Category: catalyst-ligand

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Article, Food and Chemical Toxicology called Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties, Author is Schorderet Weber, Sandra; Kaminski, Kacper P.; Perret, Jean-Luc; Leroy, Patrice; Mazurov, Anatoly; Peitsch, Manuel C.; Ivanov, Nikolai V.; Hoeng, Julia, the main research direction is Nicotiana Ctenocephalides Lucilia Caenorhabditis Rhipicephalus Ixodes antiparasitic; Parasite; Repellence; Tick; Tickicide; Tobacco alkaloid; Tobacco extract.Formula: C10H14N2.

Within the traditional pharmacopeia, tobacco (Nicotiana spp.) is often cited as an efficient pesticide. This activity is generally attributed to nicotine, but tobacco plants contain other alkaloids that could potentially contribute to this effect. In this study, we tested methanolic extracts of N. glutinosa, N. glauca, N. debneyi, and N. tabacum (putrescine N-methyltransferase line, burley TN90 and Stella, Virginia ITB 683 and K326), selected according to alkaloid content. Their antiparasitic activity was evaluated in bioassays against adult fleas (Ctenocephalides felis), blowfly (Lucilia cuprina) larva, nematodes (Caenorhabditis elegans), and ticks (Rhipicephalus sanguineus larva and adults, Ixodes ricinus nymphs). None of the extracts killed fleas and blowfly larva effectively at the concentrations tested. Only N. tabacum K326 and N. glutinosa exhibited moderate anthelmintic activity. All extracts significantly repelled R. sanguineus ticks, but not I. ricinus, and the nicotine-rich extracts rapidly knocked down all tick species and stages at high concentrations The link between nicotine and tick knockdown was confirmed by successfully testing the pure alkaloid at concentrations found in the tobacco extracts In contrast, repellent activity could not be correlated to the individually tested alkaloids (nicotine, nornicotine, anabasine, anatabine), although anatabine and nornicotine were active in the tick bioassay at high concentrations

When you point to this article, it is believed that you are also very interested in this compound(494-52-0)Formula: C10H14N2 and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5,6-Dihydro-2H-pyran-2-one( cas:3393-45-1 ) is researched.Electric Literature of C5H6O2.Souza, Diana Meneses; Machado, Luciana Lucas; Machado, Angelo Henrique Lira published the article 《First total synthesis of (±)-floribundane B: An approach based on Johnson-Claisen rearrangement of a Morita-Baylis-Hillman adduct》 about this compound( cas:3393-45-1 ) in Tetrahedron Letters. Keywords: floribundane B synthesis Johnson Claisen rearrangement; oleocanthal formal synthesis Johnson Claisen rearrangement. Let’s learn more about this compound (cas:3393-45-1).

The first total synthesis of (±)-floribundane B (I) is reported. Johnson-Claisen rearrangement of a Morita-Baylis-Hillman adduct assembled all of the stereochem. features of this secoiridoid. The formal synthesis of (±)-oleocanthal and the synthesis of a chem. constituent of olive press juice is also reported.

When you point to this article, it is believed that you are also very interested in this compound(3393-45-1)Electric Literature of C5H6O2 and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Quality Control of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Efficient Chirality Transfer in the SmI2-Mediated Cyclization of Aldehydo β-Alkoxyvinyl Sulfoxides: Asymmetric Synthesis of 3-Hydroxyoxanes.

Stereoselective syntheses of 3-hydroxyoxanes were achieved via efficient chirality transfer in the SmI2-mediated cyclization reactions of aldehydo β-alkoxyvinyl sulfoxides. The observed stereoselectivity is discussed in terms of transition state structures for the reactions. RHF, ab initio, d. functional theory, and zero-point energy calculations were done for Ph β-methoxyvinyl sulfoxide configurations to determine global min. structures.

When you point to this article, it is believed that you are also very interested in this compound(32780-06-6)Quality Control of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application of 89972-77-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Neuroprotective effect of 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine trihydrochloride, a novel inducer of nerve growth factor. Author is Yamamoto, Kyoko; Yoshikawa, Ryoko; Okuyama, Shigeru; Takahashi, Yuki; Karasawa, Yasuko; Hino, Noriko; Miyoshi, Toshio; Araki, Hiroaki; Hanabusa, Kenji.

We have identified 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.

When you point to this article, it is believed that you are also very interested in this compound(89972-77-0)Application of 89972-77-0 and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine( cas:89972-77-0 ) is researched.Application In Synthesis of 4-(p-Tolyl)-2,2:6,2-terpyridine.Wang, Xiao-xia; Liu, Han-guo; Wan, Xia; Yin, Xia; Zhou, Fu-shan; Wu, Jian-zhong published the article 《Synthesis of 4-tolyl-2,2′:6′,2”-terpyridine》 about this compound( cas:89972-77-0 ) in Huaxue Shiji. Keywords: methylphenyl terpyridine preparation cyclization. Let’s learn more about this compound (cas:89972-77-0).

3-(4-Methylphenyl)-1,5-di(2-pyridinyl)-1,5-pentanedione was prepared by reaction of 2-acetylpyridine with 4-methylbenzaldehyde at room temperature using ethanol as the solvent. Treatment of the latter compound with concentrated ammonia for 1 h in the presence of sodium hydroxide gave the title compound [i.e., 4′-(4-methylphenyl)-2,2′:6′,2”-terpyridine] in 31.7% yield. The above reaction conditions were mild and the products could be purified easily.

This literature about this compound(89972-77-0)Application In Synthesis of 4-(p-Tolyl)-2,2:6,2-terpyridinehas given us a lot of inspiration, and I hope that the research on this compound(4-(p-Tolyl)-2,2:6,2-terpyridine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A Simple and High-Throughput LC-MS-MS Method for Simultaneous Measurement of Nicotine, Cotinine, 3-OH Cotinine, Nornicotine and Anabasine in Urine and Its Application in the General Korean Population.》. Authors are Oh, Jongwon; Park, Min-Seung; Chun, Mi-Ryung; Hwang, Jung Hye; Lee, Jin-Young; Jee, Jae Hwan; Lee, Soo-Youn.The article about the compound:(S)-3-(Piperidin-2-yl)pyridinecas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1).Application In Synthesis of (S)-3-(Piperidin-2-yl)pyridine. Through the article, more information about this compound (cas:494-52-0) is conveyed.

Measuring nicotine metabolites is the most objective method for identifying smoke exposure. Liquid chromatography–tandem mass spectrometry (LC-MS-MS) can measure multiple metabolites and is sensitive enough to detect low concentrations of metabolites. Therefore, we developed a simple and high-throughput method for measuring nicotine, cotinine, trans-3′-hydroxycotinine (3-OH cotinine), nornicotine and anabasine for population-based studies using LC-MS-MS. Each 30 µL of urine sample was diluted with 90 µL of acetonitrile containing five deuterated internal standards. Chromatographic separation used a C18 column, and LC-MS-MS analysis was performed with a multiple reaction monitoring mode. The chromatographic run time for each sample was 6.5 min. The method was validated by evaluating selectivity, interference, limit of detection, lower limit of quantification, precision, accuracy, linearity, extraction recovery, matrix effect and carryover according to guidelines. Our methods required a short preparation time (∼20 min) while simultaneously measuring five markers for smoking status. No endogenous or exogenous interference was found. Our method showed excellent precision and accuracy: within-run coefficient of variation (CV) 2.9-9.4%, between-run CV 4.8-8.7% and bias -10.1 to 5.3%. Linear dynamic ranges were 1-10,000 ng/mL for nicotine, nornicotine and anabasine; 2-5,000 ng/mL for cotinine and 5-15,000 ng/mL for 3-OH cotinine. Extraction recovery was consistent (87-109%) across concentrations. No significant matrix effect or carryover was observed. The validated method was applied to 849 urine samples. In samples from the 125 current smokers, nicotine, cotinine, 3-OH cotinine, nornicotine and anabasine were detected in 97.6, 99.2, 98.4, 96.8 and 87.2%, respectively. No markers were detected in 93.9% of 609 nonsmokers. The overlapping detection of multiple markers made it possible to identify the smoking status even in current smokers with a low concentration of cotinine. Our LC-MS-MS method using a simple sample preparation technique is sensitive and effective for screening of smoking status in the general population.

This literature about this compound(494-52-0)Application In Synthesis of (S)-3-(Piperidin-2-yl)pyridinehas given us a lot of inspiration, and I hope that the research on this compound((S)-3-(Piperidin-2-yl)pyridine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2834-05-1, is researched, SMILESS is O=C(O)CCCCCCCCCCBr, Molecular C11H21BrO2Journal, Article, Photochemical & Photobiological Sciences called Fluorescence detection of pyrene-stained Bacillus subtilis LPM1 rhizobacteria from colonized patterns of tomato roots, Author is Hernandez, Monica; Ortiz-Castro, Randy; Flores-Olivas, Alberto; Moggio, Ivana; Arias, Eduardo; Valenzuela-Soto, Jose Humberto, the main research direction is fluorescence detection pyrene Bacillus tomato root.Application In Synthesis of 11-Bromoundecanoic acid.

A series of water soluble 8-alcoxypyrene-1,3,6-trisulfonic sodium salts bearing different alcoxy lateral chains and functional end groups was synthesized and the mol. structure was corroborated by NMR spectroscopy. The photophys. properties in water analyzed by UV-Vis and static and dynamic fluorescence revealed that all of the pigments emit in the blue region at a maximal wavelength of 436 nm and with fluorescence lifetimes in the range of ns. Among them, sodium 8-((10-carboxydecyl) oxy) pyrene-1,3,6-trisulfonate M1 exhibits a high fluorescence quantum yield (ϕ = 80%) and a good interaction with B. subtilis LPM1 rhizobacteria; this has been demonstrated through in vitro staining assays. Tomato plants (Solanum lycopersicon cv.Micro-Tom) increased the release of root exudates, mainly malic and fumaric acids, after 12 h of treatment with benzothiadiazole (BTH) as a foliar elicitor. However, the chemotaxis anal. demonstrated that malic acid is the most powerful chemoattractant of the rhizobacteria Bacillus subtilis LPM1: in agar plates, a major growth (60 mm) was found for a concentration of 100 mM, while in capillary tubes, the earliest response was at 30 min with 3.3 x 108 CFU mL-1. The confocal microscopic anal. carried out on the tomato roots of the pyrene stained B. subtilis LPM1 revealed that this bacterium mainly colonizes the epidermal zones, i.e. the junctions to primary roots, lateral roots and root hairs, meaning that these root hair sections are the highest colonisable sites involved in the biosynthesis of exudates. This fluorescent pyrene marker M1 represents a valuable tool to evaluate B. subtilis-plant interactions in an easy and quick test in both in vitro and in vivo tomato crops.

This literature about this compound(2834-05-1)Application In Synthesis of 11-Bromoundecanoic acidhas given us a lot of inspiration, and I hope that the research on this compound(11-Bromoundecanoic acid) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The phosphorylated regulator of chemotaxis is crucial throughout biofilm biogenesis in Shewanella oneidensis》. Authors are Boyeldieu, Anne; Ali Chaouche, Amine; Ba, Moly; Honore, Flora Ambre; Mejean, Vincent; Jourlin-Castelli, Cecile.The article about the compound:(S)-3-(Piperidin-2-yl)pyridinecas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1).Synthetic Route of C10H14N2. Through the article, more information about this compound (cas:494-52-0) is conveyed.

Abstract: The core of the chemotaxis system of Shewanella oneidensis is made of the CheA3 kinase and the CheY3 regulator. When appropriated, CheA3 phosphorylates CheY3, which, in turn, binds to the rotor of the flagellum to modify the swimming direction. In this study, we showed that phosphorylated CheY3 (CheY3-P) also plays an essential role during biogenesis of the solid-surface-associated biofilm (SSA-biofilm). Indeed, in a ΔcheY3 strain, the formation of this biofilm is abolished. Using the phospho-mimetic CheY3D56E mutant, we showed that CheY-P is required throughout the biogenesis of the biofilm but CheY3 phosphorylation is independent of CheA3 during this process. We have recently found that CheY3 interacts with two diguanylate cyclases (DGCs) and with MxdA, the c-di-GMP effector, probably triggering exopolysaccharide synthesis by the Mxd machinery. Here, we discovered two addnl. DGCs involved in SSA-biofilm development and showed that one of them interacts with CheY3. We therefore propose that CheY3-P acts together with DGCs to control SSA-biofilm formation. Interestingly, two orthologous CheY regulators complement the biofilm defect of a ΔcheY3 strain, supporting the idea that biofilm formation could involve CheY regulators in other bacteria.

This literature about this compound(494-52-0)Synthetic Route of C10H14N2has given us a lot of inspiration, and I hope that the research on this compound((S)-3-(Piperidin-2-yl)pyridine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine(SMILESS: CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1,cas:89972-77-0) is researched.Name: Copper(I) tetra(acetonitrile) tetrafluoroborate. The article 《Furin Inhibition by Compounds of Copper and Zinc》 in relation to this compound, is published in Journal of Biological Chemistry. Let’s take a look at the latest research on this compound (cas:89972-77-0).

Furin, a human subtilisin-related proprotein convertase (SPC), is emerging as an important pharmaceutical target because it processes vital proteins of many aggressive pathogens. Furin inhibitors reported as yet are peptide derivatives and proteins, with the exception of andrographolides, which are natural compounds Here we report that the small and highly stable compounds M(chelate)Cl2 (M is copper or zinc) inhibit furin and Kex2, with Cu(TTP)Cl2 and Zn(TTP)Cl2 as the most efficient inhibitors. 4′-[P-tolyl]-2,2′:6′,2”-terpyridine (TTP) inhibitor is irreversible, competitive with substrate, and affected by substituents on the chelate. The free chelates are not inhibitors. Solvated Zn2+ is less potent than its complexes. This is true also for copper and Kex2. However, solvated Cu2+ (kon of 25,000±2,500 s-1) is more potent than Cu(TTP)Cl2 (kon = 140±13 s-1) and allows recovery of furin activity prior to a second inhibition phase. A mechanism that involves coordination to the catalytic histidine is proposed for all inhibitors. Target specificity is indicated by the fact that these metal chelate inhibitors are much less potent toward Kex2, the yeast homolog of furin. For example, kon with Zn(TTP)Cl2 is 120±20 s-1 for furin, but only 1.2±0.1 s-1 for Kex2.

This literature about this compound(89972-77-0)Computed Properties of C22H17N3has given us a lot of inspiration, and I hope that the research on this compound(4-(p-Tolyl)-2,2:6,2-terpyridine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Regioselective Radical Borylation of α,β-Unsaturated Esters and Related Compounds by Visible Light Irradiation with an Organic Photocatalyst, published in 2021-06-04, which mentions a compound: 3393-45-1, Name is 5,6-Dihydro-2H-pyran-2-one, Molecular C5H6O2, Reference of 5,6-Dihydro-2H-pyran-2-one.

Radical hydroboration reactions have only recently been reported and are still rare. Here the authors describe a photoredox radical hydroboration of α,β-unsaturated esters, amides, ketones, and nitriles with NHC-boranes that uses only an organocatalyst and visible light. The conditions are mild, the substrate scope is broad, and the α/β regioselectivity is high. The reaction requires only the organocatalyst; there is no costly metal, and there are no other additives (base, cocatalyst, initiator).

This literature about this compound(3393-45-1)Reference of 5,6-Dihydro-2H-pyran-2-onehas given us a lot of inspiration, and I hope that the research on this compound(5,6-Dihydro-2H-pyran-2-one) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI