Category: 295-64-7

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 295-64-7, name is 1,4,7,10,13-Pentaazacyclopentadecane, introducing its new discovery. Safety of 1,4,7,10,13-Pentaazacyclopentadecane

A suitable functionalization of nitroindazoles with triazolyl and pyrazolyl moieties via cycloaddition reactions

The alkylation of a series of nitroindazole derivatives with 1,2-dibromoethane afforded the corresponding N-(2-bromoethyl)- and N-vinyl-nitro-1H-indazoles. The Cu(I)-catalysed azide- alkyne 1,3-dipolar cycloaddition was selected to substitute the nitroindazole core with 1,4-disubstituted triazole units after converting one of the N-(2-bromoethyl)nitroindazoles into the corresponding azide. The reactivity in 1,3-dipolar cycloaddition reactions with nitrile imines generated in situ from ethyl hydrazono-alpha-bromoglyoxylates was studied with nitroindazoles bearing a vinyl unit. The corresponding nitroindazole-pyrazoline derivatives were obtained in good to excellent yields.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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Recently we reported the use of octamer primers tailed with 5- nitroindole for use as primers in cycle sequencing reactions. Here we report the successful use of some other universal base analogues to improve the effectiveness of an octamer sequencing primer. These analogues are 5- nitroindazole, 3-nitropyrrole and benzimidazole.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 295-64-7, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 295-64-7, name is 1,4,7,10,13-Pentaazacyclopentadecane. In an article£¬Which mentioned a new discovery about 295-64-7

Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors

Thrombin, a serine protease, plays a central role in the initiation of thrombotic events. We report design, synthesis, and antithrombotic efficacy of XU817 (7), a nonpeptide 5-(amidino) indole thrombin inhibitor. Utilizing the co-crystal structure of XU817 bound in the active site of thrombin we were able to synthesize analogs with enhanced thrombin affinity.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 1,4,7,10,13-Pentaazacyclopentadecane. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 295-64-7

Targeting monoamine oxidases with multipotent ligands: An emerging strategy in the search of new drugs against neurodegenerative diseases

The socioeconomic burden of multi-factorial pathologies, such as neurodegenerative diseases (NDs), is enormous worldwide. Unfortunately, no proven disease-modifying therapy is available yet and in most cases (e.g., Alzheimer’s and Parkinson’s disease) the approved drugs exert only palliative and symptomatic effects. Nowadays, an emerging strategy for the discovery of disease-modifying drugs is based on the multi-target directed ligand (MTDL) design, an innovative shift from the traditional approach one-drug-one-target to the more ambitious one-drug-more-targets goal. Herein, we review the discovery strategy, the mechanism of action and the biopharmacological evaluation of multipotent ligands exhibiting monoamine oxidase (MAO) inhibition as the core activity with a potential for the treatment of NDs. In particular, MAO inhibitors exhibiting additional acetylcholinesterase (AChE) or nitric oxide synthase (NOS) inhibition, or ion chelation/antioxidant-radical scavenging/anti-inflammatory/A2A receptor antagonist/APP processing modulating activities have been thoroughly examined.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application of 295-64-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.295-64-7, Name is 1,4,7,10,13-Pentaazacyclopentadecane, molecular formula is C10H25N5. In a article£¬once mentioned of 295-64-7

Silica supported polyphosphoric acid catalyzed synthesis of substituted indazoles

A clean and straightforward methodology developed for the synthesis of substituted indazoles using silica supported polyphosphoric acid (PPA-SiO2) catalyzed condensation reaction between substituted 2-hydroxybenzaldehydes or acetophenones and hydrazine hydrate or phenylhydrazine. The reaction conditions are optimized for different solvents at different temperatures. The yield of the products improved to 88 to 90 % using silica supported polyphosphoric acid as a catalyst, which is reusable, cost-effective and straightforward to synthesize.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 295-64-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.295-64-7, Name is 1,4,7,10,13-Pentaazacyclopentadecane, molecular formula is C10H25N5. In a Article£¬once mentioned of 295-64-7

Adsorption and release studies of new cephalosporin from chitosan-g-poly(glycidyl methacrylate) microparticles

Porous microparticles of chitosan-g-poly(glycidyl methacrylate) were obtained by grafting chitosan onto crosslinked networks based on glycidyl methacrylate and ethylene glycol dimethacrylate using suspension polymerization technique. A new cephalosporin from the indazole class prepared by acylation of 7-Aminodesacetoxycephalosporanic acid with mixed anhydride of 5-nitroindazole-1-yl-acetic acid was used as active principle. The cephalosporin-microparticle systems were characterized by FT-IR spectroscopy, SEM and AFM analysis. Batch experiments were carried out to study the influence of initial drug concentration, temperature, contact time, drug:microparticles ratio and pH on the adsorption process of cephalosporin onto porous crosslinked microparticles. Two-parameter and three-parameter isotherm models were used to evaluate the adsorption equilibrium. The values of diffusion coefficients indicate that the cephalosporin adsorption onto microparticles was controlled by both film diffusion and pore diffusion mechanisms. The analysis of the kinetic data of the release process indicate that the release mechanism of cephalosporin from microparticles corresponds to the anomalous transport mechanism.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of 295-64-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 295-64-7, Name is 1,4,7,10,13-Pentaazacyclopentadecane, molecular formula is C10H25N5. In a Patent£¬once mentioned of 295-64-7

PYRROLONE OR PYRROLIDINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are melanin concentrating hormone receptor-1 (MCHR1) antagonists which may be used as medicaments.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 295-64-7. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 295-64-7

Synthesis and Some Transformations of 7-(Fur-2-yl)-1-methyl-1H-pyrazolo[4,3-g][1,3]benzothiazole

N-Methylation of 5-nitro-1H-indazole in a KOH?DMSO system resulted in a mixture of 1-methyl-5(6)-nitroindazoles in a ratio of 1: 2. Reduction of the isomers with tin in concentrated hydrochloric acid afforded pure 1-methyl-1H-indazole-6-amine. Condensation of the latter with furoyl chloride in 2-propanol yielded N-(1-methylindazol-6-yl)furan-2-carboxamide, treatment of which with an excess of P2S5 in anhydrous pyridine gave the corresponding carbothioamide. 7-(Fur-2-yl)-1-methyl-1H-pyrazolo[4,3-g][1,3]benzothiazole was synthesized by Jacobson oxidation of N-(1-methylindazol-6-yl) furan-2-carbothioamide with potassium ferricyanide in an alkaline medium. Some transformations of 7-(fur-2-yl)-1-methyl-1H-pyrazolo[4,3-g][1,3]- benzothiazole such as formylation and acylation were performed.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of 295-64-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.295-64-7, Name is 1,4,7,10,13-Pentaazacyclopentadecane, molecular formula is C10H25N5. In a article£¬once mentioned of 295-64-7

An expedient general synthesis of pyrrolo[3,2-e]indazoles: Domino Sonogashira/Cacchi coupling-heteroannulation reactions

A one-pot Sonogashira coupling-heteroannulation of 4-iodo-1-phenylsulfonyl- 5-trifluoroacetamidoindazole with terminal acetylenes using bis(triphenylphosphine)palladium(II) dichloride as the catalyst, cuprous iodide as the co-catalyst and triethylamine as the base in DMF furnished, after N(3)-deprotection, 7-H/substituted 3,6-dihydropyrrolo[3,2-e]indazoles in high yields. This is the first general synthesis of pyrrolo[3,2-e]indazoles. Uncatalyzed hydrodesilylation was observed during reaction with trimethylsilylacetylene, leading to the 7- unsubstituted parent pyrrolo[3,2-e]indazole.ARKAT-USA, Inc.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ category: catalyst-ligand, Which mentioned a new discovery about 295-64-7

INDAZOLE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein: W is C(=O)NHR1, C(=S)NHR1, or CH2het; Y is H, or CF; R1 is H, C16alkyl, or OC1-6alkyl; X is H, C1-6alkyl, or C3-7cycloalkyl; Z is H, halo, C1-6alkyl, OC1-6alkyl, or SC1-6alkyl; het is a five-(5) or six-(6) membered heterocyclic ring having 1-4 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen within the ring. The compounds are useful as antibacterial agents.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI