Chemistry, like all the natural sciences, Application In Synthesis of H-Pro-OH, begins with the direct observation of nature¡ª in this case, of matter.147-85-3, Name is H-Pro-OH, SMILES is O=C(O)[C@H]1NCCC1, belongs to catalyst-ligand compound. In a document, author is Lou, Shao-Jie, introduce the new discover.
Enantioselective C-H Alkenylation of Ferrocenes with Alkynes by Half-Sandwich Scandium Catalyst
The enantioselective C-H alkenylation of ferrocenes with alkynes is, in principle, a straightforward and atom-efficient route for the construction of planar-chiral ferrocene scaffolds bearing alkene functionality but has remained scarcely explored to date. Here we report for the first time the highly enantioselective C-H alkenylation of quinoline- and pyridine-substituted ferrocenes with alkynes by a half-sandwich scandium catalyst. This protocol features broad substrate scope, high enantioselectivity, and 100% atom efficiency, selectively affording a new family of planar-chiral ferrocenes bearing N/alkene functionalities. The mechanistic details have been clarified by DFT analyses. The use of a quinoline/alkene-functionalized ferrocene product as a chiral ligand for asymmetric catalysis is also demonstrated.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 147-85-3. Application In Synthesis of H-Pro-OH.
Reference:
Metal catalyst and ligand design,
,Ligand Template Strategies for Catalyst Encapsulation – NCBI