Catalyst ligands

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of compounds (1.5 mg) in 6 M HCl (1 ml) was heated to 120 C for 24 h. The solution was then evaporated to dryness and the residue redissolved in H2O (100 mul) and was then placed in a 1 ml reaction vial and treated with a 2% solution of FDAA (200 mul) in acetone followed by 1.0 M NaHCO3 (40 mul). The reaction mixture was heated at 47 C for 1 h, cooled to room temperature, and then acidified with 2.0 M HCl (20 mul). In a similar fashion, standard D- and L-amino acids were derivatized separately. The derivatives of the hydrolysates and standard amino acids were subjected to analytical HPLC analysis (Shimadzu LC-20AD, C18 column; 5 mum, 4.6 mm ¡Á 250 mm; 1.0 ml/min) at 30 C using the following gradient program: solvent A, water + 0.2% TFA; solvent B, MeCN; linear gradient 0 min 25% B, 40 min 60% B, 45 min 100% B; UV detection at 340 nm [39]., 153-94-6

As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.

Reference£º
Article; Nishanth Kumar; Mohandas; Nambisan, Bala; Peptides; vol. 53; (2014); p. 48 – 58;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

53344-72-2,53344-72-2, 6,6′-Dichloro-2,2′-bipyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried Schlenk flask was evacuated and back-filled with argon three times. (Hetero)aryl (di)halide (1 equiv), base (1.5 equiv per halogen) and a solution of SPO (1.2 equiv per halogen) in anhydrous solvent (5 mL/mmol per halogen) were added to the flask. The solution was bubbled with argon for 10 min and Pd(OAc)2 (1 mol% per halogen) and ferrocene-based bidentate phosphine ligand (2 mol% per halogen) were added to the flask simultaneously [2.5 mol% Pd(OAc)2 per halogen and 5 mol% dppf per halogen for compounds 2j, 2l, 2r, 2t, 2w]. The resulting mixture was heated at the indicated temperature for the given time. Workup procedures are described below for two different conditions. Final purification of crude products was achieved by column chromatography on silica gel (40-60 mum) using CH2Cl2-MeOH as eluent. Reaction scale and yields are shown in Table 1 (2a-w), Scheme 1 (3a-h) and Scheme 2 (4a-g). Notice that all compounds with two phosphine oxide groups are beige-to-brown solids or slowly solidifying viscous brown oils. Conditions I: ligand: dppf, solvent: DMF, base: Cs2CO3 (2d-n, 2q, 2r, 2t-w, 4a-g) or K2CO3 (3a-h), temperature: 120 C, time: 7 h (20 h for 2j, 2l, 2r, 2w). Workup: after cooling, the reaction mixture was poured into a fourfold excess of brine. The mixture was extracted three times with CH2Cl2 (40 mL/mmol each). The combined organic layers were washed with brine to remove traces of DMF, dried over Na2SO4 and then evaporated to dryness. Conditions II: ligand: dippf, solvent: toluene, base: t-BuOK, temperature: 110 C, time: 7 h. Workup: after cooling, the reaction mixture was evaporated to dryness. Then, the mixture was diluted with CH2Cl2 (40 mL/mmol) and washed with water and brine (40 mL/mmol). The organic layer was dried over Na2SO4 and the CH2Cl2 was removed under reduced pressure.

As the paragraph descriping shows that 53344-72-2 is playing an increasingly important role.

Reference£º
Article; Zakirova, Gladis G.; Mladentsev, Dmitrii Yu.; Borisova, Nataliya E.; Synthesis; vol. 51; 11; (2019); p. 2379 – 2386;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

General procedure: To a solution of amine or its hydrochloride salt (1.0 mmol) in MeOH (7 mL) K2CO3(1.0 mmol for morpholine and aniline, 2.0 mmol for benzylamine and propargylamine, 3.0 mmol for valine methyl ester hydrochloride and tacd, 4.0 mmol for cyclam, 6.0 mmol for tacn tryhydrochloride) was added and the mixture was stirred for 30 min. Then alpha-halohydrazone (1.0 mmol for morpholine and aniline, 2.0 mmol for benzylamine, propargylamine and valine methyl ester hydrochloride, 3.1 mmol for tacn and tacd or 4.2 mmol for cyclam) was added in one portion with vigorous stirring. The reaction mixture was stirred for 1 h and evaporated in vacuo.Water (50 mL) was added to the residue and further purification was performed as following:For products 2a-d, 3-9: The precipitate was filtered off and washed with appropriate solvent (water for 2a-c, MeOH for 7-9, Et2O for 3-6, acetone for 2d) and dried with air.For products 2f,g: EtOAc (50 mL) was added, the organic extract was separated, washed with brine (50 mL), dried with Na2SO4and evaporated. The residue was purified by column chromatography on silica gel (hexane-EtOAc (5:1) ? EtOAc) to give products 2fand 2g.

4730-54-5, As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.

Reference£º
Article; Semakin, Artem N.; Kokuev, Aleksandr O.; Nelyubina, Yulia V.; Sukhorukov, Alexey Yu.; Zhmurov, Petr A.; Ioffe, Sema L.; Tartakovsky, Vladimir A.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2471 – 2477;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [(C^N)2Ir(mu-Cl)]2 (small excess) and N^N ligand in CH2Cl2/CH3OH (20/4 mL) were stirred overnight at 40 C to give yellow/orange solution. It was evaporated. The residue was purified by column chromatography (silica, 20-25 g). Elution with 2.0-4.0% CH3OH in CH2Cl2 removed the impurities. Elution with 4.0-5.0% CH3OH in CH2Cl2 recovered the product as yellow or orange fraction. The product was preceded and/or followed by coloured/luminescent impurity fractions. The desired fractions were evaporated. The product was dissolved in CH3OH (4 mL), and added drop-wise to a stirred aqueous solution of KPF6 (1-1.3 g, 5.4-7.1 mmol, in 30 mL of water, large excess; Alfa Aesar) in order to convert the complex to a hexafluorophosphate salt. The resulting suspension was stirred for 30 min and filtered. Washed with water and ether. Anal. Calc. for C48H30F12IrN4P (MW 1113.95): C, 51.75; H, 2.71; N, 5.03. Found: C, 52.07; H, 2.84; N, 4.66%

1662-01-7, The synthetic route of 1662-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shavaleev, Nail M.; Scopelliti, Rosario; Graetzel, Michael; Nazeeruddin, Mohammad K.; Inorganica Chimica Acta; vol. 396; (2013); p. 17 – 20;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of the corresponding bis(isatin) 1-8 (5 mmol) and Girard?s reagent (2.5 mmol) in 7 mL of absolute ethanol were added three drops of trifluoroacetic acid. The reaction mixture was refluxed for 2 h. After spontaneous cooling of the solution to room temperature, the formed precipitate was filtered off, washed with absolute diethyl ether and dried in vacuum (12 mmHg)., 1126-58-5

The synthetic route of 1126-58-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bogdanov; Zaripova; Mustafina; Voloshina; Sapunova; Kulik; Mironov; Russian Journal of General Chemistry; vol. 89; 7; (2019); p. 1368 – 1376; Zh. Obshch. Khim.; vol. 89; 7; (2019); p. 1004 – 1012,9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62937-45-5, Example 66; 1-f5-4- (2-Methoxv- (1 R)-methvl-ethoxv)-phenyll-4- (6-methoxy-pyridin-3-vl)-4H- f . 2, 41triazol-3-vlmethvlLpyrrolidine- (2R)-carboxylic acid amide; A mixture of the product of preparation 62 (100mg, 0. 26mol), L-prolinamide (44mg, 0. 39mmol) and potassium carbonate (72mg, 0. 51mmol) were stirred in acetonitrile (10mi), for 18 hours at room temperature, and for 6 hours at 45C. The solvent was then evaporated under reduced pressure and the residue was taken up in ethyl acetate and washed with water and brine. The organic phase was dried over sodium sulfate, concentrated in vacuo, and purified by column chromatography on silica gel, eluting with dichloromethane : methanol : 0.88 ammonia, 98: 2: 0.2, to yield the title compound, 24mg. ‘H NMR (CDC13, 400MHz) d : 1.30 (d, 3H), 1.80 (m, 2H), 2.20 (t, 1H), 2.60 (m, 1H), 3. 10 (t, 1H), 3.20 (m, 1H) 3.40 (s, 3H), 3.50 (m, 1H), 3.60 (m, 1H), 3.80 (d, 1H), 3.90 (d, 1H) 4.00 (s, 3H) 4.60 (m, 1H), 5.10 (s, 1H), 6.80 (d, 1H), 6.90 (d, 2H), 7.30 (d, 2H), 7.40 (d, 1H), 8. 10 (s, 1 H). MS APCI+ m/z 467 [MH] +

62937-45-5 D-Prolinamide 447554, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/82866; (2005); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.294-90-6,1,4,7,10-Tetraazacyclododecane,as a common compound, the synthetic route is as follows.

To a suspension of cyclen (500 g, 29 rnrnol) and sodium acetate (7.86 g, 96 mrnol) in N,N-dirnethylacetarnide (DMA, 60 rnL) at 2O C was added a solution of t-butyl bromoacetate (18.7 g, 14.1 mL, 96 mmol) in DMA (20 rnL) dropwise over a period of 0.5 h. The temperature was maintained at -20 C during the addition, after which the reaction mixture was allowed to come to room temperature. After 24 h of vigorous stirring, thereaction mixture was poured into water (300 rnL) to give a clear solution. Solid KHCO3 (15 g, 150 rnrnol) was added portion wise, and 4 precipitated as a white solid. The precipitate was collected by filtration and dissolved in CHCI3 (250 mL). The solution was washed with water (100 mL), dried (MgSO4), filtered, and concentrated to about 2O3O tnL. Ether (250 mE) was added, after which HHY-330 crystallized as a white fluffy solid.Yield: 12.5 g (73%). ESI-MS found: [M+Ht = 515.5 (Moore, D. A. Org. Synth. 2008, 85,1O-14).

294-90-6, The synthetic route of 294-90-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI; EUROPEAN MOLECULAR BIOLOGY LABORATORY; HU, Hai-Yu; NAZARE, Marc; HAN LIM, Ngee; DING-PFENNIGDORFF, Danping; PLETTENBURG, Oliver; RITZELER, olaf; JURETSCHKE, Hans-Paul; SAAS, Joachim; BARTNIK, Eckart; FLORIAN, Peter; WENDT, Ulrich; SCHULTZ, Carsten; NAGASE, Hideaki; WO2015/75699; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4733-39-5, 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4733-39-5

Synthesis of the hexafluorophosphate salt of the ruthenium complexes 1-6 and 8 The ruthenium complex 1(PF6)2 was synthesized by the following procedure. [Ru(bpy)2Cl2]¡¤ (0.242 g, 0.5 mmol) and phen (0.090 g, 0.5 mmol) were mixed in ethylene glycol (15 ml). After the suspended mixture was refluxed for 7 min in the microwave oven under purging nitrogen atmosphere. The reaction mixture was cooled to room temperature and then the saturated aqueous solution of KPF6 (20 ml) was added. An orange-red product 1 began to precipitate and was collected in 60% yield. Complexes 2, 3, 4, 5, 6, and 8 were synthesized in the similar way. Complex 1¡¤(PF6)2: ESI-MS (in CH3CN, positive): m/z = 738.95 ([M-(PF6)]+ requires 738.61). 297.01 ([M]2+ requires 296.82); Anal. Calcd for RuC32H24N6P2F12: C, 43.50; H, 2.74; N, 9.51; Found: C, 43.02; H, 3.29; N, 9.40; 1H NMR (400 MHz, CD3CN): delta 7.20 (dd, 1H, J = 5.6 Hz and 6.8 Hz), 7.43 (dd, 1H, J = 6.4 Hz and 6.8 Hz), 7.52 (d, 1H, J = 5.2 Hz), 7.72 (dd, 1H, J = 4.8 Hz and 3.2 Hz), 7.83 (d, 1H, J = 5.6 Hz), 7.97 (dd, 1H, J = 7.6 Hz and 8.0 Hz), 8.07 (d, 1H, J = 5.2 Hz), 8.09 (d, 1H, J = 8.0 Hz), 8.23 (s, 1H), 8.47 (d, 1H, J = 8.0 Hz), 8.51 (d, 1H, J = 8.0 Hz), 8.60 (d, 1H, J = 8.4 Hz).

As the paragraph descriping shows that 4733-39-5 is playing an increasingly important role.

Reference£º
Article; Yoshikawa, Naokazu; Yamabe, Shinichi; Sakaki, Shigeyoshi; Kanehisa, Nobuko; Inoue, Tsuyoshi; Takashima, Hiroshi; Journal of Molecular Structure; vol. 1094; (2015); p. 98 – 108;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7089-68-1, 2-Chloro-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7089-68-1, 2-(1H-Imidazol-1-yl)-1,10-phenanthroline was prepared according to the followingmethod. 2-Chloro-1,10-phenanthroline (4.29 g, 0.02 mol) and imidazole (1.63 g,0.024 mol) were dissolved with 100 mL of DMF and potassium carbonate (4.16 g, 0.030 mol) was added into the solution. After the reactants were refluxed for 72 h at110 ¡ãC, the solvent was removed by reduced pressure distillation. The pale yellow sediment appeared after 30 mL iced water was added into the remains and fully stirred.The pale yellow solid 2-(1H-imidazol-1-yl)-1,10-phenanthroline (4.5 g, yield: 91.8percent) was obtained after the sediment was washed with iced water until the pH value of the filtratewas 7. IR (cm-1): 3086 (w), 1593 (m), 1471 (vs), 1400 (m), 1295 (m), 1229 (m),1153 (m), 1049 (m), 973 (m), 820 (s), 765 (s), 726 (m), 648 (m); 1H NMR (300 MHz,CDCl3): 9.19?9.20 (m, 1H), 8.65 (s, 1H), 8.37?8.40 (d, 1H), 8.26?8.29 (d, 1H), 8.03 (s, 1H),7.73?7.81 (m, 5H); HRMS (ESI): C15H10N4 for MH, calculated 247.0984, found247.0985; Elemental Anal. Calcd for C15H10N4 (FW 246.0905): C, 73.20; H, 4.10; N,22.77percent. Found: C, 73.46; H, 4.25; N, 23.08percent.

7089-68-1 2-Chloro-1,10-phenanthroline 355193, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Zheng, Lu-Yi; Chi, Yan-Hui; Liang, Yuan; Cottrill, Ethan; Pan, Ning; Shi, Jing-Min; Journal of Coordination Chemistry; vol. 71; 23; (2018); p. 3947 – 3954;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56-54-2,(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol,as a common compound, the synthetic route is as follows.,56-54-2

General procedure: (Part 1) To a stirred solution of Cinchona alkaloid (either Quinine, Quinidine, Cinchonine or Cinchonidine) (1 equiv.) in THF (0.1 M) was added the required arylmethyl halide compound (1.2 equiv.) at room temperature. The reaction mixture was refluxed overnight, cooled to room temperature and all volatiles were removed invacuo. The residue was then dissolved in CH2Cl2 (typically 2 mL for 1 mmol of starting material) and the resulting solution was added dropwise onto Et2O (typically 30 mL for 1 mmol of starting material) with vigorous stirring. The resulting precipitate was then filtered, washed thoroughly with Et2O, and further dried under high vacuum for 2 hours, yielding the intermediate alcohol product in an excellent yield. (Part2) This product (1 equiv.) was dissolved in CH2Cl2 (0.2 M). Methyl iodide (3 equiv.) and an aqueous sodium hydroxide solution (50 %w, 5 equiv.) were successively added at room temperature. The reaction mixturewas stirred at room temperature for 4 h, before water (typically 20 mL for 1 mmol of starting material) was added to quench the reaction. The organic layer was separated and the aqueous layer was extracted with CH2Cl2. The combined organic extracts were dried over Na2SO4, and concentrated in vacuo (N.B: washing with brine is prohibited to avoid the I/Cl anion exchange). Purification by column chromatography on silica gel, eluting with MeOH/Acetone/CH2Cl2 (0:10:90 to 10:10:90), afforded the desired Cinchona alkaloid quaternary ammonium salt in a moderate to excellent yield.

The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Antien, Kevin; Viault, Guillaume; Pouysegu, Laurent; Peixoto, Philippe A.; Quideau, Stephane; Tetrahedron; vol. 73; 26; (2017); p. 3684 – 3690;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI