Catalyst ligands

391604-55-0, 2-(2,4-Difluorophenyl)pyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a Schlenk’s flask equipped with a reflux condenser was placed (1,5-cyclooctadiene)iridium (I) chloride dimer (2.00 g, 2.98 mmol, 1 equivalent) and the interior of the flask was substituted with nitrogen. There were successively added 2-ethoxyethanol (20 mL, s/s=10) and 2-(2,4-difluorophenyl)pyridine (3.42 g, 17.88 mmol, 6.0 equivalents), and the mixture was stirred in a nitrogen atmosphere under refluxing (135C). Immediately after the addition of the ligand (2-(2,4-difluorophenyl)pyridine), the reddish suspension turned into gray and then into a dark reddish solution as the dissolution of the ligand by heating, which gave an lemon yellow suspension with stirring. After stirring for 3 hours, the solvent was distilled off from the reaction mixture under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 10/1). The column fractions were condensed, and the resulting yellow green solid material was recrystallized from hexane/dichloromethane to give 3. 53 g of the title compound (2-10) as yellow green powder in 97.4% yield. 1H NMR (500MHz CD2Cl2) : delta 5.29 (dd, J=2.5, 9.1 Hz, 4H), 6.38 (ddd, J=2.5, 9.1, 12.5Hz, 4H), 6.87 (ddd, J=1.5, 5.8, 7.2Hz, 4H), 7.87 (ddd, J=1.5, 5.8, 7.2Hz, 4H), 8.33 (ddd, J=0.7, 1.5, 8.1Hz, 4H), 9. 12 (ddd, J=0.7, 1.5, 5.8Hz, 4H).; Example 6 Production of Compound (3-10) (Bis[2-(2,4-difluorophenyl)pyridinato-N,C2′]iridium (III) acetylacetonate) (1) In a Schlenk’s flask equipped with a reflux condenser was placed (1,5-cyclooctadiene)iridium(I) chloride dimer (500 mg, 0.744 mmol, 1 equivalent) and the interior of the flask was substituted with nitrogen. There were successively added 2-ethoxyethanol (5 mL, s/s = 10) and 2-(2,4-difluorophenyl)pyridine (626 mg, 3.274 mmol, 4.4 equivalents), and the mixture was stirred in a nitrogen atmosphere under refluxing (135C) for 3 hours. The resulting lemon yellow suspension was cooled to room temperature, to which were added acetylacetone (230muL, 2.232 mmol, 3.0 equivalents) and sodium carbonate (237 mg, 2.232 mmol, 3.0 equivalents) successively, and further stirred under refluxing for 2 hours to give an yellow suspension. The solvent was distilled off from the reaction mixture under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: dichloromethane). The column fractions were condensed, and recrystallized from hexane/dichloromethane to give 896 mg of the title compound (3-10) as lemon yellow powder in 78.9%. 1H NMR (500MHz, CD2Cl2) : delta 1.80 (s, 6H), 5.31 (s, 1H), 5.50 (dd, J=2.4, 8.8Hz, 2H), 6.38 (ddd, J=2.4, 9.3, 12.5Hz, 2H), 7.24 (ddd, J=1.5, 5.7, 7.3Hz, 2H), 7.84 (ddt, J=0.6, 1.6, 7.3Hz, 2H), 8.22-8.28 (m, 2H), 8.44 (ddd, J=0.8, 1.6, 5.7Hz, 2H).; Example 10 Production of Compound (4-2) (Bis[2-(2,4-difluorophenyl)pyridinato-N,C6′]iridium (III) picolinate) In a Schlenk’s flask equipped with a reflux condenser was placed (1,5-cyclooctadiene)iridium (I) chloride dimer (500 mg, 0.744 mmol, 1.0 equivalent) and the interior of the flask was substituted with nitrogen. There were successively added 2-ethoxyethanol (5 ml, s/s=10) and 2-(2,4-difluorophenyl)pyridine (626 mg, 3.274 mmol, 4.4 equivalents), and the mixture was stirred in a nitrogen atmosphere under refluxing (135C) for 3 hours. The resulting lemon yellow suspension was cooled to room temperature, to which was added sodium picolinate (324 mg, 2.232 mmol, 3.0 equivalents), and further stirred under refluxing for 3 hours. The suspension slowly turn into orange with proceeding of the reaction. The solvent was distilled off from the reaction mixture under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 20/1). The column fractions were condensed, and the resulting yellow solid was recrystallized from hexane/dichloromethane to give 967 mg of the title compound (4-2) as lemon yellow powder in 93.6% yield. 1H NMR (500MHz CD2Cl2) delta 5.62 (dd, J=2.4, 8.7Hz, 1H), 5.85 (dd, J=2.4, 8.7Hz, 1H), 6.44 (ddd, J=2.4, 9.2, 12.6Hz, 1H), 6.50 (ddd, J=2.4, 9.2, 12.6Hz, 1H), 7.02 (ddd, J=1.5, 5.9, 7.4Hz, 1H), 7.21 (ddd, J=1.5, 5.9, 7.4Hz, 1H), 7.40 (ddd, J=1.5, 5.4, 7.6Hz, 1H), 7.46 (ddd, J=0.8, 1.6, 5.9Hz, 1H), 7.75-7.86 (m, 3H), 7.94 (dt, J=1.5, 7.6Hz, 1H), 8.20-8.28 (m, 2H), 8.28-8.37 (m, 1H), 8.69 (ddd, J=0.7, 1.6, 5.9Hz, 1H).; Example 12 Production of Compound (5-6) (tris [2-(2,4-difluorophenyl)pyridinato-N,C6′]iridium(III)) In a Schlenk’s flask equipped with a reflux condenser was placed (1,5-cyclooctadiene)iridium(I) chloride dimer (500 mg, 0.744 mmol, 1 equivalent) and the interior of the flask was substituted with nitrogen. There were successively added 2-ethoxyethanol (5 mL, s/s=10) and 2-(2,4-difluorophenyl)pyridine (626 mg, 3.274 mmol, 4.4 equivalents), and the mixture was stirred in a nitrogen atmosphere under refluxing (135C) for 3 hours. The resulting yellow green suspension was cooled to room temperature, to which w…

391604-55-0, As the paragraph descriping shows that 391604-55-0 is playing an increasingly important role.

Reference£º
Patent; TAKASAGO INTERNATIONAL CORPORATION; WO2004/43974; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

119-91-5, 2,2′-Biquinoline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1 (0.332 g, 1.0 mmol) and CuI (0.191 g, 1.0 mmol) were dissolved in 5 ml CHCl3. After a few minutes, bq (0.257 g, 1.0 mmol) in 10 ml CHCl3 was added. The mixture was stirred at 40 C for 2 h. After this time, a burgundy solution was formed. Then the solvent was evaporated to dryness. A dark red solid was crystallized from CHCl3 to give microcrystals which are soluble in CHCl3, CH2Cl2, THF, DMSO, CH3CN and CO(CH3)2. Yield 52%. Anal. Calc. for C33H42CuIN5O3P: C, 50.94; H, 5.44; N, 9.00. Found: C, 50.78; H, 6.02; N, 8.91%. MS (CHCl3): 575.1 [Cu(bq)2]+ 100%, 319.0 [Cu(bq)]+ 13%, 650.2 [Cu(bq)1]+ 10%. NMR (298 K, CHCl3) 31P{1H}: -28 s?; 1H: 8.21 s? (H3), 7.95-7.80 (H4 and H7), 7.65-7.55 (H5 and H6), 9.19 s? (H8), 2.78 s (H1-P), 2.40 s? (H2-P), 3.43 s? (H3-P); 13C{1H}:119.39 s (C1, C3), 137.63 s (C4), 128.01 s (C5), 127.53 s (C6), 130.22 s (C7), 130.93 s (C8), 146.42 s (C9), 128.61 s (C10), 55.18 s? (C1-P), 55.57 s (C2-P), 66.74 s (C3-P)., 119-91-5

As the paragraph descriping shows that 119-91-5 is playing an increasingly important role.

Reference£º
Article; Starosta, Rados?aw; Brzuszkiewicz, Anna; Bykowska, Aleksandra; Komarnicka, Urszula K.; Bazanow, Barbara; Florek, Magdalena; Gadza?a, ?ukasz; Jackulak, Natalia; Krol, Jaros?aw; Marycz, Krzysztof; Polyhedron; vol. 50; 1; (2013); p. 481 – 489;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 19 Preparation of H-D-Glu(D-Trp-0-CH(CH3)0-CO-0-cyclohexyl)-0-Et hydrochloride salt, Apo854.HCI Cbz-D-Glu(OH)-0-Et (12.1 g, 39.1 mmol), HOSu (4.60 g, 40.0 mmol) andEDCI.HCI (7.67 g, 40.0 mmol) were mixed in DMF (100 mL) under ice-water bath temperature. The reaction mixture was allowed to warm to RT then stirred for overnight. The reaction mixture was cooled again in an ice-water bath and D-Trp- OH (8.17 g, 40.0 mmol) was added. The mixture was stirred at room temperature for overnight. The mixture was poured into a beaker containing 0.5N HCI (200 mL) and ice pellets. The mixture was extracted with ethyl acetate (2×200 mL + 1×100 mL). The organic layers were combined and washed with a 0.5N HCI solution (100 mL), water (2×100 mL) and brine (100 mL), dried over MgS04, then filtered. The filtrate was concentrated via rotary evaporation under reduced pressure and the resulting solid Cbz-D-Glu(D-Trp-OH)-0-Et was triturated with10% ethyl acetate in hexanes. The precipitated white solid was collected via suction filtration (17.6 g). Yield = 90 %; 1H NMR (DMSO-D6l 400 MHz) delta ppm: 12.58 (br. s, 1 H), 10.82 (s, 1H), 8.12 (d, J = 8.1 Hz, 1 H), 7.71 (d, J = 8.1 Hz, 1 H), 7.52 (d, J = 8.1 Hz, 1H), 7.23 – 7.42 (m, 6H), 7.12 (s, 1 H), 7.06 (t, J = 7.6 Hz, 1 H), 6.97 (t, J = 7.6 Hz, 1H), 4.97 – 5.10 (m, 2H), 4.41 – 4.51 (m, 1H), 3.95 – 4.15(m, 3H), 3.15 (dd, J = 14.1 , 5.1 Hz, 1H), 2.99 (dd, J = 15.2, 8.1 Hz, 1 H), 2.09 – 2.26 (m, 2H), 1.83 – 1.96 (m. 1 H), 1.65 – 1.81 (m, 1 H), 1.16 (t, J – 7.1 Hz, 3H); MS-ESI (m/z): 496 [ +1f. To a mixture of Cbz-D-Glu(D-Trp-OH)-0-Et {4.95 g, 0.0 mmol) with potassium carbonate (4.15 g, 30.0 mmol) and sodium iodide (6.00 g, 40.0 mmol) in Lambda/,/V-dimethylformamide (30 mL) at room temperature, 1-chtoroethylcyclohexyl carbonate (6.20 g, 30.0 mmol) was added. After being stirred at room temperature for overnight, additional W,/V-dimethylformamide (30 mL) was added and the reaction mixture was stirred at 40C for overnight. The reaction mixture was diluted with ethyl acetate then washed with water (3x) then with brine. The crude product Cbz-D-Glu(D-Trp-0-CH(CH3)-0-CO-0-cyclohexyl)-0-Et was purified by column chromatography on silica gel using a solvent gradient of a mixture of ethyl acetate in hexanes (20 to 40%) as eluant. Fractions rich in product were combined together and evaporated to dryness. Thus, the desired compound Cbz-D-Glu(D-Trp-0-CH(CH3)-0-CO-0-cyclohexyl)-0-Et (4.43 g) was obtained as a pale-yellow foam. Yield = 66 %; 1H NMR (DMSO-D6> 400 MHz) delta ppm: 10.86 (or. s, 1H), 8.36 (dd, J = 17.2, 7.1 Hz, 1 H), 7.66 – 7.77 (m, 1 H), 7.46(t, J = 8.0 Hz., 1H), 7.22 – 7.42 (m, 6H), 7.10 – 7.20 (m, 1 H), 7.02 – 7.10 (m, 1 H), 6.90 – 7.02 (m, 1 H), 6.58 – 6.70 (m, 0.5H), 6.46 – 6.58 (m, 0.5H), 5.04 (br. s, 2H), 4.38 – 4.61 (m, 2H), 3.93 – 4.15 (m, 3H), 2.90 – 3.17 (m, 2H), 2.20 (br. s, 2H), 1.54 – 1.96 (m, 6H), 1.02 – 1.53 (m, 12H); MS-ESI (m/z): 666 [M+1f. Cbz-D-Glu(D-Trp-0-CH(CH3)-0-CO-0-cyclohexyl)-0-Et (2.0 g, 3.0 mmol) and 10 % Pd/C (wet, 0.6 g) was mixed in ethanol (50 mL) and 2 HCI in ether (1.7 mL, 3.4 mmol). The reaction mixture was hydrogenated in a Parr apparatus at 20-25 psi of hydrogen pressure for an hour. The mixture was filtered through Celite and the cake was washed with ethanol. The filtrate was concentrated by rotary evaporation and the residue was triturated with a mixture of ether and hexanes. Thus, H-D-Glu(D-Trp-O-CH(CH3)-0-CO-0-cyclohexyl)-0-Ethydrochloride salt (Apo854.HCI, 0.80 g) was obtained as a pink solid foam. Yield = 47%; *H NMR (DMSO-D6, 400 MHz) delta ppm: 0.94 (br. s, 1 H), 8.57 (br. s, 4H), 7.47 (t, J = 8.1 Hz, 1H), 7.34 (d, J = 8.1 Hz, 1H), 7.19 (s, 1 H), 7.07 (t, J = 7.6 Hz, 1 H), 6.88 – 7.03 (m, 1 H), 6.58 – 6.72 (q, J = 5.1 Hz, 0.5H), 6.53 (q, J = 5.1 Hz,0.5H), 4.39 – 4.63 (m, 2H), 4.00 – 4.26 (m, 2H), 3.78 – 4.00 (m, 1 H), 2.93 – 3.18 (m, 2H), 2.18 – 2.41 (m, 2H), 1.88 – 2.02 (m, 2H), 1.82 (br. s, 2H), 1.63 (br. s, 2H), 1.13 – 1.53 (m, 12H); MS-ESI (m/z): 532 [M+1]+ (free base).

153-94-6, 153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; APOTEX TECHNOLOGIES INC.; TAM, Tim, Fat; LEUNG-TOUNG, Regis; WANG, Yingsheng; ZHAO, Yanqing; XIN, Tao; LI, Wanren; WODZINSKA, Jolanta, Maria; RABADIA, Vrajlal, S.; FEENEY, Christopher, John; WO2012/129671; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

99970-84-0,99970-84-0, [2,2′-Bipyridine]-4,4′-dicarbaldehyde is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(5) Preparation of compound (6); To a compound (5) (0.13 g, 0.7 mmol) and KtOBu (0.2 g, 1.8 mmol), THF 20 mL was added, and the compound (3) (0.75 g, 1.8 mmol) was dissolved in 20 mL of THF and slowly added dropwise, and then the reaction mixture was agitated at 70 C for 12 hours. After the reaction, the solvent was removed and an organic layer was extracted with MC and separated by recrystallization.

99970-84-0 [2,2′-Bipyridine]-4,4′-dicarbaldehyde 4171663, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; DONGJIN SEMICHEM CO., LTD.; WO2009/82163; (2009); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54258-41-2, 1,10-Phenanthrolin-5-amine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

54258-41-2, 5-Amino-1,10-phenanthroline (471 mg, 2.42 mmol) and 2,6-pyridinedicarbaldehyde (135 mg, 1 mmol) were refluxed in EtOH (20 mL) containing a catalytic amount of acetic acid for 6 h, giving a suspension. The reaction mixture was filtered hot, and the solid was washed with EtOH to afford the desired product as a yellow solid. Yield: 451 mg (92.2%). 1H NMR (300 MHz, CDCl3): delta = 7.48 (s, 2H), 7.65 (dd, J = 8.1, 4.5 Hz, 2H), 7.72 (dd, J = 8.4, 4.5 Hz, 2H), 8.14 (t, J = 7.5 Hz, 1H), 8.27 (d, J = 8.4 Hz, 2H), 8.57 (d, J = 7.5 Hz, 2H), 8.82 (d, J = 8.4 Hz, 2H), 8.96 (s, 2H), 9.17 (d, J = 3.9 Hz, 2H), 9.27 (d, J = 4.2 Hz, 2H). ESI-MS: m/z 490.4 (M+H)+, 512.4 (M+Na)+. IR numax (KBr, cm-1): 3399s (br), 1626s, 1593s, 1562m, 1501m, 1486m, 1453w, 1421s, 1385m, 1337w, 1298w, 1265w, 1209w, 1142w, 1061m, 993w, 977w, 941w, 866m, 799m, 738s, 679w, 626m, 526w, 458w, 412w.

54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Cheng, Feixiang; Ren, Mingli; He, Chixian; Yin, Hongju; Inorganica Chimica Acta; vol. 450; (2016); p. 170 – 175;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1119-97-7,MitMAB,as a common compound, the synthetic route is as follows.

General procedure: In a typical synthesis of DA-La(PW11)2, an aqueous solution of (2.0 g, 0.31 mmol) K-La(PW11)2 was dropped into a chloroform solution of (1.1 g, 3.75 mmol) DA-Br. A white precipitate formed after the addition of the whole K-La(PW11)2 aqueous solution and then the product was separated after a further 1 h of stirring. The product was washed twice with H2O and dried in air [9]. DDA-La(PW11)2, TDA-La(PW11)2, HDA-La(PW11)2 and ODA-La(PW11)2 were prepared with a similar procedure. In the 1H NMR spectra, the singlet peak at 2.5 ppm and 3.3 ppm is assigned to be DMSO-d6, and the water in DMSO-d6, respectively.

1119-97-7, As the paragraph descriping shows that 1119-97-7 is playing an increasingly important role.

Reference£º
Article; Zhao, Shen; Jia, Yueqing; Song, Yu-Fei; Applied Catalysis A: General; vol. 453; (2013); p. 188 – 194;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1119-97-7, MitMAB is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1119-97-7, General procedure: Aqueous NBTA3- solution is obtained by dissolving NBTA (33.4mg, 0.075mmol) into 150mL twice distilled water. Later, 3 eqvi. NaOH (9mg, 0.225mmol) is added to the aqueous solution. After sealing, the sample is stirred at 60C for 8h to ensure completely soluble. The concentration of NBTA3- solution is calculated as 5¡Á10-5M. Then, dissolving different quaternary ammonium salts into NBTA3- solution. After stirring for 30minat room temperature (25C), NBTA3-/ammonium salts solution become transparent, which then is subjected to further instruments analysis.

1119-97-7 MitMAB 14250, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Ma; Yang; Cao; Lei; Lei; Dyes and Pigments; vol. 140; (2017); p. 131 – 140;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

14162-95-9, 4-Bromo-2,2′-bipyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

14162-95-9, A 100 mL reactor was dried by keeping it in an ovenovernight; it was closed with a rubber stopper and waspurged with argon for 20 min. In the reactor, Pd(PPh3)2Cl2,(44 mg, 0.063 mmol, 0.03 eq.) CuI (42 mg, 0.209 mmol,0.10 eq.) were added and the reactor was purged with argon.Compound 6 (0.720 g, 2.089 mmol, 1 eq.) was added as asolution in benzene (10 mL). Further benzene (20 mL) wasadded along with TEA (1.328 g, 0.726 mL, 13.128 mmol, 6eq.) and the solution was left to stir at rt under argon. The 4-bromo-2,2?-bipyridine, (0.540 g, 2.298 mmol, 1.10 eq.) DBU(3.82 g, 3.75 mL, 25.07 mmol, 12 eq.) and water (16 mg, 16mul, 0.875 mmol, 0.40 eq.) were finally added and the solutionwas put in a pre-heated oil bath 60C, and left to react undervigorous stirring for 18 h. The reaction was stopped and thebenzene was removed under vacuum by distillation. Theresidue was extracted with diethyl ether (3 ¡Á 50 mL) andwater (50 mL). The organic layer was washed with 10% HCl(3 ¡Á 50 mL) and brine (1 ¡Á 50 mL) and the organic phasewas dried with Na2SO4, filtered and evaporated under vacuum.The crude was purified by chromatography on Biotageon silica (100 g) with dichloromethane-TEA (0.5%) and afterwith a gradient from dichloromethane to dichloromethane:ethyl acetate 8:2. A yellow solid was finally obtained: 849.6mg (95%). m.p.: 153-156C. 1H NMR (200 MHz, CDCl3) delta 8.70 (m,2H, H6pyr and H6?pyr), 8.56 (s, 1H, H3pyr), 8.41 (d, J = 8.0Hz, 1H, H3?pyr), 7.83 (td, J = 7.8, 1.8 Hz, 1H, H4pyr), 7.51(dd, J = 3.7, 1.2 Hz, 1H, H3 or H3?), 7.44 (dd, J = 5.0, 1.5Hz, 1H, H5 or H5?), 7.37 (dd, J = 5.1, 1.1 Hz, 1H, H5 orH5?), 7.34-7.29 overlapping (m, J = 7.5 4.8, 1.1, 1H, H5pyror H5?pyr), 7.26 (dd, J = 5.1, 1.1 Hz, 1H, H3 or H3?), 7.20(m (dd + s), 3.5, 1.2 Hz, 2H, H4? and H5pyr or H5?pyr), 7.09(dd, J = 5.1, 3.7 Hz, 1H, H4 or H4?).7.06 (dd, J = 5.1, 3.7Hz, 1H, H4 or H4?). 13C NMR (50 MHz, CDCl3) delta 156.43(C2q-pyr), 155.65 (C2?q-pyr), 149.38 (C6-pyr or C6?-pyr),149.27 (C6-pyr or C6?-pyr), 139.97 (C3?th), 137.09 (C5?th),136.08 (C4?pyr), 135.54 (C2th), 134.64 (C2?th), 132.41(C4pyr), 128.10 (C4?th), 127.51 (C5th or C5?th), 127.07(C5th or C5?th), 126.40 (C3?pyr), 126.11 (C3?th), 125.35(C4th or C4?th), 125.16 (C4th or C?th), 124.53 (C3pyr),124.14 (C2th), 122.96 (C3th), 121.32 (C5pyr or C5?pyr),116.87 (C5pyr or C5?pyr), 91.77 (C?C), 89.69 (C?C). MS(EI, m/z): 426.09. Elemental analysis: required forC24H14N2S3, C 67.57, H 3.31, N 6.57, S 22.55, found: C67.60, H 3.28, N 6.62, S 22.50.

The synthetic route of 14162-95-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Quagliotto, Pierluigi; Prosperini, Simona; Viscardi, Guido; Letters in Organic Chemistry; vol. 14; 7; (2017); p. 472 – 478;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 1,4,7-triazacyclononane (2 mmol) in distilled ethanol (50 mL) containing molecular sieve was added 1 equiv of aldehyde. The reaction mixture was stirred at room temperature. The solution was filtered and the filtrate was evaporated under reduced pressure to yield the aminal adduct.

The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Roger, Melissa; Patinec, Veronique; Bourgeois, Martine; Tripier, Raphael; Triki, Smail; Handel, Henri; Tetrahedron; vol. 68; 27-28; (2012); p. 5637 – 5643;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,485-71-2

Example 11 (R)-1-(2-Hydroxyethyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid cinchonidine salt To cinchonidine (46.98 g (159.6 mmol)), ethyl acetate (1400 mL) was added, and while heating and stirring the resulting mixture under reflux (about 78 C.), (RS)-1-(2-hydroxyethyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid (50.00 g (159.6 mmol)) was added thereto. The resulting mixture was stirred for about 1 hour, and then gradually cooled to 20 to 30 C., and further stirred for about 1 hour at that temperature. The deposited crystal was filtered and washed with ethyl acetate (250 mL). The obtained wet crystal product was dried under reduced pressure at 40 C., whereby a crude product of the title compound (52.73 g) was obtained (yield: 54.4%). The diastereomeric excess of the obtained salt was 71.9% de. To the obtained crude product (50.00 g), ethanol (75 mL) and ethyl acetate (100 mL) were added, and the resulting mixture was heated and stirred under reflux (about 78 C.). After the mixture was stirred for about 1 hour, ethyl acetate (825 mL) was added thereto, and the resulting mixture was stirred under reflux again for about 0.5 hours. Thereafter, the mixture was cooled to 0 to 5 C. and stirred for about 1 hour at that temperature. The resulting crystal was filtered and washed with ethyl acetate (200 mL) cooled to 0 to 5 C. The obtained wet crystal product was dried under reduced pressure at 40 C., whereby the title compound was obtained (34.21 g, recovery rate: 68.4%, yield: 37.2%). The diastereomeric excess of the obtained salt was 98.7% de. 1H NMR (400 MHz, CDCl3) delta: 1.27-1.67 (m, 2H), 1.75-2.04 (m, 4H), 2.13-2.33 (m, 1H), 2.52-2.94 (m, 2H), 3.14-3.23 (m, 2H), 3.46-4.12 (m, 2H), 4.76-5.10 (m, 2H), 5.58-5.90 (m, 2H), 6.10-6.95 (m, 2H), 7.00-8.25 (m, 7H), 8.55-9.01 (m, 1H). MS (ESI): 313, 294

As the paragraph descriping shows that 485-71-2 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; Watanabe, Masashi; Okachi, Takahiro; Kawahara, Michiaki; Nagasawa, Hiroshi; Sato, Noritada; Takita, Takashi; Hasegawa, Gen; (23 pag.)US2016/96803; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI