Catalyst ligands

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D-Tryptophan (100 g), and PTSA.H20 (186.28 g) were added to allyl alcohol (1000 ml) stirred at 25 to 35C, followed by addition of toluene (500ml). The resulting mixture was stirred at 80-95C till completion of reaction, as monitored by TLC. After completion, the mass was cooled, and 5% aqueous sodium bicarbonate solution was added to it. Extraction with ethyl acetate followed by separation and concentration of the organic layer gave a residue containing H-D-Trp-OAll (11). Yield: 108.01 g (90.3%) Purity: > 95% (HPLC)

153-94-6, As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.

Reference£º
Patent; EMCURE PHARMACEUTICALS LIMITED; GURJAR, Mukund Keshav; TRIPATHY, Narendra Kumar; PRAMANIK, Chinmoy Mriganka; DESHPANDE, Ashish Pramod; (25 pag.)WO2017/178950; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

76089-77-5, Cerium(III) trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76089-77-5, General procedure: A mixture of Ce(OTf)3 (0.1388g, 0.2mmol) and C12H8N2 (phen) (0.005g) was dissolved in a mixture of CH3CN (10ml) and DMF (three drops). After the mixture was stirred for 1h, the ligand L (0.2752g, 0.8mmol) was added to this mixture. Stirring was continued for 4h at ambient temperature. After this time, any insoluble residues were removed by filtration, and the filtrate was evaporated slowly at room temperature for about one month to yield colorless crystalline products.

The synthetic route of 76089-77-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xu, Shan; Liu, Min; Yang, Yu-Ping; Jiang, Yu-Han; Li, Zhong-Feng; Jin, Qiong-Hua; Wang, Xin; Xue, Xiao-Nan; Polyhedron; vol. 87; (2014); p. 293 – 301;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: Preparation of tert-butyl-(35)-3-[({[25,5R)-6-(sulfooxy)-7-oxo-l,6- diazabicylco[3.2.1]oct-2-yl]carbonyl}amino)oxy]pyrrolidine-l-carboxylate, tetrabutyl ammonium salt (VI): To a stirred solution of ieri-butyl(35)-3-[({ [25,5i?)-6-hydroxy-7-oxo-l,6- diazabicylco[3.2.1]oct-2-yl]carbonyl}amino)oxy]pyrrolidine-l-carboxylate (V) (8.04 g, 0.0217 mol) in dimethylformamide (50 ml), was added sulfur trioxide dimethyl formamide complex (3.98 g, 0.0260 mol) in one portion, at about 10C. The stirring was continued further for 30 minute and then the reaction mixture was allowed to warm to room temperature. After 2 hour, a solution of tetrabutylammonium acetate (7.83 g, 0.0260 mol) in water (25.8 ml) was added to the resulting reaction mass under stirring. After additional 2 hour of stirring, the solvent from the reaction mixture was evaporated under reduced pressure to obtain an oily residue. The oily mass was co-evaporated with xylene (2 x 20 ml) to obtain thick mass. This mass was partitioned between dichloromethane (100 ml) and water (100 ml). The organic layer was separated and the aqueous layer re-extracted with dichloromethane (50 ml). The combined organic extracts were washed with water (3 x 50 ml), dried over anhydrous sodium sulphate and the solvent evaporated under reduced pressure. The residual oily mass was triturated with ether (3 x 50 ml), each time the ether layer was decanted and finally the residue was concentrated under reduced pressure to obtain 11.3 g of tert-butyl(3S)-3-[({ [2S,5R)-6- (sulfooxy)-7-oxo-l,6-diazabicylco[3.2.1]oct-2-yl]carbonyl}amino)oxy] pyrrolidine- 1- carboxylate, tetrabutylammonium salt (VI), as a white foam, in 75 % yield. Analysis: Mass: 449.3 (M-l, without TBA); for Molecular weight of 691.94 and Molecular formula of C32H61N5O9S; and 1H NMR (400MHz, CDC13): 59.14-9.10 (d, 1H), 4.63 (s, 1H), 4.35 (s, 1H), 3.94- 3.92 (d, 1H), 3.66-3.35 (m, 5H), 3.29-3.27 (m, 8H), 2.83-2.80 (d, 1H), 2.35-2.17 (m, 3H), 1.98-1.87 (m, 2H), 1.73 (m, 1H), 1.70-1.62 (m, 8H), 1.49-1.40 (m, 17H), 1.02-0.99 (t, 12H).

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; BIRAJDAR, Satish; DOND, Bharat; PATIL, Vijaykumar Jagdishwar; PATEL, Mahesh Vithalbhai; WO2015/110886; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1119-97-7,MitMAB,as a common compound, the synthetic route is as follows.

General procedure: A 100mL round-bottom flask was equipped with a magnetic stir bar and a reflux condenser. To xylene (10.0mL), tetradecyltrimethylammonium bromide (1.1mmol) and a heterocyclic compound (1.0mmol) were added, followed bya solution of NaOH 50% (5.0 mL). The mixture was stirred at reflux temperature for 2-18 h. After completion of thereaction, the mixture was air-jet cooled to 25 C and TLC indicated the disappearance of the starting material. The reaction mix was treated with AcOEt (4 ¡Á 20 mL), and the organic phase separated and removed under reduced pressure. The residue was purified to analytical purity by column chromatography., 1119-97-7

1119-97-7 MitMAB 14250, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Gonzalez-Gonzalez, Carlos A.; Vega, Juan Javier Mejia; Monroy, Ricardo Garcia; Gonzalez-Calderon, Davir; Corona-Becerril, David; Fuentes-Benites, Aydee; Mascarua, Joaquin Tamariz; Gonzalez-Romero, Carlos; Journal of Chemistry; vol. 2017; (2017);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Stock 0.5M solution of EuCl3 was prepared by the treatment of Eu2O3(4.400 g, 12.50 mmol) by minimum amount of concentrated HCl in aquartz crucible. The resulting solution was evaporated to dryness at 90 Cand the residue was dissolved in a minimum amount of distilled water.After that, the solution was transferred quantitatively to a volumetric flaskand the volume was adjusted to 50 mL. This solution was then kept in apolypropylene flask. To a stirred warm (40 C) solution of the ligand(3 mmol) and (1 mmol) bathophenanthroline (0.33 g) in 30 mL of ethanol,2 mL of an 0.5M aqueous solution of EuCl3 (1 mmol) were added dropwise,followed by careful addition of 3 mL (3 mmol) of an 1.0M NaOHsolution in water until the pH of the mixture reached 6-7. The mixture washeated at 50 C during 4 h in a closed flask and cooled. Further operationsdepended upon the properties of the reaction products.

1662-01-7, 1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Korshunov; Ambrozevich; Taydakov; Vashchenko; Goriachiy; Selyukov; Dmitrienko; Dyes and Pigments; vol. 163; (2019); p. 291 – 299;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

170161-27-0, Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tri-Boc cyclam S7 (437 mg, 0.873 mmol) in anhydrous CH3CN (26 mL)were added Na2CO3 (370 mg, 3.49 mmol) and propargyl bromide (-80% in toluene, 156pL, 1 .05 mmol). The reaction mixture was heated at reflux under N2 overnight. Theinsoluble salts were filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, EtOAc:hexane =7:3) to give S11 as a white foam (446 mg, 95%). RF (EtOAc:hexane = 7:3) 0.58. m.p.47-48 C (lit.45?66 m.p. 4749 C). IR Vmax/cm1 3305, 3243, 2976, 2932, 2871, 2826,1681, 1463, 1410, 1365, 1240, 1150. 1H NMR (200 MHz, CDCI3) 5 1.40 (5, 27H, 3 xC(CH), 1.55-1.75 (m, 2H, CH2CH2CH2), 1.75-1.95 (m, 2H, CH2CH2CH2), 2.12 (5, 1H,CCH), 2.46 (t, 2H, J 5.4, CH2N(CH2CCH)CH2), 2.55-2.70 (m, 2H, CH2N(CH2CCH)CH2), 3.10-3.50 (br m, 14H, 3 x CH2N(Boc)CH2 & NCH2CCH). MS (ESI) m/z539.4 ([M+H], 100%), 561.5 ([M+Na], 28%). The spectroscopic data were inagreement with those in the literature.25?26, 170161-27-0

170161-27-0 Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate 10940041, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF SYDNEY; RUTLEDGE, Peter; TODD, Matthew; TRICCAS, James Anthony; WO2014/153624; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of methyl esters of L- and D-tryptophanes chlorohydrates; :1a,b 2a,b a : D b : L[0344] Thionylchloride (0.064 mol) was slowly added to a cooled (O0C) suspension of tryptophane (0.049 mol) in methanol (150 mL). The reaction mixture was warmed up to 4O0C and stirred at this temperature for six hours. All solvents were removed and the solid residue was triturated with ether. The solid was filtered off to give the required product.[0345] D-tryptophane (2a): yield 98 %, M.p. 232-233C. NMR1H (delta, ppm,DMSO-dtheta, 300 MHz): 3.39 (2H, m, CH2); 3.63 (3H, s, CH3O); 4.20 (1 H1 t, CH, JHH = 5.5 Hz); 7.07 (2H, dt, Ar, JHH = 21 Hz, 6 Hz); 7.26 (1 H, d, H2, JHH = 3 Hz); 7.39 (1 H, d, Ar, JHH = 7.8 Hz); 7.53 (1 H, d, Ar, JHH = 7.8 Hz). NMR13C (delta, ppm, DMSO-d6, 125.76 MHz): 26.01 (s), 52.61 (d), 106.26(s), 111.45(s), 117.84(s), 118.50(s), 121.05(s), 124.80(s), 126.79(s), 136.13(s), 169.57(s). m/z 218(M+)., 153-94-6

153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; WO2008/103470; (2008); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,2-dimethylpropane-1,3-diamine (5.0?g, Aldrich) was added to a solution of HCOOH (10 equiv) and HCHO (37% aqueous solution, 10?equiv), and was heated at reflux overnight, whereupon the solution was made basic by addition of NaOH (2?M, aqueous) and extracted into diethyl ether (4?*?25?mL). The ether solution was dried over K2CO3, and the solvent removed by rotary evaporation. The resulting oil was distilled in vacuo from CaH2 to afford the product as a colorless oil (75%). 1H NMR (CDCl3, 400?MHz): delta 0.9 (m, 6H); 2.0 (m, 4H); 2.2 (m, 12H). GC-MS: [60?C (1?min) to 180?C (2?min) at 30?C¡¤min-1]; tr?=?5.2?min (158, M+)., 7328-91-8

As the paragraph descriping shows that 7328-91-8 is playing an increasingly important role.

Reference£º
Article; Large, Tao A.G.; Mahadevan, Viswanath; Keown, William; Stack, T. Daniel P.; Inorganica Chimica Acta; vol. 486; (2019); p. 782 – 792;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.448-61-3,2,4,6-Triphenylpyrylium tetrafluoroborate,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of the corresponding amine (2.0 mmol) and 2,4,6-triphenylpyrylium tetrafluoroborate (2.0 mmol) in EtOH (20 mL) in a round bottle flask was added Et3N (2.0 mmol). The mixture turned deep-brown while the educts dissolved and was stirred for 30 min at rt followed by the addition of AcOH (4.0 mmol) and heating under reflux conditions for additional 2 h. The product precipitated during the reaction. The product was dissolved directly in the flask with little acetone at the reflux temperature after the reaction was finished (no further precipitate occurred). After cooling down to rt the product crystallized as a yellow solid, which was filtered off, washed with cold EtOH and pentane and dried in vacuo., 448-61-3

448-61-3 2,4,6-Triphenylpyrylium tetrafluoroborate 9930615, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Menzel, Roberto; Kupfer, Stephan; Mede, Ralf; Goerls, Helmar; Gonzalez, Leticia; Beckert, Rainer; Tetrahedron; vol. 69; 5; (2013); p. 1489 – 1498;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: [Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to a DCMsolution (about 12 mL) of dap (10.7 mg, 98percent, 0.0500 mmol) andxantphos (59.0 mg, 98percent, 0.100 mmol) under a stream of dry argonby using Schlenk techniques at room temperature and a vacuumlinesystem, then orange-red solution was obtained quickly andstirred for 1 h at room temperature. The above process can alsobe carried out in air with the existence of oxygen. After filtrationthrough absorbent cotton, layering n-hexane onto the DCM solutionin air produced the product as bluish violet to black-blue blockcrystals in 76percent yield (63.0 mg)., 168646-54-6

As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Liu, Rong; Feng, Xiao-Yan; Li, Hao-Huai; Liu, Nian; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 92; (2015); p. 84 – 92;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI