Catalyst ligands

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials, published in 2013-07-25, which mentions a compound: 1184917-16-5, Name is 4-Bromo-2,5-dichloropyridine, Molecular C5H2BrCl2N, Computed Properties of C5H2BrCl2N.

The synthesis, preclin. profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor (I; LDK378) are described. In this initial report, preliminary structure-activity relationships (SARs) are described as well as the rational design strategy employed to overcome the development deficiencies of the first generation ALK inhibitor (II; TAE684). Compound I is currently in phase 1 and phase 2 clin. trials with substantial antitumor activity being observed in ALK-pos. cancer patients.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 89972-77-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Phenyl-substituted 2,2′:6′,2”-terpyridine as a new series of fluorescent compounds-their photophysical properties and fluorescence tuning. Author is Mutai, Toshiki; Cheon, Jin-Dong; Arita, Shinpei; Araki, Koji.

Several phenyl-substituted 2,2′:6′,2”-terpyridines (tpy) were synthesized and it was found that 4′-Ph tpy (I) exhibited the most effective fluorescence, whose quantum yield was up to 0.64 in cyclohexane. For further study on tuning the fluorescence properties, different substituents were introduced into the p-position of the Ph group. While some dyes showed their absorption and fluorescence in the same region as I, others were observed at much longer wavelengths. In addition, fluorescence maxima of some of the dyes showed a large (>130 nm) solvent dependence. The difference between ground and excited state dipole moments (Δμ) for one dye was estimated to be 15.2 D by the Lippert-Mataga equation, indicating an intramol. charge transfer (ICT) process. Semi-empirical MO calculation (MOPAC/AM1) demonstrated that the HOMO-1, HOMO, and LUMO of I and several other dyes were mainly localized on the Ph (πph), tpy (πtpy) and tpy (π*tpy) part, resp., indicating that the lowest energy absorption band of these dyes was the local excitation (πtpy-π*tpy). In the case of dyes having an electron-donating substituent, πph instead of πtpy became the HOMO. Thus, the lowest energy absorption these dyes was an ICT transition (πph-π*tpy), and a large red shift of the fluorescence occurred. In these compounds, the energy level of πph is controlled without affecting that of πtpy and π*tpy, suggesting a novel approach for tuning the color of fluorescence.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of C11H21BrO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Modulating electron transfer in ferrocene-naphthoquinone dyads: New insights in parameters influencing ET efficiency. Author is Sabuzi, Federica; Coletti, Alessia; Pomarico, Giuseppe; Floris, Barbara; Galloni, Pierluca; Conte, Valeria.

Electron transfer (ET) constitutes a key process for several biol. transformations, including solar energy conversion in bacteria and plants. Nowadays, numerous synthetic systems have been proposed to mimic such kind of natural occurring process. In this work, we elucidate the factors that mostly influence the electron transfer process in ferrocene-naphthoquinone dyads. In particular, the connection between the two redox units has been varied, in order to study the ET dependence from: (i) the distance between donor-acceptor units and (ii) the oxidation potential of the donor species. No interaction among the two moieties has been detected at the ground state, while efficient electron transfer process was observed following excitation of the naphthoquinone through UV-light, as well as upon the aid of a Lewis acid promoter in solution Moreover, DFT calculations have been performed to support the exptl. data.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C5H8O3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about An alternative synthesis of (S)-(+)-γ-hydroxymethyl-γ-butyrolactone from (D)-(+)-mannitol. Author is Takano, Seiichi; Goto, Emiko; Hirama, Michiyasu; Ogasawara, Kunio.

Dioxolane I (R = iodo), obtainable from D-mannitol in 5 steps, was treated with di-Et malonate in DMF in the presence of NaH to give 62.7% I [R = CH(CO2Et)2], which on treatment with equimolar amount of MgCl2 in refluxing AcNMe2 gave 95% title lactone II of excellent optical purity.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called DNA binding properties of novel cytotoxic gold(III) complexes of terpyridine ligands: the impact of steric and electrostatic effects, published in 2006-09-30, which mentions a compound: 89972-77-0, mainly applied to gold terpyridine functionalized preparation antitumor activity DNA binding; steric effect DNA binding gold complex functionalized terpyridine, Formula: C22H17N3.

Four Au(III) complexes of terpyridine derivatives In+ (R = H, 2-naphthyloxy, n = 2; R = PPh3, n = 3; R = NHCH2CH2SO3Na, n = 2) were synthesized and characterized by spectroscopic methods. In vitro data demonstrated that all of them showed higher cytotoxicity than cisplatin against the human nonsmall-cell lung cancer cell line (A-549), the human stomach carcinoma cell line (SGC-7901), the human cervix carcinoma cell line (HELA), the human colon carcinoma cell line (HCT-116), the human liver carcinoma cell line (BEL-7402), the murine leukemia cell line (P-388) and the human acute promyelocytic leukemia cell line (HL-60). Complex I (R = PPh3) exhibits the highest activity, with growth inhibition rates of over 80% at 10-8 mol L-1 against the A-549, HCT-116 and HELA tumor cell lines. The free ligands are also very cytotoxic against the cell lines tested. Complexes I are stable in aqueous solution for 2 days in the presence of the biol. reducing agent glutathione. The inductively coupled plasma mass spectrometry data showed that DNA isolated from cells treated with complexes I (R = H, PPh3) contained Au with Au-to-nucleotide ratios of ∼1:6,400 and 1:4,900, resp. Fluorescence titration, UV and CD analyses proved that the steric and electrostatic effects of the ligand remarkably influence the interactions of their Au(III) complexes with DNA. The DNA binding ability of the complexes was correlated with their cytotoxicity, which could potentially provide a new rationale for the future design of terpyridine-based metal complexes with antitumor potential.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of 4-(p-Tolyl)-2,2:6,2-terpyridine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Self-assembly of nanocrystalline tetra-terpyridine complexes: from molecules to mesoscopic objects.

We report the properties of a shape-persistent tetra-terpyridine ligand whose coordination to transition metal ions guides its three-dimensional self-assembly in two steps: at first, nanoscale objects form, which with time, self-assemble into micrometer structures. This work highlights the potential for control of the mol. self-assembly of mols. on the nanoscale, and the successive self-assembly of the formed supramol. nanosystems to yield mesoscopic objects.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 89972-77-0, is researched, SMILESS is CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1, Molecular C22H17N3Journal, Crystal Growth & Design called Unusual 2D → 3D Polycatenane Frameworks Based on 1D → 2D Interdigitated Layers: From Single Crystals to Submicrometer Fibers with Enhanced UV Photocatalytic Degradation Performances, Author is Guo, Jiao; Ma, Jian-Fang; Li, Jun-Jie; Yang, Jin; Xing, Shuang-Xi, the main research direction is crystal structure cobalt manganese zinc cadmium tolylterpyridine tetracarboxylate; transition metal terpyridine carboxylate MOF preparation photocatalytic activity; methylene blue photocatalytic degradation catalyzed transition metal tolylterpyridine tetracarboxylate.HPLC of Formula: 89972-77-0.

Four unusual isomorphous metal-organic frameworks, [M2(L1)(L2)2] (M = Co for 1, Mn for 2, Zn for 3, and Cd for 4), where H4L1 = tetrakis[4-(carboxyphenyl)-oxamethyl]methane acid and L2 = 4-tolyl-2,2′:6′,2”-terpyridine, were synthesized under hydrothermal conditions. Their structures were determined by single-crystal x-ray diffraction analyses and further characterized by IR spectra, elemental analyses, powder X-ray diffraction, UV-visible absorption spectra, and optical energy gaps. In 1-4, the metal atoms are linked by the L1 anions to yield a chain with a loop. Every loop of each chain is penetrated by two L2 ligand rods from the two nearest chains, resulting in an unusual 1-dimensional → 2-dimensional interdigitated network. In the 2-dimensional interdigitated network, there exist weak π-π interactions between pyridyl groups of L2 ligands. If the π-π interactions are regarded as linkers, the 2-dimensional interdigitated network belongs to an uneven (3,4)-connected layer. Also, each individual (3,4)-connected layer is polycatenated with an infinite number of other perpendicular layers, yielding an unusual 2-dimensional → 3-dimensional polycatenane framework. The luminescent properties of compounds 3 and 4 were studied. Compounds 1-4 exhibit photocatalytic activities for MB degradation under UV irradiation Submicrometer fiber 1′ shows high photocatalytic efficiency for MB degradation with respect to its corresponding macroscaled crystalline 1.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Okabe, Masami; Sun, Ruen Chu; Tam, Steve Y. K.; Todaro, Louis J.; Coffen, David L. published the article 《Synthesis of the dideoxynucleosides “”ddC”” and “”CNT”” from glutamic acid, ribonolactone, and pyrimidine bases》. Keywords: dideoxycytidine; cytidine dideoxy; deoxycyanothymidine; thymidine deoxycyano; crystal structure cyanohydroxymethyltetrahydrofuranone; mol structure cyanohydroxymethyltetrahydrofuranone.They researched the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6 ).Recommanded Product: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:32780-06-6) here.

2,3-Dideoxyribose in suitably protected form was prepared from L-glutamic acid and coupled with silylated cytosine to give a mixture of the α- and β-anomers of 2′,3′-dideoxycytidine. The anomer ratio depended on the Lewis acid used in the coupling, with EtAlCl2 favoring the β-anomer ddC (I), a potent anti-HIV drug. Conjugate addition of cyanide to a 4-[(silyloxy)methyl]butenolide prepared from D-ribonolactone gave a mixture of (racemic) α- and β-3-cyanobutyrolactones. Both isomers were reduced to lactols and coupled with thymine to give α/β-anomer pairs. The α-cyano lactone, the structure of which was established by x-ray crystallog. of II, afforded an authentic sample of the putative (but in fact inactive) anti-HIV substance known in AIDS research as CNT (III).

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kawamoto, Naoki; Hu, Yongxing; Kuwahara, Yutaka; Ihara, Hirotaka; Takafuji, Makoto researched the compound: 11-Bromoundecanoic acid( cas:2834-05-1 ).Product Details of 2834-05-1.They published the article 《A molecular shape recognitive HPLC stationary phase based on a highly ordered amphiphilic glutamide molecular gel》 about this compound( cas:2834-05-1 ) in Nanomaterials. Keywords: amphiphilic glutamide mol gel shape HPLC stationary phase; high performance liquid chromatography (HPLC); highly-oriented structure; molecular gels; phenolic compounds; stereo isomers; steroids. We’ll tell you more about this compound (cas:2834-05-1).

Chiral glutamide-derived lipids form self-assembled fibrous mol. gels that can be used as HPLC organic phases. In this study, HPLC separation efficiency was improved through the addition of branched amphiphilic glutamide lipids to the side chains of a terminally immobilized flexible polymer backbone. Poly(4-vinylpyridine) with a trimethoxysilyl group at one end was grafted onto the surface of porous silica particles (Sil-VP15, polymerization degree = 15), and the pyridyl side chains were quaternized with a glutamide lipid having a bromide group (BrG). Elemental anal. indicated that the total amount of the organic phase of the prepared stationary phase (Sil-VPG155) was 38.0 wt%, and the quaternization degree of the pyridyl groups was determined to be 32.5%. Differential scanning calorimetric anal. of a methanol suspension of Sil-VPG15 indicated that the G moieties formed a highly ordered structure below the phase transition temperature even on the silica surface, and the ordered G moieties exhibited a gel-to-liquid crystalline phase transition. Compared with a com. available octadecylated silica column, the Sil-VPG15 stationary phase showed high selectivity toward polycyclic aromatic hydrocarbons, and particularly excellent separations were obtained for geometrical and positional isomers. Sil-VPG15 also showed highly selective separation for phenol derivatives, and bio-related mols. containing phenolic groups such as steroids were successfully separated These separation abilities are probably due to multiple interactions between the elutes and the highly ordered functional groups, such as the pyridinium and amide groups, on the highly ordered mol. gel having self-assembling G moieties.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chen, Jie; He, Xian; Zhang, Xuyan; Chen, Yi; Zhao, Lu; Su, Jiaen; Qu, Shengbin; Ji, Xinwei; Wang, Tao; Li, Zhenjie; He, Chenggang; Zeng, Erqing; Jin, Yan; Lin, Zhonglong; Zou, Congming published an article about the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1 ).Category: catalyst-ligand. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:494-52-0) through the article.

Heated tobacco (Nicotiana tabacum L.) products develop rapidly because of its low toxicity. In order to evaluate the industrial applicability of the existing types of characteristic tobacco as raw materials for heated tobaccos, this research ascertained differences in the main chem. compositions in tobacco leaves from different types to establish a relationship between chem. composition and sensory evaluation to select types suitable for producing heated tobaccos. Nine tobacco types (K326, Yunyan 97, Cherry-red tobacco, Han tobacco, Dao tobacco, Tiandeng tobacco, Sun-cured yellow tobacco, fresh-cut tobacco, and aromatic tobacco) planted in Yunnan Province, China were selected. Their sensory quality was evaluated by the method for sensory evaluation of heated tobaccos and chem. composition and content of aroma substances in tobacco leaves were determined In the evaluation of sensory quality of heated tobaccos, the total score of Tiandeng tobacco was significantly higher than those of the other types, followed by Cherry-red tobacco and K326; There were significant differences in chem. composition in the nine tobacco types and the total alkaloid content in Cherry-red tobacco was notably higher than in the other tobacco types. The amounts of total sugar, reducing sugar, and starch in Han tobacco were significantly lower than other types, while the amounts of total nitrogen, potassium oxide, chloride ions, and protein were much higher than in the other tobacco types. The total amounts of polyphenols and aroma compounds in fresh-cut tobacco were significantly higher than in the other tobacco types. The contents of nornicotine, neonicotine, anatabine, and total alkaloid showed a significant pos. correlation with the total sensory evaluation score. The contents of nicotyrine and 2,3-bipyridine were significantly and neg. correlated with the total sensory evaluation score. A remarkable neg. correlation was found between starch content and score on irritation. Furthermore, the amounts of neochlorogenic acid, chlorogenic acid, caffeic acid, and total polyphenols were significantly and pos. correlated with the total sensory evaluation score. The amounts of aldehydes and phenolic compounds had a significant neg. correlation, while the amount of olefin compounds had a significant pos. correlation, with the total sensory evaluation score. These chems. in tobacco leaves can be used as in analyses screening of other suitable tobacco types, and as reference standards for selecting tobacco raw materials suitable for high-quality heated tobaccos.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI