Category: catalyst-ligand

Name: 11-Bromoundecanoic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Streamlined One-Pot Synthesis of Nitro Fatty Acids. Author is Hassan, Mohamed; Krieg, Sara-Cathrin; Ndefo Nde, Cedric; Roos, Jessica; Maier, Thorsten J.; El Rady, Eman A.; Raslan, Mohamed A.; Sadek, Kamal U.; Manolikakes, Georg.

A novel method for the synthesis of nitro fatty acids (NFAs), an intriguing class of endogenously occurring lipid mediators, is reported. This one-pot procedure enables the controlled and stereoselective construction of nitro fatty acids from a simple set of common building blocks in a highly facile manner. Thereby, this methodol. offers a streamlined, highly modular access to naturally occurring nitro fatty acids as well as non-natural NFA derivatives

《Streamlined One-Pot Synthesis of Nitro Fatty Acids》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(11-Bromoundecanoic acid)Name: 11-Bromoundecanoic acid.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of 11-Bromoundecanoic acid. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Activation of a Copper Biscarbene Mechano-Catalyst Using Single-Molecule Force Spectroscopy Supported by Quantum Chemical Calculations.

Single-mol. force spectroscopy allows study of the effect of mech. force on individual bonds. By determining the forces necessary to sufficiently activate bonds to trigger dissociation, it is possible to predict the behavior of mechanophores. The force necessary to activate a Cu biscarbene mechano-catalyst intended for self-healing materials was measured. By using a safety line bypassing the mechanophore, it was possible to pinpoint the dissociation of the studied bond and determine rupture forces to range from 1.6 to 2.6 nN at room temperature in DMSO. The average length-increase upon rupture of the Cu-C bond, due to the stretching of the safety line, agrees with quantum chem. calculations, but the values exhibit an unusual scattering. This scattering was assigned to the conformational flexibility of the mechanophore, which includes formation of a threaded structure and recoiling of the safety line.

《Activation of a Copper Biscarbene Mechano-Catalyst Using Single-Molecule Force Spectroscopy Supported by Quantum Chemical Calculations》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(11-Bromoundecanoic acid)Reference of 11-Bromoundecanoic acid.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5,6-Dihydro-2H-pyran-2-one, is researched, Molecular C5H6O2, CAS is 3393-45-1, about Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1, the main research direction is neoplasm antitumor macrocyclic inhibitor apurinic apyrimidinic endonuclease 1 APE1; crystal structure.Computed Properties of C5H6O2.

Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified as an important therapeutic target. In this work, we identified hot spots for binding of small organic mols. exptl. in high resolution crystal structures of APE1 and computationally through the use of FTMAP anal. (http://ftmap.bu.edu/). Guided by these hot spots, a library of drug-like macrocycles was docked and then screened for inhibition of APE1 endonuclease activity. In an iterative process, hot-spot-guided docking, characterization of inhibition of APE1 endonuclease, and cytotoxicity of cancer cells were used to design next generation macrocycles. To assess target selectivity in cells, selected macrocycles were analyzed for modulation of DNA damage. Taken together, our studies suggest that macrocycles represent a promising class of compounds for inhibition of APE1 in cancer cells.

《Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5,6-Dihydro-2H-pyran-2-one)Computed Properties of C5H6O2.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 11-Bromoundecanoic acid(SMILESS: O=C(O)CCCCCCCCCCBr,cas:2834-05-1) is researched.Recommanded Product: Nickel(II) bromide ethylene glycol dimethyl ether complex. The article 《Control of Director Fields in Phospholipid-Coated Liquid Crystal Droplets》 in relation to this compound, is published in Langmuir. Let’s take a look at the latest research on this compound (cas:2834-05-1).

In liquid crystal (LC) droplets, small changes in surface anchoring energy can produce large changes in the director field which result in readily detectable optical effects. This makes them attractive for use as biosensors. Coating LC droplets with a phospholipid monolayer provides a bridge between the hydrophobic world of LCs and the water-based world of biol. and makes it possible to incorporate naturally occurring biosensor systems. However, phospholipids promote strong perpendicular (homeotropic) anchoring that can inhibit switching of the director field. We show that the tendency for phospholipid layers to promote perpendicular anchoring can be suppressed by using synthetic phospholipids in which the acyl chains are terminated with bulky tert-Bu or ferrocenyl groups; the larger these end-group(s), the less likely the system is to be perpendicular/radial. Addnl., the droplet director field is found to be dependent on the nature of the LC, particularly its intrinsic surface properties, but not (apparently) on the sign of the dielec. anisotropy, the proximity to the melting/isotropic phase transition, the surface tension (in air), or the values of the Frank elastic constants

《Control of Director Fields in Phospholipid-Coated Liquid Crystal Droplets》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(11-Bromoundecanoic acid)Reference of 11-Bromoundecanoic acid.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Article, Research Support, Non-U.S. Gov’t, Scientific Reports called Constitutive activation of nitrate reductase in tobacco alters flowering time and plant biomass, Author is Lu, Jianli; Chandrakanth, Niharika N.; Lewis, Ramsey S.; Andres, Karen; Bovet, Lucien; Goepfert, Simon; Dewey, Ralph E., the main research direction is tobacco nitrate reductase flowering biomass constitutive activation.Synthetic Route of C10H14N2.

Pyridine alkaloids produced in tobacco can react with nitrosating agents such as nitrite to form tobacco-specific nitrosamines (TSNA), which are among the most notable toxicants present in tobacco smoke. The market type known as burley tobacco is particularly susceptible to TSNA formation because its corresponding cultivars exhibit a nitrogen-use-deficiency phenotype which results in high accumulation of nitrate, which, in turn, is converted to nitrite by leaf surface microbes. We have previously shown that expression of a constitutively activated nitrate reductase (NR) enzyme dramatically decreases leaf nitrate levels in burley tobacco, resulting in substantial TSNA reductions without altering the alkaloid profile. Here, we show that plants expressing a constitutively active NR construct, designated 35S:S523D-NR, display an early-flowering phenotype that is also associated with a substantial reduction in plant biomass. We hypothesized that crossing 35S:S523D-NR tobaccos with burley cultivars that flower later than normal would help mitigate the undesirable early-flowering/reduced-biomass traits while maintaining the desirable low-nitrate/TSNA phenotype. To test this, 35S:S523D-NR plants were crossed with two late-flowering cultivars, NC 775 and NC 645WZ. In both cases, the plant biomass at harvest was restored to levels similar to those in the original cultivar used for transformation while the low-nitrate/TSNA trait was maintained. Interestingly, the mechanism by which yield was restored differed markedly between the two crosses. Biomass restoration in F1 hybrids using NC 645WZ as a parent was associated with delayed flowering, as originally hypothesized. Unexpectedly, however, crosses with NC 775 displayed enhanced biomass despite maintaining the early-flowering trait of the 35S:S523D-NR parent.

《Constitutive activation of nitrate reductase in tobacco alters flowering time and plant biomass》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-3-(Piperidin-2-yl)pyridine)Synthetic Route of C10H14N2.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

HPLC of Formula: 32780-06-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Pheromones of Coleoptera. 3. Synthesis of (R)-γ-hexanolide from D-mannitol.

The title compound I was prepared in 7 steps from mannitol by isopropylidenation, oxidation-reduction (NaIO4-NaBH4) to give dioxolane II, tosylation, reaction with CH2(CO2Et)2, lactonization to furanone III, tosylation, and elimination.

Different reactions of this compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)HPLC of Formula: 32780-06-6 require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Hansen, Tina V. A.; Grencis, Richard K.; Issouf, Mohamed; Neveu, Cedric; Charvet, Claude L. published an article about the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1 ).Related Products of 494-52-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:494-52-0) through the article.

The human whipworm, Trichuris trichiura, is estimated to infect 289.6 million people globally. Control of human trichuriasis is a particular challenge, as most anthelmintics have a limited single-dose efficacy, with the striking exception of the narrow-spectrum anthelmintic, oxantel. We recently identified a novel ACR-16-like subunit from the pig whipworm, T. suis which gave rise to a functional acetylcholine receptor (nAChR) preferentially activated by oxantel. However, there is no ion channel described in the mouse model parasite T. muris so far. Here, we have identified the ACR-16-like and ACR-19 subunits from T. muris, and performed the functional characterization of the receptors in Xenopus laevis oocytes using two-electrode voltage-clamp electrophysiol. We found that the ACR-16-like subunit from T. muris formed a homomeric receptor gated by acetylcholine whereas the ACR-19 failed to create a functional channel. The subsequent pharmacol. anal. of the Tmu-ACR-16-like receptor revealed that acetylcholine and oxantel were equally potent. The Tmu-ACR-16-like was more responsive to the toxic agonist epibatidine, but insensitive to pyrantel, in contrast to the Tsu-ACR-16-like receptor. These findings confirm that the ACR-16-like nAChR from Trichuris spp. is a preferential drug target for oxantel, and highlights the pharmacol. difference between Trichuris species.

Different reactions of this compound((S)-3-(Piperidin-2-yl)pyridine)Related Products of 494-52-0 require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 89972-77-0, is researched, SMILESS is CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1, Molecular C22H17N3Journal, Shanxi Daxue Xuebao, Ziran Kexueban called Synthesis of 2,2′:6′,2”-terpyridine ligands, Author is Zhang, Lin; Wang, Guo-song; Liu, Wei-min; Wang, Zi-wei, the main research direction is terpyridine preparation ligand iron.Quality Control of 4-(p-Tolyl)-2,2:6,2-terpyridine.

Two 2,2′ : 6′,2″”-terpyridine derivative ligands was synthesized, and their structure was characterized by using 1HNMR and IR anal., and the mechanics of the synthesis was studied. The temperature and solvent of the reaction were also optimized so that the conditions were more specific and effective. The yield of two compounds were better than those reported in former references, 37% and 41%, resp. The ligands easily coordinate with Fe(II) and Fe(III) and the complexes were easily dissolved in many organic solvents.

Different reactions of this compound(4-(p-Tolyl)-2,2:6,2-terpyridine)Quality Control of 4-(p-Tolyl)-2,2:6,2-terpyridine require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

SDS of cas: 89972-77-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis of Metal-Organic Complex Arrays.

The Merrifield solid-phase peptide synthesis technique was adapted to the synthesis of homo- and heterometallic metal-organic complex arrays (MOCAs). A terpyridine-appended and Fmoc-protected L-tyrosine derivative (I) was metalated with Pt(II), Rh(III), or Ru(II) ions in solution and sequentially coupled at the surface of functionalized polymeric resin to give a metal complex triad (Rh-Pt-Ru), tetrad (Ru-Rh-Pt-Pt), pentad (Rh-Pt-Ru-Pt-Rh), and hexad (Rh-Pt-Ru-Pt-Rh-Pt) with specific metal sequence arrangements. These were cleaved from the resin, and their character was confirmed by mass spectrometry.

Different reactions of this compound(4-(p-Tolyl)-2,2:6,2-terpyridine)SDS of cas: 89972-77-0 require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

COA of Formula: C22H17N3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis and magnetic study of μ1,1-azido-bridged dinuclear manganese(II) complexes based on tripyridyl ligands. Author is Yu, Ming-Ming; Ni, Zhong-Hai; Zhao, Chong-Chao; Cui, Ai-Li; Kou, Hui-Zhong.

Three azido-bridged MnII complexes [Mn2(N3)4(ttp)2] (1), [Mn2(N3)4(ttp-N3)2] (2) and [Mn2(N3)4(ttp-N3)2]3[MnIII(ttp-N3)(N3)3]2 (3), where ttp and ttp-N3 represent 4′-p-tolyl-2,2′:6′,2”-terpyridine and 4′-p-azidomethylphenyl-2,2′:6′,2”-terpyridine, were synthesized and characterized by single-crystal x-ray diffraction anal. and magnetic studies. The Mn ions in complexes 1 and 2 are coordinated by three N atoms of the ttp or ttp-N3 ligands, and they are connected by double end-on (EO) azide ligands; this forms a dinuclear MnII system with Mn-N-Mn bridging angles of 103.5 and 103.1°. The Br atoms of the -CH2Br ligands were replaced by azido groups during the formation of complexes 2 and 3. The structure of complex 3 comprises two structurally similar MnII dimers with double end-on bridging azide groups and one mononuclear MnIII structure. The bridging Mn-N-Mn angles in 3 are 104.2, 105.1, and 106.73°. Magnetic studies indicate intramol. ferromagnetic superexchange. The strength of ferromagnetic coupling within the Mn2 cores in 1-3 is dependent on the Mn-N-Mn bridging angles. The magnetic coupling constants for intermol. exchange are 2.46(4), 2.25(2), and 1.92(4) cm-1 for 1, 2, and 3, resp., from Hamiltonian H = -2JS1S2.

The article 《Synthesis and magnetic study of μ1,1-azido-bridged dinuclear manganese(II) complexes based on tripyridyl ligands》 also mentions many details about this compound(89972-77-0)COA of Formula: C22H17N3, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI