Category: catalyst-ligand

Alijevic, Omar; McHugh, Damian; Rufener, Lucien; Mazurov, Anatoly; Hoeng, Julia; Peitsch, Manuel published the article 《An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors》. Keywords: Nicotiana solanaceae tobacco alkaloids nAChR nicotine anabasine anatabine; Anabasine; Anatabine; Nicotiana tabacum; Nicotine; Nornicotine; Solanaceae; Tobacco alkaloids; nAChR; α4β2; α7.They researched the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ).Reference of (S)-3-(Piperidin-2-yl)pyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:494-52-0) here.

Nicotinic acetylcholine receptor (nAChR) subtype-selective pharmacol. profiles of tobacco alkaloids are essential for understanding the physiol. effects of tobacco products. In this study, automated electrophysiol. was used to functionally characterize the effects of distinct groups of tobacco alkaloids on human α4β2 and α7 nAChRs. We found that, in tobacco alkaloids, pyridine as a hydrogen bond acceptor and a basic nitrogen atom at a distance of 4-7 Å are pharmacophoric elements necessary for mol. recognition by α4β2 and α7 nAChRs with various degrees of selectivity, potency, and efficacy. While four alkaloids-nicotine, nornicotine, anabasine and R-anatabine-potently activated α4β2, they were also weak agonists of α7 nAChRs. Nicotine was the most potent agonist of α4β2, while anabasine elicited the highest activation of α7. None of the tobacco alkaloids enhanced nAChR activity elicited by the endogenous ligand acetylcholine; therefore, none was considered to be a pos. allosteric modulator (PAM) of either α4β2 or α7 nAChRs. In contrast, we identified tobacco alkaloids, such as the tryptophan metabolite 6-hydroxykynurenic acid, that decreased the activity of both α4β2 and α7 nAChRs. Our study identified a class of alkaloids with pos. and neg. effects against human α4β2 and α7 nAChRs. It also revealed human α4β2 to be the principal receptor for sensing the most abundant alkaloids in tobacco leaves.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

COA of Formula: C22H17N3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Novel functional architectures via metallo-supramolecular initiators. Author is Schubert, Ulrich S.; Heller, Marcel; Hochwimmer, Georg.

Functionalized terpyridine metal complexes were used as metallo-supramol. initiators for the living cationic polymerization of 2-oxazolines. This method allows an easy and very controlled synthesis of polymers containing terpyridine enfunctionalized polymers.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Active mechanisorption driven by pumping cassettes, published in 2021, which mentions a compound: 2834-05-1, Name is 11-Bromoundecanoic acid, Molecular C11H21BrO2, Formula: C11H21BrO2.

Over the past century, adsorption has been investigated extensively in equilibrium systems, with a focus on the van der Waals interactions associated with physisorption and electronic interactions in the case of chemisorption. In this study, we demonstrate mechanisorption, which results from nonequilibrium pumping to form mech. bonds between the adsorbent and the adsorbate. This active mode of adsorption has been realized on surfaces of metal-organic frameworks grafted with arrays of mol. pumps. Adsorbates are transported from one well-defined compartment, the bulk, to another well-defined compartment, the interface, thereby creating large potential gradients in the form of chem. capacitors wherein energy is stored in metastable states. Mechanisorption extends, in a fundamental manner, the scope and potential of adsorption phenomena and offers a transformative approach to control chem. at surfaces and interfaces.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: DL-Histidine monohydrochloride monohydrate( cas:123333-71-1 ) is researched.HPLC of Formula: 123333-71-1.Amoureux, Jean-Paul; Hu, Bingwen; Trebosc, Julien published the article 《Enhanced resolution in proton solid-state NMR with very-fast MAS experiments》 about this compound( cas:123333-71-1 ) in Journal of Magnetic Resonance. Keywords: magic angle spinning proton solid state NMR. Let’s learn more about this compound (cas:123333-71-1).

We present a new smooth amplitude-modulated (SAM) method that allows to observe highly resolved 1H spectra in solid-state NMR. The method, which works mainly at fast or ultra-fast MAS speed (ν R > 25 kHz) is complementary to previous methods, such as DUMBO, FSLG/PMLG or symmetry-based sequences. The method is very robust and efficient and does not present line-shape distortions or fake peaks. The main limitation of the method is that it requires a modern console with fast electronics that must be able to define the cosine line-shape in a smooth way, without any transient. However, this limitation mainly occurs at ultra-fast MAS where the rotation period is very short.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A Near-Infrared Neutral pH Fluorescent Probe for Monitoring Minor pH Changes: Imaging in Living HepG2 and HL-7702 Cells, published in 2009-03-04, which mentions a compound: 89972-77-0, Name is 4-(p-Tolyl)-2,2:6,2-terpyridine, Molecular C22H17N3, Name: 4-(p-Tolyl)-2,2:6,2-terpyridine.

A near-neutral pH near-IR (NIR) fluorescent probe utilizing a fluorophore-spacer-receptor mol. framework that can modulate the fluorescence emission intensity through a fast photoinduced electron-transfer process was developed. The authors’ strategy was to choose tricarbocyanine (Cy), a NIR fluorescent dye with high extinction coefficients, as a fluorophore, and 4′-(aminomethylphenyl)-2,2′:6′,2”-terpyridine (Tpy) as a receptor. The pH titration indicated that Tpy-Cy can monitor the minor physiol. pH fluctuations with a pKa of ∼7.10 near physiol. pH, which is valuable for intracellular pH researches. The probe responds linearly and rapidly to minor pH fluctuations within the range of 6.70-7.90 and exhibits strong dependence on pH changes. As expected, the real-time imaging of cellular pH and the detection of pH in situ was achieved successfully in living HepG2 and HL-7702 cells by this probe. It is shown that the probe effectively avoids the influence of autofluorescence and native cellular species in biol. systems and meanwhile exhibits high sensitivity, good photostability, and excellent cell membrane permeability.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Reductive Carbon-Carbon Bond Forming Reactions with Carbonyls Mediated by Rh-H Complexes, published in 2020-10-19, which mentions a compound: 3393-45-1, Name is 5,6-Dihydro-2H-pyran-2-one, Molecular C5H6O2, Formula: C5H6O2.

Carbon-carbon bond formation is a fundamental transformation of synthetic organic chem. The research is related to reductive aldol reaction, reductive Mannich reaction, reductive α-acylation, and reductive α-carboxylation by using rhodium catalyst to achieve C-C bond formation. Rh-catalyzed reductive aldol reaction successfully gave β-hydroxy carbonyl compounds from α,β-unsaturated carbonyl compounds with aldehydes or ketones by treating with RhCl(PPh3)3 and Et2Zn. This condition could apply to other electrophiles such as imines, acid chlorides, and acid anhydrides, and the corresponding β-lactams, or β-ketocarbonyl compounds were obtained in good yields, resp. A key intermediate, Rh-H complex would play an important role to accomplish 1,4-reduction, which could easily be derived from RhCl(PPh3)3 and Et2Zn. The synthesis of a cholesterol absorption inhibitor, ezetimibe, was also achieved by using Rh-catalyzed reductive Mannich reaction as an application. We expect that the reaction could be used in a wide range of fields by further development.

As far as I know, this compound(3393-45-1)Formula: C5H6O2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine(SMILESS: CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1,cas:89972-77-0) is researched.Formula: C5H6O2. The article 《High yield preparation of 4′-(4-bromophenyl)-2,2′:6′,2″”-terpyridine by a condensation reaction. Determination of the stereochemistry of two complex byproducts by a combination of molecular mechanics and NMR spectroscopy》 in relation to this compound, is published in Acta Chemica Scandinavica. Let’s take a look at the latest research on this compound (cas:89972-77-0).

An improved high yield synthesis of 4′-(4-bromophenyl)-2,2′:6′,2″”-terpyridine from 2-acetylpyridine (I) and 4-bromobenzaldehyde (II) has been developed, using a two-step aldol condensation. In this, the intermediate azachalcone was isolated, then reacted with N-[2-oxo-2-(2-pyridyl)ethyl]pyridinium iodide, prepared from I, using ammonium acetate both as a base and as a ring closure agent. It could also be shown that one step aldol condensation of I and II gave low yields of the desired terpyridine due to facile formation of polycondensation products. Two of these, cyclohexanes III and IV, could be isolated in moderate yields from condensation reactions. The structure and relative configuration of these compounds were determined by a comparison of observed exptl. NMR parameters with theor. values, calculated by mol. mechanics.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Category: catalyst-ligand. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Circular dichroism (CD) of marmelo lactones and the effect of the unsaturation at C-5 on the Cotton effect of γ-lactone. Author is Nishida, Yoshihiro; Konno, Toshio; Ohrui, Hiroshi; Meguro, Hiroshi.

The CD of the (+)-marmelo lactone A (I) and the (+)-marmelo lactone B (II) had distinct cotton effects at 217 nm (n→π*) and 230∼235 nm (π→π*). The sign of the 217 nm bond is opposite to that of the saturated lactones III (R = CH2OH, CH2CH2CHMe2, CH2I), is independent of the C(2) configuration and the θ are higher than those of saturated lactones which indicate the formation of inherently dissym. chromophores between a lactone CO group and a C(5) double bond. This is substantiated by the CD of III (R = CO2H, CO2Et, cis-CH:CHCMe:CH2, trans-CH:CHCMe:CH2) and is not explicable based on exciton theory. Empirically the Cotton effect sign associated with n→π* transitions for the absolute configuration at C(4) of γ-lactones with a double bond at C(5) is pos. for the (4S) lactone and neg. for the (4R) lactone.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, International Journal of Molecular Sciences called Structure of nanotubes self-assembled from a monoamide organogelator, Author is Zapien-Castillo, Samuel; Diaz-Zavala, Nancy P.; Melo-Banda, Jose A.; Schwaller, Duncan; Lamps, Jean-Philippe; Schmutz, Marc; Combet, Jerome; Mesini, Philippe J., which mentions a compound: 2834-05-1, SMILESS is O=C(O)CCCCCCCCCCBr, Molecular C11H21BrO2, HPLC of Formula: 2834-05-1.

Some organic compounds are known to self-assemble into nanotubes in solutions, but the packing of the mols. into the walls of the tubes is known only in a very few cases. Herein, we study two compounds forming nanotubes in alkanes. They bear a secondary alkanamide chain linked to a benzoic acid Pr ester (HUB-3) or to a Bu ester (HUB-4). They gel alkanes for concentrations above 0.2 weight%. The structures of these gels, studied by freeze fracture electron microscopy, exhibit nanotubes: for HUB-3 their external diameters are polydisperse with a mean value of 33.3 nm; for HUB-4, they are less disperse with a mean value of 25.6 nm. The structure of the gel was investigated by small- and wide-angle X-ray scattering. The evolution of the intensities show that the tubes are metastable and transit slowly toward crystals. The intensities of the tubes of HUB-4 feature up to six oscillations. The shape of the intensities proves the tubular structure of the aggregates, and gives a measurement of 20.6 nm for the outer diameters and 11.0 nm for the inner diameters It also shows that the electron d. in the wall of the tubes is heterogeneous and is well described by a model with three layers.

In some applications, this compound(2834-05-1)HPLC of Formula: 2834-05-1 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

COA of Formula: C22H17N3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about One pot synthesis of formyl benzyl terpyridine: a simplified synthesis. Author is Gurung, Anup; Dahal, Sanjay.

Formyl Ph terpyridine was synthesized from Me Ph terpyridine using SeO2 as the oxidizing agent. SeO2 conventionally was used to oxidize allylic and aliphatic Me groups. The simple conversion of Me group attached to aromatic ring appended to heterocycle in a clean one pot synthesis paved way for synthesis of similar aldehydes extendable to other classes of compound as well.

In some applications, this compound(89972-77-0)COA of Formula: C22H17N3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI