Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， category: catalyst-ligand, Which mentioned a new discovery about 65355-00-2
A series of novel bidentatephosphite ligands, derived from methyl 3,6-anhydro-alpha-d-glucopyranoside and chlorophosphoric acid diaryl ester, were easily synthesized. These ligands were successfully employed in the Cu-catalyzed asymmetric conjugate 1,4-addition of the organozinc reagents diethylzinc and/or dimethylzinc to enones. The stereochemically matched combination of glucopyranoside and (R)-H8-binaphthyl in ligand 2,4-bis{[(R)-1,1?-H8-binaphthyl-2,2?-diyl] phosphite}-methyl 3,6-anhydro-alpha-d-glucopyranoside was essential to afford 85% ee for 3-ethylcyclohexanone with an (S)-configuration in THF, using Cu(OTf)2 as a catalytic precursor. When the reaction was carried out at lower temperatures, changing from -10 to -80 C, a marginal influence of the temperature on the enantioselectivity of the reaction was observed. The presence of the methyl substituent at the 1-position of the glucopyranoside skeleton had a negative effect on the enantioselectivity in the 1,4-addition of ZnEt2 to acyclic enones.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, category: catalyst-ligand, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 65355-00-2
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI