm1):3434(bs),3134(w),2919(w),2865(w),1650(m),1589(m).1536(m),1389(m),1106(w), 838(m),765(m).

787-70-2 [1,1′-Biphenyl]-4,4′-dicarboxylic acid 13084, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Lu, Jiu-Fu; Wang, Min-Zhen; Liu, Zhi-Hong; Journal of Molecular Structure; vol. 1098; (2015); p. 41 – 46;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54761-04-5, Ytterbium(III) trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,54761-04-5

General procedure: Compounds Ir6Ln (Ln=Eu, Tb, Er, Yb) were synthesized under similar optimized experimental conditions. A typical procedure for the preparation of [EuIr6(ppy)12(bpp)2(bppH)4](CF3SO3)¡¤18H2O (Ir6Eu) is described as below. Eu(CF3SO3)3 (0.0120g, 0.02mmol) was added to a methanol solution (5cm3) of [Ir(ppy)2(bppH)] (0.0135g, 0.02mmol). After heating the yellow solution at 100C under microwave irradiation for 30min, the filtrate was left to stand for one week at room temperature. Yellow block crystals were collected by suction filtration, washed with a minimum amount of methanol.

54761-04-5 Ytterbium(III) trifluoromethanesulfonate 2733225, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Zeng, Dai; Fan, Kun; Wang, Lu-Ping; Bao, Song-Song; Ren, Min; Zheng, Li-Min; Journal of Magnetism and Magnetic Materials; vol. 484; (2019); p. 139 – 145;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: Dried RuCl3 (0.20 g, 0.96 mmol) was dissolvedin dipropylene glycol (10 mL) and deionized water (1 mL).The solution was refluxed until the metal salt was dissolved,obtaining a dark green solution. Bipyridine (0.469 g; 3.0 mmol) wasadded, resulting in a brown solution. Ascorbic acid (0.177 g,1.0 mmol) was then added and the solution refluxed for 20 min at250 C, the brown colour changing to red. After cooling, the solutionwas diluted to 40 mL and the pH adjusted to 8 by addition of afew drops of NaOH solution (2.5 M). NaBF4 (4.0 g, 36 mmol) wasadded and the solution cooled on ice. After vacuum filtration,washing with cold water, and drying, 0.329 g [Ru(bpy)3](BF4)2product was obtained., 17217-57-1

The synthetic route of 17217-57-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; van der Westhuizen, Deidre; von Eschwege, Karel G.; Conradie, Jeanet; Electrochimica Acta; vol. 320; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

Step-1 : Synthesis of bis(2,5-dioxopyrrolidin-l-yl) biphenyl-4,4′-dicarboxylate (3399) [1182] To a stirred solution of biphenyl-4,4′-dicarboxylic acid (500 mg, 2.06 mmol) in 10 mL of DMF was added N-hydroxysuccinimide (594 mg, 5.16 mmol) and (3400) dicyclohexylcarbodiimide (1.06 g, 5.16 mmol) at 0C and the mixture stirred at RT overnight. The reaction mixture was filtered and the filtered cake was washed with EtOAc. The washings and filtrate were combined, washed with brine solution (3×20 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford a crude product that was dissolved in DCM and again filtered. The DCM layer was concentrated under reduced pressure to afford desired product (600 mg).

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David; CHAKRAVARTY, Sarvajit; RAI, Roopa; BERNALES, Sebastian; SATHE, Balaji Dashrath; URETA, Gonzalo; MCCULLAGH, Emma; WO2015/116707; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

75714-60-2, (S)-3,3′-Dibromo-2,2′-dimethoxy-1,1′-binaphthalene is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To magnesium turnings (583 mg, 24 mmol) activated with 1,2-dibromoethane in diethyl ether (4 ml), 2-bromo-1,3,5-triethylbenzene (3.86 g, 16 mmol) and diethylether (20 ml) were added alternately during 30 min. After complete addition the mixture was refluxed (oil bath heating) for 21 h. After cooling to ambient temperature, the solution was added to a mixture of (S)-3,3′-dibromo-2,2′-dimethoxy-1,1′-binaphthalene (4, 1.89 g, 4.0 mmol) and Ni(PPh3)2Cl2 (393 mg, 0.60 mmol) in anhydrous diethyl ether (40 ml). The reaction mixture was refluxed for 28 h, cooled to ambient temperature, carefully treated with saturated aqueous NH4Cl solution (40 ml) and water (40 ml), and extracted with CH2Cl2 (100 ml, 50 ml). The combined organic layers were dried (MgSO4), filtered, and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica gel using 10-15% CH2Cl2/hexane as the eluent yielding the title compound as a colorless solid (1.22 g, 48%). 1H-NMR (400 MHz, CD2Cl2): delta 7.89 (d, J = 8.1 Hz, 2H), 7.74 (s, 2H), 7.44-7.40 (m, 2H), 7.32-7.25 (m, 4H), 7.06 (s, 2H), 7.05 (m, 2H), 3.10 (s, 6H), 2.70 (q, J = 7.6 Hz, 4H), 2.51 (q, J = 7.6 Hz, 4H), 2.46 (q, J = 7.6 Hz, 4H), 1.30 (t, J = 7.6 Hz, 6H), 1.15 (t, J = 7.6 Hz, 6H), 1.08 (t, J = 7.6 Hz, 6H); 13C-NMR (100 MHz, CD2Cl2): delta 155.0, 144.0, 142.9, 142.8, 134.9, 134.4, 134.2, 131.4, 130.8, 128.3, 126.4, 125.9, 125.4 (2C), 125.3, 125.0, 60.1, 29.1, 27.4, 27.3, 15.8, 15.6, 15.4; HRMS (ESI+) (m/z): [M+Na] calcd for C46H50O2Na, 657.3703; found, 657.3708., 75714-60-2

The synthetic route of 75714-60-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Studiengesellschaft Kohle mbH; Coric, Ilija; List, Benjamin; Vellalath, Sreekumar; EP2615098; (2013); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

144222-34-4, N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The catalyst could also be generated in situ by mixing 0.02 mol equiv of [RuCl2(f>-cymene)2] and 0.04 mol equiv of the (i?,/?)-N-Tosyl-l,2-diphenylethylene-l,2-diamine in DCM (dichloromethane) in the presence of 0.04 mol equiv of IM solution KOtBu in THF. After aging for 10 min at RT(room temperature), Et3N was added followed by HCO2H and a solution of the enone in DCM.

144222-34-4, As the paragraph descriping shows that 144222-34-4 is playing an increasingly important role.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/14454; (2007); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (Part 1) To a stirred solution of Cinchona alkaloid (either Quinine, Quinidine, Cinchonine or Cinchonidine) (1 equiv.) in THF (0.1 M) was added the required arylmethyl halide compound (1.2 equiv.) at room temperature. The reaction mixture was refluxed overnight, cooled to room temperature and all volatiles were removed invacuo. The residue was then dissolved in CH2Cl2 (typically 2 mL for 1 mmol of starting material) and the resulting solution was added dropwise onto Et2O (typically 30 mL for 1 mmol of starting material) with vigorous stirring. The resulting precipitate was then filtered, washed thoroughly with Et2O, and further dried under high vacuum for 2 hours, yielding the intermediate alcohol product in an excellent yield. (Part2) This product (1 equiv.) was dissolved in CH2Cl2 (0.2 M). Methyl iodide (3 equiv.) and an aqueous sodium hydroxide solution (50 %w, 5 equiv.) were successively added at room temperature. The reaction mixturewas stirred at room temperature for 4 h, before water (typically 20 mL for 1 mmol of starting material) was added to quench the reaction. The organic layer was separated and the aqueous layer was extracted with CH2Cl2. The combined organic extracts were dried over Na2SO4, and concentrated in vacuo (N.B: washing with brine is prohibited to avoid the I/Cl anion exchange). Purification by column chromatography on silica gel, eluting with MeOH/Acetone/CH2Cl2 (0:10:90 to 10:10:90), afforded the desired Cinchona alkaloid quaternary ammonium salt in a moderate to excellent yield.

485-71-2, As the paragraph descriping shows that 485-71-2 is playing an increasingly important role.

Reference£º
Article; Antien, Kevin; Viault, Guillaume; Pouysegu, Laurent; Peixoto, Philippe A.; Quideau, Stephane; Tetrahedron; vol. 73; 26; (2017); p. 3684 – 3690;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

In a 1000 ml three-vial bottle,Under nitrogen protection,Add 200 ml of anhydrous ethanol,200 ml of toluene,21 g (0.1 mol) of 1,10-phenanthroline-5,6-diamine, 10.6 g (0.1 mol) of benzaldehyde,1 ml glacial acetic acid,After the addition, the temperature was gradually raised to reflux for 6 hours.After cooling, the reaction solution was concentrated to dryness under reduced pressure.The resulting solid was recrystallized from a mixed solvent of chloroform and ethanol.27.1 g of 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline was obtained.Yield 91.55percent.

168646-54-6, 168646-54-6 5,6-Diamino-1,10-phenanthroline 10910805, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Li Xianwei; (29 pag.)CN107973811; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13104-56-8, 4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Re(CO)5Cl (0.10 g, 0.27 mmol) and suitable Ln ligand (0.27 mmol) were dissolved in argon-saturated acetonitrile (20 mL). The resulting solution was placed in 25 mL teflon lined hydrothermal synthesis autoclave reactor and heated to 150 C. The reaction was stopped after 20 h and the autoclave was gradually cooled to room temperature for 30 h. The resulting yellow (1, 4, 7) or orange (2, 3, 5, 6, 8, 9) solid was collected by filtration, washed with diethyl ether and dried. X-ray quality orange (2 and 8) crystals were obtained by recrystallization from mixture of acetonitrile/methanol. To synthetize the complexes 1-9, standard procedure based on the heating under reflux of [Re(CO)5Cl] with molar equivalent of Ln ligand in argon-saturated acetonitrile also may be used. [ReCl(CO)3(L1)] (1): Yield: 75%. IR (KBr, cm-1): 2022(vs),1936(vs) and 1910(vs) nu(C^O); 1604(m) nu(C]N) and nu(C]C). 1HNMR (400 MHz, DMSO-d6) delta/ppm=9.11 (d, J=8.2 Hz, 1H, HC4),9.07-9.04 (m, 2H, HC1+B2), 8.79 (d, J=4.5 Hz, 1H, HA1), 8.39 (t,J=7.7 Hz, 1H, HC3), 8.22 (d, J=8.7 Hz, 2H, HD2), 8.15 (s, 1H, HB4),8.05 (t, J=8.0 Hz, 1H, HA3), 7.89 (d, J=7.6 Hz, 1H, HA4), 7.77 (t,J=6.2 Hz, 1H, HC2), 7.65-7.60 (m, 1H, HA2), 7.16 (d, J=8.6 Hz, 2H,HD3), 3.88 (s, 3H, HD5). 13C NMR (100 MHz, DMSO-d6): delta/ppm=198.25, 194.94, 191.50 (3CO), 162.18, 161.77, 158.39, 157.44,156.83, 153.13, 150.66, 149.67, 140.39, 137.37, 129.95, 127.85,127.18, 125.83, 125.59, 125.36, 123.86, 120.18, 115.29, 55.99. DSC: (Irun) Tm=308 C; (II run) Tg=246 C. C25H17N3O4ClRe(645.08 g mol-1): calcd C, 46.55; H, 2.66; N, 6.51; found: C, 46.18; H,2.80; N, 6.24.

13104-56-8, The synthetic route of 13104-56-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Klemens, Tomasz; ?witlicka, Anna; Machura, Barbara; Kula, S?awomir; Krompiec, Stanis?aw; ?aba, Katarzyna; Korzec, Mateusz; Siwy, Mariola; Janeczek, Henryk; Schab-Balcerzak, Ewa; Szalkowski, Marcin; Grzelak, Justyna; Ma?kowski, Sebastian; Dyes and Pigments; vol. 163; (2019); p. 86 – 101;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI