Catalyst ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23616-79-7,N-Benzyl-N,N-dibutylbutan-1-aminium chloride,as a common compound, the synthetic route is as follows.

Reference Example 3 Potassium carbonate (414 g) is suspended in chloroform (1.3 l), and thereto is added dropwise water (29 ml) gradually. To the mixture are added tributylbenzylammonium chloride (37 g), 2′,6′-dihydroxy-4′-methylacetophenone (100 g), and 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide (419 g), and the mixture is stirred at room temperature for 27 hours. To the mixture is added water (21 ml), and the mixture is stirred for further 2.5 hours. The mixture is neutralized with 18% hydrochloric acid (about 500 ml) under ice-cooling. To the mixture are added 18% hydrochloric acid (about 200 ml) and water (500 ml), and the chloroform layer is separated, washed with water and a saturated aqueous sodium chloride solution, dried, and concentrated. To the residue is added methanol (400 ml), and the mixture is concentrated under reduced pressure to about a half volume thereof. To the resultant is added methanol (2 l), and the mixture is heated a little, and stirred under ice-cooling for 30 minutes. The precipitates are collected by filtration, and dried under reduced pressure to give 2′-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy)-6′-hydroxy-4′-methylacetophenone (239.75 g). The physicochemical properties of the compound are the same as those of the compound obtained in Reference Example 2.

23616-79-7, As the paragraph descriping shows that 23616-79-7 is playing an increasingly important role.

Reference£º
Patent; Tanabe Seiyaku Co., Ltd.; US6048842; (2000); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33454-82-9,Lithium trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

In an Ar filled flask, 0.150 g (0.24 mmol) of [RuCI(p- cymene)(R,R-TsDPEN)] and 0.037 g (0.24 mmol) of LiOTf were combined. CH2CI2 (10 ml_) was added and the resulting orange mixture was left to stir at ambient temperature. 0.046 g of AgBF4 was then added. The orange suspension gradually darkened to brown and eventually to deep purple in colour. After 21 hours, the suspension was filtered through a 0.45 mm PTFE syringe filter. The brown filtrate was concentrated to dryness leaving a brown residue. Yield: 0.120 g (68 %). 1H and 19F(1HJ NMR (ppm, CD2CI2) showed that the product was obtained (ratio of the products: 1 :1).

33454-82-9, As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Patent; KANATA CHEMICAL TECHNOLOGIES INC.; WO2009/132443; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

130-95-0, Quinine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example: 11a-(-)-3-(Carbamoylmethyl)-5-methylhexanoic Acid Quinine Salt Aqueous acetone (795ml) was added to the amide II (53 g, 283.42 mmole) at room temperature and the reaction mixture was heated until it became homogenous. Quinine (91 .8 g, 283.42 mmole) was added to the mixture at 80 C. After 15 minutes at this temperature, another batch of quinine (5.3 g, 28.34 mmole) was added to the reaction mixture and heating was continued until the mixture became homogenous. The reaction mixture was allowed to cool down to room temperature. The precipitated solid was filtered, dried and purified to furnish the diastereoisomeric salt of the amide I as a solid which was broken down to obtain enantiomerically enriched amide I; yield: 18 g; 67.9%; HPLC purity: 99.97%., 130-95-0

130-95-0 Quinine 3034034, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Dr. Braja Sundar Pradhan; WO2012/93411; (2012); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.

4-Hydroxyphenylacetic acid (40 mg, 0.263 mmol) and cinchonidine (77.4 mg, 0.263 mmol) were dissolved in isopropanol (IPA). The solution was left to evaporate and crystals were obtained after one week

The synthetic route of 485-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Amombo Noa, Francoise M.; Jacobs, Ayesha; Journal of Molecular Structure; vol. 1114; (2016); p. 30 – 37;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6813-38-3,[2,2′-Bipyridine]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.,6813-38-3

Thionyl chloride (300muL, 4.08mmol) was added to a suspension of 16 (400mg, 1.62mmol) in MeOH (30mL) in a dropwise fashion. The mixture was heated at reflux temperature overnight. Then, the solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 and water. The organic layer was washed with saturated aqueous NaHCO3 solution and dried over Na2SO4. Filtration, evaporation in vacuo, and recrystallization in AcOEt gave 17 (400mg, 91%): mp 200-202C; 1H NMR (CDCl3, 300MHz, delta; ppm), 8.92 (2H, d, J=4.2Hz), 8.85 (2H, s), 7.91 (2H, d, J=3.3Hz); 13C NMR (CDCl3, 75MHz, delta; ppm), 166.5, 156.0, 151.1, 140.0, 123.9, 120.0; MS (ESI) m/z 273.0 (MH+).

The synthetic route of 6813-38-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Miyake, Yuka; Itoh, Yukihiro; Hatanaka, Atsushi; Suzuma, Yoshinori; Suzuki, Miki; Kodama, Hidehiko; Arai, Yoshinobu; Suzuki, Takayoshi; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 1119 – 1129;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139-07-1,N-Benzyl-N,N-dimethyldodecan-1-aminium chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 3 Preparation of 2-methoxybenzenesulfochloride A diazonium salt solution, prepared similarly to Example 1 from o-anisidine, was brought into intimate contact, at 0 C., with a solution of 100 ml of 1,2-dichloroethane and 21 g (0.33 mole) of SO2, and was then decomposed using 0.5 g of CuCl2 and 1 g of dodecyldimethylbenzylammonium chloride at 40 C. 4.3 g of a 30% strength by weight aqueous hydrogen peroxide solution (=38 millimoles of H2 O2) were then added to the mixture, and after a reaction time of 3 minutes the batch was worked up in a conventional manner. The yield of 2-methoxybenzenesulfochloride was 80%; boiling point 134-138 C./0.7 mbar.

139-07-1, As the paragraph descriping shows that 139-07-1 is playing an increasingly important role.

Reference£º
Patent; BASF Aktiengesellschaft; US4393211; (1983); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-95-0,Quinine,as a common compound, the synthetic route is as follows.

To a solution of quinine (78.2 mg, 0.2 mmol) in methanol (10 mL), a solution of ZnCl2 (27.2 mg, 0.2 mmol) in methanol (10 mL) was added. The mixture was stirred and heated at 50C for 2 h, and cooled to room temperature. The resulting solution was treated with aqueous HCl and filtered to remove staring materials. By slow evaporation of the filtrate at room temperature, white single crystals suitablefor X-ray diffraction were obtained after two weeks.The complex was identified as [(Quin)ZnCl3] (I). The yield was 78.8 mg (79.3%). IR (nu, cm-1): 3356 nu(OH), 3074 nu(CHar), 2971nu(CHaliph). For C20H25N2O2Cl3Zn anal. calcd., % C, 48.32 H, 5.07 N, 5.63Found, % C, 48.24 H, 5.02 N, 5.59, 130-95-0

The synthetic route of 130-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gu; Jia; Zhang; Russian Journal of Coordination Chemistry; vol. 44; 1; (2018); p. 52 – 58; Koord. Khim.; vol. 44; 1; (2018); p. 52 – 58,7;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

348-67-4, H-D-Met-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step (1): To a 2 L four-necked flask was added 153.10 g of D-methionine, 420 g of water, 200 mL of methanol and 158.21 g of diethyl sulfate, and the mixture was stirred at room temperature, and 45 g of concentrated sulfuric acid After the end of heating to 30 ~ 40 , 10h, the recovery of methanol under reduced pressure.After the reaction with anhydrous sodium carbonate solid to adjust the pH to 8 ~ 9, continue 40 reaction 10h.After the reaction is over,The solvent was distilled off under reduced pressure.

348-67-4, 348-67-4 H-D-Met-OH 84815, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Anhui Zhishan New Materials Co., Ltd.; Wei Kaiju; Ren Mingxiu; Cui Yang; Chen Zhongming; Xie Yineng; (9 pag.)CN106928110; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

92149-07-0,92149-07-0, 4,7-Dimethoxy-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under an argon atmosphere, add anhydrous Fe(acac)2 (127.0mg, 0.5mmol) to a 50mL Schlenk flask, and dissolve it in 6mL of anhydrous ethanol at 60 C; Then, a solution of 4,7-dimethoxy-1,10-phenanthroline (120 mg, 0.5 mmol) in ethanol (4 mL) was added dropwise to the system. The reaction was carried out at 60 C for half an hour, and then returned to room temperature and stirred overnight. The filtrate was collected by filtration, concentrated, washed twice with cold ethanol, and dried under vacuum for 12 h to obtain a dark brown solid product 17, with a yield of 60%.

The synthetic route of 92149-07-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Wang Qinggang; Wang Liang; Zhu Guangqian; Zhang Xianhui; Jing Chuyang; (29 pag.)CN110452272; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.55 parts by mass of 4-methoxythioanisole, 1.95parts by mass of silver borofluoride, 1.77 parts by mass of 1 -chloromethyl naphthalene, and 10.0 parts by mass of acetone were uniformly mixed and reacted at 25 C. for 24 hours. Afier removal of silver chloride, the reaction solution was transferred to a rotary evaporator, and the solvent was distilled off. The obtained residue was reprecipitated with 10.0 parts by mass of acetone and 10.0 parts by mass of hexane. 3.44 parts by mass of the obtained precipitate, 1.56 parts by mass of lithium trifluoromethanesulfonate, and 10.0 parts by mass of acetone were uniformly mixed and reacted at 25C. for 24 hours. 10.0 parts by mass of distilled water were added to the reaction solution to wash the product. The solvent was distilled off under reduced pressure from the organic layer to obtain 3.87 parts by mass of compound 23. The ratio of the mass of the compound B to the total mass of the compound B and the compound A was 0.965. The yield with respect to 4-methoxythioanisole was 87%. The mass of the compound B was 3.73 g, and the mass of the compoundA was0.14g., 33454-82-9

The synthetic route of 33454-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASAHI KASEI E-MATERIALS CORPORATION; SHIMURA, Tadashi; KAMIMURA, Naoya; OTANI, Akira; SHIMADA, Hitoshi; (69 pag.)US2016/229801; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI