Catalyst ligands

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (S, S)-diphenylethylenediamine (250 mg, 1.2 mmol) and triethylamine (0.5 ml) in THF is added dropwise a solution of dansyl chloride (318 mg, 1.2 mmol) in THF (2 mi) at 0C. After stirring for 16 h at RT the solvent is removed in vacuum and the residue is resolved in methylenchloride (20 ml). The organic solution is washed with NaHCO3 solution (5 ml), dried over Na2SO4, and after filtration the solvent is removed. Flash chromatography affords (S, S)-5-dimethylamino-naphthalene-1-sulfonic acid (2-amino-1, 2-diphenyl-ethyl)- amide as yellow oil, which crystallizes by drying in vacuum. Molecular weight: 445. 59.’H- NMR (400 MHz, CDCI3) : 8.36 (t, J = 7.5 Hz, 2 H), 8.17 (dd, J = 7.2 Hz, 1.2 Hz, 1 H), 7.47 (dd, J = 8. 8 Hz, 1 H), 7.34 (dd, J = 8. 5 Hz, 1 H), 7.24-7. 16 (m, 4 H), 7.11 (d, J = 7. 5 Hz, 1 H), 6.99-6. 74 (m, 6 H), 4.61 (d, J = 8.5 Hz, 1 H), 4.20 (d, J = 8.5 Hz, 1 H), 2.80 (s, 6 H).

29841-69-8, As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/92290; (2005); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.153-94-6,H-D-Trp-OH,as a common compound, the synthetic route is as follows.

Example 1 To a 1L three-necked flask was added 200mL of tetrahydrofuran, 20g D-tryptophan, 7.7g methylaminoacetonitrile, 38.2g EDC ¡¤ HCl and 1g 4-dimethylaminopyridine. The reaction was stirred at room temperature for 5 hours. After completion of the reaction, 300mL of ethyl acetate and 300mL water was added. The ethyl acetate layer was washed with 200mL saturated sodium chloride and stirred. Still stratification of the ethyl acetate layer was distilled under reduced pressure at 30C to a volume of about 200ml. The solution was recrystallized with 700ml of petroleum ether, filtered and vacuum dried at 40C to give 22.25g of compound III. HPLC purity 98%, Yield 91%., 153-94-6

153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd.; Ye, Tianjian; Yuan, Youting; Chen, Xin; Zhang, Hongxun; (7 pag.)CN105348283; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a ethanolic solution of CHME (0.82 g, 3 mmol) add an aqueous solution of Eu(NO3)3*H2O (0.33 g, 1 mmol) was added with constant stirring on magnetic stirrer. The solution was neutralized with 0.05 M NaOH solution and adjusted pH of mixture 7-8. The mixture was stirred for 3 h at 35 C and then allowed to stand for 1 h. During stirring white precipitates appeared, which were filtered and washed with doubly distilled water and then with ethanol to remove the free ligand, after that dried in air and then in vacuum desiccators. Finally the complex was dried at 50 C in hot air oven to obtain the complex. The obtained complex Eu(CHME)3*2H2O was white power with 86 %yield. The elemental analysis data for Eu(CHME)3.2H2O(C45H40O11Cl3Eu) was found (calc.) % C, 53.21 (53.24); H,4.06 (3.97); Eu, 14.92 (14.97)., 1662-01-7

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Nandal, Poonam; Khatkar; Kumar, Rajesh; Khatkar, Avni; Taxak; Journal of Fluorescence; vol. 27; 1; (2017);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-41-7, H-Ala-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of thionyl chloride (2.18 mL, 0.03 mol) inmethanol (10 mL), the appropriate amino acid (0.01 mol)was added. The resulting solution was refluxed for 5 h. Afterthis time, the solution was cooled to room temperature, thesolvent was removed under reduced pressure and the residuewas recrystallized from ethyl acetate. Yield of obtainedproducts: methyl L-phenylalanine hydrochloride – 89%,methyl L-alanine hydrochloride – 65%, methyl L-valinehydrochloride – 90%, methyl L-leucine hydrochloride -91%, methyl L-cysteine hydrochloride – 38%, methyl L-tryptophanhydrochloride – 82%., 56-41-7

56-41-7 H-Ala-OH 5950, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Majewska, Paulina; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 194; 4-6; (2019); p. 585 – 590;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: [Cu(MeCN)4]PF6 (75 mg, 0.20mmol) was added to dppp (82 mg, 0.20mmol) in 5mL of dichloromethane. Then, bpy (32 mg, 0.20mmol) was added and the solution immediately changed to yellow. The reaction mixture was stirred for 30 min at room temperature. Diethyl ether was added to the solution to precipitate the product as a yellow solid, which was filtered and washed with diethyl ether: yield, 126 mg (0.162mmol, 81percent)., 17217-57-1

As the paragraph descriping shows that 17217-57-1 is playing an increasingly important role.

Reference£º
Article; Nishikawa, Michihiro; Tsubomura, Taro; Bulletin of the Chemical Society of Japan; vol. 87; 8; (2014); p. 912 – 914;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Powdered KOH (280mg, 5mmol) was added to 10mL dry dimethyl sulfoxide (DMSO) and 8-Amino-1-octanol (152.5mg, 1.05mmol) was then added and stirred at 60C for 1h. Then, 4?-Chloro-2,2′:6?,2?-terpyridine (268mg, 1.0mmol) was added, and the resulting mixture was stirred at 60C for 48h. After cooled to room temperature, the reaction mixture was poured into deionized water (200mL) to yield precipitation, which was collected by filtration. The yellow solid was washed with deionized water, and then dried under vacuum overnight to afford 290mg of the desired product in 77% yield [30]. 1H NMR (400MHz, CDCl3) delta 8.74-8.66 (m, 2H), 8.62 (d, J=8.0Hz, 2H), 8.02 (d, J=9.1Hz, 2H), 7.85 (td, J=7.8, 1.8Hz, 2H), 7.33 (ddd, J=7.5, 4.8, 1.1Hz, 2H), 4.22 (t, J=6.4Hz, 2H), 2.69 (t, J=7.0Hz, 2H), 1.90-1.81 (m, 2H), 1.56-1.28 (m, 10H). HRMS [M+ H]+ calcd for C23H29N4O+ 377.2341; found: 377.2340. Anal Cald for C23H28N4O: C, 73.37; H, 7.50; N, 14.88; Found: C, 73.32; H, 7.85; N, 14.75., 128143-89-5

The synthetic route of 128143-89-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hou, Zhaohui; Li, Peng; Wang, Huan-Yu; Li, Zhiqiang; Li, Huanrong; Dyes and Pigments; vol. 147; (2017); p. 429 – 435;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The pentafluorinated beta-diketone ligand (3 mmol), NaOH(0.12 g, 3 mmol) and the auxiliary ligand (1 mmol) were dissolved in 30 mL ethanol and heated to 60 C under stirring. Then, the ethanolic solution of EuCl3¡¤6H2O(1 mmol) was added dropwise, and the reaction mixture was stirred at 60 C for 8 h. After cooling down, the yellow solid was precipitated and filtered off. The solidproduct was washed with deionized water and ethanol, and dried in vacuum. Yellow powder, yield 75%, mp 180-182 C; IR nu (KBr):3027(m), 2922 (m), 2853 (m), 1592 (s), 1552 (s), 1506 (s), 1281 (s), 1187 (s), 1079(m), 928 (m), 783 (s), 588 (m), 507 (m) cm-1; 1H NMR (300 MHz, CDCl3):delta 2.98(s, 3H, C=CH), delta 3.23 (s, 18H, N(CH3)2), 6.58 (br, 6H, Ar-H), 7.57 (br, 6H, Ar-H),7.99 (br, 2H, Bath-H), 8.22 (br, 4H, Bath-H), 8.68 (br, 2H, Bath-H), 8.87 (br, 4H,Bath-H), 9.53 (br, 2H, Bath-H), 11.74 (br, 2H, Bath-H) ppm. Anal. Calcd. forEuC63H49N5O6F15:C, 53.70; H, 3.51; N, 4.97; Eu, 10.79; Found C, 53.47; H, 3.47;N, 5.02; Eu, 10.93., 1662-01-7

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Wan, Yupeng; Lyu, Heng; Du, Hengyi; Wang, Dunjia; Yin, Guodong; Research on Chemical Intermediates; vol. 45; 4; (2019); p. 1669 – 1687;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2,56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.2 N-(4-Trifluoromethylbenzyl)quinidinium bromide (1b) [25] Yield: 87%; white solid; mp 218 C (decomp.); [alpha]D28 +184.2 (c 0.15, CH3OH); IR (KBr): 3398, 3209, 2954, 1621, 1589, 1509, 1373, 1427, 1325, 1227, 1241, 1170, 1125, 1068, 1021, 1003, 934, 864, 832 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.82 (d, J = 4.4 Hz, 1H), 8.02 (d, J = 9.2 Hz, 1H), 7.97 (dd, J = 10.4, 9.2 Hz, 4H), 7.77 (d, J = 4.4 Hz, 1H), 7.51 (dd, J = 9.2, 2.4 Hz, 1H), 7.44 (d, J = 2.4 Hz, 1H), 6.84 (d, J = 3.6 Hz, 1H), 6.52 (s, 1H), 6.03 (ddd, J = 17.4, 10.5, 6.9 Hz, 1H), 5.25 (s, 1H), 5.10 (d, J = 8.4 Hz, 2H), 4.85 (d, J = 12.8 Hz, 1H), 4.28-4.22 (m, 1H), 4.06 (s, 3H), 4.02-4.00 (m, 1H), 3.86 (t, J = 9.4 Hz, 1H), 3.50 (t, J = 11.4 Hz, 1H), 3.00-2.90 (m, 1H), 2.69-2.63 (m, 1H), 2.40 (t, J = 11.4 Hz, 1H), 1.91 (s, 1H), 1.79-1.75 (m, 2H), 1.15-1.07 (m, 1H). 13C NMR (100 MHz, DMSO-d6): delta = 158.0, 147.9, 144.2, 143.8, 137.7, 135.1, 133.0, 131.9, 130.9 (q, J = 31.8 Hz), 126.4, 126.3, 125.9, 123.1, 121.7, 120.8, 117.5, 103.0, 68.1, 65.2, 62.9, 56.5, 56.2, 54.5, 37.2, 26.8, 23.6, 21.1.

56-54-2 (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol 637552, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,128143-89-5

was added to a stirred suspensionof KOH (1.05 g, 18.7 mmol) in anhydrous DMSO(20 mL) at 60 C. After 60 min, 40-chloro-2,20:60,200-terpyridine (1.00 g, 3.7 mmol) was added to the mixture,which was maintained with stirring for 4 h at 70 C. Distilledwater (600 mL) was then added to the reaction mixture,and the product was extracted with CH2Cl2(3 ¡Á 200 mL). Residual water in the CH2Cl2 was removedusing Na2SO4, and the CH2Cl2 was removed using a rotaryevaporator. The desired product was recrystallized fromethyl acetate to give 0.72 g (72%) of 4. 1H NMR(300 MHz, CDCl3-d) 8.7 (d, 2H, J = 4.7 Hz), 8.6 (d, 2H,J = 7.4 Hz), 8.0 (m, 4H), 7.5 (m, 2H), 4.0 (m, 2H), 3.2(dd, 1H, J = 6.3 Hz and J = 12.5 Hz) 1.7 (s, 2H), 1.1 (d,3H, J = 6.4 Hz). 13C NMR (125 MHz, CDCl3-d) 160.2,156.5, 154.2, 148.9, 123.7, 120.8, 105.2, 70.1, 48.1, 21.4.ESI-MS (m/z) calcd. For C18H18N4O: 306.2; 307.307[M + H]+. Elemental analysis: calculated for C18H18N4O:C 70.6, H 5.9, N 18.3. Found: C 70.2, H 5.5, N 18.1.

128143-89-5 4′-Chloro-2,2′:6′,2”-terpyridine 667748, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Kim, Ka Young; Kim, Jaehyeong; Park, Hyesong; Choi, Yeonweon; Kwon, Ki-Young; Jung, Jong Hwa; Bulletin of the Korean Chemical Society; vol. 39; 8; (2018); p. 988 – 994;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76089-77-5,Cerium(III) trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

76089-77-5, Cerium trifluoromethanesulfonate (0.22 g, 3.7 ¡Á 10-4mol) and ntb (0.30 g, 7.4 ¡Á 10-4 mol) were added in 100 cm3 methanol and stirred overnight under reflux. The reaction solution was filtered and left at rest. After evaporation of solvent, white fiber solid was obtained. The solid was collected by filtration and dried in vacuo. Yield: 75%. 1H NMR (DMSO-d6, 400 MHz, 298 K) delta 7.6-7.5 (q, 2H), 7.3-7.2 (q, 2H), 4.1 (s, 2H) ppm. FT-IR (ATR): 3186-2897, 1990-1623 (aromatic, comb), 1539, 1471, 1456, 1435, 1396, 1362, 1340, 1315, 1271, 1244-1171 (-CF3), 1117, 1099, 1049, 1028, 964, 935, 906, 889, 849,737, 636 cm-1. Anal. Found: C, 43.78; H, 3.27; N, 14.04%. Calcd. for C51H42CeF9N14O9S3: C,43.68; H, 3.02; N, 13.98%.

As the paragraph descriping shows that 76089-77-5 is playing an increasingly important role.

Reference£º
Article; Harada, Takashi; Hasegawa, Ryo; Nishiyama, Katsura; Chemistry Letters; vol. 43; 9; (2014); p. 1496 – 1498;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI