Catalyst ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10534-59-5,Tetrabutylammonium acetate,as a common compound, the synthetic route is as follows.

General procedure: 1H-NMR spectra were recorded on a DRX 400 (9.4 T, 400.13 MHz) spectrometer (Bruker Espanola S.A., Madrid, Spain) at 300 K. The [Host] values in the range of 1.02 to 1.85 ¡Á 10-3 correspond to a weighted quantity of host in 2 mL of CDCl3 (S33657, deuterium content >99.8%, water content <0.01%, containing silver wire as stabilizer, Merck S.L., Mollet del Valles-Barcelona, Spain). A given quantity of the guest (about 2 ¡Á 10-2 M) was weighed in a 1 mL volumetric flask and host solution was added to reach the graduation mark; in this way we know that the host concentration remains constant. Host and guest were weighted in a AE260-Delta Range scale (error ¡À 0.00005 g, Mettler Toledo, L' Hospitalet de Llobregat-Barcelona, Spain) and eVol XR hand-held automated analytical syringes (500 muL, 50 muL) from SGE Analytical Science (Trajan Scientific Europe Ltd, Crownhill, Milton Keynes, United Kingdom) previously calibrated for CDCl3, were used to perform additions. 1H-NMR titrations were used to quantify Ka values (see Figure 5 for two representative plots)., 10534-59-5

The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Garcia, M. Angeles; Farrn, M. Angeles; Mara, Dolores Santa; Claramunt, Rosa M.; Torralba, M. Carmen; Torres, M. Rosario; Jaime, Carlors; Elguero, Jos; Molecules; vol. 20; 6; (2015); p. 9862 – 9878;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57709-61-2,1,10-Phenanthroline-2,9-dicarboxylic acid,as a common compound, the synthetic route is as follows.

57709-61-2, Dark red crystals of 2 were prepared in a similar way to 1 except forusing H2O/MeCN (10 mL, v/v=1/1) instead of MeOH. Product wasisolated in 73percent yield based on Fe. Anal. Calcd. for C32H22FeN7O8: C55.83, H 3.22, N 14.24percent Found C 54.13, H 2.88, N 12.93percent. IR (selectedbands): 3067 (m), 1638 (s), 1508 (w), 1365 (s), 1271 (s), 875(m), 812 (s), 709 (m) cm?1.

As the paragraph descriping shows that 57709-61-2 is playing an increasingly important role.

Reference£º
Article; Ramezanpour, Behnaz; Mirzaei, Masoud; Jodaian, Vida; Niknam Shahrak, Mahdi; Frontera, Antonio; Molins, Elies; Inorganica Chimica Acta; vol. 484; (2019); p. 264 – 275;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4479-74-7,4479-74-7, 2,2-Bipyridine-6,6-dicarboxylic Acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of Tb(NO3)3¡¤6H2O (0.045 g, 0.10 mmol), H2bpdc (0.024 g, 0.10 mmol) in distilled water (10 mL) that adjusted the pH value to 2.5 with 0.5 mol L-1 NaOH aqueous solution. It was then sealed in a 25 mL Teflon reactor and heated at 160 C for 72 h, and then cooled to ambient temperature at a rate of ca.2 C h-1 to give colorless block crystals of 7, yield: 57% based on H2bpdc.

The synthetic route of 4479-74-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ren, Ya-Lan; Wang, Fei; Hu, Huai-Ming; Chang, Zhuguo; Yang, Meng-Lin; Xue, Ganglin; Inorganica Chimica Acta; vol. 434; (2015); p. 104 – 112;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1126-58-5, 1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a magnetically stirred solution of substituted isatin (5mmol) in 7ml of absolute ethanol, a corresponding pyridinium acetohydrazide (5mmol) and three drops of trifluoroacetic acid were successively added. The reaction mixture was heated under reflux for 3h. After spontaneously cooling the solution to room temperature, the precipitate formed was filtered, washed with absolute ether and dried in vacuo., 1126-58-5

As the paragraph descriping shows that 1126-58-5 is playing an increasingly important role.

Reference£º
Article; Bogdanov, Andrei V.; Zaripova, Ilyuza F.; Voloshina, Alexandra D.; Sapunova, Anastasia S.; Kulik, Natalia V.; Tsivunina, Irina V.; Dobrynin, Alexey B.; Mironov, Vladimir F.; Journal of Fluorine Chemistry; vol. 227; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6249-56-5,3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride,as a common compound, the synthetic route is as follows.

6249-56-5, Example 620-Oxo-5p-pregnan-3a-yl 4-(trimethylammonium) butanoate chloride3-Carboxy-N,N,N-trimethylpropan-l -ammonium chloride (prepared according to Lindstedt and Lindstedt, 1965, 69 mg; 0.38 mmol) was suspended in anhydrous CH2C12 (1 mL) under argon. The reaction flask was cooled in ice bath and oxalyl chloride (0.5 mL; 5.82 mmol) was added dropwise, followed by catalytic amount of dry DMF (3 mu; 0.03 mmol). The heterogeneous mixture was then brought to r.t. and stirred for 16 hrs, during which all the solids dissolved. The mixture was evaporated under the reduced pressure and solid residue was dissolved in dry nitromethane (2 mL) and dry pyridine (0.10 mL; 1.24 mmol) under argon. Compound II (100 mg; 0.31 mmol) was added to this reaction mixture, which was then stirred for 4 hrs. Reaction was quenched with water (10 mL) and acidified to pH 4 with 5percent aq. HC1. Product was extracted with CHC13 (3 x 20 mL), solution was washed with brine (10 mL, dried with anhydrous MgS04 and evaporated under the reduced pressure. Trituration with benzene removed the unreacted starting steroide II and the remaining product was subsequently crystallized from CHC13 : n-heptane (1 : 1) to give needle-like crystals (134 mg; 89percent).[a]D = +88.4 (c 0.243); NMR (500 MHz, CDC13) delta 4.76-4.68 (m, 1H, 3-CH), 3.73-3.73 (bm, 2H, 4′-CH2), 3.47 (s, 9H, NCH3), 2.55 (t, 1H, J = 9.0 Hz, 17-CH), 2.49 (t, 2H, J = 6.2 Hz, 2′-CH2), 2.12 (s, 3H, 21- CH3), 0.94 (s, 3H, 19-CH3), 0.60 (s, 3H, 18-CH3). 13C NMR (101 MHz, CDC13) delta 209.47, 171.49, 75.20, 65.61, 63.79, 56.62, 53.45, 44.26, 41.83, 40.41, 39.13, 35.76, 34.96, 34.59, 32.19, 31.46, 30.27, 26.87, 26.59, 26.24, 24.37, 23.22, 22.89, 20.82, 18.46, 13.38.IR (CHC13): 2956 (NMe3+), 1722 (C=0, ester), 1699 (C=0, ketone), 1478 (NMe3+) 1386 (CH3), 1360(COCH3), 1230 (NMe3+), 1188 (CO), cm”1.ESI m/z 446.6 (100percent, [M-C1]+); HRMS-ESI m/z 446.3624 ([M-C1]+, C28H4803N requires 446.3629).For C28H48C1N03 (482,1) calculated: 69.75percent C; 10.03percent H, 7.35percent CI, 2.91percent N; found: 69.59percent C, 9.99percent H, 7.12 percent CI, 2.82percent N.

6249-56-5 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride 22620, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE V?D ?ESKE REPUBLIKY, V.V.I.; FYZIOLOGICKY USTAV AKADEMIE V?D ?ESKE REPUBLIKY, V.V.I.; CHODOUNSKA, Hana; KAPRAS, Vojt?ch; VYKLICKY, Ladislav; BOROVSKA, Ji?ina; VYKLICKY, Vojt?ch; VALE?, Karel; STUCHLIK, Ale?; RAMBOUSEK, Luka?; WO2012/110010; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13093-04-4, N1,N6-Dimethylhexane-1,6-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a four-neck 2000 mL RBF fitted with overhead stirrer, addition funnel, reflux condenser, and thermocouple, under N2, was added maleic anhydride (75g, 0.734 mol, 2.5 eq.) and dry acetonitrile (400 mL), followed by the dropwise addition of N,N’-dimethyl-1,6-hexanediamine (51.9 mL, 0.294 mol, 1 eq.), maintaining <30C. The reaction turned an orange color as the addition progressed. The reaction was heated to 450C for 2 hours, then stirred overnight at room temperature. By morning, a tan solid had precipitated. It was filtered, then dried to constant weight, giving 87.6 g (87%) of the desired product as an off-white solid. 13093-04-4, As the paragraph descriping shows that 13093-04-4 is playing an increasingly important role.

Reference£º
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2006/66031; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

554-95-0,554-95-0, Benzene-1,3,5-tricarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Trimesic acid (5 g, 23.8 mmol) was suspended in methanol (15 mL) and heated to reflux. When a clear solution obtained,1.6 mL of con.H2SO4 was added slowly and the mixture was refluxed for 6 h. After 3 h, white solid get precipitated from the solution. The mixture was cooled to room temperature, slowly neutralized with saturated NaHCO3 solution, filtered and washed with excess water until the aqueous layer turned neutral. It was then dried to yield a white solid of trimethyl-1,3,5-benzenetricarboxylate (5.72 g). LiAlH4 tablets (2.5 g, 66 mmol) were suspended and refluxed in dry THF (50 mL) under an inert N2 atmosphere. Trimethyl-1,3,5-benzenetricarboxylate (5 g, 20 mmol) was dissolved in 100 mL dry THF and added to the suspension in 1 h. The solution was then refluxed for 24 h, cooled to 0 C and acidified with 1MHCl. THFwas removed under reduced pressure and the aqueous suspension (100 mL) thus obtained was extracted with ethyl acetate for 48 h in a liquideliquid extractor to yield 1,3,5-trimethylolbenzene which appeared as colorless crystals in room temperature. The mother liquor was concentrated to yield second fraction. Both the fractions were NMR pure and the combined yield was 4.96 g.

The synthetic route of 554-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Siyad; Kumar, G.S. Vinod; Polymer; vol. 53; 19; (2012); p. 4076 – 4090;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

787-70-2, In a typical preparation, a solid mixture of H2BPDC (H2BPDC = 4,4′-biphenyldicarboxylic acid; 0.1039 g, 0.4 mmol), bpy (bpy = 4,4′-bipyridine; 0.033 g, 0.2 mmol), and Cu(NO3)2¡¤3H2O (0.105 g, 0.4 mmol) was dissolved in a mixture of DMF (DMF = N,N’-dimethylformamide; 30 ml), pyridine (0.3 ml), and methanol (3 ml). The resulting solution was stirred at 70 C for 5 min and then distributed to four 20-ml vials. The vials were then heated at 120 C in an isothermal oven for 24 h. After cooling the vials to room temperature, the solid product was removed by decanting with mother liquor and washed in DMF (3 x 10 ml) for 3 days. Solvent exchange was carried out with methanol (3 x 10 ml) at room temperature for 3 days. The material was then evacuated under vacuum at 140 C for 6 h, yielding 0.103 g of Cu2(BPDC)2(BPY) in the form of blue crystals (67.5% based on copper nitrate).

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Article; Phan, Nam T.S.; Vu, Phuong H.L.; Nguyen, Tung T.; Journal of Catalysis; vol. 306; (2013); p. 38 – 46;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1351279-73-6,4,4′,4”,4”’-(Ethene-1,1,2,2-tetrayl)tetrabenzoic acid,as a common compound, the synthetic route is as follows.

Weigh H4TCPE (30mg, 0.06mmol), Ni(NO3)2?6H2O (166mg, 0.57mmol) and L-Pro (12mg, 0.1mmol) was dissolved in 2mL water and 4mL N, N- dimethylformamide mixed solution, stirred for 12 hours until homogeneity, placed in an oven, heated at 100 deg. C for 72 hours, the oven was turned off, cooled to room temperature, a green bulk crystal was produced, filtered and dried, yield 10%.

1351279-73-6, 1351279-73-6 4,4′,4”,4”’-(Ethene-1,1,2,2-tetrayl)tetrabenzoic acid 101553689, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Dalian University of Technology; Duan, Chunying; Zhou, Zhen; Lu, Yang; He, Cheng; (12 pag.)CN105348071; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

170161-27-0, Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

500 mg of compound 17-3 and 1.3 g of compound 17-1 were dissolved in 20 mL of acetonitrile, 680 mg of potassium carbonate was added, and the mixture was heated to reflux overnight, cooled to room temperature, filtered, and concentrated. Mix sample was dissolved in dichloromethane, separated by column chromatography (PE: EA = 20: 1-1: 1) to give a colorless waxy compound 17-4 500mg, Yield: 39.6%., 170161-27-0

As the paragraph descriping shows that 170161-27-0 is playing an increasingly important role.

Reference£º
Patent; Shenzhen Xiaxiwan Pharmaceutical Technology Co., Ltd.; Qi Fei; Xia Junxia; Zhang Zaijun; Wang Liang; (27 pag.)CN109988153; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI