Okabe, Masami; Sun, Ruen Chu; Tam, Steve Y. K.; Todaro, Louis J.; Coffen, David L. published the article 《Synthesis of the dideoxynucleosides “”ddC”” and “”CNT”” from glutamic acid, ribonolactone, and pyrimidine bases》. Keywords: dideoxycytidine; cytidine dideoxy; deoxycyanothymidine; thymidine deoxycyano; crystal structure cyanohydroxymethyltetrahydrofuranone; mol structure cyanohydroxymethyltetrahydrofuranone.They researched the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6 ).Recommanded Product: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:32780-06-6) here.
2,3-Dideoxyribose in suitably protected form was prepared from L-glutamic acid and coupled with silylated cytosine to give a mixture of the α- and β-anomers of 2′,3′-dideoxycytidine. The anomer ratio depended on the Lewis acid used in the coupling, with EtAlCl2 favoring the β-anomer ddC (I), a potent anti-HIV drug. Conjugate addition of cyanide to a 4-[(silyloxy)methyl]butenolide prepared from D-ribonolactone gave a mixture of (racemic) α- and β-3-cyanobutyrolactones. Both isomers were reduced to lactols and coupled with thymine to give α/β-anomer pairs. The α-cyano lactone, the structure of which was established by x-ray crystallog. of II, afforded an authentic sample of the putative (but in fact inactive) anti-HIV substance known in AIDS research as CNT (III).
In addition to the literature in the link below, there is a lot of literature about this compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Recommanded Product: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, illustrating the importance and wide applicability of this compound(32780-06-6).
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI