Category: catalyst-ligand

Okabe, Masami; Sun, Ruen Chu; Tam, Steve Y. K.; Todaro, Louis J.; Coffen, David L. published the article 《Synthesis of the dideoxynucleosides “”ddC”” and “”CNT”” from glutamic acid, ribonolactone, and pyrimidine bases》. Keywords: dideoxycytidine; cytidine dideoxy; deoxycyanothymidine; thymidine deoxycyano; crystal structure cyanohydroxymethyltetrahydrofuranone; mol structure cyanohydroxymethyltetrahydrofuranone.They researched the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6 ).Recommanded Product: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:32780-06-6) here.

2,3-Dideoxyribose in suitably protected form was prepared from L-glutamic acid and coupled with silylated cytosine to give a mixture of the α- and β-anomers of 2′,3′-dideoxycytidine. The anomer ratio depended on the Lewis acid used in the coupling, with EtAlCl2 favoring the β-anomer ddC (I), a potent anti-HIV drug. Conjugate addition of cyanide to a 4-[(silyloxy)methyl]butenolide prepared from D-ribonolactone gave a mixture of (racemic) α- and β-3-cyanobutyrolactones. Both isomers were reduced to lactols and coupled with thymine to give α/β-anomer pairs. The α-cyano lactone, the structure of which was established by x-ray crystallog. of II, afforded an authentic sample of the putative (but in fact inactive) anti-HIV substance known in AIDS research as CNT (III).

In addition to the literature in the link below, there is a lot of literature about this compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Recommanded Product: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, illustrating the importance and wide applicability of this compound(32780-06-6).

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 89972-77-0, is researched, SMILESS is CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1, Molecular C22H17N3Journal, Crystal Growth & Design called Unusual 2D → 3D Polycatenane Frameworks Based on 1D → 2D Interdigitated Layers: From Single Crystals to Submicrometer Fibers with Enhanced UV Photocatalytic Degradation Performances, Author is Guo, Jiao; Ma, Jian-Fang; Li, Jun-Jie; Yang, Jin; Xing, Shuang-Xi, the main research direction is crystal structure cobalt manganese zinc cadmium tolylterpyridine tetracarboxylate; transition metal terpyridine carboxylate MOF preparation photocatalytic activity; methylene blue photocatalytic degradation catalyzed transition metal tolylterpyridine tetracarboxylate.HPLC of Formula: 89972-77-0.

Four unusual isomorphous metal-organic frameworks, [M2(L1)(L2)2] (M = Co for 1, Mn for 2, Zn for 3, and Cd for 4), where H4L1 = tetrakis[4-(carboxyphenyl)-oxamethyl]methane acid and L2 = 4-tolyl-2,2′:6′,2”-terpyridine, were synthesized under hydrothermal conditions. Their structures were determined by single-crystal x-ray diffraction analyses and further characterized by IR spectra, elemental analyses, powder X-ray diffraction, UV-visible absorption spectra, and optical energy gaps. In 1-4, the metal atoms are linked by the L1 anions to yield a chain with a loop. Every loop of each chain is penetrated by two L2 ligand rods from the two nearest chains, resulting in an unusual 1-dimensional → 2-dimensional interdigitated network. In the 2-dimensional interdigitated network, there exist weak π-π interactions between pyridyl groups of L2 ligands. If the π-π interactions are regarded as linkers, the 2-dimensional interdigitated network belongs to an uneven (3,4)-connected layer. Also, each individual (3,4)-connected layer is polycatenated with an infinite number of other perpendicular layers, yielding an unusual 2-dimensional → 3-dimensional polycatenane framework. The luminescent properties of compounds 3 and 4 were studied. Compounds 1-4 exhibit photocatalytic activities for MB degradation under UV irradiation Submicrometer fiber 1′ shows high photocatalytic efficiency for MB degradation with respect to its corresponding macroscaled crystalline 1.

In addition to the literature in the link below, there is a lot of literature about this compound(4-(p-Tolyl)-2,2:6,2-terpyridine)HPLC of Formula: 89972-77-0, illustrating the importance and wide applicability of this compound(89972-77-0).

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of 4-(p-Tolyl)-2,2:6,2-terpyridine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Self-assembly of nanocrystalline tetra-terpyridine complexes: from molecules to mesoscopic objects.

We report the properties of a shape-persistent tetra-terpyridine ligand whose coordination to transition metal ions guides its three-dimensional self-assembly in two steps: at first, nanoscale objects form, which with time, self-assemble into micrometer structures. This work highlights the potential for control of the mol. self-assembly of mols. on the nanoscale, and the successive self-assembly of the formed supramol. nanosystems to yield mesoscopic objects.

In addition to the literature in the link below, there is a lot of literature about this compound(4-(p-Tolyl)-2,2:6,2-terpyridine)Reference of 4-(p-Tolyl)-2,2:6,2-terpyridine, illustrating the importance and wide applicability of this compound(89972-77-0).

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called DNA binding properties of novel cytotoxic gold(III) complexes of terpyridine ligands: the impact of steric and electrostatic effects, published in 2006-09-30, which mentions a compound: 89972-77-0, mainly applied to gold terpyridine functionalized preparation antitumor activity DNA binding; steric effect DNA binding gold complex functionalized terpyridine, Formula: C22H17N3.

Four Au(III) complexes of terpyridine derivatives In+ (R = H, 2-naphthyloxy, n = 2; R = PPh3, n = 3; R = NHCH2CH2SO3Na, n = 2) were synthesized and characterized by spectroscopic methods. In vitro data demonstrated that all of them showed higher cytotoxicity than cisplatin against the human nonsmall-cell lung cancer cell line (A-549), the human stomach carcinoma cell line (SGC-7901), the human cervix carcinoma cell line (HELA), the human colon carcinoma cell line (HCT-116), the human liver carcinoma cell line (BEL-7402), the murine leukemia cell line (P-388) and the human acute promyelocytic leukemia cell line (HL-60). Complex I (R = PPh3) exhibits the highest activity, with growth inhibition rates of over 80% at 10-8 mol L-1 against the A-549, HCT-116 and HELA tumor cell lines. The free ligands are also very cytotoxic against the cell lines tested. Complexes I are stable in aqueous solution for 2 days in the presence of the biol. reducing agent glutathione. The inductively coupled plasma mass spectrometry data showed that DNA isolated from cells treated with complexes I (R = H, PPh3) contained Au with Au-to-nucleotide ratios of ∼1:6,400 and 1:4,900, resp. Fluorescence titration, UV and CD analyses proved that the steric and electrostatic effects of the ligand remarkably influence the interactions of their Au(III) complexes with DNA. The DNA binding ability of the complexes was correlated with their cytotoxicity, which could potentially provide a new rationale for the future design of terpyridine-based metal complexes with antitumor potential.

In addition to the literature in the link below, there is a lot of literature about this compound(4-(p-Tolyl)-2,2:6,2-terpyridine)Formula: C22H17N3, illustrating the importance and wide applicability of this compound(89972-77-0).

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 494-52-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Determination of nicotine-related impurities in nicotine pouches and tobacco-containing products by liquid chromatography-tandem mass spectrometry. Author is Avagyan, Rozanna; Spasova, Maya; Lindholm, Johan.

Smokeless tobacco products and nicotine-containing tobacco-free oral pouches have increased in popularity in recent years. They are associated with far fewer health hazards compared to cigarettes. Nicotine pouches are filled with non-tobacco filler and nicotine. The nicotine used in nicotine pouches usually comes from the extraction of tobacco; thus, related alkaloids may be found as impurities at low levels. Moreover, nicotine degradation products are formed because of microbial action, flavor oxidation, exposure to high temperatures, etc. Currently, there are no published or recommended methods for the anal. of nicotine degradants in nicotine pouches. Here, we present a sensitive and selective liquid chromatog.-tandem mass spectrometry method for the simultaneous determination of seven nicotine-related impurities. All seven analytes and corresponding deuterated internal standards were separated within 3.5 min, including 1 min equilibration. The method was fully validated, showing good linearity with correlation coefficients >0.996 for all analytes, good extraction yields ranging from 78% to 110%, limits of detection between 0.08 and 0.56 μg/g and limits of quantification between 0.27 and 2.04 μg/g. Although the method was mainly developed to determine the degradants of nicotine in nicotine pouches, it was validated and performed well on a broader range of tobacco-containing products.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Temple, Kayla J.; Engers, Julie L.; Long, Madeline F.; Gregro, Alison R.; Watson, Katherine J.; Chang, Sichen; Jenkins, Matthew T.; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W. researched the compound: 4-Bromo-2,5-dichloropyridine( cas:1184917-16-5 ).Quality Control of 4-Bromo-2,5-dichloropyridine.They published the article 《Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping》 about this compound( cas:1184917-16-5 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: muscarinic acetylcholine receptor M4 pos allosteric modulator SAR; M(4); Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Structure activity relationship (SAR). We’ll tell you more about this compound (cas:1184917-16-5).

This Letter details our efforts to replace the 2,4-dimethylquinoline carboxamide core of our previous M4 PAM series, which suffered from high predicted hepatic clearance and protein binding. A scaffold hopping exercise identified a novel 3,4-dimethylcinnoline carboxamide core that provided good M4 PAM activity and improved clearance and protein binding profiles.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 89972-77-0, is researched, SMILESS is CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1, Molecular C22H17N3Journal, Journal of Coordination Chemistry called Synthesis, spectroscopy, thermal behavior, and X-ray crystal structure of two lead(II) complexes with 4′-(4-tolyl)-2,2′;6′,2”-terpyridine (ttpy), Author is Saghatforoush, Lotfali; Adil, Karim; Sahin, Ertan; Babaei, Somayyeh; Musevi, Seyid Javad, the main research direction is preparation acetate bridged dimeric lead tolylterpyridine complex; crystal structure acetate bridged dimeric lead tolylterpyridine complex; cyclic voltammetry acetate bridged dimeric lead tolylterpyridine complex.COA of Formula: C22H17N3.

Two new dimeric Pb(II) complexes with 4′-(4-tolyl)-2,2′;6′,2”-terpyridine (ttpy), [Pb(ttpy)(μ-AcO)]2(PF6)2 (1) and [Pb(ttpy)(μ-AcO)I]2 (2), were synthesized and characterized by CHN elemental anal., 1H NMR, 13C NMR, IR spectroscopy, and structurally analyzed by x-ray single-crystal diffraction. The thermal stability of these compounds was studied by TGA and DTA. Single crystal x-ray anal. shows that 1 and 2 are dimeric units with Pb-(μ-AcO)2-Pb-type bridging, and the coordination number in 1 is six and in 2 is seven. The arrangement of donors suggests a gap in the coordination geometry around lead, possibly occupied by stereo-active lone pair of electrons on Pb(II), so the coordination sphere is hemidirected. Also, dimeric units are connected by a network of hydrogen bonds and π-π stacking as well. Electrochem. properties of free ligand and complexes were studied in the presence of tetra-Bu ammonium perchlorate as supporting electrolyte and by using a glassy carbon electrode. Both lead complexes show irreversible Pb(II) oxidation Cyclic voltammetry indicates that these processes are diffusion-controlled. The data from electrochem. studies show that the total limiting current of each of the studied complexes corresponds to two-electron transfer.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Product Details of 2834-05-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Electroinduced Reconfiguration of Complex Emulsions for Fabrication of Polymer Particles with Tunable Morphology. Author is Guo, Yongshun; Fang, Yanxiong; Jia, Kangle; Yu, Yue; Yu, Longfei; Li, Huanling; Zhang, Junjie; Zheng, Xiaoshan; Huang, Linjia; Wen, Wu; Mai, Yuliang.

Continuous morphol. control of anisotropic particles is always an important challenge in the field of materials. In this study, a new strategy for continuous fabrication of polymer particles with various morphologies induced by electricity is reported using complex emulsions as template. A synthetic electro-responsive surfactant containing ferrocene group is used to prepare complex emulsions, which contain a polymerizable monomer as inner phase. With the increasing time of elec. stimulation on the complex emulsions, hollow, hemispherical, mushroom-like, and spherical particles are constructed successively after photopolymerization The Marangoni effect caused by the heterogeneity in the interfacial tension at the droplet surface is the reason for the reconfigurable morphol. of the complex emulsion. The controllable complex emulsions by electricity present a versatile platform for constructing fine control of the microstructure and shape anisotropy of particles having customized shapes and functionalities, opening a new possibility for designing sophisticated architectures.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Stereospecific synthesis of (+)-muricatacin: a biologically active acetogenin derivative. Part 14, the main research direction is muricatacin stereoselective preparation configuration; configuration absolute muricatacin annonacin.Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

(4S,5S)- And (4S,5R)-(+)-muricatacin (I) and some analogs were synthesized without ambiguity about the absolute configuration at the stereogenic centers. [α]D Values show that natural I is an enantiomeric mixture with slight excess of (4R,5R)-I. The absolute configuration of annonacin was derived to be 15R,16R,19R,20R. I had lower cytotoxicity than various acetogenins from Annona muricata.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 494-52-0, is researched, Molecular C10H14N2, about Non-nicotine constituents in e-cigarette aerosol extract attenuate nicotine’s aversive effects in adolescent rats, the main research direction is nicotine conditioned taste aversion E cigarette aerosol adolescence; Adolescents; Conditioned taste aversion; Electronic cigarettes; Nicotine; Non-nicotine tobacco constituents.Product Details of 494-52-0.

Development of preclin. methodol. for evaluating the abuse liability of electronic cigarettes (ECs) in adolescents is urgently needed to inform FDA regulation of these products. The goal of this study was to compare the aversive effects of nicotine alone and EC aerosol extracts in adolescent rats as measured using conditioned taste aversion (CTA), which can be conducted during the brief adolescent period. In Experiment 1, nicotine alone (1.0 or 1.5 mg/kg, s.c.) produced significant CTA in adolescent rats in a two-bottle procedure, thereby establishing a model to study the effects of EC extracts At a nicotine dose of 1.0 mg/kg, CTA to Vuse Menthol EC extract, but not Aroma E-Juice EC extract, was attenuated compared to nicotine alone during repeated two-bottle CTA tests (Experiment 2a). At a nicotine dose of 0.5 mg/kg, CTA to Vuse Menthol EC extract did not differ from nicotine alone during the first two-bottle CTA test but extinguished more rapidly across repeated two-bottle tests (Experiment 2b). Non-nicotine constituents in Vuse Menthol EC extracts attenuated CTA in a two-bottle procedure in adolescents. This model may be useful for anticipating the abuse liability of ECs in adolescents and for modeling FDA-mandated changes in product standards for nicotine or other constituents in ECs.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI