Catalyst ligands

72914-19-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72914-19-3,4,4′-Di-tert-butyl-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

A magnetically stirred suspension of 4,4?-di-tert-butyl-2,2?-dipyridyl (118 mg, 0.44 mmol) and tetrakis(2-phenylpyridine-C2,N?)(mu-dichloro)-diiridium (214 mg, 0.2 mmol) in 10 mL of 1,2-ethanediol under nitrogen was heated to 150 C. The mixture was kept at this temperature for 15h. All the solids dissolved to yield a clear, yellow solution. After cooling the mixture to room temperature, 150 mL of water was added. The excess of bipyridine ligand was removed through three extractions with diethyl ether (50 mL), and the aqueous layer was subsequently heated to 60-70 C. NH4PF6 (1 g) in 10 mL of water was added, and the PF6 salt of the chromophore immediately precipitated. After cooling the suspension to 5 C, the yellow solid was separated through filtration, dried, and recrystallized through acetonitrile/ether diffusion. Yield: 280 mg (77%).

The synthetic route of 72914-19-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ye, Hongqiang; Ye, Qianwen; Cheng, Dongping; Li, Xiaonian; Xu, Xiaoliang; Tetrahedron Letters; vol. 59; 21; (2018); p. 2046 – 2049;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

35132-20-8, (1R,2R)-1,2-Diphenylethane-1,2-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

trans-RuH(eta1-BH4)[(R)-tolbinap][(R,R)-dpen] was synthesized. First, trans-RuCl2[(R)-tolbinap][(R,R)-dpen] was synthesized. That is, [RuCl2(benzene)]2 (129 mg; 0.258 mmol) (made by Aldrich Inc.) and (R)-TolBINAP (373 mg; 0.55 mmol) (made by AZmax Co., Ltd.) were weighed and placed in a 50 mL Schlenk reaction tube equipped with a stirrer coated with polytetrafluoroethylene, and after depressurizing the interior of the vessel to eliminate air, argon was introduced. After then adding DMF (9 mL) with a syringe, heating in an oil bath set to 100 C. was performed for 10 minutes under an argon atmosphere. After cooling the reaction solution to room temperature, (R, R)-DPEN (117 mg; 0.55 mmol) (made by Kankyo Kagaku Center Co., Ltd.) was added under an argon gas flow to the reddish-brown RuCl2[(R)-tolbinap](dmf)n solution, and stirring at 25 C. was performed for 3 hours. To a green-colored crude product obtained by distilling off the DMF under reduced pressure (1 mmHg), methylene chloride (10 mL) was added, and after dissolving as much of a yellow product as possible, a green impurity was removed by filtration. The yellow solution that was obtained by filtration whereafter concentrated to approximately 1 mL and then diethyl ether (5 mL) was added to precipitate solids. The solids obtained were separated by filtration and dried under reduced pressure(1 mmHg)to obtain trans-RuCl2[(R)-tolbinap][(R,R)-dpen] (340 mg; 0.32 mmol; yield: 58%) as a yellow powder. [TolBINAP] and [tolbinap] are abbreviations for 2,2′-bis(di-4-tolylphosphino)-1,1′-binaphthyl, ?DMF? and ?dmf? are abbreviations for N,N-dimethylformamide, and ?DPEN? and ?dpen? are abbreviations for 1,2-diphenylethylenediamine. [00030] The abovementioned trans-RuCl2[(R)-tolbinap] [(R,R)-dpen] (106.3 mg; 0.1 mmol) and sodium borohydride (94.6 mg; 2.5 mmol) (made by Nacalai Tesque, Inc.) were then weighed and placed in a 50 mL Schlenk reaction tube equipped with a stirrer coated with polytetrafluoroethylene, and after depressurizing the interior of the vessel to eliminate air, argon was introduced. After then adding a 1:1 volume ratio mixed solvent of benzene/ethanol (4 mL) with a syringe, heating in an oil bath set to 65 C. was performed for 5 minutes under an argon atmosphere. The reaction solution was thereafter stirred for 30 minutes at room temperature. After then drying and solidifying the crude product by distilling off the solvent under reduced pressure (1 mmHg), benzene (6 mL) was added under an argon gas flow to dissolve as much of a yellow product as possible and then the excess sodium borohydride was eliminated by filtration by celite (0.5 g). A yellow filtrate thus obtained was concentrated to approximately 1 ml by depressurization (1 mm Hg) and hexane (6 mL) was then added under an argon gas flow. Yellow solids thus precipitated were separated by filtration through a glass filter and dried under reduced pressure (1 mmHg) to obtain trans-RuH(eta1-BH4)[(R)-tolbinap] [(R,R)-dpen] (76.0 mg; yield: 70%; see formula (3) below) as a yellow powder. Decomposition temperature: 164 C.; 1HNMR(400 MHZ, C6D6) delta-13.60(t, 1, J=22.4 Hz, RuH), -0.40(brs, 4, BH4), 1.45(s, 3, CH3), 1.55(s, 3, CH3), 1.62(s, 3, CH3), 1.63(s, 3, CH3), 1.95(dd, 1, J=7.2 and 8.4 Hz, NHH), 2.38(d, 1, J=8.2 Hz, NHH) ,3.65(dd, 1, J=7.9 and 11.2 Hz, CHNH2), 3.82-3.88(m, 2, 2 NHH), 4.00(ddd, 1, J=7.9, 8.4 and 11.6 Hz, CHNH2), 6.13-8.12(m, 38, aromatics) ;31PNMR(161.7 MHz, C6D6) delta71.2(d, J=41.4 Hz), 75.2(d, J=41.4 Hz);IR(toluene)2316(s), 1862(s), 1092(s), 1080(s)cm-1; ESI-MS m/z1007.26([M-H]+), theoretical value (C62H60BN2P2Ru): 1007.34. The powder obtained was then recrystallized from a THF/hexane mixed solvent of a volume ratio of approximately 1:5 to obtain yellow prismatic crystals, and these were used for X-ray crystallography.

35132-20-8, 35132-20-8 (1R,2R)-1,2-Diphenylethane-1,2-diamine 2724998, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Nagoya Industrial Science Research Institute; US6720439; (2004); B1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148332-36-9,[2,2′:6′,2”-Terpyridine]-4′-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Typically, 2-(4-carboxyphenyl)-4,6-dipyrid-2-yltriazine (1.0 g,2.81 mmol) was heated to reflux in thionyl chloride (30 mL) for0.5 h, after which no solid suspension remained. The excess thionylchloride was removed by distillation and the residue was driedunder vacuum, dry methanol (60 mL) was added and the reactionmixture was heated to reflux until no solid suspension remained(2 h). The solution was cooled to room temperature and addedto H2O (300 mL) forming a voluminous precipitate of the methylester ligand which was isolated by filtration and dried in vacuowithout further purification. Typically, the ligand (0.25 g,0.68 mmol) was heated to reflux in DMF with RuCl3 (0.07 g,0.34 mmol) and AgNO3 (0.173 g, 1.02 mmol) after which the solutionwas filtered to remove AgCl(s). The filtrate was then decantedinto a solution of NH4PF6 (aq) (300 mL), and the resultant heavyprecipitate was isolated by filtration and washed with water, thendissolved in a minimal amount of acetonitrile for chromatographicpurification using silica and a 7:2 CH3CN/KNO3 (aq, sat) mixture aseluent. The collected fractions are combined, and to this addedNH4PF6 and enough DCM to effect a phase separation. After washingthe organic phase, the aqueous phase was discarded and theprocess repeated, with a final washing with water alone. Theorganic phase was dried and the residue taken up in a minimalamount of acetonitrile, then poured into H2O (300 mL) to give aheavy precipitate which was filtered and dried in vacuo. Yield:0.263 g (69percent), Rf = 0.55 (silica, 7:2 CH3CN/KNO3 (sat, aq) as eluent).1H NMR (400 MHz, CD3CN) d ppm 9.19 (d, J = 8.4 Hz, 4H), 9.14 (d,J = 7.7 Hz, 4H), 8.44 (d, J = 8.4 Hz, 4H), 8.16 (m, 4H), 7.73 (d,J = 5.3 Hz, 4H), 7.41 (m, 4H), 4.02 (s, 3H). ESI-MS: [M]2+ Cald. forC42H30N10O4Ru: 420.07475. Found: 420.07499.

148332-36-9, As the paragraph descriping shows that 148332-36-9 is playing an increasingly important role.

Reference£º
Article; Cooke, Michael W.; Santoni, Marie-Pierre; Loiseau, Frederique; Hasenknopf, Bernold; Hanan, Garry S.; Inorganica Chimica Acta; vol. 454; (2017); p. 208 – 215;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 10 mL methanolic solution of pyridine-2-carboxamide (0.3663 g, 3 mmol) and 10 mL methanolic solution of 4,4′-dimethoxy-2,2′-bipyridine (0.2162 g, 1 mmol) was stirred at room temperature for half an hour. Solution of EuCl3 was prepared by dissolving 1 mmol (0.2583 g) of EuCl3 in 10 mL of methanol and this solution was added to the ligands solution drop by drop with continuous stirring. The pH of resulting solution was maintained between 6 and 7. The reaction mixture was refluxed at 70 ¡ãC for 4 h. After refluxing for 4 h, the solution was cooled to room temperature and left as such overnight. Complex C1 was obtained as white precipitate which was filtered off, washed with methanol nd then dried under vacuum. The synthesis of complexes C2-C4 were done by adopting the same method as given above. Complex C2 was obtained from 3 mmol PCAO (0.3663 g), 1 mmol DMBP (0.2162 g) and1 mmol EuCl3 (0.2583 g), complex C3 was obtained from 3 mmol PDCA(0.4473 g), 1 mmol DMBP (0.2162 g) and 1 mmol EuCl3 (0.2583 g) and complex C4 was obtained from 3 mmol PM (0.3 mL), 1 mmol DMBP(0.2162 g) and 1 mmol EuCl3 (0.2583 g)., 17217-57-1

The synthetic route of 17217-57-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sengar, Manju; Narula, Anudeep Kumar; Materials Research Bulletin; vol. 112; (2019); p. 242 – 250;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7173-51-5, N-Decyl-N,N-dimethyldecan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7173-51-5, Didecyldimethylammonium chloride (0.025 mol) was dissolved in 40 mL distilled water and the folic acid sodium salt (0.01 mol) was added. The solution was stirred at room temperature for 30 min. After separation of the phases, the organic phase was washed with distilled, cold water until chloride ions were no longer detected using AgNO3. The organic phase was separated and solvent was evaporated. The product (90% yield), didecyldimethylammonium N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoy]-L-glutamate, was dried at 50 C. under vacuum. Product is soluble in chloroform, acetone, DMSO. It lacks miscibility with water and hexane. 1H and 13C NMR (DMSO) were obtained. Thermogravimetric analysis: Tonset5%=153 C., and Tonset=201 C. 1H and 13C NMR (DMSO) were obtained.

As the paragraph descriping shows that 7173-51-5 is playing an increasingly important role.

Reference£º
Patent; Rogers, Robin D.; Daly, Daniel T.; Swatloski, Richard P.; Hough, Whitney L.; Davis, James Hilliard; Smiglak, Marcin; Pernak, Juliusz; Spear, Scott K.; US2007/93462; (2007); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-41-7, H-Ala-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

SOCl2 (21.8mL, 0.3mol) and (S)-alanine ((S)-19, 8.91g, 0.1mol) were added to CH3OH (100mL) and the mixture was stirred at RT for 2h. The solvent was removed in vacuo, the residue was dissolved in methanol (30mL) and the organic solvent was removed in vacuo again. This procedure was repeated twice. Colorless amorphous solid, mp 103C (Ref. 39 mp 98-99C), yield 14.3g (>99%). [alpha]589=+7.9 (c=0.94, CH3OH) [Ref. 38 [alpha]589=+7.4 (c=1.76, CH3OH)].

56-41-7, The synthetic route of 56-41-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fanter, Lena; Mueller, Christoph; Schepmann, Dirk; Bracher, Franz; Wuensch, Bernhard; Bioorganic and Medicinal Chemistry; vol. 25; 17; (2017); p. 4778 – 4799;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56-54-2,(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol,as a common compound, the synthetic route is as follows.

General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.6 N-(3,5-Ditrifluoromethylbenzyl)quinidinium bromide (1f) [27] Yield: 85%; white solid; mp 177 C (decomp.); [alpha]D28 +176.1 (c 0.19, CH3OH); IR (KBr): 3394, 3201, 2954, 2664, 1622, 1509, 1473, 1432, 1374, 1281, 1214, 1226, 1178, 1135, 1027, 1005, 866, 905, 843, 828, 709, 682 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.82 (d, J = 4.8 Hz, 1H), 8.56 (s, 2H), 8.38 (s, 1H), 8.04 (d, J = 9.2 Hz, 1H), 7.77 (d, J = 4.4 Hz, 1H), 7.53 (dd, J = 7.2, 2.4 Hz 1H), 7.44 (d, J = 2.4 Hz, 1H), 6.78 (d, J = 3.2 Hz, 1H), 6.48 (s, 1H), 6.04 (ddd, J = 17.4, 10.2, 7.2 Hz, 1H), 5.28 (d, J = 2.8 Hz, 1H), 5.22 (d, J = 12.4 Hz, 2H), 5.01 (d, J = 12.8 Hz, 1H), 4.34 (t, J = 10.0 Hz, 1H), 4.10-4.13 (m, 1H), 4.06 (s, 3H), 3.80 (t, J = 9.4 Hz, 1H), 3.48 (t, J = 11.4 Hz, 1H), 3.04 (q, J = 9.6 Hz, 1H), 2.62 (q, J = 8.4 Hz, 1H), 2.42 (t, J = 11.6 Hz, 1H), 1.91 (s, 1H), 1.85-1.72 (m, 2H), 1.20-1.13 (m, 1H); 13C NMR (100 MHz, DMSO-d6): delta = 158.1, 147.9, 144.2, 143.7, 137.8, 135.1, 132.0, 131.7, 131.3 (q, J = 33.1 Hz), 130.1, 126.0, 125.0, 124.6 (q, J = 4.1 Hz), 123.7 (q, J = 271.3 Hz), 121.5, 120.9, 117.6, 103.1, 68.4, 65.2, 61.8, 56.3, 56.2, 54.7, 37.4, 26.9, 23.6, 21.1.

The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Quaternary ammonium bromide 2(a-b) (1.0 equi.) is mixed withNaBF4/KPF6/LiCF3SO3 (3.05 equi.) in the presence of 10 mL deionizedwater at room temperature with stirring for about 1 h afforded theanion exchanged di/trimeric imidazolium salts. After the anion exchangedreaction, Soxhlet extraction is carried out to remove metallicbromide., 33454-82-9

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Article; Ganapathi, Pandurangan; Ganesan, Kilivelu; Journal of Molecular Liquids; vol. 233; (2017); p. 452 – 464;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

(2); Synthesis of Rh+{2,2′-bis(diphenylphosphinyl)benzophenone} {(S,S)-DPEN}(SbF6-); Into [Rh+{2,2′-bis(diphenylphosphinyl)benzophenone}(cod)](SbF6-) obtained in the (1) after the distillation under reduced pressure were added 21.2 mg (0.1 mmol) of (S,S)-DPEN and 2 ml of methylene chloride, and then the solution was stirred under hydrogen atmosphere for 1 hour. The solvent was distilled off under reduced pressure and then the residue was dried to give 110 mg (yield: > 99%) of the title compound. 31p NMR (CDCl3) delta ppm; 48.28, 57.04 (2dd, Jp-p = 40.5 Hzo, Jp-Rh = 157.9 Hzo).

29841-69-8, As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

Reference£º
Patent; Takasago International Corporation; EP1661903; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

56-54-2, General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.4 N-(2-F-4-Br-benzyl)quinidinium bromide (1d) Yield: 79%; white solid; m.p. 174-176 C (decomp.); [alpha]D28 +143.3 (c 0.14, CH3OH); IR (KBr): 3387, 3198, 3006, 1621, 1520, 1473, 1460, 1431, 1338, 1259, 1241, 1205, 1113, 1026, 851, 828, 719 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.81 (d, J = 4.4 Hz, 1H), 8.02 (d, J = 9.2 Hz, 1H), 7.87-7.76 (m, 3H), 7.67 (dd, J = 8.4, 1.6 Hz, 1H), 7.50 (dd, J = 9.2, 2.0 Hz, 1H), 7.41 (d, J = 2.4 Hz, 1H), 6.86 (d, J = 2.8 Hz, 1H), 6.51 (s, 1H), 6.03 (ddd, J = 17.2, 10.4, 6.8 Hz, 1H), 5.25-5.23 (m, 2H), 5.06 (d, J = 12.4 Hz, 1H), 4.77 (d, J = 12.4 Hz, 1H), 4.19 (t, J = 9.6 Hz, 1H), 4.06 (s, 3H), 3.97-3.85 (m, 2H), 3.44 (t, J = 11.2 Hz, 1H), 3.12 (q, J = 10.0 Hz, 1H), 2.68-2.62 (m,1H), 2.36 (t, J = 11.2 Hz, 1H), 2.00 (s, 1H), 1.82-1.75 (m, 2H), 1.10-1.03 (m, 1H); 13C NMR (100 MHz, DMSO-d6): delta = 162.1 (d, J = 252.2 Hz), 157.9, 147.9, 144.2, 143.8, 137.6, 131.9, 129.0, 125.8, 125.5 (d, J = 10.1 Hz), 121.9, 120.7, 120.3 (d, J = 25.7 Hz), 117.5, 115.4 (d, J = 13.7 Hz), 102.8, 67.9, 65.3, 56.8, 56.1, 54.7, 37.4, 26.6, 23.7, 21.0; HRMS calcd for [C33H35F6N2O2]+: 511.1391, found 511.1398.

The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI