Category: catalyst-ligand

Radcliffe, James E.; Fasano, Valerio; Adams, Ralph W.; You, Peiran; Ingleson, Michael J. published an article about the compound: 5,6-Dihydro-2H-pyran-2-one( cas:3393-45-1,SMILESS:O=C1C=CCCO1 ).Category: catalyst-ligand. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3393-45-1) through the article.

Useful α-boryl esters can be synthesized in one step from α,β-unsaturated esters using just a simple to access NHC-BH3 (NHC = N-heterocyclic carbene) and catalytic I2. The scope of this reductive α-borylation methodol. is excellent and includes a range of alkyl, aryl substituted and cyclic and acyclic α,β-unsaturated esters. Mechanistic studies involving reductive borylation of a cyclic α,β-unsaturated ester with NHC-BD3/I2 indicated that concerted hydroboration of the alkene moiety in the α,β-unsaturated ester proceeds instead of a stepwise process involving initial 1,4-hydroboration; this is in contrast to the recently reported reductive α-silylation. The BH2(NHC) unit can be transformed into electrophilic BX2(NHC) moieties (X = halide) and the ester moiety can be reduced to the alc. with the borane unit remaining intact to form β-boryl alcs. The use of a chiral auxiliary, 8-phenylmenthyl ester, also enables effective stereo-control of the newly formed C-B bond. Combined two step ester reduction/borane oxidation forms diols, including excellent e.e. (97%) for the formation of S-3-phenylpropane-1,2-diol. This work represents a simple transition metal free route to form bench stable α-boryl esters from inexpensive starting materials.

The article 《Reductive α-borylation of α,β-unsaturated esters using NHC-BH3 activated by I2 as a metal-free route to α-boryl esters》 also mentions many details about this compound(3393-45-1)Category: catalyst-ligand, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C22H17N3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis, Structural Characterization, Photophysical, Electrochemical, and Anion-Sensing Studies of Luminescent Homo- and Heteroleptic Ruthenium(II) and Osmium(II) Complexes Based on Terpyridyl-imidazole Ligand. Author is Bhaumik, Chanchal; Saha, Debasish; Das, Shyamal; Baitalik, Sujoy.

A series of hetero- and homoleptic tridentate ruthenium(II) and osmium(II) complexes of compositions [(tpy-PhCH3)Ru(tpy-HImzphen)](ClO4)2 (1), [(H2pbbzim)Ru(tpy-HImzphen)](ClO4)2 (2), and [M(tpy-HImzphen)2](ClO4)2 [M = RuII (3) and OsII (4)], where tpy-PhCH3 = 4′-(4-methylphenyl)-2,2′:6′,2”-terpyridine, H2pbbzim = 2,6-bis(benzimidazole-2-yl)pyridine and tpy-HImzphen = 2-(4-[2,2′:6′,2”]terpyridine-4′-yl-phenyl)-1H-phenanthro[9,10-d]imidazole, were synthesized and characterized by using standard anal. and spectroscopic techniques. X-ray crystal structures of three complexes 2, 3, and 4 were determined The absorption spectra, redox behavior, and luminescence properties of the complexes were thoroughly studied. All of the complexes display moderately strong luminescence at room temperature with lifetimes at 10-55 ns. The effect of solvents on the absorption and emission spectral behavior of the complexes also was studied. The anion sensing properties of all the complexes were studied in solution using absorption, emission, and 1H NMR spectral studies and by cyclic voltammetric (CV) measurements. The complexes 1, 3, and 4 act as sensors for F- only, whereas 2 acts as sensor for F-, AcO-, and to some extent for H2PO4-. It is evident that in the presence of excess of anions deprotonation of the imidazole N-H fragment(s) occurs in all cases, an event which is signaled by the development of vivid colors visible with the naked eye. The receptor-anion binding/equilibrium constants were evaluated.

The article 《Synthesis, Structural Characterization, Photophysical, Electrochemical, and Anion-Sensing Studies of Luminescent Homo- and Heteroleptic Ruthenium(II) and Osmium(II) Complexes Based on Terpyridyl-imidazole Ligand》 also mentions many details about this compound(89972-77-0)Synthetic Route of C22H17N3, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90. Author is Wrona, Iwona E.; Gozman, Alexander; Taldone, Tony; Chiosis, Gabriela; Panek, James S..

The heat shock protein 90-inhibiting natural ansamycin natural products reblastatin I (R = MeO; R1 = H; X = CH2CH2) and autolytimycin I (R = R1 = H; X = CH2CH2), and four of their analogs I [R = MeO; R1 = H, MeOCH2, H2NHCO; X = (Z)-CH:CH, CH2CH2] lacking a quinone moiety are prepared using the chemoselective, regioselective, and stereoselective zirconium-mediated coupling reaction of a methyl-substituted alkyne with an aldehyde to give an (E)-trisubstituted allylic alc. and the copper-catalyzed macroamidation reaction of terminal amides containing a bromoarene as the key steps. The competitive binding of Hsp90α to I [R = H, MeO; R1 = H, MeOCH2, H2NHCO; X = (Z)-CH:CH, CH2CH2], an uncyclized derivative of reblastatin, a reblastatin analog lacking the carbamate ester, geldanamycin, and 17-(allylamino)-17-demethoxygeldanamycin is determined; the inhibition of human myeloid leukemia cells by I [R = MeO; R1 = H, MeOCH2, H2NHCO; X = (Z)-CH:CH, CH2CH2] and by 17-(allylamino)-17-demethoxygeldanamycin (II), a geldanamycin derivative currently under evaluation for treatment of cancer, are determined Reblastatin and autolytimycin I (R = MeO, H; R1 = H; X = CH2CH2) bind heat shock protein 90 with better affinities (26 nM and 36 nM, resp.) than II (110 nM); I (R = MeO, H; R1 = H; X = CH2CH2) are more effective at inhibiting one of the human myeloid leukemia cell lines (Kasumi-1) than II but are less effective than II at inhibiting the other (MOLM-13).

The article 《Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90》 also mentions many details about this compound(32780-06-6)Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Nett, Ryan S.; Dho, Yaereen; Low, Yun-Yee; Sattely, Elizabeth S. published an article about the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1 ).Category: catalyst-ligand. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:494-52-0) through the article.

Plants synthesize many diverse small mols. that affect function of the mammalian central nervous system, making them crucial sources of therapeutics for neurol. disorders. A notable portion of neuroactive phytochems. are lysine-derived alkaloids, but the mechanisms by which plants produce these compounds have remained largely unexplored. To better understand how plants synthesize these metabolites, we focused on biosynthesis of the Lycopodium alkaloids that are produced by club mosses, a clade of plants used traditionally as herbal medicines. Hundreds of Lycopodium alkaloids have been described, including huperzine A (HupA), an acetylcholine esterase inhibitor that has generated interest as a treatment for the symptoms of Alzheimers disease. Through combined metabolomic profiling and transcriptomics, we have identified a developmentally controlled set of biosynthetic genes, or potential regulon, for the Lycopodium alkaloids. The discovery of this putative regulon facilitated the biosynthetic reconstitution and functional characterization of six enzymes that act in the initiation and conclusion of HupA biosynthesis. This includes a type III polyketide synthase that catalyzes a crucial imine-polyketide condensation, as well as three Fe(II)/2-oxoglutarate-dependent dioxygenase (2OGD) enzymes that catalyze transformations (pyridone ring-forming desaturation, piperidine ring cleavage, and redox-neutral isomerization) within downstream HupA biosynthesis. Our results expand the diversity of known chem. transformations catalyzed by 2OGDs and provide mechanistic insight into the function of noncanonical type III PKS enzymes that generate plant alkaloid scaffolds. These data offer insight into the chem. logic of Lys-derived alkaloid biosynthesis and demonstrate the tightly coordinated coexpression of secondary metabolic genes for the biosynthesis of medicinal alkaloids.

The article 《A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis》 also mentions many details about this compound(494-52-0)Category: catalyst-ligand, you can pay attention to it or contacet with the author([email protected]) to get more information.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Formula: C5H6O2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5,6-Dihydro-2H-pyran-2-one, is researched, Molecular C5H6O2, CAS is 3393-45-1, about Anti-inflammatory and Quinone Reductase-Inducing Compounds from Beilschmiedia mannii. Author is Ahoua, Angora Remi Constant; Monteillier, Aymeric; Borlat, Frederic; Ciclet, Olivier; Marcourt, Laurence; Nejad Ebrahimi, Samad; Kone, Mamidou Witabouna; Bonfoh, Bassirou; Christen, Philippe; Cuendet, Muriel.

Previous studies on the therapeutic potential of plant species found in the diet of chimpanzees living in tai national park have shown that they could be potential candidates for the search of new mols. useful for humans. Based on the screening of some of these plants, the fruits of beilschmiedia mannii, whose dichloromethane extract showed cancer chemopreventive properties, were selected. Bioactivity-guided fractionation of the extract resulted in the isolation and identification of two pyrones, including desmethoxydihydromethysticin ( 1), found in a natural source for the first time, and a new congener, beilschmiediapyrone ( 2), as well as five known alkamides ( 3 – 7). Their structures were established by using nmr spectroscopy and mass spectrometry methods. The isolated compounds were evaluated for their cancer chemopreventive potential by using quinone reductase induction and nuclear factor-kappa b inhibition tests in hepa 1c1c7 and hek-293/nf- b-luc cells, resp. Among them, compounds 1and 2were the most active. The concentrations to double the quinone reductase activity were 7.5 mum for compound 1and 6.1 mum for compound 2. Compounds 1and 2inhibited nuclear factor-kappa b with ic 50values of 2.1 and 3.4 mum, resp. These results are promising with regard to cancer chemoprevention, especially because this plant is also used for cooking by the local population around the tai forest.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Wrona, Iwona E.; Garbada, Ana E.; Evano, Gwilherm; Panek, James S. published the article 《Total Synthesis of Reblastatin》. Keywords: reblastatin asym total synthesis hydrozirconation transmetalation aldehyde addition.They researched the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6 ).Computed Properties of C5H8O3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:32780-06-6) here.

Enantioselective total synthesis of reblastatin is described. The synthesis highlights hydrozirconation, transmetalation, aldehyde addition sequence to install E-trisubstituted olefin and C7 stereocenter, and the first use of an intramol. Buchwald-like amidation reaction to close the 19-membered macrolactam.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 11-Bromoundecanoic acid( cas:2834-05-1 ) is researched.Formula: C11H21BrO2.Fontanesi, Claudio; Como, Enrico Da; Vanossi, Davide; Montecchi, Monica; Cannio, Maria; Mondal, Prakash Chandra; Giurlani, Walter; Innocenti, Massimo; Pasquali, Luca published the article 《Redox-Active Ferrocene grafted on H-Terminated Si(111): Electrochemical Characterization of the Charge Transport Mechanism and Dynamics》 about this compound( cas:2834-05-1 ) in Scientific Reports. Keywords: hydrogen terminated silicon ferrocene electrode charge transport mechanism. Let’s learn more about this compound (cas:2834-05-1).

Electroactive self-assembled monolayers (SAMs) bearing a ferrocene (Fc) redox couple were chem. assembled on H-terminated semiconducting degenerate-doped n-type Si(111) substrate. This allows to create a Si(111)|organic-spacer|Fc hybrid interface, where the ferrocene moiety is covalently immobilized on the silicon, via two alkyl mol. spacers of different length. Organic monolayer formation was probed by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) and XPS measurements, which were also used to estimate thickness and surface assembled monolayer (SAM) surface coverage. Atomic force microscopy (AFM) measurements allowed to ascertain surface morphol. and roughness. The single electron transfer process, between the ferrocene redox probe and the Si electrode surface, was probed by cyclic voltammetry (CV) measurements. CVs recorded at different scan rates, in the 10 to 500 mV s-1 range, allowed to determine peak-to-peak separation, half-wave potential, and charge-transfer rate constant (KET). The exptl. findings suggest that the electron transfer is a one electron quasi-reversible process. The present demonstration of surface engineering of functional redox-active organometallic mol. can be efficient in the field of mol. electronics, surface-base redox chem., opto-electronic applications.

Although many compounds look similar to this compound(2834-05-1)Formula: C11H21BrO2, numerous studies have shown that this compound(SMILES:O=C(O)CCCCCCCCCCBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of C22H17N3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis of para-substituted phenylterpyridine ligands. Author is Spahni, Werner; Calzaferri, Gion.

The title compounds (I; R = MeO, Me, Br, Cl, OH) were prepared by cyclocondensation of 2-acetylpyridine with NH4OAc and 4-RC6H4CHO. I (R = BrCH2) was prepared by bromination of I (R = Me) with N-bromosuccinimide. I were readily purified via their HBr salts. Complexes of I with Fe(II) and Ru(II) were prepared

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Safety of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Studies directed towards the asymmetric total synthesis of antileukemic lignan lactones. Synthesis of optically pure key intermediate and its utility. Author is Tomioka, Kiyoshi; Koga, Kenji.

The preparation of the β-piperonyl-γ-lactone I (RR1 = O), the key intermediate in the synthesis of lignan lactones, from the chiral γ-lactone synthon II is reported. II was converted in 60% yield in three steps to the triol III, which gave 98% of the hemiacetal I (R = H, R1 = OH) on oxidation with NaIO4. Collins oxidation of I (R = H, R1 = OH) gave 89% optically pure I (RR1 = O) which was converted into several optically pure natural lignan lactones, e.g. (-)-hinokinin (IV).

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 3393-45-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5,6-Dihydro-2H-pyran-2-one, is researched, Molecular C5H6O2, CAS is 3393-45-1, about Flavor formation in frying process of green onion (Allium fistulosum L.) deep-fried oil. Author is Zhang, Ning; Sun, Baoguo; Mao, Xueying; Chen, Haitao; Zhang, Yuyu.

Fried allium oil has been widely used in traditional Chinese home cooking and recently has grown in popularity in the food manufacturing industry. Thus, phys. and chem. changes during frying process were measured to investigate the flavor formation mechanism in green onion (Allium fistulosum L.) deep-fried oil. With the increase of the oil temperature, important variations took place when the temperature rose above 140 °C during the whole frying process. A detailed study of these changes was made from both macro and micro aspects. From a macro perspective, sensory attributes including burnt, fried, oily, cooked vegetable and salty were strengthened. Meanwhile, the reference points of the oil samples on the fingerprint chart were distinguishable from others by electronic nose. In addition, contents of furans and furanones, sulfur-containing compounds, aldehydes and alcs. increased sharply according to SAFE-GC-MS anal. from a microscopic point of view, and contents of unsaturated fatty acids dropped remarkably while the saturated ones increased. These changes were considered to be caused by interactions between carbohydrates, proteins and fats in the deep-fried system and thermo degradations of sugars, amino acids and fats. The results indicated that the stage, when frying at temperatures ranging from 140 °C to 165 °C, was the most significant period for the flavor formation of the deep-fried oil.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI