Catalyst ligands

13465-09-3, Indium(III) bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step G: tert-Butyl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)-5-methylpyridin-2-yl)-3-(3-(difluoromethyl)-8-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-2,2-dimethylpropanoate. InBr3 (501 mg, 1.41 mmol) was added to a solution of 7-((6-(((tert-butyldimethylsilyl)oxy)methyl)-5-methylpyridin-2-yl)chloromethyl)-3-(difluoromethyl)-8-methyl-[1,2,4]triazolo[4,3-a]pyridine (2.2 g, 4.7 mmol), ((1-(tert-butoxy)-2-methylprop-1-en-1-yl)oxy)trimethylsilane (10.2 g, 47.1 mmol), and dichloromethane (40 mL) under N2. The resultant mixture was stirred at room-temperature for 5 days, poured it into water (30 mL) and extracted with dichloromethane (3*). These extractions resulted in several fractions that were combined, washed with brine (30 mL), dried over anhydrous Na2SO4, filtered, and concentrated to dryness under reduced pressure. The residue was purified by flash chromatography (eluent:petroleum ether/ethyl acetate; 1:0 to 3:2, gradient) to afford the title compound (1.3 g, 48%), which was used in the next step without further purification. MS (ESI): mass calcd. for C30H44F2N4O3S 574.3 m/z found 575.3 [M+H]+., 13465-09-3

13465-09-3 Indium(III) bromide 167051, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Janssen Pharmaceutica NV; Barbay, J. Kent; Chai, Wenying; Hirst, Gavin C.; Kreutter, Kevin D.; Kummer, David A.; McClure, Kelly J.; Nishimura, Rachel T.; Shih, Amy Y.; Venable, Jennifer D.; Venkatesan, Hariharan; Wei, Jianmei; (501 pag.)US2020/55874; (2020); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170161-27-0,Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate,as a common compound, the synthetic route is as follows.

To a solution of tri-Boc cyclam S7 (3.80 g, 7.59 mmol) in anhydrous CH3CN (160 mL) were added Na2CO3 (0.956 g, 9.10 mmol) and ethyl bromoacetate (1.00 mL, 9.02 mmol). The reaction mixture was stirred at reflux under Ar overnight. The insoluble salts were filtered, and the filtrate was concentrated under reduced pressure. The residuewas purified by flash column chromatography (silica gel, EtOAc:hexane = 1:2 rampingto 1:1) to give S9 as a white foam (4.06 g, 91%). RF (EtOAc:hexane = 1:1) 0.67. IRvmax/cm 2974, 2933, 2869, 1737, 1685, 1465, 1411, 1366, 1292, 1240, 1154, 1032,772, 731. 1H NMR (300 MHz, CDCI3) 5 1.26 (t, 3H, J 7.2, COOCH2CH3), 1 .46 (5, 27H, 3 C(CH3)3), 1.60-1.78 (m, 2H, CH2CH2CH2), 1.85-2.00 (m, 2H, CH2CH2CH2), 2.60-2.72(m, 2H, CH2N(CH2COOCH2CH3)CH2), 2.80-2.90 (m, 2H, CH2N(CH2COOCH2CH3)CH2),3.22-3.65 (m, 14H, 3 x CH2N(Boc)CH2 & NCH2COOCH2CH3), 4.14 (q, 2H, J 7.2, COOCH2CH3). ?3C NMR (75 MHz, CDCI3) 5 14.2, 27.0, 28.4, 45.2, 46.8, 47.1, 47.3,48.3, 51.8, 52.9, 53.6, 55.3, 60.1, 79.4, 155.4, 155.6, 170.9 (twelve carbon signals overlapping or obscured). MS (ESI) m/z 587.0 ([M+H], 6%), 609.1 ([M+Na], 100%), 1194.9 ([2M+Na], 47%). The spectroscopic data were in agreement with those in the literature.27?28, 170161-27-0

The synthetic route of 170161-27-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE UNIVERSITY OF SYDNEY; RUTLEDGE, Peter; TODD, Matthew; TRICCAS, James Anthony; WO2014/153624; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109073-77-0,[2,2′-Bipyridine]-4,4′-diyldimethanol,as a common compound, the synthetic route is as follows.

This reaction was performed under nitrogen atmosphere using freshly distilled,anhydrous solvents and reagents. Thionyl chloride (1.02 mL,14.0 mmol) was diluted with CH2Cl2 (15 mL) and the solution,cooled to 0 C, was added dropwise via syringe over 2 min to a cold(0 C) solution of lipoic acid (1.94 g, 9.36 mmol) in CH2Cl2 (25 mL).The solution was stirred at 0 C for 1 h, then the ice bath was removedand the solution was allowed to reach room temperature over 1 h. The solvents were removed in vacuo to leave lipoylchloride as a pale brown residue. This was dissolved in toluene (25 mL) and added dropwise over 30 min to a flask charged witha cold (0 C) solution of 3 (200 mg, 0.936 mmol) and Et3N (4.50 mL)in toluene (20 mL). The reaction was stirred overnight. Water(75 mL) was added, resulting in the formation of a brown precipitate.The mixture was filtered, the solid was discarded, and the organic layer was washed with water (250 mL) and dried over anhydrous Na2SO4. The solvent was removed in vacuo, to obtaina yellow crude product. This was purified by column chromatography using neutral alumina and hexane/ethyl acetate (2:1). After the less polar fraction (mostly lipoic acid) was separated, the eluentwas changed to hexane/ethyl acetate (1:4) to collect the fractions with the product. The solvent was removed in vacuo and theproduct was obtained as a yellow solid, 109073-77-0

As the paragraph descriping shows that 109073-77-0 is playing an increasingly important role.

Reference£º
Article; Kopecky, Andrew; Liu, Guangliang; Agushi, Ardian; Agrios, Alexander G.; Galoppini, Elena; Tetrahedron; vol. 70; 36; (2014); p. 6271 – 6275;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-91-5,2,2′-Biquinoline,as a common compound, the synthetic route is as follows.

General procedure: To an aqueous solution of terbium nitrate pentahydrate(1.0 mmol, 0.43 g) added an alcoholic solution of ligandHDPBD (3.2 mmol, 0.63 g) dropwise under vigorous stirringon magnetic stirrer. The pH of the resulting mixturewas adjusted to 6.5 with 0.05 M sodium hydroxide solution,resulting in the formation of white precipitates afterconstant stirring for two hours at a temperature of 50-60 C. The precipitates were filtered out and dried inhot air oven to obtained C1 complex.

119-91-5, 119-91-5 2,2′-Biquinoline 8412, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Bala, Manju; Kumar, Satish; Devi, Rekha; Khatkar, Avni; Taxak; Boora, Priti; Khatkar; Journal of Fluorescence; vol. 28; 3; (2018); p. 775 – 784;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of Tetrabutylphosphonium Tetrafluoroborate:; Tetrabutylphosphonium chloride was added into an aqueous solution with excessive amount of sodium tetrafluoroborate (molar ratio: 1/1.1) and stirred for 24 hours. Then, adequate amount of methylene dichloride was added to extract the product. A mixture of the product and the methylene dichloride was washed with water until no chlorine ion was detected by a silver nitrate solution (0.1 mol/L). A product of tetrabutylphosphonium tetrafluoroborate was obtained after removing methylene dichloride in the product by rotary evaporation and drying., 2304-30-5

The synthetic route of 2304-30-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES; US2011/21846; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (S,S)-diphenylethylenediamine (250 mg, 1.2 mmol) and triethylamine (0.5 ml) in THF is added dropwise a solution of dansyl chloride (318 mg, 1.2 mmol) in THF (2 ml) at 0 C. After stirring 16 h at RT the solvent is removed in vacuum and the residue is resolved in methylenchloride (20 ml). The organic solution is washed with NaHCO3 solution (5 ml), dried over Na2SO4 and after filtration the solvent is removed. Flash chromatographie afford (S,S)-5-dimethylamino-naphthalene-1-sulfonic acid (2-amino-1,2-diphenyl-ethyl)-amide as yellow oil which crystallizes by drying in vacuum. M: 445.59. 1H-NMR (400 MHz, CDCl3):8.36 (t, J=7.5 Hz, 2 H), 8.17 (dd, J=7.2, 1.2 Hz, 1 H), 7.47 (dd, J=8.8 Hz, 1 H), 7.34 (dd, J=8.5 Hz, 1 H), 7.24-7.16 (m, 4 H), 7.11 (d, J=7.5 Hz, 1 H), 6.99-6.74 (m, 6 H), 4.61 (d, J=8.5 Hz, 1 H), 4.20 (d, J=8.5 Hz, 1 H), 2.80 (s, 6 H).

29841-69-8, 29841-69-8 (1S,2S)-(-)-1,2-Diphenylethylenediamine 6931238, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Bilbe, Graeme; Cryan, John F.; Gentsch, Conrad; McAllister, Kevin Hall; Schmutz, Markus; Vassout, Annick; US2006/194791; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 2.21 g (10 mmol) 1-methylpyrrolidinium-l-butanesulfonate obtained in the example 2 was put in methanol, added with a solution obtained by dissolving lithium triflate 1.56 g (10 mmol) in methanol and then stirred for 12 hours. After that, the mixture solution was filtered and washed with methanol for several times and then dried, thereby providing triflate lithium 1-methylpyrrolidinium-1-butanesulfonate with 96% yields which was white solids of zwitterions.

33454-82-9, As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Patent; Korea Institute of Science and Technology; WO2006/104305; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

130-95-0, Quinine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

QN (quinine) 3.24 g (10 mmol) and sodium hydride 0.80 g (200 mmol, respectively) were weighed.2 times equivalent) was added to a three-neck reaction flask. In addition, the air is replaced by argon gas.After replacement, 30 mL of anhydrous tetrahydrofuran (anhydrous) was added under ice bath and argon protection.DMF), after stirring for 1 hour, slowly add dropwise.Add 1.5 mL of benzyl chloride (13 mmol; 1.3 equivalents) and stir while stirring.After the addition is complete, remove the ice bath. After reacting at room temperature for 6 hours, after the reaction is completed,Quenched with saturated ammonium chloride, extracted with ethyl acetate and extracted three times.The upper organic layer was collected, washed twice with water, and once with saturated brine.Dry over anhydrous sodium sulfate, filter, concentrate,Drying gave 3.93 g of a milky white solid 2a in a yield of 95%.

130-95-0, 130-95-0 Quinine 3034034, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Xinxiang Medical University; Wang Yakun; Zhang Tao; Zhang Jixia; Liu Yufei; Li Guowei; Li Nan; (14 pag.)CN108947998; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a three-necked flask equipped with a mechanical stirrer,Add anhydrous methanol 600 mL,D-tryptophan (102.1 g, 500 mmol), Room temperature stirring, using ice salt bath,The temperature of the reaction system was reduced to 0 C,A solution of thionyl chloride (71.4 g, 600 mmol)After the dropwise addition, the temperature was raised to room temperature for about 12 hours.Thin layer chromatography monitoring, when the raw material reaction is complete,Stop the reaction.After atmospheric distillation of most of the remaining thionyl chloride and methanol,Decompression in addition to thionyl chloride and methanol, cooling,To give the hydrochloride of solid tryptophan methyl ester (Isolated from air) can be used directly in the next step., 153-94-6

The synthetic route of 153-94-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Xi hua University; Yang, Weiqing; Li, Hongyang; Wang, Huizhen; (18 pag.)CN106432237; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5350-41-4,N,N,N-Trimethyl-1-phenylmethanaminium bromide,as a common compound, the synthetic route is as follows.

5350-41-4, General procedure: The desired amount of substrate, boronic acid (3 equiv), base (3equiv), Pd(OAc)2 (2.5 molpercent) and ligand (5 molpercent) were weighed out as solids, the vial was sealed and purged with argon, then solvent was added and the vial was purged again. The reactions were run for 14 h at the specified temperature. The crude material was filtered through a pad of Celite and washed three times with CHCl3. The solvent was removed under reduced pressure, an internal standard was added and the reaction was analysed by 1H NMR spectroscopy. For purification, the analysed mixture was concentrated, the product extracted with Et2O and filtered through anhydrous MgSO4 and further purified by flash column chromatography.

5350-41-4 N,N,N-Trimethyl-1-phenylmethanaminium bromide 21449, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Tuertscher, Paul L.; Davis, Holly J.; Phipps, Robert J.; Synthesis; vol. 50; 4; (2018); p. 793 – 803;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI