Synthetic Route of 55515-98-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 55515-98-5, Name is (R)-3,3′-Dimethyl-[1,1′-binaphthalene]-2,2′-diol, molecular formula is C22H18O2. In a Article£¬once mentioned of 55515-98-5
Chiral base-catalyzed aldol reaction of trimethoxysilyl enol ethers: Effect of water as an additive on stereoselectivities
An aldol reaction of trimethoxysilyl enol ether catalyzed by lithium binaphtholate is described. The aldol reaction of trimethoxysilyl enol ether derived from cyclohexanone under anhydrous conditions predominantly afforded the anti-aldol adduct with moderate enantioselectivity, whereas the reaction under aqueous conditions predominantly resulted in the syn-adduct and the enantioselectivity of the syn-adduct was considerably improved. The best enantioselectivity was obtained in the reaction of trimethoxysilyl enol ether derived from 1-indanone with cyclohexanecarboxaldehyde (97% ee (syn)). This is the first example of an aldol reaction of trimethoxysilyl enol ether catalyzed by a chiral base.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 55515-98-5, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 55515-98-5, in my other articles.
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI