Catalyst ligands

144222-34-4, N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0219] To a solution of the enone (450 mg, 1 mmol, 1.0 equiv) in 0.5 M/4.5 mL/g anhydrous PhCH3 or dichloromethane (DCM) under N2 atmosphere was added Et3N (0.14 mL, 1 mmol, 1.0 equiv) and HCO2H (0.05 mL, 1.2 mmol, 1.2 equiv) at room temperature (RT). The resulting solution was stirred for 10 min and then treated with solid (R,R)-(-)-Ru-TsDPEN-cymene complex1 (19 mg, 0.03 mmol, 0.03 equiv) all at once. The reaction mixture was then aged at RT for 2 h, at which a complete consumption of starting material was observed. Tert-butyl methyl ether-MTBE (5 mL) was added followed by 1N HCl (2 mL). The organic layer was separated, washed with saturated Na2CO3, brine, dried over MgSO4, filtered and concentrated in vacuo to give the final compound as viscous oil. [0220] The catalyst can also be generated in situ by mixing 0.02 mol equiv of [RuCl2(p-cymene)2] and 0.04 mol equiv of the (R,R)-N-Tosyl-1,2-diphenylethylene-1,2-diamine in DCM (dichloromethane) in the presence of 0.04 mol equiv of 1M solution KOtBu in THF (tetrahydrofuran). After aging for 10 min at RT, Et3N was added followed by HCO2H and a solution of the enone in DCM). [0221] The catalyst was prepared by mixing 1 mol equiv of [RuCl2(p-cymene)2], 2 mol equiv (R,R)-N-Tosyl-1,2-diphenylethylene-1,2-diamine and 4.2 mol equiv of Et3N in iPrOH at 80 C. for 1 h (hour). After solvent removal, the solid was washed with cold H2O and the recrystallized from MeOH to give the catalyst as orange solid., 144222-34-4

144222-34-4 N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide 2734565, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Billot, Xavier; Colucci, John; Han, Yongxin; Wilson, Marie-Claire; Young, Robert N.; US2004/198701; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33454-82-9,Lithium trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

Preparation 4: Ethyl Z-5-methyl-3-(trifluoromethylsulfonyloxy)-2-hexenoateA 20L jacketed reactor was charged with DCM (2.45L), ethyl 3-oxo-5- methylhexanoate (163.3g; 1 eq) and lithiunn triflate (295.86g; 2eq) under an inert atmosphere. The resulting white suspension was stirred and cooled to 0C. N, N- Diisopropylethylamine (134.8g; 182ml; 1 .1 eq) was added over 10 minutes at <10C. The suspension was stirred for 20 minutes at 0C, then triflic anhydride (294.28g; 175ml; 1 .1 eq) was added slowly to the mixture over 30 minutes at <10C. The suspension was stirred at 0C for 1 hour.A sample of the reaction mixture was taken and partitioned between MTBE and sat. NH4CI (1 ml each). The aqueous layer was extracted with MTBE (1 ml) and the combined organic extracts were filtered through cotton wool/MgSO . Analysis by GC indicated that less than 2% starting material remained.The mixture was allowed to warm from 0 to 25C over 1 hr whilst quenching with sat. NH4CI (980ml). DCM (490ml) was added and the mixture was stirred for 5 minutes, then allowed to settle and the layers were separated. The aqueous layer was extracted with DCM (490ml). The combined organic phases were then washed with 1 M HCI (2 490ml), water (490ml) and 20% brine (490ml), then stirred for 30 minutes with MgSO4 (~165g) for 15-30 minutes. The solids were removed by filtration and washed with DCM (165ml). The filtrate was concentrated under vacuum at <40C to give an orange/brown oil containing crystalline solids. The crude product was triturated with MTBE (980ml). The mixture was filtered and the solids were washed with MTBE (2 x 165ml). The filtrate was concentrated under vacuum at <40C to give the title product as an orange/brown oil: overall yield 271 g (94%; corrected for 2.1 %w/w MTBE content); 87.7% area purity by GC. 1 H NMR (CDCI3, delta= 7.20): delta 0.94 (6H, d, J = 6.7 Hz), 1 .24 (3H, t, J = 7.2 Hz), 1 .89 (1 H, hept, J = 6.8 Hz), 2.17 (2H, d, J = 7.2 Hz), 4.18 (2H, q, J = 7.2 Hz), 5.67 (1 H, s) ppm., 33454-82-9

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Patent; PFIZER MANUFACTURING IRELAND; BURRELL, Adam James Musgrave; MARTINEZ, Carlos Alberto; MCDAID, Paul Oliver; O’NEILL, Padraig Mary; WONG, John Wing; WO2012/25861; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

76089-77-5,76089-77-5, Cerium(III) trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7The above-described ligand represented by formula (B-13) (50 mg, 0.062 mmol) and cerium trifluoromethanesulfonate (35 mg, 0.060 mmol) were charged into a flask. Then, ethanol (5 mL) was added thereto and dissolved. The mixed solution was stirred for 2 hours at room temperature, and then the stirring was stopped. About 20 mL of diethyl ether was added, and the resultant mixture was left to stand overnight. After that, the produced solid was collected to obtain the above-described metal complex represented by composition formula (C-13) (hereinafter, ?metal complex (C-13)?). The collected amount was 41 mg (yield 43%).Elemental analysis: Found (%) C, 45.67; H, 4.71; N, 9.93; S, 6.54. Calcd for C53H62CeF9N10O9S3 (%) C, 45.78; H, 4.49; N, 10.07; S, 6.92.The metal complex (C-13) emitted a blue color in a solid powder state and in a solution state (acetonitrile) under ultraviolet excitation (365 nm).The emission spectrum in acetonitrile had a peak at 428.5 nm, the emission quantum yield was 25%, and the excitation life was 56 ns.

76089-77-5 Cerium(III) trifluoromethanesulfonate 2733941, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; US2012/211706; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99970-84-0,[2,2′-Bipyridine]-4,4′-dicarbaldehyde,as a common compound, the synthetic route is as follows.,99970-84-0

General procedure: 4-methyl-2,2?-bipyridine-4-formaldehyde (200mg, 1.01mmol) anddichloromethane (10 mL) were added into a 50 mL two-neck roundbottle flask under nitrogen. Then ethyl mercaptan (250 muL) and borontrifluoride ether solution (98%, 700 muL) were added into the flask.After the mixture was stirring at room temperature for one night, thesolvent were removed with rotary evaporator in vacuum. Then the saturatedsodium bicarbonate solution (50 mL) were added, the aqueoussolution was extracted with ethyl acetate five times. All organic layerswere collected and dried with anhydrous sodium sulfate, filtered andevaporated to dryness. The residue was purified by column chromatographyon silica gelwith dichloromethane as eluent to give the first bandas the product. The product is a colorless transparent oil (200mg) witha yield of 64.5%.

The synthetic route of 99970-84-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xu, Jiru; Liu, Yonghua; Li, Mei-Jin; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 219; (2019); p. 141 – 146;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13104-56-8,4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine,as a common compound, the synthetic route is as follows.

General procedure: MnCl2.4H2O (1 mmol) was dissolved in alcohol (10 mL), Ligand(1 mmol) was dissolved in CHCl3 and was added dropwise to the above solution with stirring at room temperature in 1 h. Then the solution was refluxed for 4 h. The mixture was allowed to stay overnight at -10C, after which the precipitate was filtered off, washed with diethyl ether, and dried under vacuum.

13104-56-8, As the paragraph descriping shows that 13104-56-8 is playing an increasingly important role.

Reference£º
Article; Liu, Bingqing; Luo, Wei; Li, Haixia; Qi, Xiaoyun; Hu, Quanyuan; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 45; 8; (2015); p. 1097 – 1101;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

To a solution of (S,S)-diphenylethylenediamine (250 mg, 1.2 MMOL) and triethylamine (0.5 ml) in THF is added dropwise a solution of dansyl chloride (318 mg, 1.2 MMOL) in THF (2 ml) at 0 C. After stirring 16 h at RT the solvent is removed in vacuum and the residue is resolved in METHYLENCHLORIDE (20 ml). The organic solution is washed with NaHCO3 SOLUTION (5 ml), dried over Na2SO4 AND after filtration the solvent is removed. Flash chromatographie afford (S,S)-5-dimethylamino-naphthalene-1-sulfonic acid (2-amino-1,2- diphenyl-ethyl)-amide as yellow oil which crystallizes by drying in vacuum. M: 445. 59. 1H-NMR (400 MHz, CDCI3): 8.36 (t, J=7.5 Hz, 2H), 8.17 (dd, J=7.2, 1.2 Hz, 1H), 7.47 (dd, J=8.8 Hz, 1H), 7.34 (dd, J=8.5 Hz, 1H), 7.24-7.16 (m, 4 H), 7.11 (d, J=7.5 Hz, 1H), 6.99-6.74 (m, 6 H), 4.61 (d, J=8.5 Hz, 1 H), 4.20 (d, J=8.5Hz, 1 H), 2.80 (s, 6 H)., 29841-69-8

29841-69-8 (1S,2S)-(-)-1,2-Diphenylethylenediamine 6931238, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Novartis AG; Novartis Pharma GmbH; WO2004/31155; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4733-39-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4733-39-5,2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

[CuI(MeCN)4](ClO4) (50mg, 0.15mmol), PPh3 (80.4mg, 0.30mmol) and Ph2dmp (60.7mg, 0.18mmol) in MeCN (15ml) are stirred at room temperature for 1h. Slow evaporation of a MeCN solution of 4 afforded analytically pure complex as yellow crystalline solid. Yield (93.4mg, 62.9%). Elemental analysis for C62H50ClCuN2O4P2: calcd. C 71.06, H 4.81, N 2.67%; found: C 71.12, H 4.90, N 2.62%. Selected IR (KBr, cm-1): v(Cl-O) 1110. ESI-MS (positive): m/z 947 (M+). 1H NMR (300MHz, CDCl3): delta 7.98 (s, 2H, Phen H); 7.60 (m, 6H, phenyl H); 7.57-7.53 (m, 4H, phenyl H); 7.44 (s, 2H, phen H); 7.38-7.42 (m, 6H, phenyl H); 7.26-7.21 (m, 24H, phenyl H); 2.31 (s, 6H, -CH3). 31P{1H} NMR (162MHz, CDCl3): delta 0.87 (s, PPh3). UV/Vis (CH3CN): lambdamax/nm (epsilon/mol-1dm3cm-1): 228 (68830), 287 (53890), 369 sh (3950).

4733-39-5 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline 65149, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Hu, Lin-Li; Shen, Chang; Chu, Wing-Kin; Xiang, Jing; Yu, Fei; Xiang, Ge; Nie, Yan; Kwok, Chun-Leung; Leung, Chi-Fai; Ko, Chi-Chiu; Polyhedron; vol. 127; (2017); p. 203 – 211;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

63-68-3, H-Met-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

L-Methionine (0.5 g, 1 equivalent) was suspended in methanol (30 ml C=0.1M) in a 100 ml flask equipped with a magnetic stirrer and placed under nitrogen. Thionyl chloride (0.5 ml, 2 equivalents) was added to the solution dropwise at 0 C. then heated under reflux for 16 hours. The reaction mixture was then evaporated to yield a pale yellow solid. The solid was triturated with hot diethyl ether and the solution discarded to leave the title compound 2? a white solid which was further dried under vacuum. (0.65561 g, 98% yield). [0377] 1H NMR (D2O, 500 MHz) deltaH: 4.24 (1H, m, 3) 3.79 (3H, s, 1), 2.63 (2H, t, 5), 2.25 (1H, m, 4), 2.16 (1H, m, 4), 2.06 (1H, s, 6) [0378] 13C NMR (D2O, 125 MHz) deltac: 170.58 (2), 53.64 (1), 51.70 (3), 28.71 (4), 28.41 (5), 13.85 (6). [0379] IR (neat, vmax, cm-1): 2880.8/2676.2 (CH3, CH2, CH), 2016.2, 1742.2 (C?O, ester), 1483.6, 1443.5, 1227+1194.7+1149.8+1079.5 (C-O). [0380] HRMS m/z (+ESI): C6H14NO2S, mass found=164.074 (Error=0.071 ppm), 63-68-3

The synthetic route of 63-68-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The University of Sussex; Viseux, Eddy Michel Elie; Gallop, Christopher; Bobin, Mariusz; US2014/39200; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of the corresponding bis(isatin) 1-8 (5 mmol) and Girard?s reagent (2.5 mmol) in 7 mL of absolute ethanol were added three drops of trifluoroacetic acid. The reaction mixture was refluxed for 2 h. After spontaneous cooling of the solution to room temperature, the formed precipitate was filtered off, washed with absolute diethyl ether and dried in vacuum (12 mmHg)., 1126-58-5

As the paragraph descriping shows that 1126-58-5 is playing an increasingly important role.

Reference£º
Article; Bogdanov; Zaripova; Mustafina; Voloshina; Sapunova; Kulik; Mironov; Russian Journal of General Chemistry; vol. 89; 7; (2019); p. 1368 – 1376; Zh. Obshch. Khim.; vol. 89; 7; (2019); p. 1004 – 1012,9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

1126-58-5, General procedure: To a magnetically stirred solution of substituted isatin (5mmol) in 7ml of absolute ethanol, a corresponding pyridinium acetohydrazide (5mmol) and three drops of trifluoroacetic acid were successively added. The reaction mixture was heated under reflux for 3h. After spontaneously cooling the solution to room temperature, the precipitate formed was filtered, washed with absolute ether and dried in vacuo.

1126-58-5 1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride 70773, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Bogdanov, Andrei V.; Zaripova, Ilyuza F.; Voloshina, Alexandra D.; Sapunova, Anastasia S.; Kulik, Natalia V.; Tsivunina, Irina V.; Dobrynin, Alexey B.; Mironov, Vladimir F.; Journal of Fluorine Chemistry; vol. 227; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI