Category: 32780-06-6

Safety of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Studies directed towards the asymmetric total synthesis of antileukemic lignan lactones. Synthesis of optically pure key intermediate and its utility. Author is Tomioka, Kiyoshi; Koga, Kenji.

The preparation of the β-piperonyl-γ-lactone I (RR1 = O), the key intermediate in the synthesis of lignan lactones, from the chiral γ-lactone synthon II is reported. II was converted in 60% yield in three steps to the triol III, which gave 98% of the hemiacetal I (R = H, R1 = OH) on oxidation with NaIO4. Collins oxidation of I (R = H, R1 = OH) gave 89% optically pure I (RR1 = O) which was converted into several optically pure natural lignan lactones, e.g. (-)-hinokinin (IV).

Although many compounds look similar to this compound(32780-06-6)Safety of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, numerous studies have shown that this compound(SMILES:O=C1O[C@H](CO)CC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Metal catalyst and ligand design,
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Wrona, Iwona E.; Garbada, Ana E.; Evano, Gwilherm; Panek, James S. published the article 《Total Synthesis of Reblastatin》. Keywords: reblastatin asym total synthesis hydrozirconation transmetalation aldehyde addition.They researched the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6 ).Computed Properties of C5H8O3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:32780-06-6) here.

Enantioselective total synthesis of reblastatin is described. The synthesis highlights hydrozirconation, transmetalation, aldehyde addition sequence to install E-trisubstituted olefin and C7 stereocenter, and the first use of an intramol. Buchwald-like amidation reaction to close the 19-membered macrolactam.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called Enantioselective synthesis of (-)-velbanamine and (+)-isovelbanamine using L-glutamic acid as chiral template, Author is Takano, Seiichi; Yonaga, Masahiro; Chiba, Kenji; Ogasawara, Kunio, which mentions a compound: 32780-06-6, SMILESS is O=C1O[C@H](CO)CC1, Molecular C5H8O3, Computed Properties of C5H8O3.

(-)-Velbanamine and (+)-isovelbanamine (I; R = Et, R1 = OH; R = OH, R1 = Et, resp.) were stereoselectively prepared from L-glutamic acid in 14 steps. I are potential intermediates for the Pandaca alkaloids in the natural configuration.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one(SMILESS: O=C1O[C@H](CO)CC1,cas:32780-06-6) is researched.HPLC of Formula: 123333-71-1. The article 《Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents》 in relation to this compound, is published in Nucleosides & Nucleotides. Let’s take a look at the latest research on this compound (cas:32780-06-6).

We have developed a novel class of 2-phosphonate 1,3-dioxolane nucleotide analogs, from which the guanine derivative displayed weak anti-HCMV activity. Further SAR studies led to the identification of both cis and trans guanine derivatives of THF analogs as potent anti-HCMV agents, both in vitro and in vivo, compared to ganciclovir and HPMPC.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 32780-06-6, is researched, SMILESS is O=C1O[C@H](CO)CC1, Molecular C5H8O3Journal, Article, Journal of the American Chemical Society called Stereochemical Elucidation of Streptorubin B, Author is Haynes, Stuart W.; Sydor, Paulina K.; Corre, Christophe; Song, Lijiang; Challis, Gregory L., the main research direction is stereochem streptorubin B Streptomyces enantioselective synthesis.Formula: C5H8O3.

Streptorubin B is a structurally remarkable member of the prodiginine group of antibiotics produced by several actinobacteria, including the model organism Streptomyces coelicolor A3. Transannular strain within the pyrrolophane structure of this mol. causes restricted rotation that gives rise to the possibility of (diastereomeric) atropisomers. Neither the relative nor the absolute stereochem. of streptorubin B is known. NOESY NMR experiments were used to define the relative stereochem. of the major atropisomer of streptorubin B·HCl in solution as anti. We exploited this finding together with our knowledge of streptorubin B biosynthesis in S. coelicolor to determine the absolute stereochem. of the anti atropisomer. 2-Undecylpyrrole stereoselectively labeled with deuterium at C-4′ was synthesized and fed to a mutant of S. coelicolor, which was unable to produce streptorubin B because it was blocked in 2-undecylpyrrole biosynthesis, and in which the genes responsible for the last two steps of streptorubin B biosynthesis were overexpressed. 1H and 2H NMR anal. of the stereoselectively deuterium-labeled streptorubin B·HCl produced by this mutasynthesis strategy allowed us to assign the absolute stereochem. of the major (anti) atropisomer as 7’S. HPLC analyses of streptorubin B isolated from S. coelicolor on a homochiral stationary phase and comparisons with streptorubin B derived from an enantioselective synthesis showed that the natural product consists of an approx. 88:7:5 mixture of the (7’S, anti), (7’S, syn), and (7’R, anti) stereoisomers.

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Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about A synthetic approach to the pseudopterosins using cascade technology. Author is Harrowven, David C.; Dennison, Shelagh T.; Howes, Peter.

A rapid synthetic entry toward the pseudopterosins, a class of diterpenes which display potent antiinflammatory and analgesic properties, is described. The key feature of this approach is the use of a sequential intramol., Lewis acid mediated Friedel-Crafts alkylation-Friedel-Crafts acylation sequence, viz, lactone I to phenalenone II, to establish the tricyclic carbon framework.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of the chiral synthon for the enantioselective syntheses of the eburnamine type alkaloids, published in 1982-08-01, which mentions a compound: 32780-06-6, mainly applied to eburnamine synthon chiral enantioselective, Synthetic Route of C5H8O3.

A chiral synthon (I) for the syntheses of (-)-eburnamonine (II) and related eburnamine type alkaloids has been prepared in a good yield from the known compound (III) originated from L-glutamic acid or D-mannitol.

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Metal catalyst and ligand design,
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Computed Properties of C5H8O3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Synthesis of 2′-C-α-methyl-2′,3′-dideoxynucleosides. Author is Giri, Indrajit; Bolon, Pascal J.; Chu, Chung K..

A general method for the synthesis of 2′-C-α-methyl-2′,3′-dideoxynucleosides is presented. Stereofacial selectivity of the 2-C-methylation reaction of γ-lactone I (R = SiPh2CMe3, CH2Ph, CH2OCH2CH2OMe) has been investigated, in which the presence of a bulky group at the 5-hydroxymethyl produced the α-isomer as a major product. During glycosylation, the α-Me group directed the formation of nucleosides in favor of the β-isomer. This methodol. is applied to the synthesis of some new pyrimidine and purine nucleosides.

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Synthetic Route of C5H8O3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about A facile and highly chemoselective protection of primary hydroxyl groups with 2-methyl-1-butene. Author is Figadere, Bruno; Franck, Xavier; Cave, Andre.

The chemoselective formation of tert-amyl ethers of primary hydroxyl groups in the presence of secondary hydroxyl groups is described. Thus, treatment of BuCH(OH)CH2OH with 1 equiv 2-methyl-1-butene in the presence BF3.Et2O afforded 78% BuCH(OH)CH2OCMe2Et and < 3% bis-tert-amyl ether. Compounds in my other articles are similar to this one((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Synthetic Route of C5H8O3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

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Metal catalyst and ligand design,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Diastereoselective synthesis of 2,5-disubstituted tetrahydrofuran derivatives, published in 2000-09-22, which mentions a compound: 32780-06-6, mainly applied to diastereoselective synthesis THF, Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

5-Substituted lactol I was converted to 2,5-disubstituted THF derivatives by a Lewis acid-promoted reaction with allylsilanes. High trans selectivity (12:1) was obtained when hindered allylsilane Me2C:CHCH2SiMe3 was employed. Addnl., 2,5-cis-disubstituted THF derivatives were obtained in good yields and diastereoselectivities after alkyllithium addition to a lactone, followed by Et3SiH/BF3·OEt2 reduction of the corresponding hemiketals.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI