Category: catalyst-ligand

Product Details of 89972-77-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Zn(II) complex of terpyridine for the highly selective fluorescent recognition of pyrophosphate. Author is Liang, Li Jiao; Zhao, Xi Juan; Huang, Cheng Zhi.

Pyrophosphate ion (PPi) is crucial in varieties of biol. processes and industrial applications, and thus it is very important how to recognize it with high selectivity. In this contribution, one terpyridine (tpy)-based fluorescent mol., 4-(methylphenyl)-2,2′:6′,2”-terpyridine (mptpy), was reported to display a highly selective recognition for PPi in the presence of Zn(II). After exposure toward the Zn(II) ion, the characteristic emission of mptpy at 376 nm red shifted to 406 nm with a strong enhancement upon an excitation at 280 nm, and then blue-shifted to 388 nm with the further addition of PPi. After exposure toward the Zn(II) ion, the characteristic emission of mptpy at 376 nm red shifted to 406 nm with a strong enhancement upon an excitation at 280 nm, and then blue-shifted to 388 nm with the further addition of PPi. This process could also discriminate PPi from other inorganic anions. Therefore, a tpy-based fluorescence method for the highly selective recognition of PPi could be developed.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Basic copper carbonate( cas:12069-69-1 ) is researched.Related Products of 12069-69-1.Liu, Lei; Zhu, Menghe; Ma, Zhewen; Xu, Xiaodong; Mohesen Seraji, Seyed; Yu, Bin; Sun, Ziqi; Wang, Hao; Song, Pingan published the article 《A reactive copper-organophosphate-MXene heterostructure enabled antibacterial, self-extinguishing and mechanically robust polymer nanocomposites》 about this compound( cas:12069-69-1 ) in Chemical Engineering Journal (Amsterdam, Netherlands). Keywords: epoxy resin copper phosphate nanoparticle MXene nanocomposite antibacterial. Let’s learn more about this compound (cas:12069-69-1).

The ongoing Covid-19 pandemic has raised the need for urgent antibacterial requirements for many com. important polymers, e.g., Epoxy resins (EPs). Meanwhile, intrinsic flammability and poor impact toughness are two big obstacles that greatly impede the practical applications of EPs. Hence, it has been imperative but highly challenging to create advanced EPs combining satisfactory antibacterial, fire-retardant and mech. robust performances so far. Here, we report a reactive multi-functional heterostructure, copper-organophosphate-MXene (CuP-MXene) by rational design. Our results show that with 5.0% of CuP-MXene, in addition to achieving a high antibacterial efficiency above 99.9%, the resultant EP nanocomposite exhibits satisfactory flame retardancy (UL-94 V-0 rating, peak heat release rate decreased by 64.4%) and improved mech. properties (tensile strength, elastic modulus and impact strength increased by 31.7%, 38.9%, and 25.0%, resp.) relative to virgin EP, outperforming its previous counterparts. Such a desirable performance portfolio arises from multiple synergistic effects between CuP and MXene. This work provides a general strategy for the design of multi-functional nanoadditives and advanced functional polymers, and creates more opportunities for industrial applications of EP in the areas of coatings, medical devices and furniture.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5,6-Dihydro-2H-pyran-2-one, is researched, Molecular C5H6O2, CAS is 3393-45-1, about Photochemical C-H Activation Enables Nickel-Catalyzed Olefin Dicarbofunctionalization, the main research direction is arene preparation; ether alkene aryl halide photochem CH activation nickel catalyst; thioether alkene aryl halide photochem CH activation nickel catalyst.Recommanded Product: 5,6-Dihydro-2H-pyran-2-one.

Herein, the implementation of efficient, sustainable, diaryl ketone hydrogen-atom transfer (HAT) catalysis to activate native C-H bonds for multicomponent dicarbofunctionalization of alkenes was reported. The ability to forge new carbon-carbon bonds between reagents typically viewed as commodity solvents provided a new, more atom-economic outlook for organic synthesis. Through detailed exptl. and computational investigation, the critical effect of hydrogen bonding on the reactivity of this transformation was uncovered.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 149554-29-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-(Piperazin-1-yl)nicotinonitrile, is researched, Molecular C10H12N4, CAS is 149554-29-0, about 1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity. Author is Miller-Moslin, Karen; Peukert, Stefan; Jain, Rishi K.; McEwan, Michael A.; Karki, Rajesh; Llamas, Luis; Yusuff, Naeem; He, Feng; Li, Yanhong; Sun, Yingchuan; Dai, Miao; Perez, Lawrence; Michael, Walter; Sheng, Tao; Lei, Huangshu; Zhang, Rui; Williams, Juliet; Bourret, Aaron; Ramamurthy, Arun; Yuan, Jing; Guo, Ribo; Matsumoto, Melissa; Vattay, Anthony; Maniara, Wieslawa; Amaral, Adam; Dorsch, Marion; Kelleher, Joseph F. III.

Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-mol. inhibitors of this pathway represents a promising route toward novel anticancer therapeutics. A cell-based screen performed in our laboratories identified a new class of Hh pathway inhibitors, 1-amino-4-benzylphthalazines, e.g. I, that act via antagonism of the Smoothened receptor. A variety of analogs were synthesized and their structure-activity relationships determined This optimization resulted in the discovery of high affinity Smoothened antagonists, one of which was further profiled in vivo. This compound displayed a good pharmacokinetic profile and also afforded tumor regression in a genetic mouse model of medulloblastoma.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Name: (S)-3-(Piperidin-2-yl)pyridine. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about A rapid LC-MS/MS method for simultaneous determination of nicotine and its key derivatives including hydroxylation isomers. Author is Shen, Yixiao; Zhang, Ning; Prinyawiwatkul, Witoon; Xu, Zhimin.

A rapid high pressure liquid chromatog. coupled with tandem mass spectrometry method (LC-MS/MS) was developed for simultaneously determining nicotine (NT) and its derivatives including cotinine (CT), trans-3-hydroxycotinine (HC), nornicotine (NNT), anatabine (AT), anabasine (AB) and amino ketone (4-(methylamino)-1-(3-pyridyl)1-butanone) (AK) as well as two important metabolites isomers 2-hydroxynicotine (2-HN) and 6-hydroxynicotine (6-HN) in tobacco leaves. Different from other methods, 2-HN and 6-HN isomers can be successfully separated and quantified through a combination of amide and C18 columns and optimized multiple reaction monitoring mode of tandem mass spectrometry. The limits of detections (LOD) and quantification (LOQ) of these compounds were 0.02 and 0.06 ng/mL for CT and HC, 0.05 and 0.15 ng/mL for AK and 6-HN, and 0.1 and 0.3 ng/mL for AB, NNT, AT, 2-HN and NT, resp. Their recoveries ranged from 86.1% for 2-HN to 102.2% for AK by using solvent extraction assisted with ultrasonication. The developed method was validated through determination of the compounds in different regular and genetically modified (for lowering nicotine) tobacco leaves. Conclusively, it is a robust and rapid method for simultaneous quantification of nicotine and its derivatives in tobacco products. The protocol of the method could also be applied in developing anal. method for tracking the toxic substances synthesis and metabolism in tobacco leaves or other herbal plants.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Chemical Ecology called Bioactivity, synthesis, and chirality of the sex pheromone of currant stem girdler, Janus integer, Author is James, David G.; Petroski, Richard J.; Cosse, Allard A.; Zilkowski, Bruce W.; Bartelt, Robert J., which mentions a compound: 32780-06-6, SMILESS is O=C1O[C@H](CO)CC1, Molecular C5H8O3, Recommanded Product: 32780-06-6.

It was previously reported that females of the currant stem girdler, Janus integer Norton (Hymenoptera: Cephidae), produce a compound, (Z)-9-octadecen-4-olide (I), that is sensitively detected by the antennae of males only. These characteristics suggested a pheromonal function, and this has now been confirmed with behavioral tests. Field tests conducted during two seasons in a com. red currant field showed that synthetic racemic I is attractive to male J. integer under natural conditions. A clear dose-response was evident, with greatest numbers of girdlers caught in sticky traps baited with 10 mg of the pheromone (in rubber septa) and least in traps baited with 1 mg or less. During May 2002, 10, 5, 3, and 1 mg baited traps caught means of 41.4, 26.6, 6.7, and 2.7 males/trap/visit (3-5 day intervals), resp., with a maximum of 229 males caught in a single trap baited with 5 mg. A new synthetic method for racemic I is presented. The absolute configuration of natural I from the male sawflies was determined to be (R). The potential for using the sex pheromone of J. integer to improve management of this currant and gooseberry pest is discussed.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 89972-77-0, is researched, SMILESS is CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1, Molecular C22H17N3Journal, Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry called A two-component co-crystal of Cu(II) complex of p-tolyl-terpyridine, Author is Bhattacharya, Dibyendu, the main research direction is crystal structure copper tolyl terpyridine nitrate complex preparation.Computed Properties of C22H17N3.

A unique two-component co-crystal, [Cu(L)(NO3)2][Cu(L)(NO3)(CH3OH)](NO3)·H2O (L = p-tolyl-terpyridine) has been prepared in (1:1) water-methanol medium at room temperature and characterized by single-crystal x-ray diffraction anal. The compound crystallizes in the triclinic system (space group P1̅). The structure consists of two mononuclear Cu(II) moieties, one cationic and another neutral. In the asym. unit, one Cu(II) center furnishes a five-coordinated distorted square pyramidal geometry (CuN3O2), organized by three nitrogens of L ligand and one oxygen of a monodentate nitrate anion in the equatorial position and one methanol mol. in the apical position with geometry index τ5 = 0.15. The other Cu(II) center displays a four-coordinate distorted square planar geometry (CuN3O), framed by three nitrogens of ligand L and one oxygen of a monodentate nitrate anion with geometry index τ4 = 0.29 and the tetrahedral character parameter, THCDa/100 of -1.00.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Abdel-Kader, Maged S.; Al-Taweel, Areej M.; El-Deeb, Kadriya S. published an article about the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6,SMILESS:O=C1O[C@H](CO)CC1 ).Synthetic Route of C5H8O3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:32780-06-6) through the article.

Bioactivity guided phytochem. study of the petroleum ether and butanol extracts of Clematis hirsuta resulted in the isolation of 12 compounds Rat paw edema as a model of acute inflammation was used to evaluate the anti-inflammatory activity of the extracts and the chromatog. fractions. Five known sterols and triterpenes namely: β-amyrin (1), lupeol (2), β-sitosterol (3), oleanolic acid (4) and stigmasterol glycoside (5) were isolated from the petroleum ether extract The n-butanol extract afforded two compounds reported for the first time from natural source: (S)-(+)-dihydro-5-(hydroxymethyl)-2(3H)-furanone (7) and (S)-(-)-5-hydroxymethyl-2(5H)-furanone (8). In addition, anemonin (6), dihydro-4-hydroxy-5-(hydroxymethyl)-2(3H)-furanone (2-deoxy-D-ribono-1,4-lactone) (9), biophenol (cimidahurin) (10), glucose (11) and sucrose (12) were also identified. The structures were determined from spectroscopic data including 1D- and 2D-NMR experiments

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Asymmetric [3+2] cycloaddition reaction of a chiral cyclic nitrone for the synthesis of new tropane alkaloids, published in 2020-01-03, which mentions a compound: 3393-45-1, Name is 5,6-Dihydro-2H-pyran-2-one, Molecular C5H6O2, Quality Control of 5,6-Dihydro-2H-pyran-2-one.

The 1,3-dipolar cycloaddition of a chiral nitrone with α,β-unsaturated lactones was carried out to give the corresponding isoxazolidines. Tetrahydro-1,3-oxazines with an oxa-tropane skeleton were obtained in one step by alkylation. The structures of several of these compounds were corroborated by X-ray diffraction and mol. modeling studies confirmed the results and proposed a mechanism for their formation.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5,6-Dihydro-2H-pyran-2-one( cas:3393-45-1 ) is researched.Synthetic Route of C5H6O2.Gabriel, Pablo; Almehmadi, Yaseen A.; Wong, Zeng Rong; Dixon, Darren J. published the article 《A General Iridium-Catalyzed Reductive Dienamine Synthesis Allows a Five-Step Synthesis of Catharanthine via the Elusive Dehydrosecodine》 about this compound( cas:3393-45-1 ) in Journal of the American Chemical Society. Keywords: catharanthine synthesis reductive activation; isoquinuclidine preparation reductive activation. Let’s learn more about this compound (cas:3393-45-1).

A new reductive strategy for the stereo- and regioselective synthesis of functionalized isoquinuclidines has been developed. Pivoting on the chemoselective iridium(I)-catalyzed reductive activation of β,γ-unsaturated δ-lactams, the efficiently produced reactive dienamine intermediates readily undergo [4 + 2] cycloaddition reactions with a wide range of dienophiles, resulting in the formation of bridged bicyclic amine products. This new synthetic approach was extended to aliphatic starting materials, resulting in the efficient formation of cyclohexenamine products, and readily applied as the key step in the shortest (five-step) total synthesis of vinca alkaloid catharanthine to date, proceeding via its elusive biosynthetic precursor, dehydrosecodine.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI