Category: catalyst-ligand

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about A ring-expansion route to analogs of dideoxyhydantocidin, the main research direction is dideoxy hydantocidin spirocyclic nucleoside preparation; dihydrofuranyllithium addition azetidinedione; hydroxy lactam acid catalyzed rearrangement.Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

The acid-catalyzed rearrangement of hydroxy β-lactam, formed by addition of the enantiopure dihydrofuranyllithium to N-benzyl-2,3-azetidinedione, has been investigated as a potential route to spirocyclic nucleosides.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

HPLC of Formula: 494-52-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Synthesis and structured N-acyl and thiourea derivatives citizine and anabazine.

This work presents the results of studies on the chem. transformation of the alkaloids mols. anabasine and cytisine to obtain their N-cinnamoyl derivatives (N-cinnamoylanabasine, N-cinnamoylcytisine), as well as possible ways for their further modification. The optimal conditions for the preparation of N-cinnamoylcytisine and N-cinnamoylanabasine in the acylation reactions of alkaloids with cinnamoyl chloride are considered. Hydrazinolysis of the resulting N-cinnamoylcytisine and N-cinnamoylanabasine was carried out. It was shown that the interaction of acrylamide derivatives of alkaloids (N-cinnamoylanabasine, N-cinnamoylcytisine) with hydrazine hydrate in ethanol leads to the formation of the corresponding pyrazole derivatives (N-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)anabasine, N-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)cytisine) resulting from the intramol. cyclocondensation of hydrazones of N-cinnamoyl derivatives By the interaction of cinnamoylisothiocyanate with the above alkaloids (anabasine, cytisine), new thiourea derivatives (N- cinnamoylaminothiocarbonylanabasine, N- cinnamoylaminothiocarbonylcytisine) are synthesized.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

COA of Formula: C5H8O3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Chirospecific synthesis of (S)-(+)- and (R)-(-)-5-amino-4-hydroxypentanoic acid from L- and D-glutamic acid via (S)-(+)- and (R)-(-)-5-hydroxy-2-oxopiperidine. Author is Herdeis, C..

(S)-H2NCH2CH(OH)CH2CH2CO2H [(S)-I] was prepared stereospecifically from L-glutamic acid in 6 steps. Thus, L-glutamic acid was converted to lactone II (R = CO2H), which was reduced by H3B.S(Me)2 to give II (R = CH2OH), which was O-mesylated and then treated with NaN3 to give II (R = CH2N3). The latter was hydrogenated over Pd/C to give piperidine III, which was cleaved by aqueous Ba(OH)2 to give (S)-I. (R)-I was prepared analogously from D-glutamic acid.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mishra, Dinesh; Wang, Sisi; Jin, Zhicheng; Xin, Yan; Lochner, Eric; Mattoussi, Hedi researched the compound: 11-Bromoundecanoic acid( cas:2834-05-1 ).Formula: C11H21BrO2.They published the article 《Highly fluorescent hybrid Au/Ag nanoclusters stabilized with poly(ethylene glycol)- and zwitterion-modified thiolate ligands》 about this compound( cas:2834-05-1 ) in Physical Chemistry Chemical Physics. Keywords: gold silver nanocluster preparation fluorescence. We’ll tell you more about this compound (cas:2834-05-1).

The authors report a simple strategy to grow highly fluorescing, near-IR-emitting nanoclusters (NCs) made of bimetallic Au/Ag cores, surface capped with a mixture of triphenylphosphine and various monothiol ligands. The ligands include short chain aliphatic monothiols, which yields hydrophobic NCs, and poly(ethylene glycol)- or zwitterion-appended monothiols, which yield NCs that are readily dispersible in buffer media. The reaction uses well-defined triphenylphosphine-protected Au11 clusters (as precursors) that are reacted with Ag(I)-thiolate complexes. The prepared materials are small (diameter <2 nm, as characterized by TEM) with emission peak at 730-760 nm and long lifetime (∼8-12 μs). The quantum yield measured for these materials in both hydrophobic and hydrophilic dispersions is ∼40%. High-magnification dark field STEM and XPS measurements show both metal atoms in the core, with measured binding energies that agree with reported values for nanocluster materials. The NIR emission combined with high quantum yield, small size, colloidal stability in buffer media and ease of surface functionalization afforded by the coating, make these materials suitable for studying fundamental questions and potentially useful for biol. sensing and imaging applications. Here is just a brief introduction to this compound(2834-05-1)Formula: C11H21BrO2, more information about the compound(11-Bromoundecanoic acid) is in the article, you can click the link below.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 32780-06-6, is researched, SMILESS is O=C1O[C@H](CO)CC1, Molecular C5H8O3Journal, Heterocycles called A facile entry to bicyclic systems from L-glutamic acid, Author is Frieman, Bryan A.; Bock, Charles W.; Bhat, Krishna L., the main research direction is pyrrole fused pyrrolidinone furanone nonracemic preparation; facile entry bicyclic system glutamic acid; cycloaddition TosMIC alpha beta unsaturated cyclic amide lactam; calculated mol structure intermediate product synthesis density functional theory.SDS of cas: 32780-06-6.

Nonracemic pyrrole-fused pyrrolidinone I (X = BocN; Boc = tert-butoxycarbonyl) and furanone I (X = O) were prepared in seven steps from L-glutamic acid. The key step in the preparation of I (X = BocN, O) was the construction of the pyrrole rings in a single step through cycloadditions of tosylmethyl isocyanide (TosMIC) with the nonracemic cyclic α,β-unsaturated lactam and lactone II (X = BocN, O). E.g., II (X = BocN) was prepared in six steps from L-glutamic acid by cyclocondensation in water followed by treatment with thionyl chloride in methanol to yield a nonracemic oxopyrrolidinylcarboxylate ester which was reduced to give a nonracemic oxopyrrolidinylmethanol. E.g., the nonracemic oxopyrrolidinylmethanol was silylated with tert-butyldimethylsilyl chloride and N-protected with Boc anhydride; the protected oxopyrrolidinylmethanol was deprotonated with LDA and selenylated with phenylselenyl chloride to give an intermediate which underwent elimination upon treatment with hydrogen peroxide in the presence of DMAP. E.g., addition of a solution of II (X = BocN) in DMSO/ether to a solution of TosMIC and sodium hydride in DMSO/ether and stirring for 2 h gave I (X = BocN) in 97% yield. The structures of reaction intermediates and final products were investigated using d. functional theory calculations

Here is just a brief introduction to this compound(32780-06-6)SDS of cas: 32780-06-6, more information about the compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one) is in the article, you can click the link below.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

SDS of cas: 494-52-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Preinfection effects of nectar secondary compounds on a bumble bee gut pathogen.

Bumble bee pollinators can be exposed to pathogens when foraging on flowers previously visited by infected individuals. Infectious cells may be deposited in floral nectar, providing a site for pathogens to interact with nectar secondary compounds prior to infecting bees. Some nectar secondary compounds can reduce pathogen counts in infected bumble bees, but we know less about how exposure to these compounds directly affects pathogens prior to being ingested by their host. We exposed the trypanosomatid gut pathogen, Crithidia bombi (Lipa & Triggiani 1988) (Trypanosomatida: Trypanosomatidae), to six different compounds found in nectar (aucubin, catalpol, nicotine, thymol, anabasine, and citric acid) for 1-h prior to ingestion by Bombus impatiens (Cresson 1863) (Hymenoptera: Apidae) workers that were then reared for 1 wk on a control diet. All of these compounds except citric acid reduce pathogen levels when consumed in hosts after infection, and citric acid is a common preservative found in citrus fruits and some honeys. We found that both citric acid and aucubin reduced Crithidia cell counts compared with controls. However, catalpol, nicotine, thymol, and anabasine did not have significant effects on Crithidia levels. These results suggest that Crithidia exposure in some floral nectars may reduce cell viability, resulting in a lower risk to visiting pollinators, but this effect may not be widespread across all flowering species.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Barzano, Guido; Mao, Runze; Garreau, Marion; Waser, Jerome; Hu, Xile published the article 《Tandem Photoredox and Copper-Catalyzed Decarboxylative C(sp3)-N Coupling of Anilines and Imines Using an Organic Photocatalyst》. Keywords: photoredox copper catalyzed decarboxylative carbon nitrogen coupling; coupling aniline imine alkyl amine preparation organic photocatalyst.They researched the compound: 11-Bromoundecanoic acid( cas:2834-05-1 ).Synthetic Route of C11H21BrO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2834-05-1) here.

An organic photoredox catalyst, 4CzIPN, was used in combination with a copper catalyst, CuCl, to effect decarboxylative C(sp3)-N coupling. The coupling worked with both anilines and imines as nitrogen sources and could be used to prepare a variety of alkyl amines from readily available alkyl carboxylic acids.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Lory, Pedro M. J.; Estrella-Jimenez, Maria E.; Shashack, Matthew J.; Lokesh, Ganesh L.; Natarajan, Amarnath; Gilbertson, Scott R. published the article 《Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides》. Keywords: thioxanthenone dioxide carbamoyl amino preparation BRCT hepatitis C inhibitor.They researched the compound: 6-(Piperazin-1-yl)nicotinonitrile( cas:149554-29-0 ).Quality Control of 6-(Piperazin-1-yl)nicotinonitrile. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:149554-29-0) here.

Methods appropriate for the parallel synthesis of libraries based on the thioxanthen-9-one 10,10-dioxide scaffold are reported. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and com. available 3-carboxythioxanthen-9-one 10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alk. phosphatase reported replicon system for activity against hepatitis C virus.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Formula: C5H8O3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Facile, highly stereoselective synthesis of 2′,3′-dideoxy- and 2′,3′-didehydro-2′,3′-dideoxy nucleosides via a furanoid glycal intermediate. Author is Kim, Choung Un; Misco, Peter F..

Regiospecific and highly stereoselective electrophilic addition reactions to the furanoid glycal I were used as key steps in the synthesis of 2′,3′-dideoxyadenosine (II) and 2′,3′-didehydro-3′-deoxythymidine (III) antiviral nucleosides.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI