Because enzymes can increase reaction rates by enormous factors and tend to be very specific, HPLC of Formula: C11H12N2O2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 153-94-6
Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ HPLC of Formula: C11H12N2O2, Which mentioned a new discovery about 153-94-6
Amide Bond Replacements Incorporated into CCK-B Selective “Dipeptoids”
This paper describes the chemical synthesis and CCK-B and CCK-A receptor binding affinities of a series of compounds in which the central amide bond of the CCK-B “dipeptoid” ligand tricyclo<3.3.1.13,7>dec-2-yl–<2<<1-(hydroxymethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>carbamate (4) (CCK-B IC50 = 852 nM), and tricyclo<3.3.1.13,7>dec-2-yl(R)-<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<(2-phenylethyl)amino>ethyl>carbamate (23) (CCK-B IC50 = 32 nM) is replaced by 11 different amide replacements.These replacements are the methyleneamino (CH2NH ), the reverse amide (NHCO), the ester (COO), the N-methylamide (CONMe), the thioamide (CSNH), the N-acetylmethyleneamino (CH2NAc), the cis double bond (CHCH), the ethylene (CH2CH2), the thiolester (COS), the hydroxyethylene (CHOHCH2), and a 4,5-dihydro-1,3-thiazole.Most of the replacements have weaker affinity and reduced selectivity for the CCK-B receptor than the parent amide.However, this affinity can be improved by appending a fumarate side chain to the phenethyl group e.g. tricyclo<3.3.1.13,7>dec-2-yl-3-(1H-indol-3-yl-methyl)-3-methyl-4,9-dioxo-7-phenyl-5,13-dioxa-2,8-diazatetradec-10-enoate (36) (CCK-B IC50 = 38.8 nM).Replacement of the amide of compound 4 with a 4,5-dihydro-1,3-thiazole gives tricyclo<3.3.1.13,7>dec-2-yl-<1-<4,5-dihydro-4-(phenylmethyl)-2-thiazolyl>-2-(1H-indol-3-yl)ethyl>carbamate (5), which is selective for the CCK-A receptor (CCK-A IC50 = 125 nM, CCK-B IC50 = 2580 nM, ratio = 21).The methyleneamino and hydroxyetylene replacements, which have been used elsewhere as transition-state inhibitors of enzymes, are poor mimics of the amide in these CCK-B receptor ligands.Some of the steric, lipophilic, and and hydrogen bonding properties of amide replacements incorporated into the simple amide, N-methylacetamide, have been quantified with the aid of molecular modeling.These data will contribute to the rational selection of amide bond replacements in other substrates.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, HPLC of Formula: C11H12N2O2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 153-94-6
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI