Category: catalyst-ligand

Name: (S)-3-(Piperidin-2-yl)pyridine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Increased leaf nicotine content by targeting transcription factor gene expression in commercial flue-cured tobacco (Nicotiana tabacum L.). Author is Liu, Hai; Kotova, Tatyana I.; Timko, Michael P..

Nicotine, the most abundant pyridine alkaloid in cultivated tobacco (Nicotiana tabacum L.), is a potent inhibitor of insect and animal herbivory and a neurostimulator of human brain function. Nicotine biosynthesis is controlled developmentally and can be induced by abiotic and biotic stressors via a jasmonic acid (JA)-mediated signal transduction mechanism involving members of the APETALA 2/ethylene-responsive factor (AP2/ERF) and basic helix-loop-helix (bHLH) transcription factor (TF) families. AP2/ERF and bHLH TFs work combinatorically to control nicotine biosynthesis and its subsequent accumulation in tobacco leaves. Here, we demonstrate that overexpression of the tobacco NtERF32, NtERF221/ORC1, and NtMYC2a TFs leads to significant increases in nicotine accumulation in T2 transgenic K326 tobacco plants before topping. Up to 9-fold higher nicotine production was achieved in transgenics overexpressing NtERF221/ORC1 under the control of a constitutive GmUBI3 gene promoter compared to wild-type plants. The constitutive 2XCaMV35S promoter and a novel JA-inducible 4XGAG promoter were less effective in driving high-level nicotine formation. Methyljasmonic acid (MeJA) treatment further elevated nicotine production in all transgenic lines. Our results show that targeted manipulation of NtERF221/ORC1 is an effective strategy for elevating leaf nicotine levels in com. tobacco for use in the preparation of reduced risk tobacco products for smoking replacement therapeutics.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Diastereoselective synthesis of 2,5-disubstituted tetrahydrofuran derivatives, published in 2000-09-22, which mentions a compound: 32780-06-6, mainly applied to diastereoselective synthesis THF, Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

5-Substituted lactol I was converted to 2,5-disubstituted THF derivatives by a Lewis acid-promoted reaction with allylsilanes. High trans selectivity (12:1) was obtained when hindered allylsilane Me2C:CHCH2SiMe3 was employed. Addnl., 2,5-cis-disubstituted THF derivatives were obtained in good yields and diastereoselectivities after alkyllithium addition to a lactone, followed by Et3SiH/BF3·OEt2 reduction of the corresponding hemiketals.

In some applications, this compound(32780-06-6)Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-(Piperazin-1-yl)nicotinonitrile(SMILESS: N#CC1=CN=C(N2CCNCC2)C=C1,cas:149554-29-0) is researched.Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The article 《[(S)-γ-(4-Aryl-1-piperazinyl)-L-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:149554-29-0).

In the search for an inhibitor of dipeptidyl peptidase IV (DPP-IV) highly potent both in vitro and in vivo, a series of L-prolylthiazolidine-based DPP-IV inhibitors, e.g., I, having 4-arylpiperazine or 4-arylpiperidine at the γ-position of the proline structure was synthesized. Of these compounds, the 4-(5-nitro-2-pyridyl)piperazine analog I showed a sub-nanomolar (IC50 = 0.92 nmol/L) DPP-IV inhibitory activity and a long-lasting in vivo DPP-IV inhibition profile.

In some applications, this compound(149554-29-0)Synthetic Route of C10H12N4 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C11H21BrO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Facile synthesis of gold nanoparticles capped with an ammonium-based chiral ionic liquid crystal. Author is Mangaiyarkarasi, R.; Sivaranjini, B.; Umadevi, S..

Herein, we describe a facile synthesis of stable chiral ionic liquid crystal (ILC)-capped gold nanoparticles. A new ILC containing a chiral cholesterol moiety having a terminal triethylammonium group was synthesized which exhibited an enantiotropic lamellar mesophase. Stable, monodisperse citrate-stabilized gold nanoparticles having a size of ∼60 nm were prepared and the citrate ligands on the gold nanoparticles were replaced with chiral ILC through a two-phase ligand exchange process. The resulting chiral ILC-stabilized particles were characterised using UV-visible (UV-Vis) and transmission electron microscopy (TEM) studies. Different from the citrate-stabilized nanoparticles, the ligand exchanged gold nanoparticles were dispersible in organic solvent and resulting dispersion was stable for more than observed period of 3 mo. Furthermore, the chiral ILC-decorated gold nanoparticles were found to be well dispersible in a nematic host without any aggregation and induced a vertical alignment of the nematic director.

In some applications, this compound(2834-05-1)Synthetic Route of C11H21BrO2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C5H8O3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about An alternative synthesis of (S)-(+)-γ-hydroxymethyl-γ-butyrolactone from (D)-(+)-mannitol. Author is Takano, Seiichi; Goto, Emiko; Hirama, Michiyasu; Ogasawara, Kunio.

Dioxolane I (R = iodo), obtainable from D-mannitol in 5 steps, was treated with di-Et malonate in DMF in the presence of NaH to give 62.7% I [R = CH(CO2Et)2], which on treatment with equimolar amount of MgCl2 in refluxing AcNMe2 gave 95% title lactone II of excellent optical purity.

In addition to the literature in the link below, there is a lot of literature about this compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Synthetic Route of C5H8O3, illustrating the importance and wide applicability of this compound(32780-06-6).

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of C11H21BrO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Modulating electron transfer in ferrocene-naphthoquinone dyads: New insights in parameters influencing ET efficiency. Author is Sabuzi, Federica; Coletti, Alessia; Pomarico, Giuseppe; Floris, Barbara; Galloni, Pierluca; Conte, Valeria.

Electron transfer (ET) constitutes a key process for several biol. transformations, including solar energy conversion in bacteria and plants. Nowadays, numerous synthetic systems have been proposed to mimic such kind of natural occurring process. In this work, we elucidate the factors that mostly influence the electron transfer process in ferrocene-naphthoquinone dyads. In particular, the connection between the two redox units has been varied, in order to study the ET dependence from: (i) the distance between donor-acceptor units and (ii) the oxidation potential of the donor species. No interaction among the two moieties has been detected at the ground state, while efficient electron transfer process was observed following excitation of the naphthoquinone through UV-light, as well as upon the aid of a Lewis acid promoter in solution Moreover, DFT calculations have been performed to support the exptl. data.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 89972-77-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Phenyl-substituted 2,2′:6′,2”-terpyridine as a new series of fluorescent compounds-their photophysical properties and fluorescence tuning. Author is Mutai, Toshiki; Cheon, Jin-Dong; Arita, Shinpei; Araki, Koji.

Several phenyl-substituted 2,2′:6′,2”-terpyridines (tpy) were synthesized and it was found that 4′-Ph tpy (I) exhibited the most effective fluorescence, whose quantum yield was up to 0.64 in cyclohexane. For further study on tuning the fluorescence properties, different substituents were introduced into the p-position of the Ph group. While some dyes showed their absorption and fluorescence in the same region as I, others were observed at much longer wavelengths. In addition, fluorescence maxima of some of the dyes showed a large (>130 nm) solvent dependence. The difference between ground and excited state dipole moments (Δμ) for one dye was estimated to be 15.2 D by the Lippert-Mataga equation, indicating an intramol. charge transfer (ICT) process. Semi-empirical MO calculation (MOPAC/AM1) demonstrated that the HOMO-1, HOMO, and LUMO of I and several other dyes were mainly localized on the Ph (πph), tpy (πtpy) and tpy (π*tpy) part, resp., indicating that the lowest energy absorption band of these dyes was the local excitation (πtpy-π*tpy). In the case of dyes having an electron-donating substituent, πph instead of πtpy became the HOMO. Thus, the lowest energy absorption these dyes was an ICT transition (πph-π*tpy), and a large red shift of the fluorescence occurred. In these compounds, the energy level of πph is controlled without affecting that of πtpy and π*tpy, suggesting a novel approach for tuning the color of fluorescence.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials, published in 2013-07-25, which mentions a compound: 1184917-16-5, Name is 4-Bromo-2,5-dichloropyridine, Molecular C5H2BrCl2N, Computed Properties of C5H2BrCl2N.

The synthesis, preclin. profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor (I; LDK378) are described. In this initial report, preliminary structure-activity relationships (SARs) are described as well as the rational design strategy employed to overcome the development deficiencies of the first generation ALK inhibitor (II; TAE684). Compound I is currently in phase 1 and phase 2 clin. trials with substantial antitumor activity being observed in ALK-pos. cancer patients.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Recommanded Product: 89972-77-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about The surprising lability of bis(2,2′:6′,2”-terpyridine)chromium(III) complexes. Author is Constable, Edwin C.; Housecroft, Catherine E.; Neuburger, Markus; Schoenle, Jonas; Zampese, Jennifer A..

The complex [Cr(tpy)(O3SCF3)3] (tpy = 2,2′:6′,2”-terpyridine) is readily made from [Cr(tpy)Cl3] and is a convenient precursor to [Cr(tpy)2][PF6]3 and to [Cr(tpy)(4′-(4-tolyl)tpy)][PF6]3 and [Cr(tpy)(5,5”-Me2tpy)][PF6]3 (4′-(4-tolyl)tpy = 4′-(4-tolyl)-2,2′:6′,2”-terpyridine; 5,5”-Me2tpy = 5,5”-dimethyl-2,2′:6′,2”-terpyridine); these are the first examples of heteroleptic bis(tpy) chromium(III) complexes. The single crystal structures of 2{[Cr(tpy)2][PF6]3}·5MeCN, [Cr(tpy)(4′-(4-tolyl)tpy)][PF6]3·3MeCN and [Cr(tpy)(5,5”-Me2tpy)][PF6]3·3MeCN have been determined Each cation contains the expected octahedral {Cr(tpy)2}3+ unit; in all three structures, the need to accommodate three anions per cation and the solvent mols. prevents the formation of a grid-like array of cations that is typical of many lattices containing {M(tpy)2}2+ motifs. Three reversible electrochem. processes are observed for [Cr(tpy)(4′-(4-tolyl)tpy)][PF6]3 and [Cr(tpy)(5,5”-Me2tpy)][PF6]3, consistent with those documented for [Cr(tpy)2]3+. At pH 6.36, aqueous solutions of [Cr(tpy)2][PF6]3 are stable for at least two months. However, contrary to the expectations of the d3 Cr3+ ion being a kinetically inert metal center, the tpy ligands in [Cr(tpy)2]3+ are labile in the presence of base; absorption and 1H NMR spectroscopies have been used to monitor the effects of adding NaOH to aqueous and CD3OD solutions, resp., of the homo- and heteroleptic complexes. Ligand dissociation is also observed when [Bu4N]F was added to CD3OD solutions of the complexes, but in aqueous solution, [Cr(tpy)2][PF6]3 is stable in the presence of fluoride ion.

This literature about this compound(89972-77-0)Recommanded Product: 89972-77-0has given us a lot of inspiration, and I hope that the research on this compound(4-(p-Tolyl)-2,2:6,2-terpyridine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Mamba, Feziwe Bathabile; Ndlovu, Thando; Mbizana, Siyasanga; Khan, Wesaal; Gule, Nonjabulo Prudence published an article about the compound: Basic copper carbonate( cas:12069-69-1,SMILESS:O[Cu]OC(O[Cu]O)=O ).Name: Basic copper carbonate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:12069-69-1) through the article.

Appropriate wound care is pivotal in preventing wound and postsurgery infections, which remain a serious clin. problem. In this study, we report the successful fabrication of antimicrobial and biodegradable materials for possible use in the medical field. Amino functionalized polycaprolactone (PCL [Poly(CL-co-ACL)]) was synthesized via ring opening polymerization This polymer was then functionalized via the pendant amine to induce antimicrobial efficacy. This was done through the grafting of poly(lysine) onto the amine as well as the quaternization of the amine using alkyl halides. The chem. structures of the synthesized monomers and polymers were confirmed using NMR (1H NMR and 13C NMR) spectroscopy and attenuated total reflection-Fourier transform IR spectroscopy. The mol. weights of the polymers were determined using gel permeation chromatog. Nanofibre scaffolds were produced from the polymers using the electrospinning technique and these were characterized though SEM. The antimicrobial efficacy of the fabricated materials was tested against the Gram-pos. (Staphylococcus aureus ATCC 25923) and Gram-neg. (Pseudomonas aeruginosa ATCC 27853) bacteria using the disk diffusion and shake flask methods. The polymers demonstrated excellent antimicrobial efficacy. The fibers were exceptionally biodegradable which opens a lot of applications in the biomedical space.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI