Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about First asymmetric total synthesis of (+)-steganacin. Determination of absolute stereochemistry. Author is Tomioka, Kiyoshi; Ishiguro, Tsuneo; Koga, Kenji.
(+)-Steganacin (I) was synthesized stereospecifically in 12 steps using the γ-lactone II as a chiral synthon. The key steps of the reaction were the specific asym. 1,4-addition of the chiral butenolide with lithiated trimethoxybenzaldehyde dithioacetal and the regio- and stereoselective introduction of Ac onto (+)-stegane to give I. The sign of optical rotation of I was opposite to that of natural steganacin, the absolute stereochem. of which was thus determined unequivocally.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI